Incidental Mutation 'R0317:Wdcp'
ID 25484
Institutional Source Beutler Lab
Gene Symbol Wdcp
Ensembl Gene ENSMUSG00000051721
Gene Name WD repeat and coiled coil containing
Synonyms BC068281
MMRRC Submission 038527-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.707) question?
Stock # R0317 (G1)
Quality Score 225
Status Not validated
Chromosome 12
Chromosomal Location 4893303-4910043 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 4901583 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 480 (S480G)
Ref Sequence ENSEMBL: ENSMUSP00000151585 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053034] [ENSMUST00000085793] [ENSMUST00000220170] [ENSMUST00000220215] [ENSMUST00000223551]
AlphaFold Q6NV72
Predicted Effect probably benign
Transcript: ENSMUST00000053034
AA Change: S480G

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000054102
Gene: ENSMUSG00000051721
AA Change: S480G

DomainStartEndE-ValueType
Pfam:DUF4613 2 610 1.9e-260 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000085793
AA Change: S480G

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000082948
Gene: ENSMUSG00000051721
AA Change: S480G

DomainStartEndE-ValueType
Pfam:DUF4613 2 643 2.4e-280 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219069
Predicted Effect probably benign
Transcript: ENSMUST00000220170
AA Change: S480G

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
Predicted Effect probably benign
Transcript: ENSMUST00000220215
AA Change: S480G

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000223551
AA Change: S480G

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.1%
  • 20x: 92.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T C 11: 9,243,459 (GRCm39) V1774A probably damaging Het
Adam34 G A 8: 44,105,288 (GRCm39) P119L probably benign Het
Ap3b2 T C 7: 81,113,429 (GRCm39) probably null Het
Arfip2 G A 7: 105,286,430 (GRCm39) T124M probably damaging Het
Arhgef26 T C 3: 62,330,965 (GRCm39) S560P probably damaging Het
Bcl11a A T 11: 24,122,697 (GRCm39) probably null Het
Cab39 A G 1: 85,776,881 (GRCm39) E322G probably damaging Het
Cad C A 5: 31,229,665 (GRCm39) P1382Q probably benign Het
Cc2d2a T C 5: 43,864,243 (GRCm39) probably null Het
Cela2a A T 4: 141,549,011 (GRCm39) probably null Het
Cert1 C T 13: 96,770,629 (GRCm39) R487* probably null Het
Ces1e A C 8: 93,950,667 (GRCm39) I38S probably benign Het
Ces1f A T 8: 93,990,019 (GRCm39) F364I probably benign Het
Chgb A G 2: 132,635,731 (GRCm39) T558A probably benign Het
Cnpy4 C T 5: 138,191,074 (GRCm39) Q217* probably null Het
Crlf1 A G 8: 70,951,249 (GRCm39) T43A probably benign Het
Dnah7b T A 1: 46,173,816 (GRCm39) M707K probably damaging Het
Ets2 G A 16: 95,513,193 (GRCm39) S123N probably damaging Het
Fry T C 5: 150,394,933 (GRCm39) F304S probably damaging Het
Gadd45gip1 G A 8: 85,560,745 (GRCm39) R120H probably benign Het
Gbf1 A G 19: 46,242,459 (GRCm39) T96A probably benign Het
Ggn T A 7: 28,870,515 (GRCm39) M1K probably null Het
Gm5239 A G 18: 35,669,969 (GRCm39) T112A probably benign Het
Insyn2b C A 11: 34,352,826 (GRCm39) D289E possibly damaging Het
Kifbp A T 10: 62,413,861 (GRCm39) probably null Het
Lrrc15 A T 16: 30,092,561 (GRCm39) H259Q probably benign Het
Lysmd4 A G 7: 66,876,045 (GRCm39) Y236C probably damaging Het
Med29 T C 7: 28,086,284 (GRCm39) T175A possibly damaging Het
Mfsd12 G T 10: 81,193,633 (GRCm39) D68Y probably damaging Het
Myh1 T C 11: 67,108,338 (GRCm39) L1308P probably damaging Het
Nphp4 T A 4: 152,636,388 (GRCm39) probably null Het
Or8g30 A G 9: 39,230,757 (GRCm39) I51T probably benign Het
Pdhx A G 2: 102,858,625 (GRCm39) V393A probably benign Het
Pgm5 A G 19: 24,801,763 (GRCm39) I155T possibly damaging Het
Pgr A T 9: 8,965,023 (GRCm39) I889F probably benign Het
Phactr4 T A 4: 132,114,241 (GRCm39) K51I probably damaging Het
Pum2 T A 12: 8,778,754 (GRCm39) I468K possibly damaging Het
Rab11a A G 9: 64,632,835 (GRCm39) S24P probably damaging Het
Rasef T C 4: 73,666,799 (GRCm39) Q160R probably damaging Het
Rbl2 A G 8: 91,813,772 (GRCm39) D339G probably benign Het
Recql5 A G 11: 115,785,499 (GRCm39) S666P probably benign Het
Rfc1 A T 5: 65,453,395 (GRCm39) probably null Het
Scarb1 A G 5: 125,366,756 (GRCm39) V59A probably damaging Het
Slc2a4 C T 11: 69,837,182 (GRCm39) V85M probably damaging Het
Slc6a12 A G 6: 121,335,584 (GRCm39) I291V possibly damaging Het
Slco3a1 A C 7: 74,154,174 (GRCm39) Y104D probably damaging Het
Suz12 T A 11: 79,889,904 (GRCm39) D13E probably damaging Het
Tlr1 G T 5: 65,083,310 (GRCm39) C422* probably null Het
Tmco1 T C 1: 167,153,462 (GRCm39) V114A probably damaging Het
Trpa1 T C 1: 14,951,856 (GRCm39) T948A probably benign Het
Tub A T 7: 108,620,134 (GRCm39) N93Y probably damaging Het
Ufsp2 G A 8: 46,445,270 (GRCm39) probably null Het
Veph1 T C 3: 66,079,396 (GRCm39) D373G probably benign Het
Vmn1r206 A G 13: 22,805,130 (GRCm39) S26P possibly damaging Het
Vmn2r1 T C 3: 63,989,240 (GRCm39) S60P possibly damaging Het
Wnk4 T C 11: 101,159,630 (GRCm39) S612P probably benign Het
Zfp503 T C 14: 22,036,527 (GRCm39) K130E probably benign Het
Zkscan16 G A 4: 58,957,602 (GRCm39) C628Y possibly damaging Het
Other mutations in Wdcp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00770:Wdcp APN 12 4,905,303 (GRCm39) missense probably damaging 1.00
IGL00774:Wdcp APN 12 4,905,303 (GRCm39) missense probably damaging 1.00
IGL02327:Wdcp APN 12 4,901,115 (GRCm39) missense possibly damaging 0.95
IGL02725:Wdcp APN 12 4,901,206 (GRCm39) missense probably damaging 1.00
IGL03377:Wdcp APN 12 4,900,691 (GRCm39) nonsense probably null
IGL03381:Wdcp APN 12 4,901,926 (GRCm39) missense probably damaging 1.00
R0152:Wdcp UTSW 12 4,901,583 (GRCm39) missense probably benign 0.06
R1077:Wdcp UTSW 12 4,900,685 (GRCm39) missense probably damaging 1.00
R1136:Wdcp UTSW 12 4,901,655 (GRCm39) missense possibly damaging 0.78
R1571:Wdcp UTSW 12 4,901,924 (GRCm39) nonsense probably null
R1653:Wdcp UTSW 12 4,901,815 (GRCm39) missense probably damaging 1.00
R1848:Wdcp UTSW 12 4,900,245 (GRCm39) missense possibly damaging 0.86
R4091:Wdcp UTSW 12 4,905,279 (GRCm39) missense probably null 0.00
R5126:Wdcp UTSW 12 4,900,617 (GRCm39) missense probably damaging 0.98
R6148:Wdcp UTSW 12 4,900,621 (GRCm39) missense possibly damaging 0.74
R6529:Wdcp UTSW 12 4,901,143 (GRCm39) missense probably damaging 1.00
R6800:Wdcp UTSW 12 4,901,358 (GRCm39) missense probably damaging 1.00
R7432:Wdcp UTSW 12 4,900,246 (GRCm39) missense probably damaging 1.00
R7821:Wdcp UTSW 12 4,907,975 (GRCm39) missense probably benign 0.07
R8182:Wdcp UTSW 12 4,901,850 (GRCm39) missense probably damaging 1.00
R8553:Wdcp UTSW 12 4,902,024 (GRCm39) intron probably benign
R8845:Wdcp UTSW 12 4,901,439 (GRCm39) missense probably benign 0.26
R9134:Wdcp UTSW 12 4,901,533 (GRCm39) nonsense probably null
R9609:Wdcp UTSW 12 4,900,258 (GRCm39) missense probably damaging 0.98
U24488:Wdcp UTSW 12 4,900,405 (GRCm39) missense probably damaging 1.00
X0026:Wdcp UTSW 12 4,901,077 (GRCm39) nonsense probably null
Z1088:Wdcp UTSW 12 4,900,825 (GRCm39) missense probably damaging 1.00
Z1176:Wdcp UTSW 12 4,901,785 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- TGGAACATCTGCTGAGAGTCAGGG -3'
(R):5'- AGAAAGATACTGCTGCATCGCAACC -3'

Sequencing Primer
(F):5'- GGCGCTTACTCCGACTTC -3'
(R):5'- TCGAGAGAGGATTTCCAGCTC -3'
Posted On 2013-04-16