Incidental Mutation 'R2570:Or55b10'
ID 252364
Institutional Source Beutler Lab
Gene Symbol Or55b10
Ensembl Gene ENSMUSG00000044824
Gene Name olfactory receptor family 55 subfamily B member 10
Synonyms S50, GA_x6K02T2PBJ9-5216160-5215210, MOR42-1, Olfr545
MMRRC Submission 040428-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # R2570 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 102143030-102143980 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 102143106 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 292 (N292S)
Ref Sequence ENSEMBL: ENSMUSP00000150232 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058750] [ENSMUST00000216116]
AlphaFold Q9WU94
Predicted Effect probably damaging
Transcript: ENSMUST00000058750
AA Change: N292S

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000052396
Gene: ENSMUSG00000044824
AA Change: N292S

DomainStartEndE-ValueType
Pfam:7tm_4 35 314 1.8e-73 PFAM
Pfam:7TM_GPCR_Srsx 39 311 4.3e-8 PFAM
Pfam:7tm_1 45 296 4.6e-15 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211697
AA Change: N292S
Predicted Effect probably damaging
Transcript: ENSMUST00000216116
AA Change: N292S

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217464
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 94.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice carrying a knock-out allele display a normal pattern of axonal projections to a large subset of glomeruli in the dorsal-medial and anterior-medial olfactory bulb, but also show abnormal innervation of glomeruli at the caudal margins of the olfactorybulb. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad10 T A 5: 121,768,267 (GRCm39) N763I probably damaging Het
Actr8 T C 14: 29,709,239 (GRCm39) V281A probably damaging Het
Adam1b A T 5: 121,639,811 (GRCm39) N411K probably damaging Het
Adamdec1 T A 14: 68,816,657 (GRCm39) Q77L probably damaging Het
Adgre4 T A 17: 56,085,878 (GRCm39) F59Y possibly damaging Het
Akr1c18 T C 13: 4,192,163 (GRCm39) N178S probably benign Het
Aldh1a7 T A 19: 20,677,320 (GRCm39) T434S probably benign Het
Bcl10 T A 3: 145,638,785 (GRCm39) N142K probably benign Het
C1qc T C 4: 136,617,402 (GRCm39) I231M probably benign Het
Cacna1b A T 2: 24,496,649 (GRCm39) L2307* probably null Het
Cadm2 G A 16: 66,612,271 (GRCm39) S106L probably damaging Het
Cdc42bpa G A 1: 179,977,742 (GRCm39) R1518Q possibly damaging Het
Cdk12 T G 11: 98,094,618 (GRCm39) M142R possibly damaging Het
Csmd3 CCTTTGCGCTT CCTT 15: 47,604,632 (GRCm39) probably null Het
Cspg4b C T 13: 113,455,121 (GRCm39) T389I probably benign Het
Cyp2c50 C G 19: 40,078,764 (GRCm39) H90D probably benign Het
Dach1 A G 14: 98,138,847 (GRCm39) M480T probably benign Het
Dennd1a A T 2: 37,734,795 (GRCm39) F57L probably damaging Het
Dhcr24 T C 4: 106,443,029 (GRCm39) F355L probably benign Het
Drc1 A G 5: 30,512,609 (GRCm39) R339G probably damaging Het
Efcab3 T A 11: 104,624,490 (GRCm39) S840R probably damaging Het
Efna5 A T 17: 63,188,023 (GRCm39) Y35N probably benign Het
Ehmt1 A G 2: 24,705,753 (GRCm39) V811A probably damaging Het
Fam135a A T 1: 24,061,045 (GRCm39) V1114E probably damaging Het
Frmd8 C A 19: 5,924,740 (GRCm39) R28L probably damaging Het
Gm9936 A G 5: 114,995,605 (GRCm39) probably benign Het
Hgsnat C T 8: 26,435,280 (GRCm39) W618* probably null Het
Itgal T C 7: 126,913,268 (GRCm39) F622L probably damaging Het
Kalrn C T 16: 34,130,865 (GRCm39) E451K probably damaging Het
Kat2a A T 11: 100,601,648 (GRCm39) F256I probably damaging Het
Lama4 A T 10: 38,951,354 (GRCm39) D1033V possibly damaging Het
Lama4 T A 10: 38,982,043 (GRCm39) D1757E probably damaging Het
Laptm5 T C 4: 130,659,358 (GRCm39) Y212H probably damaging Het
Lsm10 T C 4: 125,991,716 (GRCm39) L24P probably damaging Het
Mtcl3 A T 10: 29,022,761 (GRCm39) Q36L possibly damaging Het
Mtfp1 T C 11: 4,044,504 (GRCm39) E27G probably damaging Het
Ncaph2 C A 15: 89,254,678 (GRCm39) D399E probably benign Het
Ncor2 T C 5: 125,105,864 (GRCm39) probably null Het
Nek9 A C 12: 85,379,320 (GRCm39) Y195* probably null Het
Npas1 T C 7: 16,208,628 (GRCm39) D83G probably damaging Het
Nrsn2 A T 2: 152,211,741 (GRCm39) F97I possibly damaging Het
Oas1c T C 5: 120,943,503 (GRCm39) N10S probably benign Het
Or2ag12 A G 7: 106,276,874 (GRCm39) I273T probably benign Het
Or7e165 T A 9: 19,695,305 (GRCm39) L292Q probably damaging Het
Pcdha4 A T 18: 37,086,665 (GRCm39) T283S probably benign Het
Pdk1 A C 2: 71,703,904 (GRCm39) D64A possibly damaging Het
Pramel17 T C 4: 101,694,443 (GRCm39) T147A probably benign Het
Ptpdc1 C T 13: 48,739,539 (GRCm39) A631T probably benign Het
Rasal2 G T 1: 156,988,870 (GRCm39) A660E possibly damaging Het
Sgpp2 T A 1: 78,336,787 (GRCm39) V55E possibly damaging Het
Shank2 A T 7: 143,622,507 (GRCm39) I214F probably damaging Het
Slfn14 T C 11: 83,174,433 (GRCm39) N186S probably benign Het
Sptbn5 A T 2: 119,879,121 (GRCm39) noncoding transcript Het
Stradb C T 1: 59,027,743 (GRCm39) T91I probably damaging Het
Sulf2 T C 2: 165,927,721 (GRCm39) I359V probably benign Het
Tbl3 A T 17: 24,922,290 (GRCm39) M405K possibly damaging Het
Tecta G T 9: 42,243,848 (GRCm39) D2001E probably damaging Het
Tectb C G 19: 55,169,431 (GRCm39) probably benign Het
Tgfbi T A 13: 56,786,521 (GRCm39) probably null Het
Tmem132a A T 19: 10,837,106 (GRCm39) L612Q probably null Het
Tnf T C 17: 35,419,476 (GRCm39) N102S probably damaging Het
Trib3 A T 2: 152,185,156 (GRCm39) V31D probably benign Het
Ube2q2 T A 9: 55,099,140 (GRCm39) F248L probably benign Het
Usf3 T C 16: 44,036,744 (GRCm39) V408A probably benign Het
Vmn1r159 T C 7: 22,542,307 (GRCm39) M242V probably benign Het
Vmn2r105 A T 17: 20,447,585 (GRCm39) L413H probably damaging Het
Zbtb2 T G 10: 4,318,673 (GRCm39) N451T probably damaging Het
Zfp593 C A 4: 133,972,869 (GRCm39) probably benign Het
Other mutations in Or55b10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02001:Or55b10 APN 7 102,143,746 (GRCm39) missense probably benign 0.31
R1732:Or55b10 UTSW 7 102,143,247 (GRCm39) missense probably damaging 1.00
R1927:Or55b10 UTSW 7 102,143,266 (GRCm39) missense possibly damaging 0.89
R4693:Or55b10 UTSW 7 102,143,659 (GRCm39) missense probably damaging 0.98
R5777:Or55b10 UTSW 7 102,143,178 (GRCm39) missense probably benign 0.01
R6481:Or55b10 UTSW 7 102,143,346 (GRCm39) missense probably damaging 0.97
R6597:Or55b10 UTSW 7 102,143,628 (GRCm39) missense probably damaging 1.00
R7562:Or55b10 UTSW 7 102,143,227 (GRCm39) missense possibly damaging 0.90
R7715:Or55b10 UTSW 7 102,143,668 (GRCm39) missense possibly damaging 0.91
R8027:Or55b10 UTSW 7 102,143,629 (GRCm39) missense probably damaging 0.98
R8238:Or55b10 UTSW 7 102,143,827 (GRCm39) missense possibly damaging 0.65
R9094:Or55b10 UTSW 7 102,143,568 (GRCm39) missense possibly damaging 0.71
R9320:Or55b10 UTSW 7 102,144,084 (GRCm39) start gained probably benign
R9427:Or55b10 UTSW 7 102,143,206 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TGGTAGCAGTTTGGTCCCTC -3'
(R):5'- GATATGCTCCTTCTAGGCACC -3'

Sequencing Primer
(F):5'- GTAGCAGTTTGGTCCCTCTGTAC -3'
(R):5'- CCTTCAGGATCTCATCAGGTGGAG -3'
Posted On 2014-12-04