Mutagenetix > Incidental Mutation

Incidental Mutation 'R2513:Lrp2'

253549

Institutional Source

Beutler Lab

Gene Symbol

Lrp2

Ensembl Gene

ENSMUSG00000027070

Gene Name

low density lipoprotein receptor-related protein 2

Synonyms

Gp330, D230004K18Rik, b2b1625.2Clo, Megalin

MMRRC Submission

040419-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R2513 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

69424340-69586065 bp(-) (GRCm38)

Type of Mutation

splice site (5 bp from exon)

DNA Base Change (assembly)

C to T at 69506374 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000079752 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080953] [ENSMUST00000100051]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000080953

SMART Domains

Protein: ENSMUSP00000079752
Gene: ENSMUSG00000027070

Domain	Start	End	E-Value	Type
low complexity region	5	21	N/A	INTRINSIC
LDLa	27	64	5.63e-13	SMART
LDLa	66	105	2.25e-12	SMART
EGF	107	143	2.59e1	SMART
LDLa	107	144	9.29e-14	SMART
LDLa	146	181	6.18e-10	SMART
LDLa	182	219	1.08e-14	SMART
LDLa	221	258	1.05e-12	SMART
LDLa	264	302	1.66e-10	SMART
EGF	310	346	3.23e0	SMART
EGF	350	385	2.32e-1	SMART
LY	414	457	3.88e-3	SMART
LY	458	500	1.17e-6	SMART
LY	501	547	5.96e-13	SMART
LY	548	590	1.94e-12	SMART
LY	591	634	2.66e0	SMART
EGF	661	704	7.76e-3	SMART
LY	732	774	1.76e0	SMART
LY	775	817	3.64e-8	SMART
LY	818	860	1.11e-3	SMART
LY	861	903	2.11e-13	SMART
LY	905	946	9.33e-1	SMART
EGF	972	1013	1.73e0	SMART
LDLa	1024	1061	1.05e-12	SMART
LDLa	1065	1103	4.65e-14	SMART
LDLa	1109	1146	3.63e-16	SMART
LDLa	1149	1186	5.5e-16	SMART
LDLa	1187	1225	1.43e-14	SMART
LDLa	1230	1269	2.1e-12	SMART
LDLa	1271	1308	3.63e-16	SMART
LDLa	1312	1351	4.69e-10	SMART
EGF	1353	1390	9.7e-4	SMART
EGF_CA	1391	1430	6.54e-10	SMART
LY	1457	1501	1.43e-1	SMART
LY	1502	1544	2e-14	SMART
LY	1545	1590	3.03e-14	SMART
LY	1591	1633	5.48e-12	SMART
LY	1635	1677	1.18e-2	SMART
EGF	1704	1742	5.2e-4	SMART
LY	1771	1812	1.68e1	SMART
LY	1813	1856	1.91e-2	SMART
LY	1859	1911	1.88e-10	SMART
LY	1912	1954	7.69e-7	SMART
LY	1955	1994	3e1	SMART
EGF	2022	2060	1.18e-2	SMART
LY	2088	2135	1.14e1	SMART
LY	2136	2182	2.11e-4	SMART
LY	2183	2226	2.22e-12	SMART
LY	2227	2269	1.24e-10	SMART
EGF	2346	2384	2.07e1	SMART
LY	2459	2501	9.91e-10	SMART
LY	2503	2543	1.48e-8	SMART
LY	2544	2586	6.85e-13	SMART
LY	2587	2627	8.13e-1	SMART
EGF_like	2655	2694	3.5e1	SMART
LDLa	2700	2739	2.86e-14	SMART
LDLa	2741	2778	8.09e-14	SMART
LDLa	2780	2820	3.19e-12	SMART
LDLa	2822	2862	6.94e-13	SMART
LDLa	2864	2903	9.29e-14	SMART
LDLa	2907	2947	4.79e-16	SMART
LDLa	2949	2992	8.41e-12	SMART
LDLa	2994	3031	1.08e-14	SMART
LDLa	3033	3072	1.83e-12	SMART
LDLa	3076	3113	1.16e-14	SMART
EGF	3115	3153	8.57e-5	SMART
EGF_CA	3154	3194	3.56e-11	SMART
LY	3221	3263	9.77e-9	SMART
LY	3264	3306	1.22e-9	SMART
LY	3312	3358	5.44e-7	SMART
LY	3359	3401	1.83e-13	SMART
LY	3402	3443	1.41e-5	SMART
EGF	3470	3511	8.91e-3	SMART
LDLa	3513	3552	1.79e-15	SMART
LDLa	3554	3593	9.89e-9	SMART
LDLa	3595	3634	3.07e-14	SMART
LDLa	3636	3675	3.34e-15	SMART
LDLa	3679	3718	1.39e-12	SMART
LDLa	3720	3758	3.83e-15	SMART
LDLa	3760	3797	7.15e-15	SMART
LDLa	3799	3836	2.86e-14	SMART
LDLa	3843	3882	2.38e-11	SMART
LDLa	3884	3924	3.66e-12	SMART
LDLa	3929	3966	1.93e-11	SMART
EGF	3971	4008	6.3e-3	SMART
EGF_CA	4009	4050	1.36e-7	SMART
low complexity region	4072	4084	N/A	INTRINSIC
LY	4136	4178	6.2e-11	SMART
LY	4179	4222	4.32e-10	SMART
LY	4223	4266	3.78e-15	SMART
LY	4267	4306	4.53e1	SMART
EGF	4335	4367	3.46e0	SMART
EGF	4368	4413	1.53e-1	SMART
transmembrane domain	4425	4447	N/A	INTRINSIC
low complexity region	4454	4472	N/A	INTRINSIC
low complexity region	4616	4636	N/A	INTRINSIC

Predicted Effect

silent
Transcript: ENSMUST00000100051

SMART Domains

Protein: ENSMUSP00000097628
Gene: ENSMUSG00000027070

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
LDLa	27	64	5.63e-13	SMART
LDLa	66	105	2.25e-12	SMART
EGF	107	143	2.59e1	SMART
LDLa	107	144	9.29e-14	SMART
LDLa	146	181	6.18e-10	SMART
LDLa	182	219	1.08e-14	SMART
LDLa	221	258	1.05e-12	SMART
LDLa	264	302	1.66e-10	SMART
EGF	310	346	3.23e0	SMART
EGF	350	385	2.32e-1	SMART
LY	414	457	3.88e-3	SMART
LY	458	500	1.17e-6	SMART
LY	501	547	5.96e-13	SMART
LY	548	590	1.94e-12	SMART
LY	591	634	2.66e0	SMART
EGF	661	704	7.76e-3	SMART
LY	732	774	1.76e0	SMART
LY	775	817	3.64e-8	SMART
LY	818	860	1.11e-3	SMART
LY	861	903	2.11e-13	SMART
LY	905	946	9.33e-1	SMART
EGF	972	1013	1.73e0	SMART
LDLa	1024	1061	1.05e-12	SMART
LDLa	1065	1103	4.65e-14	SMART
LDLa	1109	1146	3.63e-16	SMART
LDLa	1149	1186	5.5e-16	SMART
LDLa	1187	1225	1.43e-14	SMART
LDLa	1230	1269	2.1e-12	SMART
LDLa	1271	1308	3.63e-16	SMART
LDLa	1312	1351	6.18e-10	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128742

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.4%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit lung and kidney epithelial defects, impaired B12 uptake, reduced proliferation of the neuroepithelium resulting in lack of olfactory bulbs, forebrain fusions, ventricular defects, and perinatal lethality. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 90 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	T	C	14: 32,661,852 (GRCm38)	T719A	possibly damaging	Het
9530053A07Rik	C	G	7: 28,131,635 (GRCm38)	S91C	probably damaging	Het
Abcc1	A	G	16: 14,473,009 (GRCm38)		probably null	Het
Aftph	C	T	11: 20,708,676 (GRCm38)		probably null	Het
Als2	C	A	1: 59,215,117 (GRCm38)	K360N	probably benign	Het
Atg2a	T	A	19: 6,258,046 (GRCm38)		probably null	Het
Axl	T	C	7: 25,787,516 (GRCm38)	D22G	probably benign	Het
Baiap2	G	A	11: 119,999,226 (GRCm38)	A438T	probably benign	Het
Bean1	G	C	8: 104,182,011 (GRCm38)	A7P	probably benign	Het
Birc6	C	G	17: 74,647,729 (GRCm38)	P3431R	probably damaging	Het
Camk1d	A	G	2: 5,714,236 (GRCm38)	M1T	probably null	Het
Carmil3	T	C	14: 55,503,838 (GRCm38)	Y1027H	probably damaging	Het
Ccdc6	G	A	10: 70,187,828 (GRCm38)		probably benign	Het
Cemip	C	A	7: 83,942,025 (GRCm38)	V1280L	probably benign	Het
Cfap58	C	A	19: 47,962,542 (GRCm38)	N447K	probably benign	Het
Chd3	A	G	11: 69,360,645 (GRCm38)	L520P	probably damaging	Het
Col1a2	T	A	6: 4,531,223 (GRCm38)		probably null	Het
Cpne7	A	C	8: 123,117,667 (GRCm38)		probably null	Het
Ctla4	T	C	1: 60,912,564 (GRCm38)	V84A	probably damaging	Het
Dap3	A	G	3: 88,928,258 (GRCm38)	V263A	probably benign	Het
Dhx57	T	A	17: 80,241,949 (GRCm38)		probably null	Het
Dlg5	C	A	14: 24,164,525 (GRCm38)	K663N	probably damaging	Het
Dsg3	C	A	18: 20,523,662 (GRCm38)	F196L	possibly damaging	Het
Eif2ak4	C	A	2: 118,426,583 (GRCm38)	D402E	probably damaging	Het
Fam208b	G	T	13: 3,582,150 (GRCm38)	L784I	possibly damaging	Het
Fance	T	C	17: 28,318,094 (GRCm38)	V24A	probably benign	Het
Fasn	A	T	11: 120,814,748 (GRCm38)	L1149Q	probably damaging	Het
Flg	T	A	3: 93,279,786 (GRCm38)	S182T	possibly damaging	Het
Gm128	T	A	3: 95,239,982 (GRCm38)	S334C	possibly damaging	Het
Gm3727	A	C	14: 7,264,561 (GRCm38)	H31Q	probably damaging	Het
Gm4841	T	G	18: 60,270,905 (GRCm38)	T39P	probably damaging	Het
Golgb1	G	T	16: 36,915,151 (GRCm38)	V1587L	possibly damaging	Het
Golm1	G	A	13: 59,642,258 (GRCm38)	P243S	probably benign	Het
Gstcd	C	A	3: 133,082,321 (GRCm38)	K205N	possibly damaging	Het
Gstcd	C	A	3: 133,082,320 (GRCm38)	A206S	possibly damaging	Het
Gtf3c1	A	G	7: 125,681,173 (GRCm38)	V355A	probably benign	Het
Hhatl	T	C	9: 121,789,170 (GRCm38)	D173G	probably benign	Het
Kcnu1	T	A	8: 25,905,966 (GRCm38)	C660S	probably benign	Het
Kctd8	T	C	5: 69,110,645 (GRCm38)	D374G	probably benign	Het
Kif21a	T	C	15: 90,994,391 (GRCm38)	I229V	possibly damaging	Het
L3mbtl1	A	T	2: 162,967,585 (GRCm38)	I702F	probably benign	Het
Lce1d	T	C	3: 92,685,759 (GRCm38)		probably benign	Het
Lrig1	C	T	6: 94,617,366 (GRCm38)		probably null	Het
Lrp12	A	T	15: 39,876,111 (GRCm38)	D563E	probably damaging	Het
Map3k5	G	A	10: 20,094,455 (GRCm38)	V703I	possibly damaging	Het
Mecr	A	G	4: 131,853,765 (GRCm38)	R110G	probably benign	Het
Mtrr	T	A	13: 68,566,973 (GRCm38)	K445*	probably null	Het
Nanos1	T	A	19: 60,756,552 (GRCm38)	L96Q	probably benign	Het
Olfr538	T	G	7: 140,574,156 (GRCm38)	M1R	probably null	Het
Olfr574	T	A	7: 102,949,493 (GRCm38)	F333I	probably benign	Het
Olfr807	T	A	10: 129,755,152 (GRCm38)	L99F	probably damaging	Het
Otog	T	C	7: 46,305,590 (GRCm38)		probably null	Het
Pcdhb3	T	A	18: 37,301,239 (GRCm38)	L86*	probably null	Het
Pcdhb3	A	T	18: 37,301,240 (GRCm38)	L86F	probably damaging	Het
Pcdhb3	G	T	18: 37,301,241 (GRCm38)	V87F	probably benign	Het
Pdgfd	A	G	9: 6,359,894 (GRCm38)	K322E	probably damaging	Het
Picalm	T	C	7: 90,197,009 (GRCm38)	S648P	probably damaging	Het
Pigr	T	C	1: 130,846,620 (GRCm38)	S446P	possibly damaging	Het
Pik3cb	A	C	9: 99,061,842 (GRCm38)	L636W	probably damaging	Het
Pla2g2f	A	T	4: 138,754,162 (GRCm38)	L92Q	probably damaging	Het
Plod3	G	C	5: 136,988,146 (GRCm38)	A50P	probably benign	Het
Prkar2b	C	T	12: 31,975,929 (GRCm38)	V191I	possibly damaging	Het
Prune1	C	A	3: 95,258,119 (GRCm38)	A281S	probably benign	Het
Ptges3l	A	T	11: 101,424,042 (GRCm38)	C42S	possibly damaging	Het
Reg3b	A	T	6: 78,371,819 (GRCm38)	I33L	probably benign	Het
Rel	A	G	11: 23,745,823 (GRCm38)	I188T	probably damaging	Het
Rif1	GCCACCA	GCCA	2: 52,110,324 (GRCm38)		probably benign	Het
Ripor1	G	T	8: 105,617,622 (GRCm38)	V463L	probably benign	Het
Rrm1	T	A	7: 102,460,689 (GRCm38)	D510E	probably damaging	Het
Setd7	A	G	3: 51,533,015 (GRCm38)	S202P	probably damaging	Het
Shank3	T	A	15: 89,548,686 (GRCm38)	D1211E	probably benign	Het
Slc30a1	A	T	1: 191,907,562 (GRCm38)	T186S	possibly damaging	Het
Slc4a4	G	A	5: 89,156,398 (GRCm38)	V523I	probably benign	Het
Slc9a2	T	A	1: 40,742,608 (GRCm38)		probably null	Het
Smg6	A	G	11: 74,929,676 (GRCm38)	T258A	probably damaging	Het
Sptlc1	C	T	13: 53,337,640 (GRCm38)	D408N	possibly damaging	Het
Tbl3	T	C	17: 24,704,550 (GRCm38)		probably null	Het
Tdo2	T	C	3: 81,969,505 (GRCm38)	D139G	possibly damaging	Het
Ticam1	T	A	17: 56,271,612 (GRCm38)	H161L	possibly damaging	Het
Tnfaip3	T	A	10: 19,005,659 (GRCm38)	D293V	probably benign	Het
Trim72	G	A	7: 128,004,706 (GRCm38)	V75M	possibly damaging	Het
Trip11	T	A	12: 101,837,727 (GRCm38)	N1632I	possibly damaging	Het
Tspan18	A	T	2: 93,220,095 (GRCm38)	M61K	possibly damaging	Het
Tuba8	A	T	6: 121,225,973 (GRCm38)	E415V	probably damaging	Het
Ung	A	G	5: 114,137,192 (GRCm38)	H214R	probably benign	Het
Uqcrc1	T	C	9: 108,936,768 (GRCm38)	L17P	probably damaging	Het
Usp24	A	G	4: 106,379,405 (GRCm38)		probably null	Het
Vps39	A	C	2: 120,338,787 (GRCm38)	Y245D	probably damaging	Het
Whrn	T	A	4: 63,435,412 (GRCm38)	T373S	probably benign	Het
Zc2hc1a	C	T	3: 7,516,536 (GRCm38)		probably null	Het

Other mutations in Lrp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Lrp2	APN	2	69,507,779 (GRCm38)	missense	probably damaging	1.00
IGL00594:Lrp2	APN	2	69,486,280 (GRCm38)	missense	probably benign	0.00
IGL00782:Lrp2	APN	2	69,501,645 (GRCm38)	missense	probably benign	0.14
IGL00821:Lrp2	APN	2	69,459,516 (GRCm38)	missense	probably damaging	1.00
IGL00897:Lrp2	APN	2	69,521,881 (GRCm38)	missense	possibly damaging	0.86
IGL01065:Lrp2	APN	2	69,469,436 (GRCm38)	missense	possibly damaging	0.94
IGL01087:Lrp2	APN	2	69,524,073 (GRCm38)	missense	probably damaging	1.00
IGL01095:Lrp2	APN	2	69,492,432 (GRCm38)	nonsense	probably null
IGL01131:Lrp2	APN	2	69,499,239 (GRCm38)	missense	probably damaging	1.00
IGL01350:Lrp2	APN	2	69,510,984 (GRCm38)	missense	probably damaging	0.96
IGL01352:Lrp2	APN	2	69,503,526 (GRCm38)	missense	possibly damaging	0.77
IGL01358:Lrp2	APN	2	69,552,470 (GRCm38)	splice site	probably benign
IGL01375:Lrp2	APN	2	69,478,566 (GRCm38)	splice site	probably benign
IGL01384:Lrp2	APN	2	69,483,502 (GRCm38)	missense	probably damaging	1.00
IGL01384:Lrp2	APN	2	69,453,812 (GRCm38)	missense	probably null	1.00
IGL01411:Lrp2	APN	2	69,482,267 (GRCm38)	missense	probably damaging	1.00
IGL01418:Lrp2	APN	2	69,525,286 (GRCm38)	missense	probably benign
IGL01444:Lrp2	APN	2	69,443,716 (GRCm38)	missense	possibly damaging	0.94
IGL01464:Lrp2	APN	2	69,472,439 (GRCm38)	missense	probably damaging	0.98
IGL01528:Lrp2	APN	2	69,492,460 (GRCm38)	missense	probably damaging	1.00
IGL01663:Lrp2	APN	2	69,428,706 (GRCm38)	missense	probably benign
IGL01761:Lrp2	APN	2	69,481,235 (GRCm38)	missense	possibly damaging	0.85
IGL01780:Lrp2	APN	2	69,486,184 (GRCm38)	missense	possibly damaging	0.66
IGL01994:Lrp2	APN	2	69,483,601 (GRCm38)	missense	probably benign	0.08
IGL02015:Lrp2	APN	2	69,527,578 (GRCm38)	missense	probably benign	0.00
IGL02104:Lrp2	APN	2	69,510,418 (GRCm38)	missense	probably damaging	1.00
IGL02132:Lrp2	APN	2	69,537,616 (GRCm38)	missense	probably benign	0.01
IGL02134:Lrp2	APN	2	69,513,379 (GRCm38)	critical splice acceptor site	probably null
IGL02197:Lrp2	APN	2	69,466,880 (GRCm38)	missense	probably benign	0.01
IGL02212:Lrp2	APN	2	69,451,264 (GRCm38)	missense	probably benign	0.00
IGL02240:Lrp2	APN	2	69,535,046 (GRCm38)	missense	probably benign
IGL02248:Lrp2	APN	2	69,482,808 (GRCm38)	missense	probably damaging	1.00
IGL02369:Lrp2	APN	2	69,464,636 (GRCm38)	missense	probably damaging	1.00
IGL02416:Lrp2	APN	2	69,469,633 (GRCm38)	missense	probably damaging	1.00
IGL02417:Lrp2	APN	2	69,461,305 (GRCm38)	missense	probably damaging	1.00
IGL02458:Lrp2	APN	2	69,521,773 (GRCm38)	missense	probably damaging	0.97
IGL02479:Lrp2	APN	2	69,464,801 (GRCm38)	splice site	probably benign
IGL02508:Lrp2	APN	2	69,503,430 (GRCm38)	missense	probably benign	0.04
IGL02751:Lrp2	APN	2	69,533,462 (GRCm38)	missense	possibly damaging	0.56
IGL02814:Lrp2	APN	2	69,506,736 (GRCm38)	missense	probably damaging	1.00
IGL02867:Lrp2	APN	2	69,552,450 (GRCm38)	missense	possibly damaging	0.67
IGL02889:Lrp2	APN	2	69,552,450 (GRCm38)	missense	possibly damaging	0.67
IGL02943:Lrp2	APN	2	69,455,510 (GRCm38)	missense	possibly damaging	0.86
IGL02948:Lrp2	APN	2	69,487,837 (GRCm38)	missense	probably damaging	1.00
IGL02960:Lrp2	APN	2	69,455,453 (GRCm38)	splice site	probably benign
IGL02990:Lrp2	APN	2	69,441,396 (GRCm38)	missense	possibly damaging	0.56
IGL03027:Lrp2	APN	2	69,537,553 (GRCm38)	missense	probably benign	0.43
IGL03038:Lrp2	APN	2	69,475,464 (GRCm38)	missense	probably damaging	0.99
IGL03064:Lrp2	APN	2	69,483,133 (GRCm38)	missense	probably damaging	0.98
IGL03107:Lrp2	APN	2	69,454,833 (GRCm38)	missense	probably damaging	1.00
IGL03141:Lrp2	APN	2	69,477,026 (GRCm38)	missense	probably damaging	0.99
IGL03154:Lrp2	APN	2	69,549,042 (GRCm38)	missense	probably damaging	1.00
IGL03155:Lrp2	APN	2	69,455,452 (GRCm38)	splice site	probably benign
IGL03163:Lrp2	APN	2	69,501,526 (GRCm38)	nonsense	probably null
IGL03164:Lrp2	APN	2	69,464,699 (GRCm38)	missense	probably damaging	1.00
IGL03169:Lrp2	APN	2	69,523,194 (GRCm38)	missense	probably damaging	1.00
IGL03174:Lrp2	APN	2	69,466,265 (GRCm38)	missense	probably damaging	1.00
IGL03189:Lrp2	APN	2	69,438,478 (GRCm38)	splice site	probably benign
IGL03288:Lrp2	APN	2	69,426,039 (GRCm38)	missense	probably benign	0.02
IGL03350:Lrp2	APN	2	69,438,453 (GRCm38)	missense	probably damaging	1.00
IGL03378:Lrp2	APN	2	69,431,152 (GRCm38)	missense	probably damaging	1.00
casual	UTSW	2	69,499,263 (GRCm38)	missense	probably benign
nonchalant	UTSW	2	69,489,329 (GRCm38)	missense	probably damaging	1.00
Presto	UTSW	2	69,459,531 (GRCm38)	nonsense	probably null
relaxed	UTSW	2	69,535,005 (GRCm38)	missense	probably damaging	1.00
unguarded	UTSW	2	69,465,758 (GRCm38)	missense	probably benign	0.00
Unintended	UTSW	2	69,518,443 (GRCm38)	missense	probably damaging	1.00
BB009:Lrp2	UTSW	2	69,426,027 (GRCm38)	missense	probably benign	0.00
BB019:Lrp2	UTSW	2	69,426,027 (GRCm38)	missense	probably benign	0.00
IGL02835:Lrp2	UTSW	2	69,505,304 (GRCm38)	missense	probably damaging	1.00
IGL03055:Lrp2	UTSW	2	69,458,448 (GRCm38)	missense	probably damaging	1.00
PIT4362001:Lrp2	UTSW	2	69,537,538 (GRCm38)	missense	probably damaging	1.00
PIT4504001:Lrp2	UTSW	2	69,475,403 (GRCm38)	missense	probably damaging	1.00
R0008:Lrp2	UTSW	2	69,516,551 (GRCm38)	missense	probably benign	0.42
R0008:Lrp2	UTSW	2	69,516,551 (GRCm38)	missense	probably benign	0.42
R0044:Lrp2	UTSW	2	69,527,555 (GRCm38)	missense	probably benign	0.01
R0044:Lrp2	UTSW	2	69,527,555 (GRCm38)	missense	probably damaging	0.96
R0048:Lrp2	UTSW	2	69,465,627 (GRCm38)	missense	probably damaging	1.00
R0098:Lrp2	UTSW	2	69,475,412 (GRCm38)	missense	probably damaging	1.00
R0098:Lrp2	UTSW	2	69,475,412 (GRCm38)	missense	probably damaging	1.00
R0103:Lrp2	UTSW	2	69,477,040 (GRCm38)	missense	probably benign
R0167:Lrp2	UTSW	2	69,425,658 (GRCm38)	missense	possibly damaging	0.95
R0226:Lrp2	UTSW	2	69,537,563 (GRCm38)	missense	probably null	1.00
R0243:Lrp2	UTSW	2	69,428,630 (GRCm38)	missense	probably benign	0.00
R0308:Lrp2	UTSW	2	69,482,982 (GRCm38)	splice site	probably benign
R0323:Lrp2	UTSW	2	69,469,639 (GRCm38)	missense	probably damaging	1.00
R0372:Lrp2	UTSW	2	69,535,043 (GRCm38)	missense	probably benign	0.10
R0374:Lrp2	UTSW	2	69,430,307 (GRCm38)	missense	probably damaging	1.00
R0391:Lrp2	UTSW	2	69,460,337 (GRCm38)	splice site	probably benign
R0391:Lrp2	UTSW	2	69,456,858 (GRCm38)	missense	probably damaging	0.99
R0395:Lrp2	UTSW	2	69,433,077 (GRCm38)	missense	possibly damaging	0.89
R0401:Lrp2	UTSW	2	69,479,148 (GRCm38)	missense	probably damaging	0.98
R0471:Lrp2	UTSW	2	69,525,234 (GRCm38)	missense	probably damaging	0.97
R0483:Lrp2	UTSW	2	69,507,801 (GRCm38)	missense	probably damaging	0.99
R0502:Lrp2	UTSW	2	69,511,017 (GRCm38)	missense	probably damaging	1.00
R0542:Lrp2	UTSW	2	69,428,654 (GRCm38)	missense	probably benign	0.00
R0544:Lrp2	UTSW	2	69,491,931 (GRCm38)	missense	probably benign	0.18
R0548:Lrp2	UTSW	2	69,537,638 (GRCm38)	splice site	probably benign
R0593:Lrp2	UTSW	2	69,467,006 (GRCm38)	missense	probably benign
R0608:Lrp2	UTSW	2	69,486,243 (GRCm38)	missense	probably benign	0.02
R0633:Lrp2	UTSW	2	69,448,120 (GRCm38)	missense	probably damaging	1.00
R0691:Lrp2	UTSW	2	69,451,380 (GRCm38)	missense	probably benign	0.19
R0718:Lrp2	UTSW	2	69,510,948 (GRCm38)	missense	probably damaging	1.00
R0737:Lrp2	UTSW	2	69,448,169 (GRCm38)	missense	probably damaging	0.96
R0771:Lrp2	UTSW	2	69,507,990 (GRCm38)	missense	probably damaging	1.00
R0784:Lrp2	UTSW	2	69,518,365 (GRCm38)	missense	probably benign	0.32
R0885:Lrp2	UTSW	2	69,482,353 (GRCm38)	missense	possibly damaging	0.75
R0947:Lrp2	UTSW	2	69,487,838 (GRCm38)	missense	probably damaging	1.00
R1235:Lrp2	UTSW	2	69,524,036 (GRCm38)	missense	probably damaging	1.00
R1293:Lrp2	UTSW	2	69,523,302 (GRCm38)	splice site	probably null
R1301:Lrp2	UTSW	2	69,428,604 (GRCm38)	missense	probably damaging	0.98
R1387:Lrp2	UTSW	2	69,456,918 (GRCm38)	missense	probably damaging	1.00
R1459:Lrp2	UTSW	2	69,483,394 (GRCm38)	missense	probably damaging	0.99
R1459:Lrp2	UTSW	2	69,460,477 (GRCm38)	missense	probably damaging	1.00
R1529:Lrp2	UTSW	2	69,523,182 (GRCm38)	missense	probably damaging	1.00
R1543:Lrp2	UTSW	2	69,500,730 (GRCm38)	missense	probably damaging	1.00
R1546:Lrp2	UTSW	2	69,502,610 (GRCm38)	missense	probably damaging	1.00
R1550:Lrp2	UTSW	2	69,502,661 (GRCm38)	missense	possibly damaging	0.74
R1590:Lrp2	UTSW	2	69,466,763 (GRCm38)	critical splice donor site	probably null
R1689:Lrp2	UTSW	2	69,503,529 (GRCm38)	missense	probably benign	0.09
R1693:Lrp2	UTSW	2	69,510,418 (GRCm38)	missense	probably damaging	1.00
R1753:Lrp2	UTSW	2	69,496,489 (GRCm38)	missense	possibly damaging	0.87
R1799:Lrp2	UTSW	2	69,503,530 (GRCm38)	missense	probably benign	0.04
R1834:Lrp2	UTSW	2	69,466,880 (GRCm38)	missense	probably benign	0.01
R1921:Lrp2	UTSW	2	69,523,287 (GRCm38)	missense	probably damaging	1.00
R2000:Lrp2	UTSW	2	69,467,090 (GRCm38)	missense	probably damaging	1.00
R2077:Lrp2	UTSW	2	69,507,843 (GRCm38)	missense	probably damaging	1.00
R2092:Lrp2	UTSW	2	69,536,021 (GRCm38)	missense	probably benign	0.25
R2093:Lrp2	UTSW	2	69,536,021 (GRCm38)	missense	probably benign	0.25
R2108:Lrp2	UTSW	2	69,506,624 (GRCm38)	missense	possibly damaging	0.75
R2117:Lrp2	UTSW	2	69,483,385 (GRCm38)	missense	probably benign	0.05
R2122:Lrp2	UTSW	2	69,483,707 (GRCm38)	missense	probably damaging	1.00
R2134:Lrp2	UTSW	2	69,511,067 (GRCm38)	missense	probably damaging	1.00
R2207:Lrp2	UTSW	2	69,467,028 (GRCm38)	missense	possibly damaging	0.94
R2248:Lrp2	UTSW	2	69,511,010 (GRCm38)	missense	probably damaging	1.00
R2264:Lrp2	UTSW	2	69,482,366 (GRCm38)	missense	possibly damaging	0.88
R2316:Lrp2	UTSW	2	69,491,847 (GRCm38)	missense	possibly damaging	0.75
R2984:Lrp2	UTSW	2	69,425,814 (GRCm38)	splice site	probably null
R3085:Lrp2	UTSW	2	69,467,135 (GRCm38)	missense	probably benign	0.05
R3103:Lrp2	UTSW	2	69,431,984 (GRCm38)	missense	probably benign	0.00
R3727:Lrp2	UTSW	2	69,510,429 (GRCm38)	missense	probably damaging	1.00
R3730:Lrp2	UTSW	2	69,464,579 (GRCm38)	missense	probably damaging	0.99
R3730:Lrp2	UTSW	2	69,534,907 (GRCm38)	critical splice donor site	probably null
R3731:Lrp2	UTSW	2	69,464,579 (GRCm38)	missense	probably damaging	0.99
R3731:Lrp2	UTSW	2	69,534,907 (GRCm38)	critical splice donor site	probably null
R3764:Lrp2	UTSW	2	69,496,336 (GRCm38)	missense	probably damaging	1.00
R3768:Lrp2	UTSW	2	69,505,105 (GRCm38)	missense	probably benign	0.34
R3778:Lrp2	UTSW	2	69,509,204 (GRCm38)	missense	probably benign	0.00
R3808:Lrp2	UTSW	2	69,501,548 (GRCm38)	missense	probably damaging	1.00
R3809:Lrp2	UTSW	2	69,501,548 (GRCm38)	missense	probably damaging	1.00
R3813:Lrp2	UTSW	2	69,464,579 (GRCm38)	missense	probably damaging	0.99
R3828:Lrp2	UTSW	2	69,426,012 (GRCm38)	missense	probably benign	0.03
R3852:Lrp2	UTSW	2	69,537,565 (GRCm38)	missense	probably damaging	0.96
R3877:Lrp2	UTSW	2	69,459,472 (GRCm38)	critical splice donor site	probably null
R3877:Lrp2	UTSW	2	69,549,047 (GRCm38)	missense	probably damaging	1.00
R3922:Lrp2	UTSW	2	69,506,376 (GRCm38)	missense	probably benign
R4081:Lrp2	UTSW	2	69,513,273 (GRCm38)	missense	probably damaging	0.98
R4082:Lrp2	UTSW	2	69,513,273 (GRCm38)	missense	probably damaging	0.98
R4118:Lrp2	UTSW	2	69,430,262 (GRCm38)	critical splice donor site	probably null
R4193:Lrp2	UTSW	2	69,467,143 (GRCm38)	missense	probably damaging	1.00
R4284:Lrp2	UTSW	2	69,480,094 (GRCm38)	missense	possibly damaging	0.95
R4322:Lrp2	UTSW	2	69,425,991 (GRCm38)	nonsense	probably null
R4352:Lrp2	UTSW	2	69,432,182 (GRCm38)	critical splice donor site	probably null
R4407:Lrp2	UTSW	2	69,502,517 (GRCm38)	missense	probably damaging	1.00
R4408:Lrp2	UTSW	2	69,467,169 (GRCm38)	missense	probably benign	0.09
R4416:Lrp2	UTSW	2	69,527,231 (GRCm38)	missense	probably benign	0.18
R4426:Lrp2	UTSW	2	69,506,348 (GRCm38)	missense	probably benign	0.00
R4510:Lrp2	UTSW	2	69,480,062 (GRCm38)	missense	possibly damaging	0.58
R4511:Lrp2	UTSW	2	69,480,062 (GRCm38)	missense	possibly damaging	0.58
R4553:Lrp2	UTSW	2	69,513,285 (GRCm38)	missense	probably benign	0.13
R4591:Lrp2	UTSW	2	69,536,075 (GRCm38)	missense	probably damaging	1.00
R4612:Lrp2	UTSW	2	69,458,427 (GRCm38)	nonsense	probably null
R4622:Lrp2	UTSW	2	69,460,349 (GRCm38)	missense	possibly damaging	0.87
R4632:Lrp2	UTSW	2	69,489,129 (GRCm38)	splice site	probably null
R4633:Lrp2	UTSW	2	69,461,417 (GRCm38)	missense	probably benign	0.16
R4636:Lrp2	UTSW	2	69,436,639 (GRCm38)	missense	possibly damaging	0.93
R4657:Lrp2	UTSW	2	69,466,993 (GRCm38)	missense	probably damaging	1.00
R4667:Lrp2	UTSW	2	69,489,298 (GRCm38)	missense	probably benign	0.02
R4712:Lrp2	UTSW	2	69,506,551 (GRCm38)	missense	probably damaging	1.00
R4713:Lrp2	UTSW	2	69,487,966 (GRCm38)	missense	probably damaging	1.00
R4720:Lrp2	UTSW	2	69,481,173 (GRCm38)	missense	probably damaging	0.99
R4732:Lrp2	UTSW	2	69,533,555 (GRCm38)	missense	probably benign
R4733:Lrp2	UTSW	2	69,533,555 (GRCm38)	missense	probably benign
R4777:Lrp2	UTSW	2	69,482,264 (GRCm38)	missense	probably damaging	1.00
R4779:Lrp2	UTSW	2	69,459,715 (GRCm38)	missense	possibly damaging	0.75
R4786:Lrp2	UTSW	2	69,537,956 (GRCm38)	missense	probably damaging	1.00
R4842:Lrp2	UTSW	2	69,469,411 (GRCm38)	missense	probably benign	0.06
R4845:Lrp2	UTSW	2	69,509,241 (GRCm38)	missense	possibly damaging	0.71
R4846:Lrp2	UTSW	2	69,479,113 (GRCm38)	missense	probably damaging	1.00
R4938:Lrp2	UTSW	2	69,472,368 (GRCm38)	missense	probably damaging	0.98
R4951:Lrp2	UTSW	2	69,535,988 (GRCm38)	missense	probably damaging	1.00
R4990:Lrp2	UTSW	2	69,481,388 (GRCm38)	missense	probably benign	0.01
R5075:Lrp2	UTSW	2	69,465,758 (GRCm38)	missense	probably benign	0.00
R5078:Lrp2	UTSW	2	69,501,530 (GRCm38)	missense	possibly damaging	0.93
R5102:Lrp2	UTSW	2	69,489,158 (GRCm38)	missense	probably damaging	0.98
R5124:Lrp2	UTSW	2	69,501,490 (GRCm38)	missense	probably damaging	0.97
R5131:Lrp2	UTSW	2	69,430,342 (GRCm38)	missense	possibly damaging	0.74
R5141:Lrp2	UTSW	2	69,552,349 (GRCm38)	splice site	probably null
R5223:Lrp2	UTSW	2	69,524,053 (GRCm38)	missense	probably damaging	0.99
R5236:Lrp2	UTSW	2	69,456,819 (GRCm38)	splice site	probably null
R5267:Lrp2	UTSW	2	69,548,978 (GRCm38)	missense	possibly damaging	0.83
R5290:Lrp2	UTSW	2	69,513,354 (GRCm38)	missense	probably damaging	1.00
R5333:Lrp2	UTSW	2	69,525,228 (GRCm38)	missense	probably benign	0.01
R5355:Lrp2	UTSW	2	69,454,838 (GRCm38)	nonsense	probably null
R5356:Lrp2	UTSW	2	69,464,708 (GRCm38)	missense	possibly damaging	0.74
R5369:Lrp2	UTSW	2	69,459,560 (GRCm38)	missense	probably benign	0.04
R5486:Lrp2	UTSW	2	69,437,465 (GRCm38)	missense	probably benign	0.04
R5554:Lrp2	UTSW	2	69,552,424 (GRCm38)	missense	possibly damaging	0.92
R5584:Lrp2	UTSW	2	69,451,288 (GRCm38)	missense	probably damaging	1.00
R5585:Lrp2	UTSW	2	69,464,624 (GRCm38)	missense	possibly damaging	0.77
R5587:Lrp2	UTSW	2	69,499,263 (GRCm38)	missense	probably benign
R5605:Lrp2	UTSW	2	69,523,299 (GRCm38)	missense	probably damaging	1.00
R5637:Lrp2	UTSW	2	69,472,418 (GRCm38)	missense	probably damaging	1.00
R5647:Lrp2	UTSW	2	69,519,914 (GRCm38)	missense	probably null	0.80
R5686:Lrp2	UTSW	2	69,511,061 (GRCm38)	missense	possibly damaging	0.88
R5691:Lrp2	UTSW	2	69,502,553 (GRCm38)	missense	probably damaging	1.00
R5724:Lrp2	UTSW	2	69,451,382 (GRCm38)	missense	probably damaging	0.99
R5726:Lrp2	UTSW	2	69,509,147 (GRCm38)	missense	probably damaging	1.00
R5743:Lrp2	UTSW	2	69,466,877 (GRCm38)	missense	probably damaging	1.00
R5777:Lrp2	UTSW	2	69,455,525 (GRCm38)	missense	probably damaging	1.00
R5841:Lrp2	UTSW	2	69,480,153 (GRCm38)	missense	probably benign	0.00
R5892:Lrp2	UTSW	2	69,442,776 (GRCm38)	missense	probably benign
R5951:Lrp2	UTSW	2	69,496,323 (GRCm38)	splice site	probably null
R5974:Lrp2	UTSW	2	69,459,548 (GRCm38)	missense	probably damaging	1.00
R5980:Lrp2	UTSW	2	69,535,005 (GRCm38)	missense	probably damaging	1.00
R6046:Lrp2	UTSW	2	69,506,754 (GRCm38)	missense	probably damaging	1.00
R6113:Lrp2	UTSW	2	69,483,557 (GRCm38)	missense	possibly damaging	0.76
R6146:Lrp2	UTSW	2	69,511,001 (GRCm38)	missense	probably benign	0.00
R6177:Lrp2	UTSW	2	69,510,419 (GRCm38)	frame shift	probably null
R6180:Lrp2	UTSW	2	69,503,524 (GRCm38)	missense	possibly damaging	0.85
R6219:Lrp2	UTSW	2	69,469,478 (GRCm38)	missense	probably damaging	1.00
R6228:Lrp2	UTSW	2	69,482,366 (GRCm38)	missense	possibly damaging	0.88
R6265:Lrp2	UTSW	2	69,466,340 (GRCm38)	missense	probably damaging	1.00
R6312:Lrp2	UTSW	2	69,436,681 (GRCm38)	missense	probably damaging	1.00
R6337:Lrp2	UTSW	2	69,438,467 (GRCm38)	missense	probably damaging	1.00
R6376:Lrp2	UTSW	2	69,483,443 (GRCm38)	missense	probably benign	0.02
R6385:Lrp2	UTSW	2	69,495,784 (GRCm38)	missense	probably benign	0.22
R6429:Lrp2	UTSW	2	69,461,287 (GRCm38)	missense	probably damaging	1.00
R6458:Lrp2	UTSW	2	69,505,156 (GRCm38)	missense	probably benign	0.00
R6524:Lrp2	UTSW	2	69,436,639 (GRCm38)	missense	possibly damaging	0.93
R6555:Lrp2	UTSW	2	69,509,303 (GRCm38)	missense	probably benign	0.00
R6594:Lrp2	UTSW	2	69,439,923 (GRCm38)	missense	possibly damaging	0.58
R6599:Lrp2	UTSW	2	69,469,405 (GRCm38)	missense	probably damaging	1.00
R6655:Lrp2	UTSW	2	69,453,858 (GRCm38)	missense	probably benign	0.01
R6718:Lrp2	UTSW	2	69,483,780 (GRCm38)	missense	probably benign	0.09
R6736:Lrp2	UTSW	2	69,448,211 (GRCm38)	missense	probably benign	0.02
R6738:Lrp2	UTSW	2	69,458,488 (GRCm38)	missense	probably damaging	0.97
R6799:Lrp2	UTSW	2	69,483,904 (GRCm38)	missense	probably damaging	1.00
R6846:Lrp2	UTSW	2	69,518,443 (GRCm38)	missense	probably damaging	1.00
R6856:Lrp2	UTSW	2	69,513,268 (GRCm38)	missense	probably damaging	1.00
R6861:Lrp2	UTSW	2	69,513,377 (GRCm38)	missense	possibly damaging	0.77
R6888:Lrp2	UTSW	2	69,524,141 (GRCm38)	missense	probably damaging	0.98
R6897:Lrp2	UTSW	2	69,510,502 (GRCm38)	missense	probably benign
R6902:Lrp2	UTSW	2	69,459,503 (GRCm38)	missense	probably damaging	1.00
R6908:Lrp2	UTSW	2	69,472,365 (GRCm38)	missense	probably damaging	1.00
R6918:Lrp2	UTSW	2	69,489,305 (GRCm38)	missense	probably damaging	1.00
R6989:Lrp2	UTSW	2	69,472,455 (GRCm38)	missense	probably damaging	1.00
R7022:Lrp2	UTSW	2	69,483,208 (GRCm38)	missense	probably damaging	1.00
R7025:Lrp2	UTSW	2	69,483,028 (GRCm38)	missense	possibly damaging	0.90
R7026:Lrp2	UTSW	2	69,521,787 (GRCm38)	missense	probably damaging	0.97
R7138:Lrp2	UTSW	2	69,465,745 (GRCm38)	missense	possibly damaging	0.94
R7145:Lrp2	UTSW	2	69,454,808 (GRCm38)	critical splice donor site	probably null
R7150:Lrp2	UTSW	2	69,488,051 (GRCm38)	missense	probably damaging	0.99
R7165:Lrp2	UTSW	2	69,506,573 (GRCm38)	missense	probably damaging	0.99
R7174:Lrp2	UTSW	2	69,433,072 (GRCm38)	missense	probably benign	0.11
R7204:Lrp2	UTSW	2	69,472,533 (GRCm38)	missense	probably benign	0.25
R7275:Lrp2	UTSW	2	69,459,531 (GRCm38)	nonsense	probably null
R7278:Lrp2	UTSW	2	69,486,352 (GRCm38)	missense	probably damaging	1.00
R7296:Lrp2	UTSW	2	69,482,381 (GRCm38)	missense	probably benign	0.04
R7315:Lrp2	UTSW	2	69,491,822 (GRCm38)	missense	probably damaging	0.98
R7342:Lrp2	UTSW	2	69,479,290 (GRCm38)	missense	possibly damaging	0.95
R7351:Lrp2	UTSW	2	69,448,142 (GRCm38)	missense	probably damaging	1.00
R7352:Lrp2	UTSW	2	69,472,397 (GRCm38)	missense	probably benign	0.04
R7366:Lrp2	UTSW	2	69,483,806 (GRCm38)	missense	probably damaging	1.00
R7373:Lrp2	UTSW	2	69,500,692 (GRCm38)	missense	probably damaging	1.00
R7446:Lrp2	UTSW	2	69,459,674 (GRCm38)	missense	probably damaging	0.99
R7446:Lrp2	UTSW	2	69,432,213 (GRCm38)	missense	probably damaging	1.00
R7451:Lrp2	UTSW	2	69,513,333 (GRCm38)	missense	probably damaging	1.00
R7492:Lrp2	UTSW	2	69,537,581 (GRCm38)	missense	probably damaging	0.99
R7571:Lrp2	UTSW	2	69,516,403 (GRCm38)	missense	probably damaging	1.00
R7638:Lrp2	UTSW	2	69,477,008 (GRCm38)	critical splice donor site	probably null
R7664:Lrp2	UTSW	2	69,506,732 (GRCm38)	missense	probably damaging	1.00
R7686:Lrp2	UTSW	2	69,489,237 (GRCm38)	missense	probably damaging	1.00
R7711:Lrp2	UTSW	2	69,479,343 (GRCm38)	critical splice acceptor site	probably null
R7737:Lrp2	UTSW	2	69,496,438 (GRCm38)	missense	possibly damaging	0.77
R7763:Lrp2	UTSW	2	69,503,388 (GRCm38)	missense	probably damaging	0.99
R7775:Lrp2	UTSW	2	69,501,539 (GRCm38)	missense	possibly damaging	0.74
R7824:Lrp2	UTSW	2	69,501,539 (GRCm38)	missense	possibly damaging	0.74
R7840:Lrp2	UTSW	2	69,464,784 (GRCm38)	missense	probably damaging	0.98
R7878:Lrp2	UTSW	2	69,507,809 (GRCm38)	missense	probably damaging	1.00
R7878:Lrp2	UTSW	2	69,507,810 (GRCm38)	missense	probably damaging	1.00
R7895:Lrp2	UTSW	2	69,458,479 (GRCm38)	missense	probably damaging	0.97
R7898:Lrp2	UTSW	2	69,441,366 (GRCm38)	missense	probably benign	0.00
R7912:Lrp2	UTSW	2	69,428,672 (GRCm38)	missense	probably benign	0.03
R7923:Lrp2	UTSW	2	69,438,388 (GRCm38)	missense	possibly damaging	0.75
R7932:Lrp2	UTSW	2	69,426,027 (GRCm38)	missense	probably benign	0.00
R7940:Lrp2	UTSW	2	69,432,197 (GRCm38)	missense	possibly damaging	0.91
R7954:Lrp2	UTSW	2	69,503,523 (GRCm38)	missense	possibly damaging	0.61
R8007:Lrp2	UTSW	2	69,506,505 (GRCm38)	missense	probably benign	0.02
R8084:Lrp2	UTSW	2	69,509,369 (GRCm38)	missense	probably damaging	0.97
R8087:Lrp2	UTSW	2	69,448,129 (GRCm38)	missense	probably damaging	1.00
R8090:Lrp2	UTSW	2	69,464,745 (GRCm38)	missense	possibly damaging	0.94
R8110:Lrp2	UTSW	2	69,506,453 (GRCm38)	missense	probably benign
R8129:Lrp2	UTSW	2	69,430,280 (GRCm38)	missense	possibly damaging	0.75
R8155:Lrp2	UTSW	2	69,482,998 (GRCm38)	missense	possibly damaging	0.74
R8182:Lrp2	UTSW	2	69,489,329 (GRCm38)	missense	probably damaging	1.00
R8239:Lrp2	UTSW	2	69,481,267 (GRCm38)	nonsense	probably null
R8247:Lrp2	UTSW	2	69,431,087 (GRCm38)	missense	possibly damaging	0.76
R8327:Lrp2	UTSW	2	69,491,924 (GRCm38)	missense	probably damaging	1.00
R8355:Lrp2	UTSW	2	69,516,484 (GRCm38)	missense	probably damaging	0.99
R8404:Lrp2	UTSW	2	69,514,241 (GRCm38)	nonsense	probably null
R8427:Lrp2	UTSW	2	69,451,297 (GRCm38)	missense	probably damaging	0.97
R8463:Lrp2	UTSW	2	69,491,906 (GRCm38)	missense	probably damaging	1.00
R8502:Lrp2	UTSW	2	69,514,241 (GRCm38)	nonsense	probably null
R8529:Lrp2	UTSW	2	69,500,642 (GRCm38)	missense	probably damaging	0.96
R8673:Lrp2	UTSW	2	69,472,460 (GRCm38)	missense	probably damaging	1.00
R8698:Lrp2	UTSW	2	69,458,423 (GRCm38)	missense	probably benign	0.37
R8698:Lrp2	UTSW	2	69,448,239 (GRCm38)	missense	probably benign	0.39
R8708:Lrp2	UTSW	2	69,459,613 (GRCm38)	missense	probably damaging	1.00
R8716:Lrp2	UTSW	2	69,443,794 (GRCm38)	missense	probably benign	0.04
R8723:Lrp2	UTSW	2	69,486,304 (GRCm38)	missense	probably damaging	1.00
R8787:Lrp2	UTSW	2	69,552,401 (GRCm38)	missense	probably damaging	1.00
R8903:Lrp2	UTSW	2	69,549,038 (GRCm38)	missense	possibly damaging	0.68
R8944:Lrp2	UTSW	2	69,511,004 (GRCm38)	missense	probably damaging	1.00
R9069:Lrp2	UTSW	2	69,501,652 (GRCm38)	missense	probably damaging	1.00
R9076:Lrp2	UTSW	2	69,519,916 (GRCm38)	missense	probably benign	0.01
R9155:Lrp2	UTSW	2	69,461,369 (GRCm38)	nonsense	probably null
R9173:Lrp2	UTSW	2	69,469,387 (GRCm38)	missense	probably damaging	1.00
R9254:Lrp2	UTSW	2	69,503,547 (GRCm38)	missense	probably benign	0.09
R9256:Lrp2	UTSW	2	69,510,959 (GRCm38)	missense	probably benign	0.03
R9291:Lrp2	UTSW	2	69,480,035 (GRCm38)	missense	probably damaging	1.00
R9335:Lrp2	UTSW	2	69,428,639 (GRCm38)	missense	probably benign	0.01
R9357:Lrp2	UTSW	2	69,506,573 (GRCm38)	missense	probably damaging	0.99
R9368:Lrp2	UTSW	2	69,527,635 (GRCm38)	missense	probably damaging	0.99
R9453:Lrp2	UTSW	2	69,458,488 (GRCm38)	missense	probably damaging	1.00
R9546:Lrp2	UTSW	2	69,456,821 (GRCm38)	critical splice donor site	probably null
R9554:Lrp2	UTSW	2	69,431,153 (GRCm38)	missense	probably damaging	1.00
R9597:Lrp2	UTSW	2	69,430,359 (GRCm38)	missense	probably benign	0.02
R9601:Lrp2	UTSW	2	69,459,584 (GRCm38)	missense	probably damaging	1.00
R9623:Lrp2	UTSW	2	69,477,079 (GRCm38)	missense	probably benign	0.09
RF016:Lrp2	UTSW	2	69,509,205 (GRCm38)	missense	probably benign
X0011:Lrp2	UTSW	2	69,519,998 (GRCm38)	missense	probably damaging	1.00
X0023:Lrp2	UTSW	2	69,436,600 (GRCm38)	missense	probably damaging	0.99
Z1176:Lrp2	UTSW	2	69,507,881 (GRCm38)	missense	possibly damaging	0.88
Z1176:Lrp2	UTSW	2	69,480,042 (GRCm38)	missense	possibly damaging	0.66
Z1177:Lrp2	UTSW	2	69,496,468 (GRCm38)	missense	probably damaging	1.00
Z1177:Lrp2	UTSW	2	69,472,453 (GRCm38)	missense	probably benign	0.03
Z1177:Lrp2	UTSW	2	69,451,280 (GRCm38)	missense	probably damaging	1.00
Z1177:Lrp2	UTSW	2	69,509,289 (GRCm38)	missense	probably benign	0.00
Z1177:Lrp2	UTSW	2	69,501,641 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCGGTTCTATGACAAGTTCCG -3'
(R):5'- TGATTGCAGGGACATGAGTG -3'

Sequencing Primer
(F):5'- AATGAGAAGTGTTATGCAGTCATC -3'
(R):5'- CATGAGTGATGAGAAGGACTGTCC -3'

Posted On

2014-12-04