Incidental Mutation 'IGL00225:Ivns1abp'
| ID |
2523 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Ivns1abp
|
| Ensembl Gene |
ENSMUSG00000023150 |
| Gene Name |
influenza virus NS1A binding protein |
| Synonyms |
1190004M08Rik, 1700126I16Rik, Nd1-L, HSPC068, NS1-BP, ND1, Nd1-S, NS-1 |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.405)
|
| Stock # |
IGL00225
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
1 |
| Chromosomal Location |
151220228-151240173 bp(+) (GRCm39) |
| Type of Mutation |
splice site (3 bp from exon) |
| DNA Base Change (assembly) |
A to G
at 151226863 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107518
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023918]
[ENSMUST00000097543]
[ENSMUST00000111887]
[ENSMUST00000186745]
|
| AlphaFold |
Q920Q8 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000023918
|
| SMART Domains |
Protein: ENSMUSP00000023918
Gene: ENSMUSG00000023150
| Domain | Start | End | E-Value | Type |
|---|
|
BTB
|
32 |
129 |
1.89e-25 |
SMART |
|
BACK
|
134 |
233 |
3.39e-8 |
SMART |
|
low complexity region
|
325 |
338 |
N/A |
INTRINSIC |
|
Kelch
|
369 |
415 |
4.78e-15 |
SMART |
|
Kelch
|
416 |
463 |
2.16e-13 |
SMART |
|
Kelch
|
464 |
512 |
2.15e-8 |
SMART |
|
Kelch
|
513 |
559 |
1.58e-15 |
SMART |
|
Kelch
|
560 |
606 |
1.61e-12 |
SMART |
|
Kelch
|
607 |
641 |
1.85e-1 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000097543
|
| SMART Domains |
Protein: ENSMUSP00000095150
Gene: ENSMUSG00000023150
| Domain | Start | End | E-Value | Type |
|---|
|
BTB
|
32 |
129 |
1.89e-25 |
SMART |
|
Pfam:BACK
|
134 |
189 |
3.3e-8 |
PFAM |
|
low complexity region
|
283 |
296 |
N/A |
INTRINSIC |
|
Kelch
|
327 |
373 |
4.78e-15 |
SMART |
|
Kelch
|
374 |
421 |
2.16e-13 |
SMART |
|
Kelch
|
422 |
470 |
2.15e-8 |
SMART |
|
Kelch
|
471 |
517 |
1.58e-15 |
SMART |
|
Kelch
|
518 |
564 |
1.61e-12 |
SMART |
|
Kelch
|
565 |
599 |
1.85e-1 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000111887
|
| SMART Domains |
Protein: ENSMUSP00000107518
Gene: ENSMUSG00000023150
| Domain | Start | End | E-Value | Type |
|---|
|
BTB
|
32 |
129 |
1.89e-25 |
SMART |
|
BACK
|
134 |
219 |
7.04e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000186745
|
| SMART Domains |
Protein: ENSMUSP00000140708
Gene: ENSMUSG00000023150
| Domain | Start | End | E-Value | Type |
|---|
|
BTB
|
32 |
129 |
1.89e-25 |
SMART |
|
BACK
|
134 |
219 |
7.04e-6 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit some early lethality, increased cellular sensitivity to cytochalasin and doxorubicin, and doxorubicin-induced cardiotoxicity. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 20 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Flii |
T |
C |
11: 60,614,241 (GRCm39) |
N93D |
probably benign |
Het |
| Gm8356 |
T |
C |
14: 17,693,287 (GRCm39) |
K24E |
probably damaging |
Het |
| Hars1 |
G |
A |
18: 36,901,225 (GRCm39) |
T409M |
probably damaging |
Het |
| Kcnq4 |
G |
A |
4: 120,555,213 (GRCm39) |
Q657* |
probably null |
Het |
| Kdm4c |
T |
G |
4: 74,263,804 (GRCm39) |
V696G |
probably benign |
Het |
| Klrb1f |
T |
A |
6: 129,030,138 (GRCm39) |
|
probably benign |
Het |
| Lrp4 |
G |
A |
2: 91,325,371 (GRCm39) |
V1399I |
probably benign |
Het |
| LTO1 |
G |
A |
7: 144,471,405 (GRCm39) |
G86D |
possibly damaging |
Het |
| Mki67 |
A |
G |
7: 135,291,849 (GRCm39) |
V3168A |
probably benign |
Het |
| Nf1 |
T |
A |
11: 79,286,731 (GRCm39) |
I177K |
probably damaging |
Het |
| Nnt |
A |
T |
13: 119,506,533 (GRCm39) |
N371K |
probably damaging |
Het |
| Or13a27 |
A |
G |
7: 139,925,123 (GRCm39) |
Y260H |
probably damaging |
Het |
| Or5p52 |
C |
T |
7: 107,502,311 (GRCm39) |
P129L |
probably damaging |
Het |
| Prkdc |
G |
T |
16: 15,627,508 (GRCm39) |
V3389L |
possibly damaging |
Het |
| Prr16 |
T |
A |
18: 51,436,192 (GRCm39) |
Y224N |
possibly damaging |
Het |
| Ptgs1 |
G |
A |
2: 36,127,231 (GRCm39) |
C39Y |
probably damaging |
Het |
| Sla |
T |
C |
15: 66,654,479 (GRCm39) |
D269G |
possibly damaging |
Het |
| Stk38l |
T |
A |
6: 146,659,971 (GRCm39) |
M1K |
probably null |
Het |
| Trim24 |
T |
A |
6: 37,880,583 (GRCm39) |
N160K |
possibly damaging |
Het |
| Zfp451 |
A |
G |
1: 33,825,621 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Ivns1abp |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01616:Ivns1abp
|
APN |
1 |
151,237,294 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02061:Ivns1abp
|
APN |
1 |
151,227,324 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02630:Ivns1abp
|
APN |
1 |
151,235,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8562:Ivns1abp
|
UTSW |
1 |
151,230,446 (GRCm39) |
missense |
probably damaging |
0.98 |
|
PIT1430001:Ivns1abp
|
UTSW |
1 |
151,237,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0107:Ivns1abp
|
UTSW |
1 |
151,237,321 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0609:Ivns1abp
|
UTSW |
1 |
151,235,896 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1104:Ivns1abp
|
UTSW |
1 |
151,235,860 (GRCm39) |
missense |
probably benign |
0.42 |
|
R1463:Ivns1abp
|
UTSW |
1 |
151,237,291 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1512:Ivns1abp
|
UTSW |
1 |
151,236,688 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1512:Ivns1abp
|
UTSW |
1 |
151,236,687 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1521:Ivns1abp
|
UTSW |
1 |
151,227,309 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1550:Ivns1abp
|
UTSW |
1 |
151,237,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2047:Ivns1abp
|
UTSW |
1 |
151,227,382 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2435:Ivns1abp
|
UTSW |
1 |
151,239,061 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4471:Ivns1abp
|
UTSW |
1 |
151,236,990 (GRCm39) |
missense |
probably benign |
0.29 |
|
R5011:Ivns1abp
|
UTSW |
1 |
151,238,953 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5667:Ivns1abp
|
UTSW |
1 |
151,229,760 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5671:Ivns1abp
|
UTSW |
1 |
151,229,760 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6505:Ivns1abp
|
UTSW |
1 |
151,236,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8357:Ivns1abp
|
UTSW |
1 |
151,229,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8457:Ivns1abp
|
UTSW |
1 |
151,229,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Ivns1abp
|
UTSW |
1 |
151,226,784 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Posted On |
2011-12-09 |
Incidental Mutation