Incidental Mutation 'R2520:Or2ad1'
ID 254404
Institutional Source Beutler Lab
Gene Symbol Or2ad1
Ensembl Gene ENSMUSG00000045474
Gene Name olfactory receptor family 2 subfamily AD member 1
Synonyms MOR256-15, Olfr1368, GA_x6K02T2QHY8-12104556-12105500
MMRRC Submission 040424-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.111) question?
Stock # R2520 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 21326281-21327225 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 21326746 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 160 (C160*)
Ref Sequence ENSEMBL: ENSMUSP00000149549 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055298] [ENSMUST00000216039]
AlphaFold Q8VFG3
Predicted Effect probably null
Transcript: ENSMUST00000055298
AA Change: C160*
SMART Domains Protein: ENSMUSP00000050942
Gene: ENSMUSG00000045474
AA Change: C160*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.8e-49 PFAM
Pfam:7tm_1 41 290 1.6e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206267
Predicted Effect probably null
Transcript: ENSMUST00000216039
AA Change: C160*
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700109H08Rik A T 5: 3,625,773 (GRCm39) N70I probably damaging Het
4930503B20Rik G A 3: 146,356,261 (GRCm39) R216W probably damaging Het
Abcb9 C T 5: 124,218,091 (GRCm39) probably null Het
Arhgdia A T 11: 120,470,852 (GRCm39) V72E probably damaging Het
Arsb A T 13: 94,077,207 (GRCm39) K525* probably null Het
Bckdha A C 7: 25,341,124 (GRCm39) I79S probably benign Het
Carm1 G A 9: 21,494,893 (GRCm39) probably null Het
Cers5 G A 15: 99,634,262 (GRCm39) T362I probably damaging Het
Clec4b2 T A 6: 123,177,942 (GRCm39) F86I probably damaging Het
Crispld1 G A 1: 17,821,000 (GRCm39) D347N probably damaging Het
Csf3r A T 4: 125,929,145 (GRCm39) T352S probably benign Het
Daam2 G A 17: 49,787,785 (GRCm39) Q443* probably null Het
Dcbld1 A G 10: 52,195,641 (GRCm39) D283G probably damaging Het
Dpp9 T C 17: 56,513,868 (GRCm39) E82G probably damaging Het
Dync1li1 A G 9: 114,518,074 (GRCm39) D42G probably null Het
Eml6 T C 11: 29,741,993 (GRCm39) H1130R probably damaging Het
Enox1 A T 14: 77,819,839 (GRCm39) Y198F probably damaging Het
Epop A G 11: 97,519,554 (GRCm39) L185P probably benign Het
Frem1 A T 4: 82,868,527 (GRCm39) C1485S probably damaging Het
Gbf1 T A 19: 46,253,806 (GRCm39) S571T probably benign Het
Gm5965 A T 16: 88,575,414 (GRCm39) I196F probably null Het
Gm8237 T A 14: 5,863,642 (GRCm38) I8L possibly damaging Het
Gria2 A C 3: 80,614,269 (GRCm39) N590K probably damaging Het
Hectd2 T A 19: 36,589,633 (GRCm39) probably null Het
Hmcn1 T A 1: 150,619,398 (GRCm39) T1239S possibly damaging Het
Hps3 A T 3: 20,083,194 (GRCm39) D167E probably damaging Het
Htr1a A G 13: 105,581,881 (GRCm39) S374G probably benign Het
Il16 C T 7: 83,301,202 (GRCm39) G307S probably benign Het
Ipmk T C 10: 71,217,047 (GRCm39) F198S probably damaging Het
Lyz2 T A 10: 117,114,558 (GRCm39) I124F probably damaging Het
Maea T C 5: 33,515,854 (GRCm39) V47A probably damaging Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Mrgpra1 A T 7: 46,985,020 (GRCm39) C220S possibly damaging Het
Myo5c A T 9: 75,204,931 (GRCm39) K1595* probably null Het
Naga G T 15: 82,214,295 (GRCm39) D405E probably benign Het
Nanog T A 6: 122,690,418 (GRCm39) N249K probably benign Het
Nhlh1 G T 1: 171,881,570 (GRCm39) R99S probably damaging Het
Ntrk2 T A 13: 59,202,090 (GRCm39) probably null Het
Nudt2 A G 4: 41,480,354 (GRCm39) E79G probably benign Het
Or4f60 A T 2: 111,902,013 (GRCm39) M305K probably benign Het
Or52n2 T A 7: 104,542,080 (GRCm39) I252F probably benign Het
Pitpnm2 T C 5: 124,267,464 (GRCm39) D592G probably damaging Het
Prps1l3 T C 12: 57,285,369 (GRCm39) V53A probably damaging Het
Psmd2 T G 16: 20,481,826 (GRCm39) V853G probably damaging Het
Pycard A G 7: 127,592,677 (GRCm39) I50T possibly damaging Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Rnf168 T A 16: 32,097,221 (GRCm39) S99T probably benign Het
Rph3al A G 11: 75,797,373 (GRCm39) S108P possibly damaging Het
Sdk1 G A 5: 142,071,526 (GRCm39) A979T probably benign Het
Sec16a G A 2: 26,331,368 (GRCm39) Q216* probably null Het
Slc35f3 T A 8: 127,121,312 (GRCm39) V391E possibly damaging Het
Slf1 T A 13: 77,199,384 (GRCm39) I666F probably damaging Het
Slfn14 A G 11: 83,167,013 (GRCm39) V834A probably damaging Het
Tab2 G A 10: 7,783,245 (GRCm39) P679L probably damaging Het
Tbc1d10b A G 7: 126,799,455 (GRCm39) probably null Het
Tmeff1 T A 4: 48,604,679 (GRCm39) C91S probably damaging Het
Tmem108 G T 9: 103,366,481 (GRCm39) N503K possibly damaging Het
Trbv28 A G 6: 41,248,541 (GRCm39) T24A probably damaging Het
Trim34b A G 7: 103,980,446 (GRCm39) E178G probably damaging Het
Trmt1l T A 1: 151,329,696 (GRCm39) H546Q probably benign Het
Ttc39d A G 17: 80,523,799 (GRCm39) I153V probably benign Het
Ttll13 T C 7: 79,899,964 (GRCm39) V101A probably damaging Het
Ubash3b A T 9: 40,926,243 (GRCm39) H501Q probably damaging Het
Upf3a T A 8: 13,846,443 (GRCm39) probably null Het
Usp48 A G 4: 137,352,562 (GRCm39) S94G probably benign Het
Wdr86 T C 5: 24,917,573 (GRCm39) *381W probably null Het
Wdr90 G A 17: 26,074,326 (GRCm39) P680S probably damaging Het
Zbtb22 G A 17: 34,135,956 (GRCm39) V34M probably damaging Het
Zbtb8a A G 4: 129,253,689 (GRCm39) probably null Het
Zfhx4 C T 3: 5,468,418 (GRCm39) P2859S probably benign Het
Zfp512b A G 2: 181,231,295 (GRCm39) V295A probably damaging Het
Zfp608 A T 18: 55,121,578 (GRCm39) V3E possibly damaging Het
Zfp748 G T 13: 67,694,781 (GRCm39) D32E possibly damaging Het
Other mutations in Or2ad1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03354:Or2ad1 APN 13 21,326,654 (GRCm39) missense probably damaging 1.00
IGL03385:Or2ad1 APN 13 21,326,657 (GRCm39) missense probably benign 0.01
R0137:Or2ad1 UTSW 13 21,326,336 (GRCm39) missense possibly damaging 0.86
R1168:Or2ad1 UTSW 13 21,326,787 (GRCm39) missense probably benign 0.04
R1212:Or2ad1 UTSW 13 21,326,337 (GRCm39) missense probably benign 0.16
R1214:Or2ad1 UTSW 13 21,326,337 (GRCm39) missense probably benign 0.16
R1237:Or2ad1 UTSW 13 21,326,337 (GRCm39) missense probably benign 0.16
R1238:Or2ad1 UTSW 13 21,326,337 (GRCm39) missense probably benign 0.16
R1239:Or2ad1 UTSW 13 21,326,337 (GRCm39) missense probably benign 0.16
R1280:Or2ad1 UTSW 13 21,326,337 (GRCm39) missense probably benign 0.16
R1309:Or2ad1 UTSW 13 21,326,337 (GRCm39) missense probably benign 0.16
R1436:Or2ad1 UTSW 13 21,327,162 (GRCm39) missense probably benign 0.01
R1443:Or2ad1 UTSW 13 21,326,337 (GRCm39) missense probably benign 0.16
R1444:Or2ad1 UTSW 13 21,326,337 (GRCm39) missense probably benign 0.16
R1602:Or2ad1 UTSW 13 21,326,820 (GRCm39) missense probably damaging 0.99
R1627:Or2ad1 UTSW 13 21,327,125 (GRCm39) missense probably damaging 0.99
R1649:Or2ad1 UTSW 13 21,326,912 (GRCm39) missense probably damaging 1.00
R1781:Or2ad1 UTSW 13 21,326,934 (GRCm39) missense probably benign 0.08
R1858:Or2ad1 UTSW 13 21,326,564 (GRCm39) missense probably damaging 1.00
R4873:Or2ad1 UTSW 13 21,326,450 (GRCm39) missense probably damaging 1.00
R4875:Or2ad1 UTSW 13 21,326,450 (GRCm39) missense probably damaging 1.00
R5009:Or2ad1 UTSW 13 21,326,435 (GRCm39) missense probably benign 0.01
R6222:Or2ad1 UTSW 13 21,327,047 (GRCm39) missense probably damaging 1.00
R7031:Or2ad1 UTSW 13 21,327,170 (GRCm39) missense probably benign
R7126:Or2ad1 UTSW 13 21,326,888 (GRCm39) missense probably damaging 1.00
R7691:Or2ad1 UTSW 13 21,327,140 (GRCm39) missense probably benign
R7875:Or2ad1 UTSW 13 21,327,093 (GRCm39) missense probably damaging 1.00
R7966:Or2ad1 UTSW 13 21,326,356 (GRCm39) nonsense probably null
R8015:Or2ad1 UTSW 13 21,326,303 (GRCm39) missense probably benign
R8155:Or2ad1 UTSW 13 21,327,062 (GRCm39) missense probably damaging 1.00
R8247:Or2ad1 UTSW 13 21,326,295 (GRCm39) missense probably benign
R8787:Or2ad1 UTSW 13 21,326,453 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- ACCTTGTCGCTGACTTGATC -3'
(R):5'- AGGGTGTGTACTCCAGTTCTTC -3'

Sequencing Primer
(F):5'- CACAGCTTGAGTGATAACTGC -3'
(R):5'- TCTTTGCCCTGGACCTGGG -3'
Posted On 2014-12-04