Incidental Mutation 'R2656:Zc3h7b'
ID 252799
Institutional Source Beutler Lab
Gene Symbol Zc3h7b
Ensembl Gene ENSMUSG00000022390
Gene Name zinc finger CCCH type containing 7B
Synonyms Scrg3
MMRRC Submission 040431-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.229) question?
Stock # R2656 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 81629299-81680470 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 81664631 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 497 (Y497N)
Ref Sequence ENSEMBL: ENSMUSP00000105181 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109554]
AlphaFold F8VPP8
Predicted Effect probably damaging
Transcript: ENSMUST00000109554
AA Change: Y497N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105181
Gene: ENSMUSG00000022390
AA Change: Y497N

DomainStartEndE-ValueType
Pfam:TPR_11 34 113 2.3e-12 PFAM
Pfam:TPR_1 82 115 2.4e-6 PFAM
Pfam:TPR_8 82 115 8.2e-4 PFAM
Pfam:TPR_8 116 143 4.8e-3 PFAM
low complexity region 294 309 N/A INTRINSIC
low complexity region 340 354 N/A INTRINSIC
ZnF_C3H1 482 508 2.15e1 SMART
ZnF_C3H1 612 638 2.03e1 SMART
ZnF_C3H1 757 782 8.31e0 SMART
ZnF_C2H2 843 867 2.86e-1 SMART
ZnF_C3H1 889 914 7.81e-1 SMART
low complexity region 959 981 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229044
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230368
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230590
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231108
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq, Jul 2008]
Allele List at MGI

All alleles(9) : Gene trapped(9)

Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam22 A G 5: 8,167,696 (GRCm39) C655R probably damaging Het
Adgrf3 A T 5: 30,401,436 (GRCm39) V864D possibly damaging Het
Angptl3 A G 4: 98,926,201 (GRCm39) I444V probably benign Het
Atp8b2 C T 3: 89,849,065 (GRCm39) A1090T probably benign Het
Bcl2l2 C T 14: 55,122,889 (GRCm39) R47C probably benign Het
Ces2a G A 8: 105,462,766 (GRCm39) M118I probably benign Het
Cyp4a29 T G 4: 115,106,921 (GRCm39) L193V possibly damaging Het
Dpp8 A G 9: 64,988,086 (GRCm39) Y877C probably damaging Het
Enpp6 C T 8: 47,535,453 (GRCm39) R33* probably null Het
Fsip2 G A 2: 82,809,389 (GRCm39) D1903N possibly damaging Het
Ggt1 T A 10: 75,417,219 (GRCm39) Y5* probably null Het
Gm14412 A T 2: 177,006,993 (GRCm39) C301S unknown Het
Gpatch2l T A 12: 86,335,584 (GRCm39) D428E probably damaging Het
Grin2b C T 6: 135,710,427 (GRCm39) G1040S probably damaging Het
Has2 T C 15: 56,545,224 (GRCm39) D126G possibly damaging Het
Itgam T G 7: 127,715,987 (GRCm39) L1120R probably null Het
Kank4 T C 4: 98,667,194 (GRCm39) N418D probably damaging Het
Kcnk3 T C 5: 30,780,015 (GRCm39) V355A possibly damaging Het
Lonrf2 C T 1: 38,855,041 (GRCm39) probably null Het
Lrp1b A T 2: 41,401,593 (GRCm39) C240S probably damaging Het
Mapk8ip3 T G 17: 25,131,781 (GRCm39) E386A probably damaging Het
Mtmr14 A G 6: 113,217,327 (GRCm39) I80V probably benign Het
Nav2 A C 7: 49,195,690 (GRCm39) D961A probably damaging Het
Nmt2 A G 2: 3,308,050 (GRCm39) D107G probably benign Het
Nsd1 A G 13: 55,394,681 (GRCm39) K761E probably damaging Het
Ogdh A G 11: 6,298,678 (GRCm39) T641A probably benign Het
Ogdhl T G 14: 32,054,783 (GRCm39) F244V possibly damaging Het
Or2ag17 T A 7: 106,389,720 (GRCm39) T163S probably damaging Het
Or51k1 G A 7: 103,661,072 (GRCm39) S279L probably damaging Het
Or5b102 A T 19: 13,041,348 (GRCm39) H191L probably benign Het
Or5b97 A G 19: 12,879,030 (GRCm39) I38T probably benign Het
Pfpl T C 19: 12,407,600 (GRCm39) I617T probably benign Het
Ppfia2 T G 10: 106,701,268 (GRCm39) probably null Het
Prickle1 T C 15: 93,401,251 (GRCm39) E411G probably benign Het
Prpsap2 C A 11: 61,621,051 (GRCm39) M343I probably benign Het
Prpsap2 A G 11: 61,643,717 (GRCm39) V72A probably benign Het
Ranbp17 A T 11: 33,193,122 (GRCm39) D977E probably benign Het
Rin1 T C 19: 5,102,204 (GRCm39) S238P probably damaging Het
Scap C T 9: 110,203,087 (GRCm39) R254W probably damaging Het
Scn3a T C 2: 65,356,862 (GRCm39) D194G probably damaging Het
Shisa7 T C 7: 4,832,818 (GRCm39) H481R possibly damaging Het
Slc6a6 T C 6: 91,718,029 (GRCm39) Y323H probably damaging Het
Thoc2l A G 5: 104,667,181 (GRCm39) I568V probably benign Het
Tlr9 T C 9: 106,101,140 (GRCm39) S144P probably benign Het
Tmem69 T A 4: 116,410,787 (GRCm39) K61M probably damaging Het
Ttc21a A G 9: 119,770,331 (GRCm39) D134G probably damaging Het
Ttn A G 2: 76,724,614 (GRCm39) probably benign Het
Vwf A G 6: 125,532,324 (GRCm39) T26A probably benign Het
Zbtb16 A T 9: 48,743,988 (GRCm39) I108N probably damaging Het
Zfp652 A G 11: 95,640,155 (GRCm39) S27G probably damaging Het
Zfp808 A G 13: 62,320,666 (GRCm39) T632A possibly damaging Het
Znhit6 T C 3: 145,283,924 (GRCm39) probably null Het
Other mutations in Zc3h7b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01726:Zc3h7b APN 15 81,656,000 (GRCm39) missense possibly damaging 0.95
IGL01955:Zc3h7b APN 15 81,676,205 (GRCm39) missense probably benign 0.10
IGL02526:Zc3h7b APN 15 81,677,338 (GRCm39) missense probably benign 0.10
IGL02582:Zc3h7b APN 15 81,653,341 (GRCm39) missense probably benign 0.05
IGL02736:Zc3h7b APN 15 81,676,175 (GRCm39) missense probably benign 0.02
F6893:Zc3h7b UTSW 15 81,662,872 (GRCm39) missense possibly damaging 0.94
R0212:Zc3h7b UTSW 15 81,660,529 (GRCm39) missense probably benign 0.00
R0242:Zc3h7b UTSW 15 81,653,031 (GRCm39) splice site probably benign
R0471:Zc3h7b UTSW 15 81,666,169 (GRCm39) missense probably damaging 1.00
R0590:Zc3h7b UTSW 15 81,661,199 (GRCm39) missense possibly damaging 0.74
R1530:Zc3h7b UTSW 15 81,661,289 (GRCm39) missense probably benign
R1563:Zc3h7b UTSW 15 81,661,289 (GRCm39) missense probably benign
R1565:Zc3h7b UTSW 15 81,661,289 (GRCm39) missense probably benign
R1566:Zc3h7b UTSW 15 81,653,035 (GRCm39) missense possibly damaging 0.91
R1670:Zc3h7b UTSW 15 81,661,268 (GRCm39) missense probably benign
R1712:Zc3h7b UTSW 15 81,661,289 (GRCm39) missense probably benign
R1727:Zc3h7b UTSW 15 81,652,230 (GRCm39) missense probably damaging 1.00
R2069:Zc3h7b UTSW 15 81,676,529 (GRCm39) missense probably damaging 0.98
R2375:Zc3h7b UTSW 15 81,676,703 (GRCm39) missense probably benign 0.17
R4660:Zc3h7b UTSW 15 81,676,451 (GRCm39) missense probably benign 0.07
R4764:Zc3h7b UTSW 15 81,653,384 (GRCm39) critical splice donor site probably null
R4815:Zc3h7b UTSW 15 81,677,864 (GRCm39) missense probably damaging 1.00
R4999:Zc3h7b UTSW 15 81,663,334 (GRCm39) missense probably damaging 1.00
R5086:Zc3h7b UTSW 15 81,677,375 (GRCm39) missense probably damaging 0.96
R5169:Zc3h7b UTSW 15 81,657,515 (GRCm39) missense probably benign 0.01
R5395:Zc3h7b UTSW 15 81,656,702 (GRCm39) missense possibly damaging 0.50
R5407:Zc3h7b UTSW 15 81,670,092 (GRCm39) missense probably damaging 0.99
R5587:Zc3h7b UTSW 15 81,656,059 (GRCm39) missense possibly damaging 0.80
R5721:Zc3h7b UTSW 15 81,657,499 (GRCm39) missense probably benign 0.02
R6001:Zc3h7b UTSW 15 81,676,236 (GRCm39) missense possibly damaging 0.89
R6151:Zc3h7b UTSW 15 81,662,911 (GRCm39) critical splice donor site probably null
R6248:Zc3h7b UTSW 15 81,667,386 (GRCm39) missense probably damaging 1.00
R6397:Zc3h7b UTSW 15 81,677,055 (GRCm39) missense probably benign 0.03
R6502:Zc3h7b UTSW 15 81,653,252 (GRCm39) missense probably benign 0.01
R7248:Zc3h7b UTSW 15 81,655,988 (GRCm39) missense possibly damaging 0.46
R7397:Zc3h7b UTSW 15 81,653,354 (GRCm39) missense possibly damaging 0.50
R7450:Zc3h7b UTSW 15 81,667,281 (GRCm39) missense probably benign
R7471:Zc3h7b UTSW 15 81,664,682 (GRCm39) missense probably damaging 1.00
R7575:Zc3h7b UTSW 15 81,662,086 (GRCm39) nonsense probably null
R7645:Zc3h7b UTSW 15 81,664,803 (GRCm39) missense probably damaging 1.00
R7650:Zc3h7b UTSW 15 81,677,851 (GRCm39) missense possibly damaging 0.81
R7881:Zc3h7b UTSW 15 81,664,679 (GRCm39) missense probably damaging 1.00
R7918:Zc3h7b UTSW 15 81,653,189 (GRCm39) missense probably damaging 0.98
R8001:Zc3h7b UTSW 15 81,663,461 (GRCm39) nonsense probably null
R8504:Zc3h7b UTSW 15 81,664,719 (GRCm39) missense probably damaging 1.00
R8855:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8856:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8857:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8865:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8866:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8867:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R8868:Zc3h7b UTSW 15 81,656,681 (GRCm39) missense probably benign 0.01
R9071:Zc3h7b UTSW 15 81,677,964 (GRCm39) makesense probably null
R9136:Zc3h7b UTSW 15 81,653,312 (GRCm39) missense probably damaging 1.00
R9169:Zc3h7b UTSW 15 81,661,184 (GRCm39) missense probably benign 0.19
R9701:Zc3h7b UTSW 15 81,676,505 (GRCm39) missense probably damaging 1.00
R9802:Zc3h7b UTSW 15 81,676,505 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CACTGGGGCCTGGTAATTAG -3'
(R):5'- CATGGTGGTCTGATGAACGG -3'

Sequencing Primer
(F):5'- CCTGGTAATTAGGAAAAGGATCCATC -3'
(R):5'- CAGGCAGGTACCTCACAGAG -3'
Posted On 2014-12-04