Incidental Mutation 'R2866:Or8k39'
ID 253202
Institutional Source Beutler Lab
Gene Symbol Or8k39
Ensembl Gene ENSMUSG00000111711
Gene Name olfactory receptor family 8 subfamily K member 39
Synonyms Olfr1089, MOR193-1, GA_x6K02T2Q125-48226321-48225386
MMRRC Submission 040455-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.245) question?
Stock # R2866 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 86563019-86563954 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 86563773 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 61 (F61Y)
Gene Model predicted gene model for transcript(s): [ENSMUST00000214317]
AlphaFold A0A1L1SRK6
Predicted Effect possibly damaging
Transcript: ENSMUST00000099876
AA Change: F61Y

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000097461
Gene: ENSMUSG00000075173
AA Change: F61Y

DomainStartEndE-ValueType
Pfam:7tm_4 31 310 4.7e-47 PFAM
Pfam:7tm_1 41 290 2e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214317
AA Change: F61Y

PolyPhen 2 Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atmin T A 8: 117,683,112 (GRCm39) D257E probably benign Het
Best1 T C 19: 9,963,585 (GRCm39) E532G probably benign Het
Cenpj T C 14: 56,789,637 (GRCm39) H804R probably benign Het
Clec2g T C 6: 128,925,719 (GRCm39) S43P probably benign Het
Col8a2 A G 4: 126,204,992 (GRCm39) probably benign Het
Cpz T C 5: 35,659,705 (GRCm39) K647E probably benign Het
Csmd2 T C 4: 128,308,185 (GRCm39) probably null Het
Ctss A G 3: 95,452,717 (GRCm39) K166R probably benign Het
Cyp2c23 T C 19: 43,993,885 (GRCm39) R494G probably damaging Het
Cyp2c68 A G 19: 39,677,589 (GRCm39) I467T probably damaging Het
Dcaf11 A T 14: 55,803,202 (GRCm39) T299S possibly damaging Het
Dennd1b A G 1: 139,098,019 (GRCm39) S762G possibly damaging Het
Epb42 C T 2: 120,856,402 (GRCm39) A381T possibly damaging Het
Fhad1 A G 4: 141,648,099 (GRCm39) Y256H probably benign Het
Gfra1 C T 19: 58,227,739 (GRCm39) A395T possibly damaging Het
Gm10323 C A 13: 67,002,574 (GRCm39) C55F probably benign Het
Greb1 T C 12: 16,749,551 (GRCm39) S1092G probably damaging Het
Grid1 A T 14: 35,284,516 (GRCm39) D753V probably damaging Het
Grin2b A G 6: 135,710,637 (GRCm39) F970L probably damaging Het
Kcnma1 A T 14: 23,423,275 (GRCm39) N682K probably benign Het
Lat2 T A 5: 134,634,798 (GRCm39) D114V probably damaging Het
Lcat C T 8: 106,666,511 (GRCm39) C337Y probably damaging Het
Mapk10 C T 5: 103,186,548 (GRCm39) D25N probably benign Het
Mroh7 C T 4: 106,548,287 (GRCm39) G1064R probably damaging Het
Muc21 T C 17: 35,930,599 (GRCm39) probably benign Het
Or10h5 T A 17: 33,435,252 (GRCm39) H22L probably benign Het
Or51ah3 A T 7: 103,210,064 (GRCm39) I127F probably damaging Het
Or5p5 T A 7: 107,414,126 (GRCm39) C112S probably benign Het
Polr1has A T 17: 37,276,052 (GRCm39) R211S possibly damaging Het
Psg27 T A 7: 18,295,818 (GRCm39) D209V probably benign Het
Ptgir A G 7: 16,640,794 (GRCm39) M29V possibly damaging Het
Pzp A G 6: 128,502,227 (GRCm39) S41P possibly damaging Het
Rab23 A T 1: 33,777,376 (GRCm39) K163N possibly damaging Het
Rilpl2 T C 5: 124,615,898 (GRCm39) D84G probably damaging Het
Sorl1 A G 9: 41,881,077 (GRCm39) I2148T probably benign Het
Tead1 A G 7: 112,358,694 (GRCm39) E2G probably damaging Het
Tigd4 A G 3: 84,501,259 (GRCm39) N59D possibly damaging Het
Tmprss15 T A 16: 78,832,121 (GRCm39) D345V possibly damaging Het
Togaram2 T C 17: 72,016,592 (GRCm39) S649P probably benign Het
Ucp2 T C 7: 100,146,459 (GRCm39) V95A probably benign Het
Usp17lb T C 7: 104,489,955 (GRCm39) D323G probably damaging Het
Zfp677 A T 17: 21,617,518 (GRCm39) K192* probably null Het
Zmym2 T A 14: 57,165,705 (GRCm39) I676K probably damaging Het
Other mutations in Or8k39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00332:Or8k39 APN 2 86,563,579 (GRCm39) missense possibly damaging 0.90
IGL00944:Or8k39 APN 2 86,563,905 (GRCm39) missense possibly damaging 0.80
IGL01478:Or8k39 APN 2 86,563,673 (GRCm39) nonsense probably null
IGL01636:Or8k39 APN 2 86,563,945 (GRCm39) nonsense probably null
IGL01887:Or8k39 APN 2 86,563,030 (GRCm39) missense probably benign 0.03
IGL02008:Or8k39 APN 2 86,563,521 (GRCm39) missense possibly damaging 0.90
IGL02470:Or8k39 APN 2 86,563,929 (GRCm39) missense probably damaging 0.97
IGL02560:Or8k39 APN 2 86,563,578 (GRCm39) missense probably damaging 1.00
R1782:Or8k39 UTSW 2 86,563,026 (GRCm39) missense probably benign 0.03
R2234:Or8k39 UTSW 2 86,563,921 (GRCm39) missense possibly damaging 0.94
R3027:Or8k39 UTSW 2 86,563,930 (GRCm39) missense possibly damaging 0.79
R4275:Or8k39 UTSW 2 86,563,936 (GRCm39) missense probably damaging 1.00
R4799:Or8k39 UTSW 2 86,563,018 (GRCm39) splice site probably null
R5016:Or8k39 UTSW 2 86,563,090 (GRCm39) missense probably benign 0.17
R5154:Or8k39 UTSW 2 86,563,121 (GRCm39) nonsense probably null
R5355:Or8k39 UTSW 2 86,563,680 (GRCm39) missense probably damaging 1.00
R5624:Or8k39 UTSW 2 86,563,149 (GRCm39) missense probably benign 0.45
R6265:Or8k39 UTSW 2 86,563,299 (GRCm39) missense probably damaging 0.99
R7382:Or8k39 UTSW 2 86,563,129 (GRCm39) missense probably benign 0.02
R8009:Or8k39 UTSW 2 86,563,848 (GRCm39) missense probably damaging 0.99
R8850:Or8k39 UTSW 2 86,563,302 (GRCm39) missense probably damaging 0.99
R9652:Or8k39 UTSW 2 86,563,636 (GRCm39) missense probably damaging 1.00
X0028:Or8k39 UTSW 2 86,563,092 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ATTGTAGAGCAGAGGGTTGC -3'
(R):5'- CATGGAGAGACAGAACTTCACAGTC -3'

Sequencing Primer
(F):5'- TTGCAGATGGCCACATAGTG -3'
(R):5'- GCTGAAGGGTCCATTGTT -3'
Posted On 2014-12-04