Incidental Mutation 'R2861:Vmn2r72'
ID 252718
Institutional Source Beutler Lab
Gene Symbol Vmn2r72
Ensembl Gene ENSMUSG00000051877
Gene Name vomeronasal 2, receptor 72
Synonyms EG244114, Vmn2r72-ps
MMRRC Submission 040451-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R2861 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 85386992-85404189 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 85400044 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 335 (I335N)
Ref Sequence ENSEMBL: ENSMUSP00000133014 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063425]
AlphaFold D3Z4N8
Predicted Effect probably damaging
Transcript: ENSMUST00000063425
AA Change: I335N

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: I335N

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 82 469 2.3e-28 PFAM
Pfam:NCD3G 512 564 1.2e-18 PFAM
Pfam:7tm_3 594 832 4e-53 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.7%
  • 20x: 96.1%
Validation Efficiency 100% (54/54)
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,259,057 (GRCm39) S2928G probably damaging Het
Abcc9 C T 6: 142,571,736 (GRCm39) V1131M probably benign Het
Abcd1 T A X: 72,781,064 (GRCm39) L713H probably damaging Het
Actg1 T C 11: 120,237,627 (GRCm39) I52V probably benign Het
Ang G T 14: 51,339,275 (GRCm39) D139Y probably damaging Het
Ano1 C T 7: 144,143,749 (GRCm39) G1011E probably damaging Het
Apoe T C 7: 19,431,479 (GRCm39) Y46C probably damaging Het
Ash1l T C 3: 88,961,785 (GRCm39) W2386R probably damaging Het
Asph T C 4: 9,598,277 (GRCm39) D250G probably damaging Het
Atr A G 9: 95,756,296 (GRCm39) N836S probably benign Het
Bltp1 G A 3: 37,019,998 (GRCm39) S2079N probably damaging Het
Btg3 A G 16: 78,161,868 (GRCm39) V114A probably damaging Het
C2 T C 17: 35,082,854 (GRCm39) T471A possibly damaging Het
C4b T A 17: 34,953,732 (GRCm39) S959C probably damaging Het
Cap1 A T 4: 122,758,518 (GRCm39) S221T probably benign Het
Capn2 A T 1: 182,300,485 (GRCm39) probably benign Het
Cd38 A G 5: 44,058,775 (GRCm39) S130G probably damaging Het
Cd8b1 A G 6: 71,311,085 (GRCm39) R202G probably damaging Het
Col22a1 A G 15: 71,687,792 (GRCm39) probably null Het
Cps1 A T 1: 67,205,534 (GRCm39) E519V probably benign Het
Cyp2c38 G A 19: 39,449,138 (GRCm39) R72W probably benign Het
Cyp3a16 A T 5: 145,392,309 (GRCm39) Y215* probably null Het
Dennd10 T C 19: 60,803,232 (GRCm39) S80P probably benign Het
F5 A T 1: 164,012,533 (GRCm39) K482N probably damaging Het
Gab1 T C 8: 81,511,382 (GRCm39) M488V probably benign Het
Gabpb1 A G 2: 126,495,494 (GRCm39) I86T probably damaging Het
Gbx2 C T 1: 89,856,853 (GRCm39) R179Q probably damaging Het
Gm11938 C A 11: 99,493,972 (GRCm39) R41L probably damaging Het
Gpn1 A G 5: 31,654,664 (GRCm39) D72G probably damaging Het
Greb1 A G 12: 16,761,746 (GRCm39) S545P probably benign Het
Hsd3b7 T G 7: 127,401,442 (GRCm39) L189R probably damaging Het
Iglc1 T C 16: 18,880,660 (GRCm39) probably benign Het
Il18r1 T C 1: 40,537,717 (GRCm39) V494A possibly damaging Het
Inka1 T C 9: 107,861,603 (GRCm39) T238A probably benign Het
Itsn2 C A 12: 4,750,315 (GRCm39) probably benign Het
Kcnn1 T C 8: 71,299,179 (GRCm39) K487R probably benign Het
Kdf1 G A 4: 133,255,852 (GRCm39) E190K probably damaging Het
Klhdc10 G A 6: 30,402,139 (GRCm39) R48H unknown Het
Lama3 G T 18: 12,586,807 (GRCm39) L723F probably damaging Het
Lama5 T C 2: 179,829,040 (GRCm39) T2034A probably benign Het
Maged1 G A X: 93,582,530 (GRCm39) P366S probably damaging Het
Med14 A G X: 12,585,936 (GRCm39) I521T probably benign Het
Mia2 A G 12: 59,201,196 (GRCm39) K841E probably damaging Het
Mrgbp G A 2: 180,225,203 (GRCm39) R53Q possibly damaging Het
Nmnat2 G A 1: 152,988,171 (GRCm39) V267I probably benign Het
Opn4 A G 14: 34,315,785 (GRCm39) probably null Het
Or2d2b T A 7: 106,705,675 (GRCm39) H131L probably benign Het
Or4f56 G T 2: 111,703,818 (GRCm39) C127* probably null Het
Or5p66 A G 7: 107,886,169 (GRCm39) S55P probably damaging Het
Or6k6 A G 1: 173,945,298 (GRCm39) Y95H probably damaging Het
Ovgp1 T C 3: 105,893,883 (GRCm39) probably benign Het
Parp16 G T 9: 65,141,086 (GRCm39) D219Y probably damaging Het
Pitpnm2 G C 5: 124,259,500 (GRCm39) H1224Q probably damaging Het
Pkd1 C T 17: 24,784,420 (GRCm39) T322I probably benign Het
Pkhd1l1 A C 15: 44,404,267 (GRCm39) T2299P probably damaging Het
Plin4 T C 17: 56,413,668 (GRCm39) D319G probably damaging Het
Ppp6r3 A C 19: 3,571,782 (GRCm39) S122R possibly damaging Het
Pwwp3b G A X: 138,137,429 (GRCm39) G656S possibly damaging Het
Rims1 A T 1: 22,503,227 (GRCm39) F653I probably benign Het
Rnf113a1 A G X: 36,455,736 (GRCm39) E231G probably damaging Het
Rnf41 T C 10: 128,274,023 (GRCm39) L225P possibly damaging Het
Ryr2 T C 13: 11,607,979 (GRCm39) E876G probably damaging Het
Slc25a10 G A 11: 120,386,003 (GRCm39) V115M probably damaging Het
Snx13 T A 12: 35,188,116 (GRCm39) I798N probably benign Het
Sri A T 5: 8,117,540 (GRCm39) Q178L probably benign Het
Tex14 T G 11: 87,365,243 (GRCm39) D62E probably damaging Het
Tshz1 G T 18: 84,033,105 (GRCm39) H434Q probably damaging Het
Vegfd A G X: 163,168,879 (GRCm39) E57G probably damaging Het
Vmn2r112 T A 17: 22,822,096 (GRCm39) V258E probably damaging Het
Vmn2r59 A G 7: 41,696,427 (GRCm39) I105T possibly damaging Het
Vmn2r6 G T 3: 64,454,760 (GRCm39) T513N probably benign Het
Wiz G T 17: 32,580,680 (GRCm39) T257K probably damaging Het
Xirp1 T C 9: 119,848,881 (GRCm39) M1V probably null Het
Xirp1 A G 9: 119,847,444 (GRCm39) S41P probably benign Het
Other mutations in Vmn2r72
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00931:Vmn2r72 APN 7 85,398,854 (GRCm39) missense probably benign 0.01
IGL01019:Vmn2r72 APN 7 85,387,542 (GRCm39) missense probably benign 0.26
IGL01445:Vmn2r72 APN 7 85,398,854 (GRCm39) missense probably benign 0.06
IGL02076:Vmn2r72 APN 7 85,387,575 (GRCm39) missense probably damaging 1.00
IGL02082:Vmn2r72 APN 7 85,387,374 (GRCm39) missense probably benign 0.00
IGL02086:Vmn2r72 APN 7 85,387,374 (GRCm39) missense probably benign 0.00
IGL02089:Vmn2r72 APN 7 85,387,374 (GRCm39) missense probably benign 0.00
IGL02125:Vmn2r72 APN 7 85,399,919 (GRCm39) missense probably benign 0.00
IGL02146:Vmn2r72 APN 7 85,387,170 (GRCm39) missense probably damaging 1.00
IGL02272:Vmn2r72 APN 7 85,399,901 (GRCm39) missense probably benign
IGL02514:Vmn2r72 APN 7 85,387,907 (GRCm39) missense possibly damaging 0.90
IGL02662:Vmn2r72 APN 7 85,387,391 (GRCm39) missense probably benign 0.26
IGL02697:Vmn2r72 APN 7 85,387,879 (GRCm39) missense probably benign 0.36
IGL02733:Vmn2r72 APN 7 85,401,021 (GRCm39) missense probably benign 0.05
IGL03070:Vmn2r72 APN 7 85,401,249 (GRCm39) splice site probably benign
IGL03150:Vmn2r72 APN 7 85,400,384 (GRCm39) missense probably damaging 1.00
IGL03159:Vmn2r72 APN 7 85,404,162 (GRCm39) missense probably benign 0.05
IGL03333:Vmn2r72 APN 7 85,400,075 (GRCm39) missense probably benign 0.10
R0081:Vmn2r72 UTSW 7 85,401,044 (GRCm39) missense probably benign 0.01
R0090:Vmn2r72 UTSW 7 85,404,084 (GRCm39) missense probably benign
R0655:Vmn2r72 UTSW 7 85,387,319 (GRCm39) nonsense probably null
R0778:Vmn2r72 UTSW 7 85,398,947 (GRCm39) missense probably benign 0.00
R1169:Vmn2r72 UTSW 7 85,400,517 (GRCm39) missense probably benign 0.01
R1172:Vmn2r72 UTSW 7 85,401,152 (GRCm39) missense probably damaging 1.00
R1173:Vmn2r72 UTSW 7 85,401,152 (GRCm39) missense probably damaging 1.00
R1175:Vmn2r72 UTSW 7 85,401,152 (GRCm39) missense probably damaging 1.00
R1248:Vmn2r72 UTSW 7 85,398,396 (GRCm39) missense probably benign 0.02
R1302:Vmn2r72 UTSW 7 85,387,465 (GRCm39) missense probably damaging 1.00
R1506:Vmn2r72 UTSW 7 85,398,419 (GRCm39) missense probably benign
R1632:Vmn2r72 UTSW 7 85,401,000 (GRCm39) missense probably benign 0.13
R1775:Vmn2r72 UTSW 7 85,387,378 (GRCm39) missense probably benign 0.01
R1962:Vmn2r72 UTSW 7 85,398,369 (GRCm39) missense probably benign 0.00
R2201:Vmn2r72 UTSW 7 85,387,444 (GRCm39) missense probably benign 0.12
R2290:Vmn2r72 UTSW 7 85,387,549 (GRCm39) missense probably damaging 1.00
R2327:Vmn2r72 UTSW 7 85,387,464 (GRCm39) missense probably damaging 1.00
R2424:Vmn2r72 UTSW 7 85,400,161 (GRCm39) missense probably damaging 1.00
R2655:Vmn2r72 UTSW 7 85,400,477 (GRCm39) missense possibly damaging 0.95
R2860:Vmn2r72 UTSW 7 85,400,044 (GRCm39) missense probably damaging 0.99
R2862:Vmn2r72 UTSW 7 85,400,044 (GRCm39) missense probably damaging 0.99
R3009:Vmn2r72 UTSW 7 85,398,850 (GRCm39) missense probably benign 0.00
R3797:Vmn2r72 UTSW 7 85,387,285 (GRCm39) missense probably benign 0.44
R3798:Vmn2r72 UTSW 7 85,387,285 (GRCm39) missense probably benign 0.44
R3902:Vmn2r72 UTSW 7 85,398,943 (GRCm39) missense possibly damaging 0.52
R3959:Vmn2r72 UTSW 7 85,400,339 (GRCm39) missense probably benign 0.36
R3974:Vmn2r72 UTSW 7 85,399,017 (GRCm39) missense probably damaging 1.00
R4399:Vmn2r72 UTSW 7 85,387,708 (GRCm39) missense probably damaging 1.00
R4421:Vmn2r72 UTSW 7 85,387,708 (GRCm39) missense probably damaging 1.00
R4426:Vmn2r72 UTSW 7 85,387,036 (GRCm39) nonsense probably null
R4522:Vmn2r72 UTSW 7 85,401,134 (GRCm39) missense probably benign 0.44
R4523:Vmn2r72 UTSW 7 85,401,134 (GRCm39) missense probably benign 0.44
R4533:Vmn2r72 UTSW 7 85,401,134 (GRCm39) missense probably benign 0.44
R4691:Vmn2r72 UTSW 7 85,387,119 (GRCm39) nonsense probably null
R4781:Vmn2r72 UTSW 7 85,387,069 (GRCm39) missense probably benign 0.14
R4863:Vmn2r72 UTSW 7 85,399,806 (GRCm39) missense possibly damaging 0.91
R4952:Vmn2r72 UTSW 7 85,400,317 (GRCm39) missense probably benign
R4991:Vmn2r72 UTSW 7 85,400,338 (GRCm39) missense probably damaging 0.99
R4995:Vmn2r72 UTSW 7 85,387,693 (GRCm39) missense probably damaging 1.00
R5095:Vmn2r72 UTSW 7 85,387,061 (GRCm39) missense probably damaging 0.98
R5174:Vmn2r72 UTSW 7 85,387,048 (GRCm39) missense probably benign 0.00
R5276:Vmn2r72 UTSW 7 85,387,462 (GRCm39) missense possibly damaging 0.90
R5395:Vmn2r72 UTSW 7 85,400,105 (GRCm39) missense possibly damaging 0.71
R5560:Vmn2r72 UTSW 7 85,401,150 (GRCm39) missense probably damaging 0.96
R5933:Vmn2r72 UTSW 7 85,387,058 (GRCm39) missense probably benign 0.05
R6033:Vmn2r72 UTSW 7 85,387,137 (GRCm39) missense probably damaging 1.00
R6033:Vmn2r72 UTSW 7 85,387,137 (GRCm39) missense probably damaging 1.00
R6354:Vmn2r72 UTSW 7 85,399,747 (GRCm39) critical splice donor site probably null
R6362:Vmn2r72 UTSW 7 85,400,382 (GRCm39) missense probably damaging 1.00
R6594:Vmn2r72 UTSW 7 85,398,892 (GRCm39) missense probably benign 0.32
R6794:Vmn2r72 UTSW 7 85,387,204 (GRCm39) missense probably damaging 1.00
R7113:Vmn2r72 UTSW 7 85,399,011 (GRCm39) splice site probably null
R7189:Vmn2r72 UTSW 7 85,404,125 (GRCm39) missense probably benign 0.36
R7266:Vmn2r72 UTSW 7 85,387,482 (GRCm39) nonsense probably null
R7323:Vmn2r72 UTSW 7 85,399,771 (GRCm39) missense probably benign
R7426:Vmn2r72 UTSW 7 85,400,348 (GRCm39) missense probably benign
R7606:Vmn2r72 UTSW 7 85,400,362 (GRCm39) missense possibly damaging 0.91
R7651:Vmn2r72 UTSW 7 85,401,146 (GRCm39) missense probably damaging 1.00
R7688:Vmn2r72 UTSW 7 85,404,098 (GRCm39) missense probably benign 0.32
R7753:Vmn2r72 UTSW 7 85,399,834 (GRCm39) missense probably damaging 1.00
R7843:Vmn2r72 UTSW 7 85,398,838 (GRCm39) missense probably benign 0.01
R8157:Vmn2r72 UTSW 7 85,400,441 (GRCm39) missense probably benign 0.09
R8254:Vmn2r72 UTSW 7 85,400,227 (GRCm39) missense probably damaging 1.00
R8389:Vmn2r72 UTSW 7 85,401,168 (GRCm39) missense probably damaging 0.99
R8444:Vmn2r72 UTSW 7 85,387,383 (GRCm39) missense probably benign
R8989:Vmn2r72 UTSW 7 85,404,134 (GRCm39) missense probably benign 0.10
R9015:Vmn2r72 UTSW 7 85,398,388 (GRCm39) missense probably benign 0.01
R9080:Vmn2r72 UTSW 7 85,387,464 (GRCm39) missense probably damaging 1.00
R9269:Vmn2r72 UTSW 7 85,400,411 (GRCm39) missense probably benign 0.03
R9317:Vmn2r72 UTSW 7 85,404,022 (GRCm39) missense probably benign 0.04
R9509:Vmn2r72 UTSW 7 85,404,075 (GRCm39) missense probably benign
Z1176:Vmn2r72 UTSW 7 85,398,399 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ATGGGCCACAGCATGTATAG -3'
(R):5'- AGACTATGCCTCTCCCATAGATC -3'

Sequencing Primer
(F):5'- GCCACAGCATGTATAGCATTG -3'
(R):5'- CCATAGATCTTGTCCTCCATTGG -3'
Posted On 2014-12-04