Mutagenetix > Incidental Mutation

Incidental Mutation 'R0313:Lama2'

25343

Institutional Source

Beutler Lab

Gene Symbol

Lama2

Ensembl Gene

ENSMUSG00000019899

Gene Name

laminin, alpha 2

Synonyms

mer, merosin

MMRRC Submission

038523-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.321) question?

Stock #

R0313 (G1)

Quality Score

193

Status

Validated

Chromosome

Chromosomal Location

26857281-27493021 bp(-) (GRCm39)

Type of Mutation

splice site (5 bp from exon)

DNA Base Change (assembly)

C to A at 26869394 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092639]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000092639

SMART Domains

Protein: ENSMUSP00000090304
Gene: ENSMUSG00000019899

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
LamNT	29	281	5.35e-129	SMART
EGF_Lam	283	337	2.11e-4	SMART
EGF_Lam	340	407	1.59e-8	SMART
EGF_Lam	410	462	5.44e-7	SMART
EGF_Lam	465	511	9.05e-4	SMART
LamB	574	706	2.26e-44	SMART
Pfam:Laminin_EGF	715	745	2.8e-4	PFAM
EGF_Lam	753	800	4.03e-10	SMART
EGF_Lam	803	858	3.01e-9	SMART
EGF_Lam	861	911	1.35e-11	SMART
EGF_Lam	914	960	7.23e-12	SMART
EGF_Lam	963	1007	5.87e-12	SMART
EGF_Lam	1010	1053	1.28e-12	SMART
EGF_Lam	1056	1099	2.37e-7	SMART
EGF_Lam	1102	1159	3.22e-9	SMART
LamB	1225	1360	1.95e-57	SMART
EGF_like	1364	1413	8.13e-1	SMART
EGF_Lam	1416	1462	5.48e-12	SMART
EGF_Lam	1465	1520	1.27e-7	SMART
EGF_Lam	1523	1567	2.4e-8	SMART
Pfam:Laminin_I	1584	1849	2e-92	PFAM
Blast:MA	1881	2113	1e-112	BLAST
LamG	2162	2307	1.28e-25	SMART
LamG	2356	2500	2.2e-33	SMART
LamG	2542	2688	3.31e-28	SMART
low complexity region	2725	2741	N/A	INTRINSIC
LamG	2781	2914	2.25e-39	SMART
LamG	2956	3092	1.53e-32	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000186279

Predicted Effect

probably null
Transcript: ENSMUST00000219763

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 98.8%
3x: 97.7%
10x: 94.9%
20x: 88.5%

Validation Efficiency

98% (40/41)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted and spontaneous mutations exhibit progressive growth retardation, ataxia, muscle atrophy and degeneration, infertility, and premature lethality. Muscle fiber degeneration is evident as early as the first week of life. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg2	A	G	6: 58,649,082 (GRCm39)	E309G	probably benign	Het
Ankmy1	C	T	1: 92,813,943 (GRCm39)	G412D	probably damaging	Het
Cc2d1a	G	A	8: 84,863,598 (GRCm39)	T542I	probably benign	Het
Cldn18	T	C	9: 99,580,967 (GRCm39)	I94V	probably benign	Het
Cobll1	G	A	2: 64,926,088 (GRCm39)	R1195*	probably null	Het
Dnah7b	A	G	1: 46,246,803 (GRCm39)	T1660A	probably damaging	Het
Dzip3	G	T	16: 48,757,424 (GRCm39)	Q870K	probably damaging	Het
Ebf4	T	C	2: 130,148,707 (GRCm39)		probably benign	Het
Ecpas	A	G	4: 58,811,892 (GRCm39)	I1411T	probably benign	Het
Esyt2	T	C	12: 116,311,428 (GRCm39)	L439P	probably damaging	Het
Fbxl17	G	A	17: 63,663,846 (GRCm39)	R67C	probably damaging	Het
Haspin	A	G	11: 73,027,124 (GRCm39)	V655A	probably damaging	Het
Kmt2c	T	C	5: 25,549,928 (GRCm39)	E1351G	probably damaging	Het
Lcp1	A	G	14: 75,436,873 (GRCm39)	E73G	probably damaging	Het
Ltv1	C	T	10: 13,058,604 (GRCm39)		probably null	Het
Mcmdc2	A	G	1: 10,002,366 (GRCm39)	Y529C	probably damaging	Het
Myo3b	T	A	2: 70,179,303 (GRCm39)	Y1172*	probably null	Het
Ncf1	T	C	5: 134,258,421 (GRCm39)	M1V	probably null	Het
Or4k47	C	T	2: 111,451,945 (GRCm39)	S158N	possibly damaging	Het
Or6c8b	A	G	10: 128,882,695 (GRCm39)	V79A	possibly damaging	Het
Or8c10	T	C	9: 38,279,600 (GRCm39)	S243P	probably damaging	Het
Pcif1	A	T	2: 164,726,339 (GRCm39)	H80L	probably damaging	Het
Pclo	T	C	5: 14,728,887 (GRCm39)		probably benign	Het
Polr2a	T	C	11: 69,625,906 (GRCm39)	Y1710C	unknown	Het
Ppp1r37	G	A	7: 19,267,923 (GRCm39)	T324I	probably damaging	Het
Prmt1	T	C	7: 44,628,172 (GRCm39)	D176G	probably benign	Het
Scn5a	T	C	9: 119,363,637 (GRCm39)	D501G	probably damaging	Het
Ska2	A	G	11: 87,008,640 (GRCm39)	I89M	possibly damaging	Het
Slc39a7	G	A	17: 34,248,518 (GRCm39)	A375V	probably damaging	Het
Ssrp1	T	A	2: 84,871,898 (GRCm39)	I374N	probably damaging	Het
Stox2	C	T	8: 47,645,169 (GRCm39)	G828R	probably damaging	Het
Tcam1	G	A	11: 106,174,904 (GRCm39)	E120K	probably benign	Het
Uqcrc1	C	A	9: 108,777,642 (GRCm39)	R114S	possibly damaging	Het
Usp38	A	T	8: 81,711,071 (GRCm39)	L988*	probably null	Het
Vmn2r5	T	A	3: 64,411,248 (GRCm39)	H440L	probably benign	Het
Wdr12	A	T	1: 60,121,738 (GRCm39)	I271N	possibly damaging	Het
Xylt2	C	T	11: 94,560,720 (GRCm39)		probably benign	Het

Other mutations in Lama2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00392:Lama2	APN	10	27,064,261 (GRCm39)	missense	probably benign	0.01
IGL00467:Lama2	APN	10	27,343,193 (GRCm39)	splice site	probably benign
IGL00470:Lama2	APN	10	27,119,738 (GRCm39)	missense	probably benign	0.22
IGL00517:Lama2	APN	10	27,073,326 (GRCm39)	missense	probably benign	0.01
IGL00541:Lama2	APN	10	27,064,302 (GRCm39)	missense	probably benign	0.14
IGL00931:Lama2	APN	10	26,882,772 (GRCm39)	missense	possibly damaging	0.92
IGL00951:Lama2	APN	10	26,906,281 (GRCm39)	missense	probably benign	0.03
IGL00988:Lama2	APN	10	27,245,011 (GRCm39)	nonsense	probably null
IGL01098:Lama2	APN	10	26,907,108 (GRCm39)	missense	possibly damaging	0.66
IGL01152:Lama2	APN	10	27,084,425 (GRCm39)	missense	probably benign	0.00
IGL01293:Lama2	APN	10	27,107,632 (GRCm39)	missense	probably benign	0.38
IGL01338:Lama2	APN	10	27,064,268 (GRCm39)	missense	probably benign	0.13
IGL01609:Lama2	APN	10	27,220,417 (GRCm39)	missense	probably benign	0.03
IGL01643:Lama2	APN	10	26,946,368 (GRCm39)	splice site	probably benign
IGL01675:Lama2	APN	10	27,064,050 (GRCm39)	missense	possibly damaging	0.77
IGL01681:Lama2	APN	10	27,141,041 (GRCm39)	missense	probably benign	0.33
IGL01694:Lama2	APN	10	26,882,738 (GRCm39)	missense	possibly damaging	0.75
IGL01705:Lama2	APN	10	27,065,270 (GRCm39)	splice site	probably benign
IGL01885:Lama2	APN	10	26,981,135 (GRCm39)	nonsense	probably null
IGL01935:Lama2	APN	10	27,298,600 (GRCm39)	missense	probably damaging	0.98
IGL01994:Lama2	APN	10	27,343,199 (GRCm39)	critical splice donor site	probably null
IGL02041:Lama2	APN	10	26,860,322 (GRCm39)	missense	probably damaging	1.00
IGL02067:Lama2	APN	10	27,052,792 (GRCm39)	missense	probably benign	0.02
IGL02097:Lama2	APN	10	27,014,956 (GRCm39)	missense	probably benign	0.09
IGL02179:Lama2	APN	10	26,946,360 (GRCm39)	missense	probably benign	0.01
IGL02268:Lama2	APN	10	26,877,112 (GRCm39)	splice site	probably benign
IGL02302:Lama2	APN	10	27,088,039 (GRCm39)	missense	probably benign	0.06
IGL02363:Lama2	APN	10	27,242,062 (GRCm39)	missense	probably damaging	1.00
IGL02378:Lama2	APN	10	26,919,652 (GRCm39)	missense	probably damaging	0.99
IGL02642:Lama2	APN	10	27,343,269 (GRCm39)	missense	probably damaging	1.00
IGL02676:Lama2	APN	10	26,994,489 (GRCm39)	missense	probably benign	0.00
IGL02695:Lama2	APN	10	26,876,771 (GRCm39)	missense	probably benign
IGL02735:Lama2	APN	10	26,980,124 (GRCm39)	missense	probably damaging	1.00
IGL02794:Lama2	APN	10	26,917,227 (GRCm39)	missense	possibly damaging	0.73
IGL02823:Lama2	APN	10	26,877,141 (GRCm39)	missense	probably damaging	1.00
IGL02869:Lama2	APN	10	26,891,534 (GRCm39)	missense	probably damaging	0.99
IGL02942:Lama2	APN	10	26,917,216 (GRCm39)	missense	probably damaging	1.00
IGL03201:Lama2	APN	10	27,220,566 (GRCm39)	nonsense	probably null
IGL03268:Lama2	APN	10	27,298,649 (GRCm39)	missense	probably damaging	1.00
IGL03288:Lama2	APN	10	27,245,047 (GRCm39)	missense	probably damaging	1.00
IGL03380:Lama2	APN	10	26,926,261 (GRCm39)	missense	probably damaging	1.00
IGL03407:Lama2	APN	10	27,223,017 (GRCm39)	missense	probably damaging	1.00
cowboy	UTSW	10	26,919,639 (GRCm39)	frame shift	probably null
petri	UTSW	10	26,869,394 (GRCm39)	splice site	probably null
PIT4362001:Lama2	UTSW	10	27,245,132 (GRCm39)	missense	probably damaging	1.00
PIT4382001:Lama2	UTSW	10	27,080,901 (GRCm39)	missense	probably damaging	1.00
PIT4431001:Lama2	UTSW	10	26,977,426 (GRCm39)	missense	probably damaging	1.00
R0038:Lama2	UTSW	10	26,862,793 (GRCm39)	missense	probably benign	0.02
R0038:Lama2	UTSW	10	26,862,793 (GRCm39)	missense	probably benign	0.02
R0114:Lama2	UTSW	10	26,869,064 (GRCm39)	nonsense	probably null
R0142:Lama2	UTSW	10	27,063,841 (GRCm39)	missense	probably benign
R0376:Lama2	UTSW	10	26,891,542 (GRCm39)	missense	possibly damaging	0.68
R0412:Lama2	UTSW	10	27,066,621 (GRCm39)	missense	possibly damaging	0.58
R0472:Lama2	UTSW	10	26,866,863 (GRCm39)	missense	probably damaging	1.00
R0607:Lama2	UTSW	10	27,065,127 (GRCm39)	missense	probably benign	0.34
R0648:Lama2	UTSW	10	26,865,372 (GRCm39)	missense	probably benign	0.00
R0667:Lama2	UTSW	10	27,220,406 (GRCm39)	splice site	probably null
R0760:Lama2	UTSW	10	26,920,429 (GRCm39)	critical splice donor site	probably null
R1240:Lama2	UTSW	10	26,917,120 (GRCm39)	missense	probably damaging	1.00
R1385:Lama2	UTSW	10	27,100,039 (GRCm39)	missense	probably benign	0.11
R1433:Lama2	UTSW	10	27,063,750 (GRCm39)	missense	probably damaging	1.00
R1434:Lama2	UTSW	10	27,084,366 (GRCm39)	missense	probably damaging	1.00
R1574:Lama2	UTSW	10	27,200,750 (GRCm39)	missense	possibly damaging	0.65
R1574:Lama2	UTSW	10	27,200,750 (GRCm39)	missense	possibly damaging	0.65
R1645:Lama2	UTSW	10	27,244,981 (GRCm39)	missense	probably damaging	1.00
R1702:Lama2	UTSW	10	27,066,525 (GRCm39)	missense	probably benign
R1703:Lama2	UTSW	10	27,142,667 (GRCm39)	missense	probably damaging	1.00
R1769:Lama2	UTSW	10	27,084,403 (GRCm39)	missense	probably benign
R1769:Lama2	UTSW	10	27,084,402 (GRCm39)	missense	probably damaging	1.00
R1846:Lama2	UTSW	10	27,088,092 (GRCm39)	missense	probably damaging	1.00
R1859:Lama2	UTSW	10	26,907,078 (GRCm39)	missense	possibly damaging	0.51
R1871:Lama2	UTSW	10	26,860,490 (GRCm39)	missense	probably damaging	1.00
R1903:Lama2	UTSW	10	27,064,395 (GRCm39)	missense	probably damaging	1.00
R1906:Lama2	UTSW	10	26,932,523 (GRCm39)	critical splice donor site	probably null
R1958:Lama2	UTSW	10	26,857,594 (GRCm39)	missense	probably damaging	0.97
R1959:Lama2	UTSW	10	27,298,614 (GRCm39)	missense	probably damaging	1.00
R1977:Lama2	UTSW	10	26,866,796 (GRCm39)	splice site	probably null
R2063:Lama2	UTSW	10	27,040,922 (GRCm39)	missense	probably damaging	1.00
R2079:Lama2	UTSW	10	27,245,049 (GRCm39)	missense	probably damaging	0.99
R2085:Lama2	UTSW	10	27,080,837 (GRCm39)	nonsense	probably null
R2125:Lama2	UTSW	10	26,920,449 (GRCm39)	nonsense	probably null
R2140:Lama2	UTSW	10	26,930,690 (GRCm39)	splice site	probably null
R2219:Lama2	UTSW	10	26,919,565 (GRCm39)	missense	probably damaging	0.99
R2259:Lama2	UTSW	10	26,907,123 (GRCm39)	missense	probably benign	0.00
R2265:Lama2	UTSW	10	26,868,932 (GRCm39)	missense	probably damaging	1.00
R2266:Lama2	UTSW	10	26,862,793 (GRCm39)	missense	probably benign	0.02
R2267:Lama2	UTSW	10	26,868,932 (GRCm39)	missense	probably damaging	1.00
R2268:Lama2	UTSW	10	26,868,932 (GRCm39)	missense	probably damaging	1.00
R2269:Lama2	UTSW	10	26,868,932 (GRCm39)	missense	probably damaging	1.00
R2862:Lama2	UTSW	10	27,298,608 (GRCm39)	nonsense	probably null
R2912:Lama2	UTSW	10	26,876,799 (GRCm39)	missense	probably benign
R2999:Lama2	UTSW	10	26,865,417 (GRCm39)	missense	probably benign	0.18
R3034:Lama2	UTSW	10	26,877,231 (GRCm39)	missense	probably benign	0.11
R3081:Lama2	UTSW	10	26,877,231 (GRCm39)	missense	probably benign	0.11
R3107:Lama2	UTSW	10	26,877,231 (GRCm39)	missense	probably benign	0.11
R3109:Lama2	UTSW	10	26,877,231 (GRCm39)	missense	probably benign	0.11
R3436:Lama2	UTSW	10	26,877,231 (GRCm39)	missense	probably benign	0.11
R3437:Lama2	UTSW	10	26,877,231 (GRCm39)	missense	probably benign	0.11
R3706:Lama2	UTSW	10	27,014,992 (GRCm39)	missense	probably damaging	1.00
R3780:Lama2	UTSW	10	27,335,335 (GRCm39)	missense	probably damaging	1.00
R3807:Lama2	UTSW	10	27,066,661 (GRCm39)	frame shift	probably null
R3919:Lama2	UTSW	10	26,994,501 (GRCm39)	missense	probably damaging	1.00
R4014:Lama2	UTSW	10	26,860,372 (GRCm39)	missense	probably damaging	1.00
R4131:Lama2	UTSW	10	26,917,170 (GRCm39)	missense	probably benign	0.00
R4190:Lama2	UTSW	10	27,142,660 (GRCm39)	missense	probably damaging	0.96
R4273:Lama2	UTSW	10	27,223,050 (GRCm39)	missense	probably damaging	1.00
R4358:Lama2	UTSW	10	26,860,489 (GRCm39)	missense	probably damaging	1.00
R4407:Lama2	UTSW	10	27,088,124 (GRCm39)	small deletion	probably benign
R4415:Lama2	UTSW	10	26,865,340 (GRCm39)	nonsense	probably null
R4426:Lama2	UTSW	10	27,298,554 (GRCm39)	missense	probably damaging	1.00
R4590:Lama2	UTSW	10	26,865,410 (GRCm39)	missense	probably benign	0.00
R4615:Lama2	UTSW	10	26,857,520 (GRCm39)	missense	probably damaging	0.99
R4736:Lama2	UTSW	10	27,080,925 (GRCm39)	missense	probably damaging	1.00
R4754:Lama2	UTSW	10	26,994,527 (GRCm39)	missense	possibly damaging	0.58
R4791:Lama2	UTSW	10	27,343,267 (GRCm39)	missense	probably damaging	1.00
R4834:Lama2	UTSW	10	26,882,745 (GRCm39)	missense	probably benign	0.30
R4856:Lama2	UTSW	10	26,919,639 (GRCm39)	frame shift	probably null
R4858:Lama2	UTSW	10	26,919,639 (GRCm39)	frame shift	probably null
R4859:Lama2	UTSW	10	26,919,639 (GRCm39)	frame shift	probably null
R4897:Lama2	UTSW	10	26,919,639 (GRCm39)	frame shift	probably null
R4898:Lama2	UTSW	10	26,919,639 (GRCm39)	frame shift	probably null
R4899:Lama2	UTSW	10	26,919,639 (GRCm39)	frame shift	probably null
R4907:Lama2	UTSW	10	27,040,942 (GRCm39)	missense	probably benign	0.11
R4911:Lama2	UTSW	10	27,014,923 (GRCm39)	missense	probably damaging	1.00
R4924:Lama2	UTSW	10	27,245,137 (GRCm39)	missense	probably damaging	0.98
R5023:Lama2	UTSW	10	27,066,500 (GRCm39)	missense	probably damaging	0.97
R5057:Lama2	UTSW	10	27,040,982 (GRCm39)	missense	probably damaging	1.00
R5070:Lama2	UTSW	10	27,226,247 (GRCm39)	critical splice donor site	probably null
R5116:Lama2	UTSW	10	26,994,556 (GRCm39)	missense	probably benign	0.08
R5177:Lama2	UTSW	10	27,066,699 (GRCm39)	missense	possibly damaging	0.94
R5198:Lama2	UTSW	10	27,222,999 (GRCm39)	missense	probably damaging	0.96
R5289:Lama2	UTSW	10	27,088,069 (GRCm39)	nonsense	probably null
R5327:Lama2	UTSW	10	27,014,942 (GRCm39)	missense	probably benign
R5424:Lama2	UTSW	10	26,860,392 (GRCm39)	missense	probably damaging	1.00
R5469:Lama2	UTSW	10	26,917,185 (GRCm39)	missense	possibly damaging	0.92
R5620:Lama2	UTSW	10	26,866,876 (GRCm39)	missense	probably damaging	0.99
R5667:Lama2	UTSW	10	27,066,540 (GRCm39)	missense	probably damaging	1.00
R5671:Lama2	UTSW	10	27,066,540 (GRCm39)	missense	probably damaging	1.00
R5815:Lama2	UTSW	10	26,862,847 (GRCm39)	missense	probably damaging	1.00
R5917:Lama2	UTSW	10	27,066,693 (GRCm39)	missense	probably damaging	1.00
R5935:Lama2	UTSW	10	26,891,494 (GRCm39)	missense	probably benign
R5976:Lama2	UTSW	10	27,066,672 (GRCm39)	missense	probably benign	0.00
R5979:Lama2	UTSW	10	27,111,728 (GRCm39)	missense	probably damaging	0.99
R6004:Lama2	UTSW	10	27,111,781 (GRCm39)	missense	probably benign	0.01
R6180:Lama2	UTSW	10	26,857,495 (GRCm39)	missense	probably benign	0.03
R6198:Lama2	UTSW	10	27,064,018 (GRCm39)	missense	probably damaging	1.00
R6257:Lama2	UTSW	10	26,862,895 (GRCm39)	missense	possibly damaging	0.85
R6271:Lama2	UTSW	10	26,899,325 (GRCm39)	missense	possibly damaging	0.67
R6322:Lama2	UTSW	10	27,066,543 (GRCm39)	missense	probably damaging	0.96
R6354:Lama2	UTSW	10	27,088,064 (GRCm39)	missense	probably damaging	1.00
R6431:Lama2	UTSW	10	26,929,027 (GRCm39)	missense	possibly damaging	0.50
R6499:Lama2	UTSW	10	26,907,154 (GRCm39)	missense	probably damaging	1.00
R6535:Lama2	UTSW	10	26,980,127 (GRCm39)	missense	probably damaging	1.00
R6545:Lama2	UTSW	10	27,052,793 (GRCm39)	missense	probably benign
R6636:Lama2	UTSW	10	27,000,564 (GRCm39)	missense	probably benign	0.13
R6891:Lama2	UTSW	10	27,204,078 (GRCm39)	nonsense	probably null
R6891:Lama2	UTSW	10	27,204,068 (GRCm39)	nonsense	probably null
R6902:Lama2	UTSW	10	26,857,625 (GRCm39)	missense	probably damaging	1.00
R6908:Lama2	UTSW	10	26,907,192 (GRCm39)	splice site	probably null
R7168:Lama2	UTSW	10	27,242,148 (GRCm39)	critical splice acceptor site	probably null
R7233:Lama2	UTSW	10	27,107,659 (GRCm39)	missense	probably damaging	1.00
R7272:Lama2	UTSW	10	27,000,552 (GRCm39)	missense	probably damaging	1.00
R7274:Lama2	UTSW	10	26,995,976 (GRCm39)	missense	probably damaging	0.99
R7419:Lama2	UTSW	10	27,142,630 (GRCm39)	missense	probably benign
R7423:Lama2	UTSW	10	27,088,222 (GRCm39)	missense	probably benign	0.00
R7554:Lama2	UTSW	10	27,031,492 (GRCm39)	missense	probably damaging	1.00
R7569:Lama2	UTSW	10	27,141,046 (GRCm39)	missense	probably damaging	1.00
R7574:Lama2	UTSW	10	26,882,726 (GRCm39)	missense	probably benign	0.03
R7584:Lama2	UTSW	10	26,980,257 (GRCm39)	missense	possibly damaging	0.78
R7586:Lama2	UTSW	10	26,977,389 (GRCm39)	missense	probably benign	0.00
R7603:Lama2	UTSW	10	27,142,676 (GRCm39)	missense	possibly damaging	0.55
R7691:Lama2	UTSW	10	27,084,389 (GRCm39)	missense	possibly damaging	0.67
R7750:Lama2	UTSW	10	26,866,920 (GRCm39)	missense	probably damaging	0.97
R7841:Lama2	UTSW	10	27,031,529 (GRCm39)	missense	probably benign	0.00
R7864:Lama2	UTSW	10	26,932,611 (GRCm39)	missense	probably benign	0.08
R7960:Lama2	UTSW	10	26,869,094 (GRCm39)	missense	probably benign	0.04
R7964:Lama2	UTSW	10	27,099,977 (GRCm39)	critical splice donor site	probably null
R7980:Lama2	UTSW	10	27,239,609 (GRCm39)	missense	probably damaging	0.98
R8013:Lama2	UTSW	10	27,220,494 (GRCm39)	missense	probably benign	0.00
R8028:Lama2	UTSW	10	27,204,145 (GRCm39)	missense	probably benign	0.13
R8097:Lama2	UTSW	10	27,066,660 (GRCm39)	nonsense	probably null
R8100:Lama2	UTSW	10	26,917,113 (GRCm39)	missense	probably benign	0.03
R8110:Lama2	UTSW	10	26,866,866 (GRCm39)	missense	probably damaging	1.00
R8122:Lama2	UTSW	10	26,930,592 (GRCm39)	missense	possibly damaging	0.87
R8264:Lama2	UTSW	10	27,343,218 (GRCm39)	missense	probably benign	0.07
R8315:Lama2	UTSW	10	27,298,655 (GRCm39)	missense	probably damaging	1.00
R8318:Lama2	UTSW	10	26,860,334 (GRCm39)	missense	probably damaging	1.00
R8419:Lama2	UTSW	10	27,298,559 (GRCm39)	missense	probably benign	0.26
R8475:Lama2	UTSW	10	26,977,369 (GRCm39)	missense	possibly damaging	0.69
R8735:Lama2	UTSW	10	27,066,530 (GRCm39)	missense	probably damaging	1.00
R8754:Lama2	UTSW	10	26,877,147 (GRCm39)	missense	possibly damaging	0.83
R8817:Lama2	UTSW	10	27,063,869 (GRCm39)	missense	probably damaging	1.00
R8851:Lama2	UTSW	10	27,242,119 (GRCm39)	missense	possibly damaging	0.94
R8859:Lama2	UTSW	10	27,335,384 (GRCm39)	missense	possibly damaging	0.58
R8886:Lama2	UTSW	10	27,245,157 (GRCm39)	splice site	probably benign
R8937:Lama2	UTSW	10	26,862,816 (GRCm39)	missense	probably damaging	1.00
R8993:Lama2	UTSW	10	27,298,710 (GRCm39)	missense	possibly damaging	0.91
R9025:Lama2	UTSW	10	26,860,367 (GRCm39)	missense	probably benign	0.00
R9027:Lama2	UTSW	10	27,080,881 (GRCm39)	missense	probably damaging	1.00
R9047:Lama2	UTSW	10	26,882,697 (GRCm39)	missense	possibly damaging	0.50
R9075:Lama2	UTSW	10	26,857,588 (GRCm39)	missense	probably damaging	1.00
R9135:Lama2	UTSW	10	27,298,515 (GRCm39)	missense	probably damaging	1.00
R9165:Lama2	UTSW	10	26,929,022 (GRCm39)	critical splice donor site	probably null
R9192:Lama2	UTSW	10	27,204,181 (GRCm39)	missense	possibly damaging	0.95
R9254:Lama2	UTSW	10	27,298,685 (GRCm39)	missense	probably damaging	0.96
R9326:Lama2	UTSW	10	26,906,193 (GRCm39)	missense	probably benign	0.04
R9356:Lama2	UTSW	10	27,088,186 (GRCm39)	missense	probably damaging	0.99
R9358:Lama2	UTSW	10	27,492,761 (GRCm39)	missense	unknown
R9358:Lama2	UTSW	10	27,064,378 (GRCm39)	missense	possibly damaging	0.95
R9376:Lama2	UTSW	10	26,994,620 (GRCm39)	missense	probably benign	0.11
R9381:Lama2	UTSW	10	27,064,023 (GRCm39)	nonsense	probably null
R9397:Lama2	UTSW	10	26,981,117 (GRCm39)	missense	probably benign	0.01
R9460:Lama2	UTSW	10	27,298,475 (GRCm39)	missense	probably damaging	1.00
R9478:Lama2	UTSW	10	26,891,478 (GRCm39)	missense	probably damaging	0.98
R9503:Lama2	UTSW	10	26,865,440 (GRCm39)	missense	possibly damaging	0.57
R9514:Lama2	UTSW	10	27,100,015 (GRCm39)	missense	probably benign	0.00
R9515:Lama2	UTSW	10	26,877,170 (GRCm39)	missense	probably benign	0.23
R9516:Lama2	UTSW	10	27,100,015 (GRCm39)	missense	probably benign	0.00
R9533:Lama2	UTSW	10	26,862,871 (GRCm39)	missense	probably damaging	1.00
R9619:Lama2	UTSW	10	27,064,282 (GRCm39)	missense	probably damaging	1.00
R9721:Lama2	UTSW	10	27,343,338 (GRCm39)	missense	possibly damaging	0.58

Predicted Primers

PCR Primer
(F):5'- GCCTGATTCAGCTTCAGTTCGTACC -3'
(R):5'- ACTCCAACAGCAACATTGTCCGTG -3'

Sequencing Primer
(F):5'- CAAGAGTCTCGTTAGGCTAAAAC -3'
(R):5'- AGCAACATTGTCCGTGTATCTG -3'

Posted On

2013-04-16