Incidental Mutation 'R2516:Drosha'
ID 253845
Institutional Source Beutler Lab
Gene Symbol Drosha
Ensembl Gene ENSMUSG00000022191
Gene Name drosha, ribonuclease type III
Synonyms Etohi2, 1110013A17Rik, Rnasen
MMRRC Submission 040420-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.962) question?
Stock # R2516 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 12824901-12935377 bp(+) (GRCm39)
Type of Mutation splice site (6 bp from exon)
DNA Base Change (assembly) T to C at 12859551 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000129279 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090292] [ENSMUST00000169061]
AlphaFold Q5HZJ0
Predicted Effect probably null
Transcript: ENSMUST00000090292
SMART Domains Protein: ENSMUSP00000087762
Gene: ENSMUSG00000022191

DomainStartEndE-ValueType
low complexity region 13 32 N/A INTRINSIC
low complexity region 43 69 N/A INTRINSIC
low complexity region 72 102 N/A INTRINSIC
low complexity region 109 137 N/A INTRINSIC
low complexity region 142 169 N/A INTRINSIC
low complexity region 185 200 N/A INTRINSIC
low complexity region 227 269 N/A INTRINSIC
low complexity region 273 301 N/A INTRINSIC
low complexity region 357 370 N/A INTRINSIC
low complexity region 387 410 N/A INTRINSIC
low complexity region 472 499 N/A INTRINSIC
SCOP:d1jfza_ 878 902 4e-4 SMART
RIBOc 942 1076 1.73e-45 SMART
Blast:RIBOc 1086 1112 1e-6 BLAST
RIBOc 1121 1253 1.6e-49 SMART
DSRM 1260 1332 5.75e-20 SMART
coiled coil region 1346 1370 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000129031
SMART Domains Protein: ENSMUSP00000121499
Gene: ENSMUSG00000022191

DomainStartEndE-ValueType
low complexity region 115 142 N/A INTRINSIC
SCOP:d1jfza_ 521 545 6e-4 SMART
RIBOc 585 719 1.73e-45 SMART
Blast:RIBOc 729 755 1e-6 BLAST
RIBOc 764 896 1.6e-49 SMART
DSRM 903 975 5.75e-20 SMART
coiled coil region 988 1012 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150211
Predicted Effect probably null
Transcript: ENSMUST00000169061
SMART Domains Protein: ENSMUSP00000129279
Gene: ENSMUSG00000022191

DomainStartEndE-ValueType
low complexity region 13 32 N/A INTRINSIC
low complexity region 43 69 N/A INTRINSIC
low complexity region 72 102 N/A INTRINSIC
low complexity region 109 137 N/A INTRINSIC
low complexity region 142 169 N/A INTRINSIC
low complexity region 185 200 N/A INTRINSIC
low complexity region 227 269 N/A INTRINSIC
low complexity region 273 301 N/A INTRINSIC
low complexity region 357 370 N/A INTRINSIC
low complexity region 387 410 N/A INTRINSIC
low complexity region 472 499 N/A INTRINSIC
SCOP:d1jfza_ 878 902 4e-4 SMART
RIBOc 942 1076 1.73e-45 SMART
Blast:RIBOc 1086 1112 1e-6 BLAST
RIBOc 1121 1253 1.6e-49 SMART
DSRM 1260 1332 5.75e-20 SMART
coiled coil region 1346 1370 N/A INTRINSIC
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 98% (65/66)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]
PHENOTYPE: Mice heterozygous for a knock-out allele and a conditional allele activated in the immune system exhibit increased inflammation in multiple systems, cachexia and premature death. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 A T 2: 69,159,673 (GRCm39) I6N possibly damaging Het
Aen T C 7: 78,555,616 (GRCm39) V188A probably damaging Het
Afg3l1 A G 8: 124,228,693 (GRCm39) E753G probably damaging Het
Alas1 G A 9: 106,115,859 (GRCm39) T385I probably damaging Het
Alms1 C A 6: 85,644,945 (GRCm39) probably benign Het
Ankrd65 A G 4: 155,875,868 (GRCm39) T30A possibly damaging Het
App T C 16: 84,775,117 (GRCm39) S582G probably damaging Het
Arfgef1 A T 1: 10,223,879 (GRCm39) V1473E possibly damaging Het
Arhgap21 G A 2: 20,859,809 (GRCm39) P1196S probably damaging Het
Arhgap24 A G 5: 103,039,776 (GRCm39) T238A probably benign Het
Atf7 T C 15: 102,437,439 (GRCm39) probably benign Het
Best1 G T 19: 9,970,675 (GRCm39) S55* probably null Het
Capn11 A G 17: 45,944,725 (GRCm39) V514A probably damaging Het
Cep104 T A 4: 154,073,603 (GRCm39) M52K probably damaging Het
Clca3a1 C T 3: 144,443,619 (GRCm39) probably null Het
Cyp3a25 T C 5: 145,939,837 (GRCm39) probably null Het
Dmxl2 G A 9: 54,307,378 (GRCm39) P2197S probably damaging Het
Exosc9 A G 3: 36,617,311 (GRCm39) K355R probably benign Het
Fut1 A C 7: 45,268,622 (GRCm39) H192P probably benign Het
Gm572 T A 4: 148,748,841 (GRCm39) V166D possibly damaging Het
Gm9966 C T 7: 95,607,735 (GRCm39) P19S unknown Het
Gmds C T 13: 32,284,456 (GRCm39) V219I probably damaging Het
Gsn G A 2: 35,173,965 (GRCm39) E25K probably benign Het
Il4i1 T C 7: 44,489,315 (GRCm39) F368S probably damaging Het
Irak1bp1 T C 9: 82,712,373 (GRCm39) L98P probably damaging Het
Khdrbs3 T C 15: 68,896,544 (GRCm39) probably benign Het
Kndc1 T C 7: 139,501,738 (GRCm39) I925T probably damaging Het
Laptm4a T C 12: 8,988,151 (GRCm39) I296T probably benign Het
Lpl A T 8: 69,340,170 (GRCm39) H55L probably benign Het
Lrrk2 C A 15: 91,640,130 (GRCm39) N1558K probably benign Het
Mfsd2a A G 4: 122,844,280 (GRCm39) L289P probably damaging Het
Mmrn2 T A 14: 34,120,759 (GRCm39) M543K probably benign Het
Mnat1 T C 12: 73,228,550 (GRCm39) probably benign Het
Msto1 A T 3: 88,819,200 (GRCm39) probably null Het
Mtus1 A G 8: 41,535,776 (GRCm39) Y647H probably damaging Het
Nars1 A T 18: 64,638,087 (GRCm39) V289E probably damaging Het
Oit3 T A 10: 59,264,167 (GRCm39) K322N probably damaging Het
Oit3 G A 10: 59,277,507 (GRCm39) probably benign Het
Or4k1 T C 14: 50,377,440 (GRCm39) I219V probably benign Het
Or5b113 T A 19: 13,342,557 (GRCm39) C188* probably null Het
Or5m12 A G 2: 85,734,900 (GRCm39) I166T probably benign Het
Or6c211 G A 10: 129,506,155 (GRCm39) R78W probably damaging Het
Pecr A T 1: 72,316,469 (GRCm39) C79S probably damaging Het
Plekhn1 T C 4: 156,307,116 (GRCm39) D478G probably damaging Het
Pls1 A T 9: 95,658,616 (GRCm39) M264K probably benign Het
Ptprj C A 2: 90,305,340 (GRCm39) probably benign Het
Pygm A G 19: 6,447,631 (GRCm39) D646G probably benign Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Scn8a T C 15: 100,867,043 (GRCm39) V283A probably benign Het
Shisa5 T C 9: 108,885,575 (GRCm39) probably null Het
Slc10a4 A G 5: 73,165,848 (GRCm39) I246V possibly damaging Het
Slc1a1 A T 19: 28,870,312 (GRCm39) I104F probably benign Het
Slc22a8 A G 19: 8,587,559 (GRCm39) Y511C probably benign Het
Slc6a5 A G 7: 49,606,210 (GRCm39) N706S probably benign Het
Sos2 T C 12: 69,697,433 (GRCm39) K96E probably damaging Het
Stom G A 2: 35,205,977 (GRCm39) R251* probably null Het
Sycp1 T C 3: 102,752,382 (GRCm39) E800G probably benign Het
Tab2 G A 10: 7,783,245 (GRCm39) P679L probably damaging Het
Tiam2 G A 17: 3,503,657 (GRCm39) V945I probably damaging Het
Trpm5 G T 7: 142,628,254 (GRCm39) P1007Q probably damaging Het
Uchl1 T G 5: 66,839,956 (GRCm39) I139S probably damaging Het
Vmn1r232 A G 17: 21,134,288 (GRCm39) I104T possibly damaging Het
Vmn2r97 G A 17: 19,167,814 (GRCm39) M689I probably benign Het
Zc3h18 A T 8: 123,129,904 (GRCm39) probably benign Het
Zfhx4 C T 3: 5,468,418 (GRCm39) P2859S probably benign Het
Zfp456 T C 13: 67,510,491 (GRCm39) K99R probably benign Het
Other mutations in Drosha
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00576:Drosha APN 15 12,883,280 (GRCm39) missense probably damaging 0.99
IGL00736:Drosha APN 15 12,834,045 (GRCm39) missense unknown
IGL00963:Drosha APN 15 12,926,083 (GRCm39) missense probably damaging 0.99
IGL01010:Drosha APN 15 12,827,375 (GRCm39) unclassified probably benign
IGL01340:Drosha APN 15 12,834,109 (GRCm39) intron probably benign
IGL01481:Drosha APN 15 12,842,525 (GRCm39) missense probably benign
IGL01714:Drosha APN 15 12,878,870 (GRCm39) missense probably damaging 1.00
IGL01721:Drosha APN 15 12,846,198 (GRCm39) nonsense probably null
IGL01765:Drosha APN 15 12,902,766 (GRCm39) missense probably damaging 1.00
IGL01893:Drosha APN 15 12,866,736 (GRCm39) splice site probably benign
IGL01944:Drosha APN 15 12,889,805 (GRCm39) missense probably damaging 1.00
IGL02285:Drosha APN 15 12,833,950 (GRCm39) missense unknown
IGL02970:Drosha APN 15 12,914,042 (GRCm39) missense probably damaging 0.98
IGL02990:Drosha APN 15 12,827,353 (GRCm39) unclassified probably benign
IGL03019:Drosha APN 15 12,846,185 (GRCm39) missense probably damaging 1.00
IGL03279:Drosha APN 15 12,859,478 (GRCm39) missense probably benign 0.03
IGL03390:Drosha APN 15 12,885,069 (GRCm39) splice site probably null
tippicanoe UTSW 15 12,859,551 (GRCm39) splice site probably null
Tyler UTSW 15 12,861,792 (GRCm39) missense probably benign 0.45
R0115:Drosha UTSW 15 12,846,216 (GRCm39) missense probably benign 0.15
R0352:Drosha UTSW 15 12,837,374 (GRCm39) missense unknown
R0401:Drosha UTSW 15 12,926,117 (GRCm39) nonsense probably null
R0541:Drosha UTSW 15 12,907,474 (GRCm39) missense probably benign 0.09
R0784:Drosha UTSW 15 12,867,764 (GRCm39) splice site probably benign
R0918:Drosha UTSW 15 12,842,619 (GRCm39) critical splice donor site probably null
R1473:Drosha UTSW 15 12,912,606 (GRCm39) missense probably benign 0.04
R1503:Drosha UTSW 15 12,848,159 (GRCm39) missense probably benign 0.02
R1526:Drosha UTSW 15 12,914,070 (GRCm39) missense probably damaging 1.00
R1809:Drosha UTSW 15 12,890,198 (GRCm39) missense probably null 1.00
R1859:Drosha UTSW 15 12,878,804 (GRCm39) missense probably benign 0.14
R2004:Drosha UTSW 15 12,915,467 (GRCm39) missense probably damaging 0.98
R2060:Drosha UTSW 15 12,924,245 (GRCm39) missense possibly damaging 0.94
R3691:Drosha UTSW 15 12,834,724 (GRCm39) missense unknown
R3784:Drosha UTSW 15 12,890,615 (GRCm39) missense possibly damaging 0.82
R3789:Drosha UTSW 15 12,912,623 (GRCm39) nonsense probably null
R3790:Drosha UTSW 15 12,912,623 (GRCm39) nonsense probably null
R4020:Drosha UTSW 15 12,837,422 (GRCm39) missense possibly damaging 0.96
R4817:Drosha UTSW 15 12,914,133 (GRCm39) missense probably damaging 0.97
R4989:Drosha UTSW 15 12,935,093 (GRCm39) missense probably benign 0.05
R5080:Drosha UTSW 15 12,842,229 (GRCm39) missense probably benign 0.01
R5132:Drosha UTSW 15 12,837,377 (GRCm39) missense unknown
R5215:Drosha UTSW 15 12,885,219 (GRCm39) intron probably benign
R5386:Drosha UTSW 15 12,842,207 (GRCm39) missense probably benign
R5457:Drosha UTSW 15 12,926,115 (GRCm39) missense probably benign 0.26
R5536:Drosha UTSW 15 12,929,797 (GRCm39) missense possibly damaging 0.58
R5800:Drosha UTSW 15 12,902,733 (GRCm39) missense probably damaging 1.00
R5800:Drosha UTSW 15 12,865,153 (GRCm39) missense probably damaging 1.00
R5915:Drosha UTSW 15 12,935,152 (GRCm39) missense probably damaging 0.97
R5988:Drosha UTSW 15 12,834,582 (GRCm39) intron probably benign
R6033:Drosha UTSW 15 12,926,085 (GRCm39) missense probably benign 0.25
R6033:Drosha UTSW 15 12,926,085 (GRCm39) missense probably benign 0.25
R6063:Drosha UTSW 15 12,834,156 (GRCm39) intron probably benign
R6391:Drosha UTSW 15 12,889,803 (GRCm39) nonsense probably null
R6492:Drosha UTSW 15 12,861,792 (GRCm39) missense probably benign 0.45
R6799:Drosha UTSW 15 12,912,623 (GRCm39) nonsense probably null
R6870:Drosha UTSW 15 12,907,479 (GRCm39) missense probably benign 0.17
R6920:Drosha UTSW 15 12,834,396 (GRCm39) missense unknown
R7101:Drosha UTSW 15 12,865,153 (GRCm39) missense probably damaging 1.00
R7142:Drosha UTSW 15 12,924,232 (GRCm39) missense possibly damaging 0.70
R7275:Drosha UTSW 15 12,846,169 (GRCm39) missense possibly damaging 0.73
R7337:Drosha UTSW 15 12,846,285 (GRCm39) missense possibly damaging 0.80
R7471:Drosha UTSW 15 12,889,742 (GRCm39) missense probably damaging 1.00
R7538:Drosha UTSW 15 12,926,329 (GRCm39) missense probably damaging 1.00
R7559:Drosha UTSW 15 12,842,508 (GRCm39) missense probably damaging 0.96
R7651:Drosha UTSW 15 12,859,522 (GRCm39) missense probably benign 0.30
R7652:Drosha UTSW 15 12,859,522 (GRCm39) missense probably benign 0.30
R7653:Drosha UTSW 15 12,859,522 (GRCm39) missense probably benign 0.30
R7727:Drosha UTSW 15 12,881,731 (GRCm39) missense probably damaging 1.00
R7780:Drosha UTSW 15 12,848,172 (GRCm39) missense probably benign 0.01
R8068:Drosha UTSW 15 12,883,276 (GRCm39) nonsense probably null
R8283:Drosha UTSW 15 12,890,587 (GRCm39) missense possibly damaging 0.47
R8523:Drosha UTSW 15 12,834,408 (GRCm39) missense unknown
R8985:Drosha UTSW 15 12,924,187 (GRCm39) missense possibly damaging 0.66
R9418:Drosha UTSW 15 12,885,167 (GRCm39) missense probably benign 0.02
R9501:Drosha UTSW 15 12,928,992 (GRCm39) missense probably damaging 1.00
R9674:Drosha UTSW 15 12,890,170 (GRCm39) missense probably damaging 1.00
Z1177:Drosha UTSW 15 12,842,178 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GATGTGAAGCTGACAGTGTAGTC -3'
(R):5'- CAGCACCATAATTCACTGGC -3'

Sequencing Primer
(F):5'- GTAAAGTGTTTTCATTCCCCT -3'
(R):5'- CACTGGCTATACATTTGGTTATTGC -3'
Posted On 2014-12-04