Incidental Mutation 'IGL00229:Lactb2'
ID 2543
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lactb2
Ensembl Gene ENSMUSG00000025937
Gene Name lactamase, beta 2
Synonyms E430032H21Rik, Cgi-83
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # IGL00229
Quality Score
Chromosome 1
Chromosomal Location 13623330-13660546 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 13660374 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 26 (M26T)
Ref Sequence ENSEMBL: ENSMUSP00000027071 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027071]
AlphaFold Q99KR3
Predicted Effect probably damaging
Transcript: ENSMUST00000027071
AA Change: M26T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027071
Gene: ENSMUSG00000025937
AA Change: M26T

Lactamase_B 30 199 6.69e-30 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Male mice homozygous for a null allele exhibit at 40 days of age preceeded by decreased body size, lethargy, enlarged and pale liver and hepatic steatosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9030624J02Rik T A 7: 118,804,191 (GRCm38) probably benign Het
Abca4 A G 3: 122,170,954 (GRCm38) T929A probably damaging Het
Adam6b G A 12: 113,491,393 (GRCm38) R610H probably damaging Het
Adamts12 T A 15: 11,311,599 (GRCm38) M1314K probably benign Het
Alg6 T A 4: 99,753,054 (GRCm38) F152I probably damaging Het
Aopep A G 13: 63,199,500 (GRCm38) probably benign Het
Arid5b A G 10: 68,128,975 (GRCm38) S289P probably damaging Het
Axin1 T C 17: 26,194,072 (GRCm38) F780L probably damaging Het
C9 C T 15: 6,483,231 (GRCm38) S278L possibly damaging Het
Calr4 A T 4: 109,244,115 (GRCm38) I65F probably damaging Het
Cdh23 A G 10: 60,523,548 (GRCm38) V260A probably benign Het
Ddx25 T C 9: 35,543,595 (GRCm38) probably benign Het
Dppa4 A G 16: 48,291,083 (GRCm38) T92A possibly damaging Het
Ercc5 T C 1: 44,163,898 (GRCm38) Y232H probably damaging Het
Exoc4 A G 6: 33,918,399 (GRCm38) probably null Het
Fam149a A G 8: 45,351,786 (GRCm38) V253A probably damaging Het
Fam209 C T 2: 172,474,182 (GRCm38) T159I probably damaging Het
Gcfc2 A T 6: 81,936,015 (GRCm38) N265I probably damaging Het
Glud1 T C 14: 34,336,130 (GRCm38) V366A probably benign Het
Hdac10 T C 15: 89,128,442 (GRCm38) T3A probably damaging Het
Ifnar1 T C 16: 91,489,782 (GRCm38) S54P probably damaging Het
Itpr2 T C 6: 146,144,185 (GRCm38) Y2561C probably damaging Het
Klhl30 A G 1: 91,354,157 (GRCm38) E160G possibly damaging Het
Kmt2d A T 15: 98,862,333 (GRCm38) S1015T unknown Het
Lactbl1 A T 4: 136,631,051 (GRCm38) D111V probably damaging Het
Lig4 T C 8: 9,972,775 (GRCm38) Y335C probably damaging Het
Lrrc8e T A 8: 4,235,921 (GRCm38) D715E probably benign Het
Med6 A T 12: 81,579,574 (GRCm38) V142D possibly damaging Het
Men1 G A 19: 6,337,207 (GRCm38) probably null Het
Mettl13 A G 1: 162,535,865 (GRCm38) V600A possibly damaging Het
Mpdz A T 4: 81,310,224 (GRCm38) C1314* probably null Het
Nbeal2 A G 9: 110,635,869 (GRCm38) V1009A probably damaging Het
Nmur2 A G 11: 56,040,777 (GRCm38) L36P probably damaging Het
Nudt2 T A 4: 41,480,474 (GRCm38) L119Q probably damaging Het
Or5b117 T C 19: 13,453,840 (GRCm38) M226V possibly damaging Het
Osbpl3 C T 6: 50,323,068 (GRCm38) E519K probably damaging Het
Pak6 A T 2: 118,689,845 (GRCm38) T106S possibly damaging Het
Pggt1b T G 18: 46,280,719 (GRCm38) Q34P probably benign Het
Phactr4 T C 4: 132,370,992 (GRCm38) T322A possibly damaging Het
Plekhj1 T C 10: 80,796,602 (GRCm38) probably null Het
Pnpt1 T C 11: 29,154,217 (GRCm38) probably null Het
Pramel32 A G 4: 88,629,053 (GRCm38) I214T probably damaging Het
Prr14l T C 5: 32,830,676 (GRCm38) I492V probably benign Het
Ranbp2 C A 10: 58,477,256 (GRCm38) A1266E probably damaging Het
Riok3 G A 18: 12,137,020 (GRCm38) D140N probably damaging Het
Rsph4a G A 10: 33,914,343 (GRCm38) E643K probably damaging Het
Scara3 T G 14: 65,933,121 (GRCm38) E103A probably benign Het
Sgk3 T C 1: 9,868,384 (GRCm38) V33A probably damaging Het
Slc38a4 A G 15: 96,999,494 (GRCm38) F480S probably damaging Het
Slc44a1 G A 4: 53,543,571 (GRCm38) V372M probably damaging Het
Slc9a2 A G 1: 40,767,737 (GRCm38) Y728C probably benign Het
Sox4 C A 13: 28,952,973 (GRCm38) G17W probably damaging Het
Spidr A T 16: 15,895,578 (GRCm38) L847Q probably damaging Het
Sptb A G 12: 76,620,753 (GRCm38) S857P probably benign Het
Syde1 A G 10: 78,585,809 (GRCm38) V636A probably damaging Het
Syna A G 5: 134,559,717 (GRCm38) L126P possibly damaging Het
Taar2 A G 10: 23,941,368 (GRCm38) T269A possibly damaging Het
Tapbp C T 17: 33,925,704 (GRCm38) T258I probably damaging Het
Tcf20 T A 15: 82,857,142 (GRCm38) Q36L possibly damaging Het
Tmem131l A T 3: 83,942,500 (GRCm38) M260K probably damaging Het
Tnc T A 4: 64,016,824 (GRCm38) probably benign Het
Ugp2 T A 11: 21,354,345 (GRCm38) E27D probably benign Het
Wdr27 A T 17: 14,928,310 (GRCm38) C140* probably null Het
Wnt2b T C 3: 104,953,133 (GRCm38) T153A possibly damaging Het
Xirp2 A T 2: 67,513,375 (GRCm38) T1987S probably benign Het
Zfp36l1 C A 12: 80,110,464 (GRCm38) G48C probably damaging Het
Zfp474 A T 18: 52,638,493 (GRCm38) I73F possibly damaging Het
Zfp790 T A 7: 29,828,563 (GRCm38) F224L probably benign Het
Other mutations in Lactb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00595:Lactb2 APN 1 13,630,126 (GRCm38) missense probably benign 0.05
IGL00730:Lactb2 APN 1 13,647,516 (GRCm38) splice site probably benign
R0371:Lactb2 UTSW 1 13,650,760 (GRCm38) missense possibly damaging 0.69
R0782:Lactb2 UTSW 1 13,647,451 (GRCm38) missense probably benign 0.18
R1670:Lactb2 UTSW 1 13,660,417 (GRCm38) missense probably damaging 0.99
R2324:Lactb2 UTSW 1 13,638,296 (GRCm38) missense probably damaging 1.00
R2418:Lactb2 UTSW 1 13,660,339 (GRCm38) missense possibly damaging 0.93
R3500:Lactb2 UTSW 1 13,660,449 (GRCm38) start codon destroyed probably null 1.00
R4345:Lactb2 UTSW 1 13,660,350 (GRCm38) missense probably damaging 1.00
R4664:Lactb2 UTSW 1 13,647,400 (GRCm38) missense probably damaging 1.00
R4665:Lactb2 UTSW 1 13,647,400 (GRCm38) missense probably damaging 1.00
R4716:Lactb2 UTSW 1 13,638,395 (GRCm38) missense probably damaging 1.00
R5363:Lactb2 UTSW 1 13,630,132 (GRCm38) missense probably benign 0.22
R5658:Lactb2 UTSW 1 13,627,418 (GRCm38) missense probably benign 0.03
R5734:Lactb2 UTSW 1 13,660,387 (GRCm38) missense probably damaging 1.00
R5918:Lactb2 UTSW 1 13,650,730 (GRCm38) missense probably benign 0.32
R6419:Lactb2 UTSW 1 13,638,235 (GRCm38) nonsense probably null
Posted On 2011-12-09