Incidental Mutation 'R2571:Chil6'
ID252475
Institutional Source Beutler Lab
Gene Symbol Chil6
Ensembl Gene ENSMUSG00000027902
Gene Namechitinase-like 6
SynonymsBYm, BC051070
MMRRC Submission 040429-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.051) question?
Stock #R2571 (G1)
Quality Score225
Status Not validated
Chromosome3
Chromosomal Location106387384-106406182 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 106390393 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 229 (Y229*)
Ref Sequence ENSEMBL: ENSMUSP00000029510 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029510]
Predicted Effect probably null
Transcript: ENSMUST00000029510
AA Change: Y229*
SMART Domains Protein: ENSMUSP00000029510
Gene: ENSMUSG00000027902
AA Change: Y229*

DomainStartEndE-ValueType
Glyco_18 39 382 3.04e-122 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,249,885 N2438S probably benign Het
Ago3 G A 4: 126,363,811 R476W probably damaging Het
Akap8 T C 17: 32,315,455 E339G probably damaging Het
Apba2 T C 7: 64,745,750 V658A probably damaging Het
BC049730 A G 7: 24,713,394 I76V probably benign Het
Bcl3 T C 7: 19,809,527 D338G probably damaging Het
Ccdc138 T C 10: 58,513,222 Y197H probably benign Het
Ccdc162 T A 10: 41,552,397 Q499L probably damaging Het
Ccser1 G A 6: 61,422,960 C21Y probably damaging Het
Cntnap5a C T 1: 116,184,362 R461C probably damaging Het
Col19a1 T A 1: 24,374,631 R407S unknown Het
Crlf3 A T 11: 80,047,513 F433I probably benign Het
Csmd3 CCTTTGCGCTT CCTT 15: 47,741,236 probably null Het
Dnah10 A T 5: 124,775,478 R1867W probably damaging Het
Dsg3 T C 18: 20,540,005 V911A probably benign Het
Dzip3 T C 16: 48,972,218 probably null Het
Evpl T C 11: 116,237,969 Q10R unknown Het
Glra3 C T 8: 56,110,481 A337V probably benign Het
Gm8909 C T 17: 36,167,661 G132R possibly damaging Het
Hcfc2 T C 10: 82,709,023 F163S probably damaging Het
Hells T C 19: 38,959,733 V701A possibly damaging Het
Helz A G 11: 107,613,952 T422A probably benign Het
Hhat G A 1: 192,553,022 T442I probably damaging Het
Hmces A T 6: 87,936,220 Q319L possibly damaging Het
Ighv1-62-1 T A 12: 115,386,757 T97S probably damaging Het
Impad1 C T 4: 4,778,192 probably null Het
Kcne2 C T 16: 92,296,912 T109I probably damaging Het
Kcnq1 T G 7: 143,107,696 L113R probably benign Het
Kdm5d T C Y: 940,932 S1106P probably benign Het
Kel C A 6: 41,688,067 A588S possibly damaging Het
Kmt2e T A 5: 23,501,887 F1483I probably benign Het
Krt4 T A 15: 101,921,257 N279Y probably damaging Het
Lama4 T A 10: 39,042,675 M384K possibly damaging Het
Lepr C T 4: 101,768,172 T508I possibly damaging Het
Map1lc3b T A 8: 121,593,474 probably null Het
Me1 T C 9: 86,654,698 H108R probably damaging Het
Mindy4 T C 6: 55,284,785 S560P probably damaging Het
Mmp3 T A 9: 7,451,844 I394N possibly damaging Het
Mmrn2 T C 14: 34,402,939 S826P probably damaging Het
Olfr702 T A 7: 106,823,726 M267L probably benign Het
Osbpl7 T C 11: 97,054,841 L138P probably damaging Het
Pcdhga11 G A 18: 37,756,868 E310K probably damaging Het
Pcif1 A G 2: 164,884,211 D39G probably damaging Het
Ppp1r21 C T 17: 88,545,382 T63I probably benign Het
Prickle2 T C 6: 92,705,400 Q25R probably benign Het
Ptk2 A G 15: 73,231,919 L94P probably damaging Het
Ptprg T C 14: 12,122,135 F333S probably benign Het
Rag2 T A 2: 101,629,967 H207Q probably damaging Het
Rps6ka1 G T 4: 133,860,612 probably null Het
Rps6ka4 G T 19: 6,838,103 H174Q probably damaging Het
Rreb1 C A 13: 37,899,637 T92K probably damaging Het
Ryr1 A T 7: 29,009,562 M4793K unknown Het
Ryr1 T A 7: 29,036,126 M4076L possibly damaging Het
Sec16a A C 2: 26,439,331 S891A probably benign Het
Sgsh A G 11: 119,350,514 Y132H probably damaging Het
Sos2 T A 12: 69,635,718 E242V possibly damaging Het
Spata31d1c G T 13: 65,036,384 R580L probably damaging Het
Spata9 C A 13: 75,967,761 probably benign Het
Tead2 T A 7: 45,225,770 V202E probably damaging Het
Thada T C 17: 84,454,640 K168E probably damaging Het
Tmem64 T C 4: 15,266,718 I256T probably damaging Het
Tra2a G T 6: 49,252,487 probably benign Het
Trim30a T A 7: 104,429,326 N181I possibly damaging Het
Ttc13 A C 8: 124,683,799 Y372D probably damaging Het
Vit T C 17: 78,586,745 V192A probably benign Het
Vmn2r69 T C 7: 85,415,556 T41A probably benign Het
Vps13d C A 4: 145,149,136 K1600N probably benign Het
Xpnpep3 A T 15: 81,450,926 H420L probably damaging Het
Zfp322a A G 13: 23,356,444 L376P probably damaging Het
Zfp619 T C 7: 39,537,171 L875P probably damaging Het
Zic5 T A 14: 122,459,478 Q575L unknown Het
Other mutations in Chil6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01411:Chil6 APN 3 106388825 missense probably damaging 1.00
IGL01735:Chil6 APN 3 106388688 critical splice donor site probably null
IGL01795:Chil6 APN 3 106388792 missense probably damaging 0.96
IGL02505:Chil6 APN 3 106405962 missense probably benign
IGL03164:Chil6 APN 3 106394398 missense probably benign 0.04
cold_cut UTSW 3 106389974 missense probably damaging 1.00
R0409:Chil6 UTSW 3 106404176 missense probably benign 0.44
R1761:Chil6 UTSW 3 106394338 missense probably damaging 1.00
R1967:Chil6 UTSW 3 106391154 missense possibly damaging 0.84
R3024:Chil6 UTSW 3 106388770 missense probably damaging 1.00
R3829:Chil6 UTSW 3 106405958 missense probably benign 0.00
R4835:Chil6 UTSW 3 106405974 nonsense probably null
R4851:Chil6 UTSW 3 106389928 missense possibly damaging 0.61
R4948:Chil6 UTSW 3 106388672 intron probably benign
R5056:Chil6 UTSW 3 106394343 missense probably damaging 1.00
R5244:Chil6 UTSW 3 106389974 missense probably damaging 1.00
R5555:Chil6 UTSW 3 106389952 missense possibly damaging 0.87
R5594:Chil6 UTSW 3 106394429 splice site probably null
R5633:Chil6 UTSW 3 106388752 missense probably damaging 1.00
R6194:Chil6 UTSW 3 106404876 critical splice donor site probably null
R6587:Chil6 UTSW 3 106404881 missense probably benign
R6613:Chil6 UTSW 3 106389875 missense probably benign 0.25
R6641:Chil6 UTSW 3 106388924 missense possibly damaging 0.61
R6651:Chil6 UTSW 3 106404260 missense probably damaging 1.00
R7094:Chil6 UTSW 3 106404170 missense probably damaging 0.96
R7161:Chil6 UTSW 3 106394412 missense probably benign 0.01
R7653:Chil6 UTSW 3 106394325 missense possibly damaging 0.82
X0026:Chil6 UTSW 3 106388968 missense probably benign 0.02
X0064:Chil6 UTSW 3 106404319 nonsense probably null
Predicted Primers PCR Primer
(F):5'- GTCAATGAGACGTGATTGATGAATT -3'
(R):5'- AAATGTCATCTTTTGCTGGAGTAGG -3'

Sequencing Primer
(F):5'- GCATCGCTTATCTGTGCA -3'
(R):5'- TCTGAGAGTGTCTACCAGCAACTG -3'
Posted On2014-12-04