Incidental Mutation 'R2872:Atp6v1g1'
ID 253862
Institutional Source Beutler Lab
Gene Symbol Atp6v1g1
Ensembl Gene ENSMUSG00000039105
Gene Name ATPase, H+ transporting, lysosomal V1 subunit G1
Synonyms VAG1, Atp6g1, Vma10, ATP6J, 1810024D14Rik, lysosomal 13kDa
MMRRC Submission 040460-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.947) question?
Stock # R2872 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 63463002-63468938 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 63468258 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 87 (Y87C)
Ref Sequence ENSEMBL: ENSMUSP00000048770 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035301]
AlphaFold Q9CR51
Predicted Effect probably benign
Transcript: ENSMUST00000035301
AA Change: Y87C

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000048770
Gene: ENSMUSG00000039105
AA Change: Y87C

DomainStartEndE-ValueType
Pfam:V-ATPase_G 3 107 2e-41 PFAM
Meta Mutation Damage Score 0.0869 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.6%
  • 10x: 94.5%
  • 20x: 80.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b A G 11: 109,846,002 (GRCm39) C811R possibly damaging Het
Ak8 T C 2: 28,632,732 (GRCm39) I317T possibly damaging Het
Als2 A G 1: 59,250,296 (GRCm39) S483P probably damaging Het
Arhgef10 T C 8: 15,025,093 (GRCm39) probably null Het
Arhgef10 A G 8: 15,025,666 (GRCm39) I459V probably benign Het
Armc2 C T 10: 41,842,696 (GRCm39) probably null Het
Atp12a A G 14: 56,624,407 (GRCm39) R952G possibly damaging Het
Cilk1 A T 9: 78,047,382 (GRCm39) probably null Het
Col12a1 A T 9: 79,606,831 (GRCm39) F531I probably damaging Het
Csmd2 T C 4: 128,451,511 (GRCm39) F113S unknown Het
Ctnnd1 C T 2: 84,451,232 (GRCm39) V123I possibly damaging Het
Cyp4a14 C A 4: 115,344,498 (GRCm39) G456W probably damaging Het
Cyp4a30b A G 4: 115,315,559 (GRCm39) H260R possibly damaging Het
Eef2 GCCC GCCCC 10: 81,014,601 (GRCm39) probably null Het
Frmpd4 A T X: 166,260,243 (GRCm39) D1166E probably benign Het
Gpr156 T A 16: 37,812,585 (GRCm39) V307D probably damaging Het
Gpr35 G A 1: 92,910,848 (GRCm39) V187I probably benign Het
Gria2 G A 3: 80,609,799 (GRCm39) T670I probably damaging Het
Hdac10 G T 15: 89,010,059 (GRCm39) Q300K possibly damaging Het
Hdhd2 T C 18: 77,042,702 (GRCm39) F44L probably damaging Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Hmcn1 A T 1: 150,614,467 (GRCm39) V1313D possibly damaging Het
Ift172 C T 5: 31,415,205 (GRCm39) V1335I probably benign Het
Igsf9b A G 9: 27,233,519 (GRCm39) I340V probably benign Het
Kif1c A G 11: 70,614,907 (GRCm39) E567G probably damaging Het
Klf8 A T X: 152,165,678 (GRCm39) E82D probably damaging Het
Matr3 T A 18: 35,705,349 (GRCm39) S91R probably benign Het
Mideas C T 12: 84,203,245 (GRCm39) G886S probably benign Het
Mroh2a GCCC GC 1: 88,159,979 (GRCm39) probably null Het
Mtor T A 4: 148,624,487 (GRCm39) M2089K probably benign Het
Myo9b T C 8: 71,743,610 (GRCm39) Y224H probably benign Het
Nlrc3 T C 16: 3,775,190 (GRCm39) D774G possibly damaging Het
Notum A G 11: 120,551,022 (GRCm39) V48A probably benign Het
Nox3 T C 17: 3,733,191 (GRCm39) H240R probably damaging Het
Nsun2 A G 13: 69,777,801 (GRCm39) T425A probably damaging Het
Or10g1 T G 14: 52,648,318 (GRCm39) T4P probably benign Het
Or10z1 T C 1: 174,078,092 (GRCm39) S134G probably benign Het
Or1o4 A G 17: 37,590,867 (GRCm39) V148A possibly damaging Het
Or52u1 T C 7: 104,237,700 (GRCm39) S230P possibly damaging Het
Ostc T C 3: 130,497,157 (GRCm39) N80S probably damaging Het
Otud4 T A 8: 80,387,702 (GRCm39) N300K possibly damaging Het
Palmd T C 3: 116,717,400 (GRCm39) R366G possibly damaging Het
Paqr5 A T 9: 61,876,061 (GRCm39) probably null Het
Parp1 A G 1: 180,401,230 (GRCm39) D45G probably damaging Het
Pcdhga9 T A 18: 37,870,524 (GRCm39) Y118N possibly damaging Het
Pkd1l2 C T 8: 117,764,903 (GRCm39) V1332I probably benign Het
Plcl1 A T 1: 55,736,309 (GRCm39) D550V probably benign Het
Plekhg1 T G 10: 3,913,982 (GRCm39) S1235A probably benign Het
Plekhg5 T A 4: 152,191,960 (GRCm39) C433S probably benign Het
Plin2 A G 4: 86,586,915 (GRCm39) M1T probably null Het
Polg2 A G 11: 106,666,251 (GRCm39) probably null Het
Ppp1r7 T A 1: 93,285,585 (GRCm39) probably null Het
Prdx4 A G X: 154,123,460 (GRCm39) V15A probably benign Het
Rapgef6 T A 11: 54,552,001 (GRCm39) F956L probably damaging Het
Rasl12 A G 9: 65,315,605 (GRCm39) N83S probably benign Het
Rel T C 11: 23,711,129 (GRCm39) I13V probably benign Het
Reln C T 5: 22,254,789 (GRCm39) V527I possibly damaging Het
Sel1l3 C T 5: 53,295,225 (GRCm39) W792* probably null Het
Shoc1 A C 4: 59,093,850 (GRCm39) L226R probably damaging Het
Slc39a8 T A 3: 135,592,554 (GRCm39) probably null Het
Slc6a9 T A 4: 117,706,578 (GRCm39) M1K probably null Het
Smpdl3a T A 10: 57,678,626 (GRCm39) F143Y possibly damaging Het
Spsb4 G T 9: 96,878,071 (GRCm39) T84K probably damaging Het
Tbc1d8 A G 1: 39,444,398 (GRCm39) F187S probably damaging Het
Tdpoz3 T A 3: 93,733,735 (GRCm39) F137I probably benign Het
Tgm7 G A 2: 120,940,174 (GRCm39) probably benign Het
Tnni3k C T 3: 154,644,387 (GRCm39) probably null Het
Tpd52 A T 3: 9,068,466 (GRCm39) Y16* probably null Het
Trpa1 A G 1: 14,957,844 (GRCm39) C705R probably damaging Het
Ttn A G 2: 76,581,195 (GRCm39) S23233P probably damaging Het
Uevld T C 7: 46,597,693 (GRCm39) D154G probably null Het
Ugt1a1 AT A 1: 88,140,093 (GRCm39) probably null Het
Zfp292 G A 4: 34,808,595 (GRCm39) T1483M probably damaging Het
Other mutations in Atp6v1g1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0694:Atp6v1g1 UTSW 4 63,468,230 (GRCm39) missense probably benign 0.42
R1401:Atp6v1g1 UTSW 4 63,466,878 (GRCm39) missense probably benign 0.42
R2086:Atp6v1g1 UTSW 4 63,468,304 (GRCm39) missense probably benign 0.00
R2870:Atp6v1g1 UTSW 4 63,468,258 (GRCm39) missense probably benign 0.00
R2870:Atp6v1g1 UTSW 4 63,468,258 (GRCm39) missense probably benign 0.00
R2871:Atp6v1g1 UTSW 4 63,468,258 (GRCm39) missense probably benign 0.00
R2871:Atp6v1g1 UTSW 4 63,468,258 (GRCm39) missense probably benign 0.00
R2872:Atp6v1g1 UTSW 4 63,468,258 (GRCm39) missense probably benign 0.00
R2873:Atp6v1g1 UTSW 4 63,468,258 (GRCm39) missense probably benign 0.00
R3436:Atp6v1g1 UTSW 4 63,468,255 (GRCm39) missense probably benign
R3437:Atp6v1g1 UTSW 4 63,468,255 (GRCm39) missense probably benign
R4580:Atp6v1g1 UTSW 4 63,468,269 (GRCm39) missense probably benign 0.14
Predicted Primers PCR Primer
(F):5'- ACACAGCTTTTCTCACAGGTTAC -3'
(R):5'- CCAGCTCTGTGGAGGTTTTC -3'

Sequencing Primer
(F):5'- CATTCTCTTACTAAGGAGCCGGG -3'
(R):5'- CCTATTCTATGGGGGCAGATCTC -3'
Posted On 2014-12-04