Incidental Mutation 'R2656:Nmt2'
ID 252703
Institutional Source Beutler Lab
Gene Symbol Nmt2
Ensembl Gene ENSMUSG00000026643
Gene Name N-myristoyltransferase 2
Synonyms hNMT-2, A930001K02Rik
MMRRC Submission 040431-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R2656 (G1)
Quality Score 165
Status Not validated
Chromosome 2
Chromosomal Location 3285249-3329914 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 3308050 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 107 (D107G)
Ref Sequence ENSEMBL: ENSMUSP00000080600 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081932] [ENSMUST00000091504] [ENSMUST00000102989]
AlphaFold O70311
Predicted Effect probably benign
Transcript: ENSMUST00000081932
AA Change: D107G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000080600
Gene: ENSMUSG00000026643
AA Change: D107G

DomainStartEndE-ValueType
low complexity region 5 16 N/A INTRINSIC
low complexity region 46 58 N/A INTRINSIC
Pfam:NMT 170 327 1e-78 PFAM
Pfam:NMT_C 341 528 2.9e-83 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000091504
SMART Domains Protein: ENSMUSP00000089085
Gene: ENSMUSG00000026643

DomainStartEndE-ValueType
low complexity region 19 30 N/A INTRINSIC
Pfam:NMT 124 283 2e-84 PFAM
Pfam:NMT_C 297 484 1.4e-87 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000102989
SMART Domains Protein: ENSMUSP00000100054
Gene: ENSMUSG00000026643

DomainStartEndE-ValueType
low complexity region 5 16 N/A INTRINSIC
low complexity region 46 58 N/A INTRINSIC
Pfam:NMT 137 296 7.8e-85 PFAM
Pfam:NMT_C 310 497 6.4e-88 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155761
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
PHENOTYPE: Mice homozygous for a conditional allele knocked out in T cells exhibit reduced T cell, double positive T cell and single positive T cell numbers. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam22 A G 5: 8,167,696 (GRCm39) C655R probably damaging Het
Adgrf3 A T 5: 30,401,436 (GRCm39) V864D possibly damaging Het
Angptl3 A G 4: 98,926,201 (GRCm39) I444V probably benign Het
Atp8b2 C T 3: 89,849,065 (GRCm39) A1090T probably benign Het
Bcl2l2 C T 14: 55,122,889 (GRCm39) R47C probably benign Het
Ces2a G A 8: 105,462,766 (GRCm39) M118I probably benign Het
Cyp4a29 T G 4: 115,106,921 (GRCm39) L193V possibly damaging Het
Dpp8 A G 9: 64,988,086 (GRCm39) Y877C probably damaging Het
Enpp6 C T 8: 47,535,453 (GRCm39) R33* probably null Het
Fsip2 G A 2: 82,809,389 (GRCm39) D1903N possibly damaging Het
Ggt1 T A 10: 75,417,219 (GRCm39) Y5* probably null Het
Gm14412 A T 2: 177,006,993 (GRCm39) C301S unknown Het
Gpatch2l T A 12: 86,335,584 (GRCm39) D428E probably damaging Het
Grin2b C T 6: 135,710,427 (GRCm39) G1040S probably damaging Het
Has2 T C 15: 56,545,224 (GRCm39) D126G possibly damaging Het
Itgam T G 7: 127,715,987 (GRCm39) L1120R probably null Het
Kank4 T C 4: 98,667,194 (GRCm39) N418D probably damaging Het
Kcnk3 T C 5: 30,780,015 (GRCm39) V355A possibly damaging Het
Lonrf2 C T 1: 38,855,041 (GRCm39) probably null Het
Lrp1b A T 2: 41,401,593 (GRCm39) C240S probably damaging Het
Mapk8ip3 T G 17: 25,131,781 (GRCm39) E386A probably damaging Het
Mtmr14 A G 6: 113,217,327 (GRCm39) I80V probably benign Het
Nav2 A C 7: 49,195,690 (GRCm39) D961A probably damaging Het
Nsd1 A G 13: 55,394,681 (GRCm39) K761E probably damaging Het
Ogdh A G 11: 6,298,678 (GRCm39) T641A probably benign Het
Ogdhl T G 14: 32,054,783 (GRCm39) F244V possibly damaging Het
Or2ag17 T A 7: 106,389,720 (GRCm39) T163S probably damaging Het
Or51k1 G A 7: 103,661,072 (GRCm39) S279L probably damaging Het
Or5b102 A T 19: 13,041,348 (GRCm39) H191L probably benign Het
Or5b97 A G 19: 12,879,030 (GRCm39) I38T probably benign Het
Pfpl T C 19: 12,407,600 (GRCm39) I617T probably benign Het
Ppfia2 T G 10: 106,701,268 (GRCm39) probably null Het
Prickle1 T C 15: 93,401,251 (GRCm39) E411G probably benign Het
Prpsap2 C A 11: 61,621,051 (GRCm39) M343I probably benign Het
Prpsap2 A G 11: 61,643,717 (GRCm39) V72A probably benign Het
Ranbp17 A T 11: 33,193,122 (GRCm39) D977E probably benign Het
Rin1 T C 19: 5,102,204 (GRCm39) S238P probably damaging Het
Scap C T 9: 110,203,087 (GRCm39) R254W probably damaging Het
Scn3a T C 2: 65,356,862 (GRCm39) D194G probably damaging Het
Shisa7 T C 7: 4,832,818 (GRCm39) H481R possibly damaging Het
Slc6a6 T C 6: 91,718,029 (GRCm39) Y323H probably damaging Het
Thoc2l A G 5: 104,667,181 (GRCm39) I568V probably benign Het
Tlr9 T C 9: 106,101,140 (GRCm39) S144P probably benign Het
Tmem69 T A 4: 116,410,787 (GRCm39) K61M probably damaging Het
Ttc21a A G 9: 119,770,331 (GRCm39) D134G probably damaging Het
Ttn A G 2: 76,724,614 (GRCm39) probably benign Het
Vwf A G 6: 125,532,324 (GRCm39) T26A probably benign Het
Zbtb16 A T 9: 48,743,988 (GRCm39) I108N probably damaging Het
Zc3h7b T A 15: 81,664,631 (GRCm39) Y497N probably damaging Het
Zfp652 A G 11: 95,640,155 (GRCm39) S27G probably damaging Het
Zfp808 A G 13: 62,320,666 (GRCm39) T632A possibly damaging Het
Znhit6 T C 3: 145,283,924 (GRCm39) probably null Het
Other mutations in Nmt2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00783:Nmt2 APN 2 3,315,846 (GRCm39) missense probably damaging 1.00
IGL00784:Nmt2 APN 2 3,315,846 (GRCm39) missense probably damaging 1.00
IGL01871:Nmt2 APN 2 3,313,711 (GRCm39) missense probably damaging 1.00
IGL02617:Nmt2 APN 2 3,315,750 (GRCm39) missense probably benign 0.15
Faul UTSW 2 3,306,341 (GRCm39) splice site probably null
ANU05:Nmt2 UTSW 2 3,315,731 (GRCm39) missense probably benign
R0278:Nmt2 UTSW 2 3,326,424 (GRCm39) missense probably benign 0.00
R0524:Nmt2 UTSW 2 3,306,474 (GRCm39) missense probably benign
R0743:Nmt2 UTSW 2 3,315,822 (GRCm39) nonsense probably null
R0884:Nmt2 UTSW 2 3,315,822 (GRCm39) nonsense probably null
R1895:Nmt2 UTSW 2 3,323,672 (GRCm39) missense probably benign 0.11
R1946:Nmt2 UTSW 2 3,323,672 (GRCm39) missense probably benign 0.11
R1957:Nmt2 UTSW 2 3,326,419 (GRCm39) missense possibly damaging 0.95
R2037:Nmt2 UTSW 2 3,310,618 (GRCm39) missense probably damaging 1.00
R3422:Nmt2 UTSW 2 3,285,425 (GRCm39) missense possibly damaging 0.82
R3835:Nmt2 UTSW 2 3,315,723 (GRCm39) splice site probably benign
R3955:Nmt2 UTSW 2 3,313,535 (GRCm39) missense probably benign 0.00
R4701:Nmt2 UTSW 2 3,323,678 (GRCm39) missense probably benign
R5032:Nmt2 UTSW 2 3,285,429 (GRCm39) missense probably benign
R6373:Nmt2 UTSW 2 3,325,988 (GRCm39) missense probably benign 0.05
R6396:Nmt2 UTSW 2 3,315,738 (GRCm39) missense probably benign 0.18
R6410:Nmt2 UTSW 2 3,317,215 (GRCm39) missense probably damaging 1.00
R6863:Nmt2 UTSW 2 3,306,341 (GRCm39) splice site probably null
R6865:Nmt2 UTSW 2 3,315,766 (GRCm39) missense probably damaging 1.00
R7100:Nmt2 UTSW 2 3,313,950 (GRCm39) missense probably benign
R7139:Nmt2 UTSW 2 3,285,352 (GRCm39) missense probably benign 0.01
R7516:Nmt2 UTSW 2 3,313,767 (GRCm39) missense probably damaging 1.00
R9098:Nmt2 UTSW 2 3,306,315 (GRCm39) intron probably benign
R9581:Nmt2 UTSW 2 3,317,212 (GRCm39) missense possibly damaging 0.80
X0067:Nmt2 UTSW 2 3,325,998 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ATGGGCACAGGATGTAGTTG -3'
(R):5'- GCTGTGCTACAAGTAACAGC -3'

Sequencing Primer
(F):5'- GCACAGGATGTAGTTGGTATTTAG -3'
(R):5'- TTGAGACAAGGTCTCCCT -3'
Posted On 2014-12-04