Incidental Mutation 'R2859:Fmo9'
ID |
252608 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Fmo9
|
Ensembl Gene |
ENSMUSG00000026560 |
Gene Name |
flavin containing monooxygenase 9 |
Synonyms |
4831428F09Rik |
MMRRC Submission |
040449-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.063)
|
Stock # |
R2859 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
1 |
Chromosomal Location |
166489624-166509414 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to C
at 166501236 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Phenylalanine to Cysteine
at position 237
(F237C)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000027843
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027843]
[ENSMUST00000148677]
|
AlphaFold |
Q8C116 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000027843
AA Change: F237C
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000027843 Gene: ENSMUSG00000026560 AA Change: F237C
Domain | Start | End | E-Value | Type |
Pfam:FMO-like
|
3 |
535 |
1.2e-252 |
PFAM |
Pfam:Pyr_redox_2
|
4 |
262 |
2.9e-12 |
PFAM |
Pfam:Pyr_redox_3
|
7 |
221 |
2.3e-14 |
PFAM |
Pfam:NAD_binding_8
|
8 |
83 |
1.2e-6 |
PFAM |
Pfam:K_oxygenase
|
77 |
334 |
8.9e-11 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000148677
AA Change: F186C
PolyPhen 2
Score 0.511 (Sensitivity: 0.88; Specificity: 0.90)
|
SMART Domains |
Protein: ENSMUSP00000114750 Gene: ENSMUSG00000026560 AA Change: F186C
Domain | Start | End | E-Value | Type |
Pfam:FMO-like
|
1 |
484 |
1.6e-222 |
PFAM |
Pfam:Pyr_redox_3
|
3 |
170 |
1.2e-12 |
PFAM |
Pfam:K_oxygenase
|
28 |
283 |
6.2e-11 |
PFAM |
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.1%
|
Validation Efficiency |
100% (40/40) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 38 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca17 |
T |
C |
17: 24,500,288 (GRCm39) |
Y1301C |
possibly damaging |
Het |
Amfr |
A |
T |
8: 94,731,842 (GRCm39) |
N11K |
probably damaging |
Het |
Cadm3 |
A |
G |
1: 173,174,112 (GRCm39) |
S34P |
possibly damaging |
Het |
Cd109 |
CATTTATTTATTTATTTATTTATTTATTTATTTAT |
CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT |
9: 78,619,782 (GRCm39) |
|
probably benign |
Het |
Cdh23 |
C |
T |
10: 60,218,432 (GRCm39) |
|
probably null |
Het |
Ceacam1 |
T |
A |
7: 25,173,442 (GRCm39) |
I249F |
probably damaging |
Het |
Cuzd1 |
C |
T |
7: 130,917,863 (GRCm39) |
V246M |
probably damaging |
Het |
Ehd2 |
A |
T |
7: 15,698,054 (GRCm39) |
V61E |
probably damaging |
Het |
Fibin |
C |
T |
2: 110,192,542 (GRCm39) |
R200H |
probably damaging |
Het |
Garin3 |
T |
C |
11: 46,296,039 (GRCm39) |
I137T |
probably damaging |
Het |
Hivep2 |
C |
A |
10: 14,004,713 (GRCm39) |
T437K |
probably benign |
Het |
Iqgap3 |
C |
A |
3: 88,014,903 (GRCm39) |
S873* |
probably null |
Het |
Ism2 |
T |
C |
12: 87,346,437 (GRCm39) |
M15V |
unknown |
Het |
Itk |
T |
G |
11: 46,235,662 (GRCm39) |
|
probably benign |
Het |
Mastl |
C |
A |
2: 23,029,979 (GRCm39) |
C249F |
probably damaging |
Het |
Mink1 |
T |
C |
11: 70,503,334 (GRCm39) |
V1143A |
probably damaging |
Het |
Mrgprb4 |
T |
A |
7: 47,848,084 (GRCm39) |
R281S |
possibly damaging |
Het |
Mthfd1 |
T |
C |
12: 76,335,699 (GRCm39) |
Y258H |
probably damaging |
Het |
Ntmt1 |
A |
G |
2: 30,712,377 (GRCm39) |
H140R |
probably damaging |
Het |
Or1j12 |
T |
C |
2: 36,343,142 (GRCm39) |
S182P |
probably benign |
Het |
Or3a10 |
C |
T |
11: 73,935,653 (GRCm39) |
G149D |
possibly damaging |
Het |
Or3a1b |
T |
C |
11: 74,012,808 (GRCm39) |
I231T |
probably damaging |
Het |
Or9e1 |
T |
A |
11: 58,732,708 (GRCm39) |
V256E |
probably benign |
Het |
Parm1 |
A |
G |
5: 91,742,165 (GRCm39) |
T178A |
possibly damaging |
Het |
Patl1 |
T |
C |
19: 11,901,195 (GRCm39) |
F282L |
probably damaging |
Het |
Phospho2 |
T |
C |
2: 69,626,195 (GRCm39) |
V117A |
possibly damaging |
Het |
Ppp4r3a |
T |
C |
12: 101,008,906 (GRCm39) |
|
probably null |
Het |
Pramel29 |
A |
G |
4: 143,936,192 (GRCm39) |
S23P |
probably benign |
Het |
Rbm17 |
A |
G |
2: 11,595,515 (GRCm39) |
F230S |
possibly damaging |
Het |
Robo3 |
C |
A |
9: 37,339,400 (GRCm39) |
G196* |
probably null |
Het |
Samhd1 |
A |
G |
2: 156,948,149 (GRCm39) |
|
probably null |
Het |
Setx |
GTGGCT |
GT |
2: 29,044,073 (GRCm39) |
1814 |
probably null |
Het |
Thbs4 |
A |
G |
13: 92,927,216 (GRCm39) |
F91S |
probably benign |
Het |
Trim34b |
A |
T |
7: 103,985,439 (GRCm39) |
N358I |
probably benign |
Het |
Ulk1 |
A |
G |
5: 110,942,495 (GRCm39) |
L255P |
probably damaging |
Het |
Vmn2r104 |
T |
A |
17: 20,268,455 (GRCm39) |
I5F |
possibly damaging |
Het |
Vrk2 |
C |
A |
11: 26,433,324 (GRCm39) |
S286I |
possibly damaging |
Het |
Zswim3 |
T |
C |
2: 164,662,309 (GRCm39) |
L263P |
probably damaging |
Het |
|
Other mutations in Fmo9 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00886:Fmo9
|
APN |
1 |
166,507,714 (GRCm39) |
splice site |
probably null |
|
IGL01796:Fmo9
|
APN |
1 |
166,490,904 (GRCm39) |
missense |
probably benign |
0.31 |
IGL03005:Fmo9
|
APN |
1 |
166,502,088 (GRCm39) |
missense |
probably benign |
0.02 |
IGL03115:Fmo9
|
APN |
1 |
166,505,220 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03163:Fmo9
|
APN |
1 |
166,502,019 (GRCm39) |
missense |
possibly damaging |
0.77 |
R0089:Fmo9
|
UTSW |
1 |
166,494,878 (GRCm39) |
missense |
probably benign |
0.05 |
R0570:Fmo9
|
UTSW |
1 |
166,502,031 (GRCm39) |
missense |
probably null |
0.00 |
R1520:Fmo9
|
UTSW |
1 |
166,495,024 (GRCm39) |
missense |
probably benign |
0.19 |
R1779:Fmo9
|
UTSW |
1 |
166,490,868 (GRCm39) |
missense |
probably benign |
0.18 |
R1783:Fmo9
|
UTSW |
1 |
166,501,217 (GRCm39) |
missense |
probably benign |
0.01 |
R2858:Fmo9
|
UTSW |
1 |
166,501,236 (GRCm39) |
missense |
probably damaging |
1.00 |
R3851:Fmo9
|
UTSW |
1 |
166,490,936 (GRCm39) |
missense |
probably benign |
0.00 |
R3924:Fmo9
|
UTSW |
1 |
166,492,221 (GRCm39) |
missense |
probably benign |
0.03 |
R4470:Fmo9
|
UTSW |
1 |
166,507,799 (GRCm39) |
missense |
probably damaging |
1.00 |
R4728:Fmo9
|
UTSW |
1 |
166,490,880 (GRCm39) |
missense |
possibly damaging |
0.82 |
R5538:Fmo9
|
UTSW |
1 |
166,501,198 (GRCm39) |
missense |
probably benign |
0.01 |
R5650:Fmo9
|
UTSW |
1 |
166,491,015 (GRCm39) |
missense |
probably damaging |
1.00 |
R5820:Fmo9
|
UTSW |
1 |
166,492,170 (GRCm39) |
missense |
possibly damaging |
0.67 |
R6163:Fmo9
|
UTSW |
1 |
166,494,962 (GRCm39) |
missense |
probably benign |
|
R6229:Fmo9
|
UTSW |
1 |
166,505,126 (GRCm39) |
missense |
possibly damaging |
0.64 |
R6243:Fmo9
|
UTSW |
1 |
166,494,938 (GRCm39) |
missense |
probably benign |
0.45 |
R6375:Fmo9
|
UTSW |
1 |
166,492,164 (GRCm39) |
critical splice donor site |
probably null |
|
R7144:Fmo9
|
UTSW |
1 |
166,505,189 (GRCm39) |
missense |
probably benign |
0.40 |
R7236:Fmo9
|
UTSW |
1 |
166,504,140 (GRCm39) |
missense |
probably damaging |
1.00 |
R7316:Fmo9
|
UTSW |
1 |
166,491,215 (GRCm39) |
missense |
probably benign |
0.21 |
R7341:Fmo9
|
UTSW |
1 |
166,504,115 (GRCm39) |
missense |
probably damaging |
1.00 |
R7382:Fmo9
|
UTSW |
1 |
166,491,229 (GRCm39) |
splice site |
probably null |
|
R7589:Fmo9
|
UTSW |
1 |
166,501,997 (GRCm39) |
missense |
possibly damaging |
0.61 |
R7679:Fmo9
|
UTSW |
1 |
166,495,058 (GRCm39) |
missense |
probably benign |
0.01 |
R8110:Fmo9
|
UTSW |
1 |
166,491,095 (GRCm39) |
missense |
probably benign |
0.03 |
R8500:Fmo9
|
UTSW |
1 |
166,502,039 (GRCm39) |
missense |
probably damaging |
1.00 |
R9098:Fmo9
|
UTSW |
1 |
166,492,199 (GRCm39) |
missense |
possibly damaging |
0.48 |
R9301:Fmo9
|
UTSW |
1 |
166,494,794 (GRCm39) |
missense |
probably damaging |
1.00 |
R9400:Fmo9
|
UTSW |
1 |
166,505,243 (GRCm39) |
missense |
probably benign |
0.09 |
R9401:Fmo9
|
UTSW |
1 |
166,505,189 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1088:Fmo9
|
UTSW |
1 |
166,501,114 (GRCm39) |
critical splice donor site |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- GGAACCAAAAGTTGACTTGTCTTC -3'
(R):5'- TGACTAAGCACAGCATGGTGG -3'
Sequencing Primer
(F):5'- CTTGTCTTCAAAGTAAAATGCTCACC -3'
(R):5'- ATGGTGGTCACTGTCCAAC -3'
|
Posted On |
2014-12-04 |