Incidental Mutation 'R2656:Dpp8'
ID 252764
Institutional Source Beutler Lab
Gene Symbol Dpp8
Ensembl Gene ENSMUSG00000032393
Gene Name dipeptidylpeptidase 8
Synonyms 2310004I03Rik, 4932434F09Rik
MMRRC Submission 040431-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.167) question?
Stock # R2656 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 64939696-64989933 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 64988086 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 877 (Y877C)
Ref Sequence ENSEMBL: ENSMUSP00000126065 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034960] [ENSMUST00000167773] [ENSMUST00000217434]
AlphaFold Q80YA7
Predicted Effect probably damaging
Transcript: ENSMUST00000034960
AA Change: Y877C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000034960
Gene: ENSMUSG00000032393
AA Change: Y877C

DomainStartEndE-ValueType
low complexity region 144 154 N/A INTRINSIC
Pfam:DPPIV_N 168 589 1e-100 PFAM
Pfam:Peptidase_S15 636 830 7.3e-11 PFAM
Pfam:Abhydrolase_5 671 860 4.8e-9 PFAM
Pfam:Peptidase_S9 676 885 6.5e-62 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000167773
AA Change: Y877C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000126065
Gene: ENSMUSG00000032393
AA Change: Y877C

DomainStartEndE-ValueType
low complexity region 144 154 N/A INTRINSIC
Pfam:DPPIV_N 168 589 3.3e-102 PFAM
Pfam:Peptidase_S15 636 830 7.3e-11 PFAM
Pfam:Abhydrolase_5 670 860 6.5e-9 PFAM
Pfam:Peptidase_S9 677 885 8.6e-63 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214247
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214559
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214678
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217328
Predicted Effect probably benign
Transcript: ENSMUST00000217434
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam22 A G 5: 8,167,696 (GRCm39) C655R probably damaging Het
Adgrf3 A T 5: 30,401,436 (GRCm39) V864D possibly damaging Het
Angptl3 A G 4: 98,926,201 (GRCm39) I444V probably benign Het
Atp8b2 C T 3: 89,849,065 (GRCm39) A1090T probably benign Het
Bcl2l2 C T 14: 55,122,889 (GRCm39) R47C probably benign Het
Ces2a G A 8: 105,462,766 (GRCm39) M118I probably benign Het
Cyp4a29 T G 4: 115,106,921 (GRCm39) L193V possibly damaging Het
Enpp6 C T 8: 47,535,453 (GRCm39) R33* probably null Het
Fsip2 G A 2: 82,809,389 (GRCm39) D1903N possibly damaging Het
Ggt1 T A 10: 75,417,219 (GRCm39) Y5* probably null Het
Gm14412 A T 2: 177,006,993 (GRCm39) C301S unknown Het
Gpatch2l T A 12: 86,335,584 (GRCm39) D428E probably damaging Het
Grin2b C T 6: 135,710,427 (GRCm39) G1040S probably damaging Het
Has2 T C 15: 56,545,224 (GRCm39) D126G possibly damaging Het
Itgam T G 7: 127,715,987 (GRCm39) L1120R probably null Het
Kank4 T C 4: 98,667,194 (GRCm39) N418D probably damaging Het
Kcnk3 T C 5: 30,780,015 (GRCm39) V355A possibly damaging Het
Lonrf2 C T 1: 38,855,041 (GRCm39) probably null Het
Lrp1b A T 2: 41,401,593 (GRCm39) C240S probably damaging Het
Mapk8ip3 T G 17: 25,131,781 (GRCm39) E386A probably damaging Het
Mtmr14 A G 6: 113,217,327 (GRCm39) I80V probably benign Het
Nav2 A C 7: 49,195,690 (GRCm39) D961A probably damaging Het
Nmt2 A G 2: 3,308,050 (GRCm39) D107G probably benign Het
Nsd1 A G 13: 55,394,681 (GRCm39) K761E probably damaging Het
Ogdh A G 11: 6,298,678 (GRCm39) T641A probably benign Het
Ogdhl T G 14: 32,054,783 (GRCm39) F244V possibly damaging Het
Or2ag17 T A 7: 106,389,720 (GRCm39) T163S probably damaging Het
Or51k1 G A 7: 103,661,072 (GRCm39) S279L probably damaging Het
Or5b102 A T 19: 13,041,348 (GRCm39) H191L probably benign Het
Or5b97 A G 19: 12,879,030 (GRCm39) I38T probably benign Het
Pfpl T C 19: 12,407,600 (GRCm39) I617T probably benign Het
Ppfia2 T G 10: 106,701,268 (GRCm39) probably null Het
Prickle1 T C 15: 93,401,251 (GRCm39) E411G probably benign Het
Prpsap2 C A 11: 61,621,051 (GRCm39) M343I probably benign Het
Prpsap2 A G 11: 61,643,717 (GRCm39) V72A probably benign Het
Ranbp17 A T 11: 33,193,122 (GRCm39) D977E probably benign Het
Rin1 T C 19: 5,102,204 (GRCm39) S238P probably damaging Het
Scap C T 9: 110,203,087 (GRCm39) R254W probably damaging Het
Scn3a T C 2: 65,356,862 (GRCm39) D194G probably damaging Het
Shisa7 T C 7: 4,832,818 (GRCm39) H481R possibly damaging Het
Slc6a6 T C 6: 91,718,029 (GRCm39) Y323H probably damaging Het
Thoc2l A G 5: 104,667,181 (GRCm39) I568V probably benign Het
Tlr9 T C 9: 106,101,140 (GRCm39) S144P probably benign Het
Tmem69 T A 4: 116,410,787 (GRCm39) K61M probably damaging Het
Ttc21a A G 9: 119,770,331 (GRCm39) D134G probably damaging Het
Ttn A G 2: 76,724,614 (GRCm39) probably benign Het
Vwf A G 6: 125,532,324 (GRCm39) T26A probably benign Het
Zbtb16 A T 9: 48,743,988 (GRCm39) I108N probably damaging Het
Zc3h7b T A 15: 81,664,631 (GRCm39) Y497N probably damaging Het
Zfp652 A G 11: 95,640,155 (GRCm39) S27G probably damaging Het
Zfp808 A G 13: 62,320,666 (GRCm39) T632A possibly damaging Het
Znhit6 T C 3: 145,283,924 (GRCm39) probably null Het
Other mutations in Dpp8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00519:Dpp8 APN 9 64,985,290 (GRCm39) missense probably damaging 1.00
IGL00576:Dpp8 APN 9 64,951,111 (GRCm39) missense probably benign 0.32
IGL01303:Dpp8 APN 9 64,962,294 (GRCm39) splice site probably benign
IGL01506:Dpp8 APN 9 64,970,699 (GRCm39) splice site probably benign
IGL01544:Dpp8 APN 9 64,962,270 (GRCm39) missense probably benign 0.05
IGL02387:Dpp8 APN 9 64,952,998 (GRCm39) missense probably damaging 1.00
IGL02567:Dpp8 APN 9 64,986,058 (GRCm39) nonsense probably null
IGL02611:Dpp8 APN 9 64,963,075 (GRCm39) missense probably benign 0.15
IGL02723:Dpp8 APN 9 64,949,549 (GRCm39) missense possibly damaging 0.91
IGL02927:Dpp8 APN 9 64,967,551 (GRCm39) missense probably benign 0.09
IGL03116:Dpp8 APN 9 64,973,749 (GRCm39) missense probably damaging 0.96
IGL03135:Dpp8 APN 9 64,960,322 (GRCm39) splice site probably null
IGL03356:Dpp8 APN 9 64,953,069 (GRCm39) missense probably benign 0.00
almaviva UTSW 9 64,983,085 (GRCm39) missense probably damaging 1.00
bartolo UTSW 9 64,986,000 (GRCm39) missense probably damaging 1.00
Cherubino UTSW 9 64,962,205 (GRCm39) missense probably benign
rosina UTSW 9 64,983,066 (GRCm39) missense possibly damaging 0.88
IGL03050:Dpp8 UTSW 9 64,962,118 (GRCm39) missense probably benign 0.00
R0498:Dpp8 UTSW 9 64,953,077 (GRCm39) splice site probably benign
R0594:Dpp8 UTSW 9 64,944,280 (GRCm39) missense probably damaging 1.00
R0675:Dpp8 UTSW 9 64,973,784 (GRCm39) splice site probably benign
R0699:Dpp8 UTSW 9 64,962,176 (GRCm39) missense probably benign 0.01
R0831:Dpp8 UTSW 9 64,985,961 (GRCm39) missense possibly damaging 0.56
R1148:Dpp8 UTSW 9 64,961,114 (GRCm39) critical splice donor site probably null
R1148:Dpp8 UTSW 9 64,961,114 (GRCm39) critical splice donor site probably null
R1512:Dpp8 UTSW 9 64,971,096 (GRCm39) splice site probably benign
R1515:Dpp8 UTSW 9 64,986,030 (GRCm39) missense probably benign 0.04
R1546:Dpp8 UTSW 9 64,970,775 (GRCm39) missense possibly damaging 0.76
R1556:Dpp8 UTSW 9 64,958,761 (GRCm39) missense probably damaging 1.00
R2027:Dpp8 UTSW 9 64,986,056 (GRCm39) missense probably damaging 1.00
R2104:Dpp8 UTSW 9 64,981,849 (GRCm39) splice site probably null
R2113:Dpp8 UTSW 9 64,971,150 (GRCm39) missense probably benign 0.00
R4237:Dpp8 UTSW 9 64,962,205 (GRCm39) missense probably benign
R4238:Dpp8 UTSW 9 64,962,205 (GRCm39) missense probably benign
R4239:Dpp8 UTSW 9 64,962,205 (GRCm39) missense probably benign
R4595:Dpp8 UTSW 9 64,983,085 (GRCm39) missense probably damaging 1.00
R4614:Dpp8 UTSW 9 64,973,678 (GRCm39) missense probably benign 0.00
R4946:Dpp8 UTSW 9 64,963,200 (GRCm39) missense probably benign 0.00
R5338:Dpp8 UTSW 9 64,971,206 (GRCm39) nonsense probably null
R5378:Dpp8 UTSW 9 64,985,296 (GRCm39) missense probably damaging 1.00
R5506:Dpp8 UTSW 9 64,985,391 (GRCm39) splice site probably null
R5644:Dpp8 UTSW 9 64,953,017 (GRCm39) nonsense probably null
R5862:Dpp8 UTSW 9 64,953,004 (GRCm39) missense probably benign 0.03
R6437:Dpp8 UTSW 9 64,981,860 (GRCm39) missense probably benign 0.01
R6783:Dpp8 UTSW 9 64,970,844 (GRCm39) missense possibly damaging 0.76
R6863:Dpp8 UTSW 9 64,942,290 (GRCm39) missense probably damaging 0.98
R7192:Dpp8 UTSW 9 64,953,068 (GRCm39) missense possibly damaging 0.70
R7461:Dpp8 UTSW 9 64,960,402 (GRCm39) missense possibly damaging 0.86
R7514:Dpp8 UTSW 9 64,986,036 (GRCm39) missense probably damaging 1.00
R7548:Dpp8 UTSW 9 64,944,517 (GRCm39) missense probably damaging 1.00
R7584:Dpp8 UTSW 9 64,986,064 (GRCm39) missense probably damaging 0.98
R7605:Dpp8 UTSW 9 64,962,240 (GRCm39) missense probably benign 0.33
R7613:Dpp8 UTSW 9 64,960,402 (GRCm39) missense possibly damaging 0.86
R7665:Dpp8 UTSW 9 64,986,000 (GRCm39) missense probably damaging 1.00
R7698:Dpp8 UTSW 9 64,949,618 (GRCm39) missense probably benign 0.00
R7844:Dpp8 UTSW 9 64,952,949 (GRCm39) missense probably damaging 0.99
R7935:Dpp8 UTSW 9 64,944,262 (GRCm39) missense possibly damaging 0.82
R8079:Dpp8 UTSW 9 64,951,017 (GRCm39) missense probably damaging 1.00
R8121:Dpp8 UTSW 9 64,985,362 (GRCm39) missense probably benign 0.10
R8315:Dpp8 UTSW 9 64,988,133 (GRCm39) makesense probably null
R8419:Dpp8 UTSW 9 64,988,037 (GRCm39) missense probably benign 0.34
R8516:Dpp8 UTSW 9 64,985,291 (GRCm39) missense probably damaging 1.00
R8524:Dpp8 UTSW 9 64,950,989 (GRCm39) missense probably damaging 1.00
R8896:Dpp8 UTSW 9 64,985,318 (GRCm39) missense possibly damaging 0.88
R8922:Dpp8 UTSW 9 64,981,793 (GRCm39) missense probably benign 0.02
R8935:Dpp8 UTSW 9 64,983,066 (GRCm39) missense possibly damaging 0.88
R9463:Dpp8 UTSW 9 64,973,700 (GRCm39) nonsense probably null
R9518:Dpp8 UTSW 9 64,981,866 (GRCm39) missense possibly damaging 0.90
R9732:Dpp8 UTSW 9 64,970,862 (GRCm39) critical splice donor site probably null
R9751:Dpp8 UTSW 9 64,960,453 (GRCm39) missense probably null 0.65
Z1177:Dpp8 UTSW 9 64,973,767 (GRCm39) missense probably damaging 1.00
Z1177:Dpp8 UTSW 9 64,971,148 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- GGAGAGGCATTGTTCCATATTG -3'
(R):5'- GCATGGCACCAAATTTACTTTC -3'

Sequencing Primer
(F):5'- TGAGCTTGGACTACATGAGACCC -3'
(R):5'- TCAGAAATAGATCTTATGTGGCAGG -3'
Posted On 2014-12-04