Incidental Mutation 'R2519:Eif4g3'
| ID |
254168 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Eif4g3
|
| Ensembl Gene |
ENSMUSG00000028760 |
| Gene Name |
eukaryotic translation initiation factor 4 gamma, 3 |
| Synonyms |
4930523M17Rik, G1-419-52, repro8, 1500002J22Rik, eIF4GII |
| MMRRC Submission |
040423-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.404)
|
| Stock # |
R2519 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
137719090-137934397 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 137824629 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Tyrosine
at position 278
(F278Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000145147
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000058133]
[ENSMUST00000084214]
[ENSMUST00000084215]
[ENSMUST00000105830]
[ENSMUST00000105831]
[ENSMUST00000139759]
[ENSMUST00000155142]
[ENSMUST00000203828]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000058133
AA Change: F133Y
PolyPhen 2
Score 0.113 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000059465
Gene: ENSMUSG00000028760
AA Change: F133Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
113 |
140 |
N/A |
INTRINSIC |
|
low complexity region
|
167 |
172 |
N/A |
INTRINSIC |
|
PDB:1LJ2|D
|
174 |
199 |
1e-9 |
PDB |
|
low complexity region
|
212 |
228 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000084214
AA Change: F113Y
PolyPhen 2
Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000081232
Gene: ENSMUSG00000028760
AA Change: F113Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
43 |
N/A |
INTRINSIC |
|
low complexity region
|
93 |
120 |
N/A |
INTRINSIC |
|
low complexity region
|
147 |
152 |
N/A |
INTRINSIC |
|
PDB:1LJ2|D
|
154 |
179 |
8e-9 |
PDB |
|
low complexity region
|
192 |
207 |
N/A |
INTRINSIC |
|
low complexity region
|
269 |
310 |
N/A |
INTRINSIC |
|
low complexity region
|
427 |
444 |
N/A |
INTRINSIC |
|
low complexity region
|
534 |
550 |
N/A |
INTRINSIC |
|
low complexity region
|
579 |
588 |
N/A |
INTRINSIC |
|
low complexity region
|
592 |
616 |
N/A |
INTRINSIC |
|
Blast:MIF4G
|
617 |
708 |
5e-49 |
BLAST |
|
Blast:MIF4G
|
722 |
765 |
5e-16 |
BLAST |
|
MIF4G
|
768 |
996 |
1.42e-65 |
SMART |
|
low complexity region
|
1086 |
1109 |
N/A |
INTRINSIC |
|
MA3
|
1215 |
1327 |
9.29e-38 |
SMART |
|
eIF5C
|
1487 |
1574 |
7.92e-36 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000084215
AA Change: F95Y
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000081233
Gene: ENSMUSG00000028760
AA Change: F95Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
25 |
N/A |
INTRINSIC |
|
low complexity region
|
75 |
102 |
N/A |
INTRINSIC |
|
low complexity region
|
129 |
134 |
N/A |
INTRINSIC |
|
PDB:1LJ2|D
|
136 |
161 |
8e-9 |
PDB |
|
low complexity region
|
174 |
189 |
N/A |
INTRINSIC |
|
low complexity region
|
251 |
292 |
N/A |
INTRINSIC |
|
low complexity region
|
409 |
426 |
N/A |
INTRINSIC |
|
low complexity region
|
516 |
532 |
N/A |
INTRINSIC |
|
low complexity region
|
561 |
570 |
N/A |
INTRINSIC |
|
low complexity region
|
574 |
598 |
N/A |
INTRINSIC |
|
Blast:MIF4G
|
599 |
690 |
4e-49 |
BLAST |
|
Blast:MIF4G
|
704 |
747 |
5e-16 |
BLAST |
|
MIF4G
|
750 |
978 |
1.42e-65 |
SMART |
|
low complexity region
|
1068 |
1113 |
N/A |
INTRINSIC |
|
MA3
|
1216 |
1328 |
9.29e-38 |
SMART |
|
eIF5C
|
1488 |
1575 |
7.92e-36 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105830
AA Change: F106Y
PolyPhen 2
Score 0.110 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000101456
Gene: ENSMUSG00000028760
AA Change: F106Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
36 |
N/A |
INTRINSIC |
|
low complexity region
|
86 |
113 |
N/A |
INTRINSIC |
|
low complexity region
|
140 |
145 |
N/A |
INTRINSIC |
|
PDB:1LJ2|D
|
147 |
172 |
1e-7 |
PDB |
|
low complexity region
|
261 |
302 |
N/A |
INTRINSIC |
|
low complexity region
|
419 |
436 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105831
AA Change: F102Y
PolyPhen 2
Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000101457
Gene: ENSMUSG00000028760
AA Change: F102Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
32 |
N/A |
INTRINSIC |
|
low complexity region
|
82 |
109 |
N/A |
INTRINSIC |
|
low complexity region
|
136 |
141 |
N/A |
INTRINSIC |
|
PDB:1LJ2|D
|
143 |
168 |
8e-9 |
PDB |
|
low complexity region
|
181 |
196 |
N/A |
INTRINSIC |
|
low complexity region
|
258 |
299 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
433 |
N/A |
INTRINSIC |
|
low complexity region
|
523 |
539 |
N/A |
INTRINSIC |
|
low complexity region
|
568 |
577 |
N/A |
INTRINSIC |
|
low complexity region
|
581 |
605 |
N/A |
INTRINSIC |
|
Blast:MIF4G
|
606 |
697 |
4e-49 |
BLAST |
|
Blast:MIF4G
|
711 |
754 |
5e-16 |
BLAST |
|
MIF4G
|
757 |
985 |
1.42e-65 |
SMART |
|
low complexity region
|
1075 |
1098 |
N/A |
INTRINSIC |
|
MA3
|
1204 |
1316 |
9.29e-38 |
SMART |
|
eIF5C
|
1476 |
1563 |
7.92e-36 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000139759
AA Change: F102Y
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000116927
Gene: ENSMUSG00000028760
AA Change: F102Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
32 |
N/A |
INTRINSIC |
|
low complexity region
|
82 |
109 |
N/A |
INTRINSIC |
|
low complexity region
|
136 |
141 |
N/A |
INTRINSIC |
|
PDB:1LJ2|D
|
143 |
168 |
3e-10 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000155142
AA Change: F106Y
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000122972
Gene: ENSMUSG00000028760
AA Change: F106Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
36 |
N/A |
INTRINSIC |
|
low complexity region
|
86 |
113 |
N/A |
INTRINSIC |
|
low complexity region
|
140 |
145 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000203828
AA Change: F278Y
PolyPhen 2
Score 0.366 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000145147
Gene: ENSMUSG00000028760
AA Change: F278Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
41 |
81 |
N/A |
INTRINSIC |
|
low complexity region
|
193 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
258 |
285 |
N/A |
INTRINSIC |
|
low complexity region
|
312 |
317 |
N/A |
INTRINSIC |
|
PDB:1LJ2|D
|
319 |
344 |
9e-9 |
PDB |
|
low complexity region
|
357 |
372 |
N/A |
INTRINSIC |
|
low complexity region
|
434 |
475 |
N/A |
INTRINSIC |
|
low complexity region
|
592 |
609 |
N/A |
INTRINSIC |
|
low complexity region
|
699 |
715 |
N/A |
INTRINSIC |
|
low complexity region
|
744 |
753 |
N/A |
INTRINSIC |
|
low complexity region
|
757 |
781 |
N/A |
INTRINSIC |
|
Blast:MIF4G
|
782 |
873 |
9e-49 |
BLAST |
|
Blast:MIF4G
|
887 |
930 |
5e-16 |
BLAST |
|
MIF4G
|
933 |
1161 |
6e-68 |
SMART |
|
coiled coil region
|
1174 |
1201 |
N/A |
INTRINSIC |
|
low complexity region
|
1251 |
1296 |
N/A |
INTRINSIC |
|
MA3
|
1399 |
1511 |
3.9e-40 |
SMART |
|
eIF5C
|
1671 |
1758 |
3.9e-38 |
SMART |
|
| Meta Mutation Damage Score |
0.0919 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.4%
|
| Validation Efficiency |
99% (72/73) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
PHENOTYPE: Mice homozygous for an ENU induced allele exhibit decreased testes weight, azoospermia, and arrested male meiosis. Mice homozygous for a gene trapped allele exhibit small testes. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(27) : Gene trapped(27) |
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933408J17Rik |
G |
A |
10: 93,425,450 (GRCm39) |
|
probably benign |
Het |
| Abtb3 |
T |
A |
10: 85,487,475 (GRCm39) |
V981D |
probably damaging |
Het |
| Actn1 |
A |
T |
12: 80,239,163 (GRCm39) |
H247Q |
probably damaging |
Het |
| Adgre1 |
T |
C |
17: 57,717,956 (GRCm39) |
C323R |
probably damaging |
Het |
| Adgrf2 |
T |
A |
17: 43,021,298 (GRCm39) |
I509F |
probably damaging |
Het |
| Aknad1 |
A |
T |
3: 108,663,784 (GRCm39) |
T331S |
probably damaging |
Het |
| Aldh1a3 |
T |
C |
7: 66,072,047 (GRCm39) |
D39G |
probably benign |
Het |
| Alms1 |
C |
A |
6: 85,644,945 (GRCm39) |
|
probably benign |
Het |
| Ankhd1 |
T |
G |
18: 36,711,596 (GRCm39) |
|
probably null |
Het |
| Arfgef2 |
T |
C |
2: 166,723,164 (GRCm39) |
S1535P |
probably benign |
Het |
| Bicc1 |
T |
C |
10: 70,766,474 (GRCm39) |
E916G |
probably damaging |
Het |
| Birc2 |
A |
T |
9: 7,821,180 (GRCm39) |
D381E |
possibly damaging |
Het |
| Carnmt1 |
A |
G |
19: 18,671,075 (GRCm39) |
I316V |
probably benign |
Het |
| Cdk2ap1rt |
A |
G |
11: 48,716,950 (GRCm39) |
I76T |
probably damaging |
Het |
| Chd6 |
T |
A |
2: 160,871,796 (GRCm39) |
Y213F |
possibly damaging |
Het |
| Coq7 |
A |
T |
7: 118,109,371 (GRCm39) |
W226R |
unknown |
Het |
| Cyp2d9 |
G |
A |
15: 82,338,719 (GRCm39) |
|
probably null |
Het |
| Ddx42 |
T |
A |
11: 106,136,155 (GRCm39) |
N635K |
probably damaging |
Het |
| Dmtf1 |
T |
C |
5: 9,179,323 (GRCm39) |
T292A |
possibly damaging |
Het |
| Dnajb8 |
T |
C |
6: 88,199,857 (GRCm39) |
V131A |
probably benign |
Het |
| Dock6 |
T |
C |
9: 21,727,629 (GRCm39) |
E1367G |
possibly damaging |
Het |
| Dvl1 |
T |
A |
4: 155,940,000 (GRCm39) |
Y377* |
probably null |
Het |
| Fancg |
A |
T |
4: 43,008,787 (GRCm39) |
L150H |
probably damaging |
Het |
| Fastkd5 |
T |
C |
2: 130,458,114 (GRCm39) |
T159A |
possibly damaging |
Het |
| Fkrp |
G |
T |
7: 16,544,877 (GRCm39) |
Y328* |
probably null |
Het |
| Fmo3 |
A |
T |
1: 162,785,874 (GRCm39) |
V372D |
probably damaging |
Het |
| Gsta5 |
T |
G |
9: 78,211,721 (GRCm39) |
L161R |
probably damaging |
Het |
| Gtf2h4 |
C |
A |
17: 35,981,801 (GRCm39) |
G143W |
probably damaging |
Het |
| Hivep2 |
C |
A |
10: 14,004,713 (GRCm39) |
T437K |
probably benign |
Het |
| Hmcn1 |
A |
T |
1: 150,649,571 (GRCm39) |
Y638* |
probably null |
Het |
| Ighv11-2 |
T |
A |
12: 114,011,912 (GRCm39) |
Q101L |
probably damaging |
Het |
| Lgalsl2 |
A |
T |
7: 5,362,833 (GRCm39) |
I155F |
probably damaging |
Het |
| Lipf |
G |
T |
19: 33,942,925 (GRCm39) |
V78L |
probably damaging |
Het |
| Magi3 |
T |
C |
3: 103,923,081 (GRCm39) |
E1212G |
probably benign |
Het |
| Mfap5 |
T |
C |
6: 122,502,948 (GRCm39) |
S75P |
probably damaging |
Het |
| Mn1 |
C |
A |
5: 111,566,418 (GRCm39) |
H129Q |
possibly damaging |
Het |
| Morc3 |
A |
G |
16: 93,659,427 (GRCm39) |
|
probably null |
Het |
| Mrc2 |
G |
A |
11: 105,239,257 (GRCm39) |
|
probably null |
Het |
| Myo5c |
A |
G |
9: 75,157,718 (GRCm39) |
I224V |
probably damaging |
Het |
| Nup58 |
T |
C |
14: 60,460,808 (GRCm39) |
T486A |
probably benign |
Het |
| Or5m13b |
A |
G |
2: 85,753,951 (GRCm39) |
Y113C |
probably damaging |
Het |
| Or8b46 |
T |
A |
9: 38,450,281 (GRCm39) |
V30D |
probably damaging |
Het |
| Parp14 |
A |
T |
16: 35,678,573 (GRCm39) |
L465Q |
possibly damaging |
Het |
| Pcare |
C |
T |
17: 72,058,642 (GRCm39) |
S345N |
probably damaging |
Het |
| Plcd3 |
A |
T |
11: 102,971,226 (GRCm39) |
I110N |
possibly damaging |
Het |
| Prx |
A |
G |
7: 27,217,668 (GRCm39) |
E862G |
probably benign |
Het |
| Rad50 |
G |
A |
11: 53,598,012 (GRCm39) |
|
probably benign |
Het |
| Rbm15 |
A |
G |
3: 107,238,149 (GRCm39) |
S750P |
probably benign |
Het |
| Reln |
C |
A |
5: 22,549,367 (GRCm39) |
A14S |
unknown |
Het |
| Rph3a |
T |
C |
5: 121,092,485 (GRCm39) |
Y372C |
probably damaging |
Het |
| Serpine2 |
T |
A |
1: 79,777,256 (GRCm39) |
H187L |
possibly damaging |
Het |
| Slc11a2 |
T |
C |
15: 100,299,204 (GRCm39) |
D122G |
probably damaging |
Het |
| Slc25a32 |
A |
T |
15: 38,959,450 (GRCm39) |
V289E |
probably damaging |
Het |
| Slc25a46 |
A |
T |
18: 31,735,814 (GRCm39) |
S142T |
probably benign |
Het |
| Srm |
A |
G |
4: 148,675,961 (GRCm39) |
|
probably null |
Het |
| Srsf5 |
A |
G |
12: 80,995,870 (GRCm39) |
D123G |
probably damaging |
Het |
| Stab1 |
A |
T |
14: 30,876,829 (GRCm39) |
C832S |
probably damaging |
Het |
| Stab2 |
A |
C |
10: 86,770,704 (GRCm39) |
|
probably benign |
Het |
| Suds3 |
T |
C |
5: 117,233,018 (GRCm39) |
N282S |
probably damaging |
Het |
| Taar9 |
A |
T |
10: 23,985,152 (GRCm39) |
V94E |
probably damaging |
Het |
| Taf2 |
C |
A |
15: 54,915,643 (GRCm39) |
A428S |
probably benign |
Het |
| Tbk1 |
G |
T |
10: 121,393,164 (GRCm39) |
T462K |
probably benign |
Het |
| Tcaf2 |
T |
G |
6: 42,606,365 (GRCm39) |
I530L |
possibly damaging |
Het |
| Tigd4 |
A |
G |
3: 84,501,221 (GRCm39) |
Y46C |
probably damaging |
Het |
| Topors |
G |
T |
4: 40,261,714 (GRCm39) |
Y523* |
probably null |
Het |
| Tpte |
T |
C |
8: 22,823,176 (GRCm39) |
|
probably benign |
Het |
| Trpv5 |
T |
A |
6: 41,651,284 (GRCm39) |
Q254L |
probably damaging |
Het |
| Trpv6 |
G |
A |
6: 41,601,550 (GRCm39) |
Q457* |
probably null |
Het |
| Ush2a |
A |
T |
1: 187,999,304 (GRCm39) |
M205L |
probably benign |
Het |
| Vmn1r90 |
A |
T |
7: 14,295,643 (GRCm39) |
Y152N |
probably damaging |
Het |
| Vmn2r124 |
T |
A |
17: 18,294,280 (GRCm39) |
V789D |
probably damaging |
Het |
| Vmn2r99 |
T |
C |
17: 19,598,970 (GRCm39) |
I218T |
probably damaging |
Het |
| Vstm2b |
T |
C |
7: 40,552,299 (GRCm39) |
V248A |
probably benign |
Het |
| Wnk2 |
T |
C |
13: 49,224,505 (GRCm39) |
K1019E |
probably damaging |
Het |
| Zfhx4 |
C |
T |
3: 5,468,418 (GRCm39) |
P2859S |
probably benign |
Het |
| Zfp229 |
T |
A |
17: 21,964,568 (GRCm39) |
F266Y |
possibly damaging |
Het |
| Zfp616 |
T |
A |
11: 73,975,094 (GRCm39) |
C454* |
probably null |
Het |
|
| Other mutations in Eif4g3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01817:Eif4g3
|
APN |
4 |
137,847,673 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02171:Eif4g3
|
APN |
4 |
137,853,900 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02487:Eif4g3
|
APN |
4 |
137,930,689 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02514:Eif4g3
|
APN |
4 |
137,853,505 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02622:Eif4g3
|
APN |
4 |
137,824,677 (GRCm39) |
splice site |
probably benign |
|
|
IGL02725:Eif4g3
|
APN |
4 |
137,897,782 (GRCm39) |
splice site |
probably benign |
|
|
IGL02735:Eif4g3
|
APN |
4 |
137,853,522 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL03008:Eif4g3
|
APN |
4 |
137,847,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03077:Eif4g3
|
APN |
4 |
137,853,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
N/A - 535:Eif4g3
|
UTSW |
4 |
137,847,739 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0013:Eif4g3
|
UTSW |
4 |
137,903,159 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0193:Eif4g3
|
UTSW |
4 |
137,873,687 (GRCm39) |
splice site |
probably benign |
|
|
R0240:Eif4g3
|
UTSW |
4 |
137,897,873 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0240:Eif4g3
|
UTSW |
4 |
137,897,873 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0563:Eif4g3
|
UTSW |
4 |
137,903,151 (GRCm39) |
splice site |
probably benign |
|
|
R0841:Eif4g3
|
UTSW |
4 |
137,893,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0884:Eif4g3
|
UTSW |
4 |
137,879,087 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R1116:Eif4g3
|
UTSW |
4 |
137,819,086 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1145:Eif4g3
|
UTSW |
4 |
137,893,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1145:Eif4g3
|
UTSW |
4 |
137,893,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1192:Eif4g3
|
UTSW |
4 |
137,898,497 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1401:Eif4g3
|
UTSW |
4 |
137,933,395 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1535:Eif4g3
|
UTSW |
4 |
137,824,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1571:Eif4g3
|
UTSW |
4 |
137,847,719 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1576:Eif4g3
|
UTSW |
4 |
137,824,181 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1607:Eif4g3
|
UTSW |
4 |
137,853,874 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1618:Eif4g3
|
UTSW |
4 |
137,933,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1793:Eif4g3
|
UTSW |
4 |
137,898,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1823:Eif4g3
|
UTSW |
4 |
137,907,802 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1857:Eif4g3
|
UTSW |
4 |
137,903,187 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1907:Eif4g3
|
UTSW |
4 |
137,885,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2041:Eif4g3
|
UTSW |
4 |
137,832,617 (GRCm39) |
splice site |
probably benign |
|
|
R2106:Eif4g3
|
UTSW |
4 |
137,810,230 (GRCm39) |
start gained |
probably benign |
|
|
R2124:Eif4g3
|
UTSW |
4 |
137,912,053 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2301:Eif4g3
|
UTSW |
4 |
137,899,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3033:Eif4g3
|
UTSW |
4 |
137,830,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3870:Eif4g3
|
UTSW |
4 |
137,824,211 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4542:Eif4g3
|
UTSW |
4 |
137,930,728 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4582:Eif4g3
|
UTSW |
4 |
137,898,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4607:Eif4g3
|
UTSW |
4 |
137,853,769 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4608:Eif4g3
|
UTSW |
4 |
137,853,769 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4658:Eif4g3
|
UTSW |
4 |
137,933,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4736:Eif4g3
|
UTSW |
4 |
137,925,408 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4739:Eif4g3
|
UTSW |
4 |
137,925,408 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4739:Eif4g3
|
UTSW |
4 |
137,910,510 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4740:Eif4g3
|
UTSW |
4 |
137,925,408 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4760:Eif4g3
|
UTSW |
4 |
137,811,629 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4825:Eif4g3
|
UTSW |
4 |
137,921,392 (GRCm39) |
missense |
probably benign |
|
|
R4826:Eif4g3
|
UTSW |
4 |
137,905,256 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4941:Eif4g3
|
UTSW |
4 |
137,897,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5040:Eif4g3
|
UTSW |
4 |
137,824,200 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5070:Eif4g3
|
UTSW |
4 |
137,873,610 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5155:Eif4g3
|
UTSW |
4 |
137,854,054 (GRCm39) |
missense |
probably benign |
0.36 |
|
R5226:Eif4g3
|
UTSW |
4 |
137,824,105 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5229:Eif4g3
|
UTSW |
4 |
137,824,105 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5303:Eif4g3
|
UTSW |
4 |
137,853,873 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5369:Eif4g3
|
UTSW |
4 |
137,910,645 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5394:Eif4g3
|
UTSW |
4 |
137,830,709 (GRCm39) |
splice site |
probably null |
|
|
R5665:Eif4g3
|
UTSW |
4 |
137,853,900 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5678:Eif4g3
|
UTSW |
4 |
137,879,053 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5695:Eif4g3
|
UTSW |
4 |
137,890,744 (GRCm39) |
splice site |
probably null |
|
|
R5704:Eif4g3
|
UTSW |
4 |
137,918,003 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5924:Eif4g3
|
UTSW |
4 |
137,929,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6214:Eif4g3
|
UTSW |
4 |
137,785,314 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6278:Eif4g3
|
UTSW |
4 |
137,915,394 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6519:Eif4g3
|
UTSW |
4 |
137,721,319 (GRCm39) |
missense |
probably benign |
|
|
R6659:Eif4g3
|
UTSW |
4 |
137,905,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6720:Eif4g3
|
UTSW |
4 |
137,903,143 (GRCm39) |
splice site |
probably null |
|
|
R6812:Eif4g3
|
UTSW |
4 |
137,830,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6922:Eif4g3
|
UTSW |
4 |
137,824,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7175:Eif4g3
|
UTSW |
4 |
137,853,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7176:Eif4g3
|
UTSW |
4 |
137,898,497 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7598:Eif4g3
|
UTSW |
4 |
137,921,435 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7618:Eif4g3
|
UTSW |
4 |
137,898,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7805:Eif4g3
|
UTSW |
4 |
137,873,665 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7935:Eif4g3
|
UTSW |
4 |
137,824,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7983:Eif4g3
|
UTSW |
4 |
137,878,904 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8261:Eif4g3
|
UTSW |
4 |
137,898,429 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8371:Eif4g3
|
UTSW |
4 |
137,824,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8499:Eif4g3
|
UTSW |
4 |
137,893,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8670:Eif4g3
|
UTSW |
4 |
137,885,823 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8672:Eif4g3
|
UTSW |
4 |
137,853,823 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R8744:Eif4g3
|
UTSW |
4 |
137,721,372 (GRCm39) |
small deletion |
probably benign |
|
|
R8767:Eif4g3
|
UTSW |
4 |
137,930,779 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8771:Eif4g3
|
UTSW |
4 |
137,907,848 (GRCm39) |
nonsense |
probably null |
|
|
R8989:Eif4g3
|
UTSW |
4 |
137,912,059 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9292:Eif4g3
|
UTSW |
4 |
137,921,382 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9294:Eif4g3
|
UTSW |
4 |
137,917,968 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9607:Eif4g3
|
UTSW |
4 |
137,893,045 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9617:Eif4g3
|
UTSW |
4 |
137,824,190 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF008:Eif4g3
|
UTSW |
4 |
137,903,235 (GRCm39) |
missense |
probably damaging |
0.98 |
|
X0067:Eif4g3
|
UTSW |
4 |
137,890,930 (GRCm39) |
critical splice donor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CATAGCCAAGCCTTCATGTCTTG -3'
(R):5'- CCCTTTGGGTGTCACTGATAC -3'
Sequencing Primer
(F):5'- GTAGACGGTCTCTGCACATG -3'
(R):5'- ATAGTCATTTCCTTGTAAGCTACTCC -3'
|
| Posted On |
2014-12-04 |
Incidental Mutation