Incidental Mutation 'R2656:Adgrf3'
ID 252733
Institutional Source Beutler Lab
Gene Symbol Adgrf3
Ensembl Gene ENSMUSG00000067642
Gene Name adhesion G protein-coupled receptor F3
Synonyms Gpr113, LOC381628, PGR23
MMRRC Submission 040431-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2656 (G1)
Quality Score 209
Status Not validated
Chromosome 5
Chromosomal Location 30193431-30205722 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 30196438 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 864 (V864D)
Ref Sequence ENSEMBL: ENSMUSP00000085440 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088117] [ENSMUST00000125367]
AlphaFold Q58Y75
Predicted Effect possibly damaging
Transcript: ENSMUST00000088117
AA Change: V864D

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000085440
Gene: ENSMUSG00000067642
AA Change: V864D

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 85 97 N/A INTRINSIC
Blast:IG 163 252 2e-20 BLAST
Blast:CCP 341 399 1e-6 BLAST
low complexity region 403 415 N/A INTRINSIC
low complexity region 471 483 N/A INTRINSIC
GPS 632 684 2.68e-17 SMART
Pfam:7tm_2 687 935 1e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000125367
SMART Domains Protein: ENSMUSP00000120958
Gene: ENSMUSG00000067642

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam22 A G 5: 8,117,696 (GRCm38) C655R probably damaging Het
Angptl3 A G 4: 99,037,964 (GRCm38) I444V probably benign Het
Atp8b2 C T 3: 89,941,758 (GRCm38) A1090T probably benign Het
Bcl2l2 C T 14: 54,885,432 (GRCm38) R47C probably benign Het
Ces2a G A 8: 104,736,134 (GRCm38) M118I probably benign Het
Cyp4a29 T G 4: 115,249,724 (GRCm38) L193V possibly damaging Het
Dpp8 A G 9: 65,080,804 (GRCm38) Y877C probably damaging Het
Enpp6 C T 8: 47,082,418 (GRCm38) R33* probably null Het
Fsip2 G A 2: 82,979,045 (GRCm38) D1903N possibly damaging Het
Ggt1 T A 10: 75,581,385 (GRCm38) Y5* probably null Het
Gm14412 A T 2: 177,315,200 (GRCm38) C301S unknown Het
Gpatch2l T A 12: 86,288,810 (GRCm38) D428E probably damaging Het
Grin2b C T 6: 135,733,429 (GRCm38) G1040S probably damaging Het
Has2 T C 15: 56,681,828 (GRCm38) D126G possibly damaging Het
Itgam T G 7: 128,116,815 (GRCm38) L1120R probably null Het
Kank4 T C 4: 98,778,957 (GRCm38) N418D probably damaging Het
Kcnk3 T C 5: 30,622,671 (GRCm38) V355A possibly damaging Het
Lonrf2 C T 1: 38,815,960 (GRCm38) probably null Het
Lrp1b A T 2: 41,511,581 (GRCm38) C240S probably damaging Het
Mapk8ip3 T G 17: 24,912,807 (GRCm38) E386A probably damaging Het
Mtmr14 A G 6: 113,240,366 (GRCm38) I80V probably benign Het
Nav2 A C 7: 49,545,942 (GRCm38) D961A probably damaging Het
Nmt2 A G 2: 3,307,013 (GRCm38) D107G probably benign Het
Nsd1 A G 13: 55,246,868 (GRCm38) K761E probably damaging Het
Ogdh A G 11: 6,348,678 (GRCm38) T641A probably benign Het
Ogdhl T G 14: 32,332,826 (GRCm38) F244V possibly damaging Het
Or2ag17 T A 7: 106,790,513 (GRCm38) T163S probably damaging Het
Or51k1 G A 7: 104,011,865 (GRCm38) S279L probably damaging Het
Or5b102 A T 19: 13,063,984 (GRCm38) H191L probably benign Het
Or5b97 A G 19: 12,901,666 (GRCm38) I38T probably benign Het
Pfpl T C 19: 12,430,236 (GRCm38) I617T probably benign Het
Ppfia2 T G 10: 106,865,407 (GRCm38) probably null Het
Prickle1 T C 15: 93,503,370 (GRCm38) E411G probably benign Het
Prpsap2 C A 11: 61,730,225 (GRCm38) M343I probably benign Het
Prpsap2 A G 11: 61,752,891 (GRCm38) V72A probably benign Het
Ranbp17 A T 11: 33,243,122 (GRCm38) D977E probably benign Het
Rin1 T C 19: 5,052,176 (GRCm38) S238P probably damaging Het
Scap C T 9: 110,374,019 (GRCm38) R254W probably damaging Het
Scn3a T C 2: 65,526,518 (GRCm38) D194G probably damaging Het
Shisa7 T C 7: 4,829,819 (GRCm38) H481R possibly damaging Het
Slc6a6 T C 6: 91,741,048 (GRCm38) Y323H probably damaging Het
Thoc2l A G 5: 104,519,315 (GRCm38) I568V probably benign Het
Tlr9 T C 9: 106,223,941 (GRCm38) S144P probably benign Het
Tmem69 T A 4: 116,553,590 (GRCm38) K61M probably damaging Het
Ttc21a A G 9: 119,941,265 (GRCm38) D134G probably damaging Het
Ttn A G 2: 76,894,270 (GRCm38) probably benign Het
Vwf A G 6: 125,555,361 (GRCm38) T26A probably benign Het
Zbtb16 A T 9: 48,832,688 (GRCm38) I108N probably damaging Het
Zc3h7b T A 15: 81,780,430 (GRCm38) Y497N probably damaging Het
Zfp652 A G 11: 95,749,329 (GRCm38) S27G probably damaging Het
Zfp808 A G 13: 62,172,852 (GRCm38) T632A possibly damaging Het
Znhit6 T C 3: 145,578,169 (GRCm38) probably null Het
Other mutations in Adgrf3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03080:Adgrf3 APN 5 30,196,829 (GRCm38) missense probably benign 0.02
IGL03171:Adgrf3 APN 5 30,196,294 (GRCm38) missense probably damaging 1.00
R0010:Adgrf3 UTSW 5 30,205,609 (GRCm38) splice site probably benign
R0042:Adgrf3 UTSW 5 30,197,428 (GRCm38) missense probably damaging 1.00
R0140:Adgrf3 UTSW 5 30,196,381 (GRCm38) missense probably benign 0.19
R0617:Adgrf3 UTSW 5 30,195,080 (GRCm38) missense probably benign 0.25
R0748:Adgrf3 UTSW 5 30,196,876 (GRCm38) missense probably damaging 1.00
R1291:Adgrf3 UTSW 5 30,199,534 (GRCm38) missense probably damaging 0.99
R1330:Adgrf3 UTSW 5 30,195,095 (GRCm38) missense probably benign 0.24
R1468:Adgrf3 UTSW 5 30,202,229 (GRCm38) splice site probably benign
R1695:Adgrf3 UTSW 5 30,203,555 (GRCm38) missense probably benign 0.05
R1716:Adgrf3 UTSW 5 30,197,551 (GRCm38) missense probably benign 0.03
R1844:Adgrf3 UTSW 5 30,199,213 (GRCm38) missense probably damaging 0.96
R1935:Adgrf3 UTSW 5 30,202,306 (GRCm38) missense probably benign 0.00
R1936:Adgrf3 UTSW 5 30,202,306 (GRCm38) missense probably benign 0.00
R2059:Adgrf3 UTSW 5 30,199,491 (GRCm38) missense possibly damaging 0.91
R2913:Adgrf3 UTSW 5 30,196,994 (GRCm38) missense probably damaging 1.00
R2914:Adgrf3 UTSW 5 30,196,994 (GRCm38) missense probably damaging 1.00
R2987:Adgrf3 UTSW 5 30,197,360 (GRCm38) missense probably damaging 1.00
R3797:Adgrf3 UTSW 5 30,196,823 (GRCm38) missense possibly damaging 0.49
R3798:Adgrf3 UTSW 5 30,196,823 (GRCm38) missense possibly damaging 0.49
R3799:Adgrf3 UTSW 5 30,196,823 (GRCm38) missense possibly damaging 0.49
R3934:Adgrf3 UTSW 5 30,200,434 (GRCm38) unclassified probably benign
R4043:Adgrf3 UTSW 5 30,204,362 (GRCm38) missense probably benign 0.00
R4080:Adgrf3 UTSW 5 30,197,369 (GRCm38) nonsense probably null
R4575:Adgrf3 UTSW 5 30,202,257 (GRCm38) missense probably benign 0.00
R4754:Adgrf3 UTSW 5 30,197,617 (GRCm38) critical splice acceptor site probably null
R4819:Adgrf3 UTSW 5 30,198,444 (GRCm38) missense possibly damaging 0.66
R4893:Adgrf3 UTSW 5 30,200,478 (GRCm38) missense probably benign 0.00
R4991:Adgrf3 UTSW 5 30,199,148 (GRCm38) missense probably benign 0.26
R5686:Adgrf3 UTSW 5 30,197,306 (GRCm38) missense probably damaging 1.00
R5965:Adgrf3 UTSW 5 30,205,639 (GRCm38) missense probably benign 0.00
R5997:Adgrf3 UTSW 5 30,198,362 (GRCm38) critical splice donor site probably null
R6103:Adgrf3 UTSW 5 30,196,267 (GRCm38) missense probably damaging 1.00
R6244:Adgrf3 UTSW 5 30,197,533 (GRCm38) missense probably benign 0.17
R6409:Adgrf3 UTSW 5 30,197,314 (GRCm38) missense probably damaging 0.96
R6575:Adgrf3 UTSW 5 30,196,524 (GRCm38) missense possibly damaging 0.72
R6745:Adgrf3 UTSW 5 30,203,603 (GRCm38) missense probably benign 0.31
R6790:Adgrf3 UTSW 5 30,196,387 (GRCm38) missense probably benign 0.00
R6813:Adgrf3 UTSW 5 30,197,521 (GRCm38) missense probably damaging 0.96
R7202:Adgrf3 UTSW 5 30,204,380 (GRCm38) nonsense probably null
R7250:Adgrf3 UTSW 5 30,195,682 (GRCm38) missense probably damaging 1.00
R7353:Adgrf3 UTSW 5 30,198,497 (GRCm38) missense probably damaging 0.98
R7634:Adgrf3 UTSW 5 30,202,247 (GRCm38) missense probably benign 0.01
R7658:Adgrf3 UTSW 5 30,197,206 (GRCm38) missense probably benign 0.41
R8037:Adgrf3 UTSW 5 30,199,512 (GRCm38) missense probably damaging 1.00
R8281:Adgrf3 UTSW 5 30,197,303 (GRCm38) missense possibly damaging 0.46
R8717:Adgrf3 UTSW 5 30,198,581 (GRCm38) unclassified probably benign
R8857:Adgrf3 UTSW 5 30,197,067 (GRCm38) nonsense probably null
R8926:Adgrf3 UTSW 5 30,200,448 (GRCm38) missense possibly damaging 0.46
R9391:Adgrf3 UTSW 5 30,195,073 (GRCm38) missense possibly damaging 0.94
R9446:Adgrf3 UTSW 5 30,196,959 (GRCm38) missense probably benign 0.01
R9522:Adgrf3 UTSW 5 30,199,484 (GRCm38) missense possibly damaging 0.90
Z1088:Adgrf3 UTSW 5 30,199,120 (GRCm38) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- ACCTGGAGGCTGTTGAGAATG -3'
(R):5'- AGCACGTAGTCCTCTCACTG -3'

Sequencing Primer
(F):5'- CTGTTGAGAATGGAAAAGGCGTAGTG -3'
(R):5'- ACGTAGTCCTCTCACTGATGGTG -3'
Posted On 2014-12-04