Incidental Mutation 'R2915:Tdrd9'
ID 254859
Institutional Source Beutler Lab
Gene Symbol Tdrd9
Ensembl Gene ENSMUSG00000054003
Gene Name tudor domain containing 9
Synonyms 4930441E05Rik
MMRRC Submission 040502-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.192) question?
Stock # R2915 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 111937993-112035288 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 112006895 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Asparagine at position 920 (D920N)
Ref Sequence ENSEMBL: ENSMUSP00000078022 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079009]
AlphaFold Q14BI7
Predicted Effect probably damaging
Transcript: ENSMUST00000079009
AA Change: D920N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000078022
Gene: ENSMUSG00000054003
AA Change: D920N

DomainStartEndE-ValueType
low complexity region 29 40 N/A INTRINSIC
low complexity region 70 81 N/A INTRINSIC
DEXDc 132 327 5.64e-21 SMART
HELICc 404 502 3.22e-16 SMART
low complexity region 547 561 N/A INTRINSIC
HA2 565 666 1.9e-20 SMART
TUDOR 944 1003 1.52e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000191808
Predicted Effect probably benign
Transcript: ENSMUST00000192125
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193586
Meta Mutation Damage Score 0.3443 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 98% (50/51)
MGI Phenotype PHENOTYPE: Male homozygous mice are sterile, displaying small testis, arrest of male meiosis and abnormal spermatocyte morphology. Females are fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aif1 G A 17: 35,391,127 (GRCm39) P44L probably benign Het
Arhgap11a A G 2: 113,663,853 (GRCm39) V810A probably damaging Het
B3gnt6 T C 7: 97,842,800 (GRCm39) N387D probably benign Het
Col5a2 C G 1: 45,452,656 (GRCm39) G358R probably damaging Het
Cracr2a A G 6: 127,588,468 (GRCm39) K209R probably damaging Het
Dmkn A G 7: 30,464,741 (GRCm39) N32S unknown Het
Dusp13b T A 14: 21,790,205 (GRCm39) N47I probably damaging Het
Elmo2 A G 2: 165,139,573 (GRCm39) probably benign Het
Ephb6 T C 6: 41,591,172 (GRCm39) F110L probably damaging Het
Gabrb2 T A 11: 42,482,734 (GRCm39) N197K probably benign Het
Gdnf T A 15: 7,845,130 (GRCm39) V41E possibly damaging Het
Gm21915 A G 9: 40,582,083 (GRCm39) I59V possibly damaging Het
Gprin2 C T 14: 33,917,038 (GRCm39) G244D possibly damaging Het
Grin2d T C 7: 45,482,781 (GRCm39) probably benign Het
Ice2 A G 9: 69,318,122 (GRCm39) D241G probably benign Het
Mios C T 6: 8,214,935 (GRCm39) R44C possibly damaging Het
Nlrp5-ps T C 7: 14,320,636 (GRCm39) noncoding transcript Het
Nyap2 C T 1: 81,065,188 (GRCm39) R67* probably null Het
Or4d6 G A 19: 12,085,989 (GRCm39) P81L probably benign Het
Or4f14 G T 2: 111,743,064 (GRCm39) D70E probably damaging Het
Or5m8 T A 2: 85,822,389 (GRCm39) V76E probably damaging Het
Or5t9 T C 2: 86,659,570 (GRCm39) I158T probably benign Het
Or8g19 G T 9: 39,055,762 (GRCm39) R122L possibly damaging Het
Otop2 G A 11: 115,219,972 (GRCm39) A271T probably benign Het
Otulin A G 15: 27,619,716 (GRCm39) probably benign Het
Pax1 A G 2: 147,210,348 (GRCm39) Y361C probably damaging Het
Pcdhb12 A T 18: 37,570,693 (GRCm39) N613I probably damaging Het
Plekha5 A G 6: 140,534,925 (GRCm39) K173E probably damaging Het
Plin4 T A 17: 56,411,389 (GRCm39) T881S probably damaging Het
Poli A G 18: 70,655,771 (GRCm39) probably null Het
Prex2 T A 1: 11,240,077 (GRCm39) F898I probably damaging Het
Prr14l A T 5: 32,987,112 (GRCm39) H794Q probably benign Het
Prss1 A T 6: 41,439,545 (GRCm39) I93F probably benign Het
Ptpro C T 6: 137,391,239 (GRCm39) probably benign Het
Rad1 T C 15: 10,486,728 (GRCm39) C42R probably damaging Het
Rnf20 A G 4: 49,638,769 (GRCm39) E197G probably benign Het
Setx A G 2: 29,062,336 (GRCm39) E2260G probably damaging Het
Sgk1 C T 10: 21,872,500 (GRCm39) R171W probably damaging Het
Six2 A G 17: 85,992,616 (GRCm39) S296P probably damaging Het
Smg1 T A 7: 117,810,102 (GRCm39) probably benign Het
Spred2 T C 11: 19,948,215 (GRCm39) V41A probably damaging Het
Ssu2 A T 6: 112,354,566 (GRCm39) C219* probably null Het
Tbc1d9b T A 11: 50,040,563 (GRCm39) V360D possibly damaging Het
Tyrp1 A G 4: 80,755,692 (GRCm39) T154A possibly damaging Het
Vrk3 C T 7: 44,424,866 (GRCm39) T427M probably benign Het
Wac A C 18: 7,926,131 (GRCm39) M596L possibly damaging Het
Zfhx2 G T 14: 55,302,014 (GRCm39) P1990Q probably damaging Het
Zfp853 T C 5: 143,275,332 (GRCm39) E96G unknown Het
Zzef1 G A 11: 72,801,152 (GRCm39) probably null Het
Other mutations in Tdrd9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01339:Tdrd9 APN 12 112,006,868 (GRCm39) missense probably damaging 1.00
IGL01373:Tdrd9 APN 12 112,006,868 (GRCm39) missense probably damaging 1.00
IGL01542:Tdrd9 APN 12 112,013,423 (GRCm39) missense possibly damaging 0.94
IGL02967:Tdrd9 APN 12 111,958,922 (GRCm39) missense possibly damaging 0.50
IGL03063:Tdrd9 APN 12 112,010,733 (GRCm39) missense probably benign 0.00
IGL03107:Tdrd9 APN 12 112,009,274 (GRCm39) missense probably damaging 0.98
R0433:Tdrd9 UTSW 12 111,992,015 (GRCm39) nonsense probably null
R0453:Tdrd9 UTSW 12 112,034,673 (GRCm39) missense probably benign
R0655:Tdrd9 UTSW 12 112,006,899 (GRCm39) missense probably damaging 1.00
R0666:Tdrd9 UTSW 12 111,974,014 (GRCm39) intron probably benign
R1073:Tdrd9 UTSW 12 111,989,693 (GRCm39) missense probably damaging 1.00
R1280:Tdrd9 UTSW 12 112,005,842 (GRCm39) missense probably damaging 1.00
R1386:Tdrd9 UTSW 12 112,011,238 (GRCm39) missense probably benign 0.21
R1521:Tdrd9 UTSW 12 112,002,844 (GRCm39) missense probably damaging 1.00
R1601:Tdrd9 UTSW 12 111,989,687 (GRCm39) nonsense probably null
R1651:Tdrd9 UTSW 12 111,991,140 (GRCm39) missense probably damaging 0.97
R1715:Tdrd9 UTSW 12 112,002,873 (GRCm39) missense possibly damaging 0.62
R1854:Tdrd9 UTSW 12 112,011,246 (GRCm39) missense probably damaging 1.00
R1905:Tdrd9 UTSW 12 112,030,061 (GRCm39) splice site probably benign
R2386:Tdrd9 UTSW 12 111,982,334 (GRCm39) missense probably damaging 1.00
R2863:Tdrd9 UTSW 12 111,997,695 (GRCm39) missense probably benign
R2958:Tdrd9 UTSW 12 112,008,106 (GRCm39) missense probably damaging 0.97
R4033:Tdrd9 UTSW 12 111,958,973 (GRCm39) missense possibly damaging 0.58
R4087:Tdrd9 UTSW 12 111,979,920 (GRCm39) nonsense probably null
R4237:Tdrd9 UTSW 12 112,034,059 (GRCm39) nonsense probably null
R4482:Tdrd9 UTSW 12 111,980,935 (GRCm39) critical splice donor site probably null
R4501:Tdrd9 UTSW 12 112,009,243 (GRCm39) missense probably benign 0.00
R4502:Tdrd9 UTSW 12 111,960,259 (GRCm39) missense probably damaging 1.00
R4715:Tdrd9 UTSW 12 112,008,123 (GRCm39) missense probably benign 0.00
R4803:Tdrd9 UTSW 12 111,963,269 (GRCm39) nonsense probably null
R5218:Tdrd9 UTSW 12 112,029,909 (GRCm39) intron probably benign
R5275:Tdrd9 UTSW 12 112,018,346 (GRCm39) nonsense probably null
R5295:Tdrd9 UTSW 12 112,018,346 (GRCm39) nonsense probably null
R5301:Tdrd9 UTSW 12 112,002,963 (GRCm39) critical splice donor site probably null
R5339:Tdrd9 UTSW 12 111,993,556 (GRCm39) missense probably damaging 1.00
R5500:Tdrd9 UTSW 12 111,989,702 (GRCm39) missense probably benign 0.02
R5573:Tdrd9 UTSW 12 111,964,336 (GRCm39) splice site probably null
R5590:Tdrd9 UTSW 12 112,018,414 (GRCm39) missense probably benign 0.01
R5891:Tdrd9 UTSW 12 112,009,153 (GRCm39) missense probably damaging 1.00
R6056:Tdrd9 UTSW 12 111,951,475 (GRCm39) missense probably damaging 1.00
R6057:Tdrd9 UTSW 12 111,979,720 (GRCm39) missense possibly damaging 0.85
R6125:Tdrd9 UTSW 12 112,034,632 (GRCm39) missense possibly damaging 0.89
R6254:Tdrd9 UTSW 12 111,992,334 (GRCm39) splice site probably null
R6335:Tdrd9 UTSW 12 112,008,186 (GRCm39) critical splice donor site probably null
R6345:Tdrd9 UTSW 12 112,001,042 (GRCm39) missense probably damaging 0.99
R6792:Tdrd9 UTSW 12 111,993,547 (GRCm39) missense probably benign 0.01
R6956:Tdrd9 UTSW 12 112,002,788 (GRCm39) splice site probably benign
R6987:Tdrd9 UTSW 12 111,992,027 (GRCm39) missense possibly damaging 0.82
R7090:Tdrd9 UTSW 12 111,958,904 (GRCm39) missense probably benign
R7158:Tdrd9 UTSW 12 112,002,800 (GRCm39) missense probably benign 0.08
R7220:Tdrd9 UTSW 12 111,980,888 (GRCm39) missense probably damaging 1.00
R7478:Tdrd9 UTSW 12 111,951,476 (GRCm39) missense probably damaging 1.00
R7489:Tdrd9 UTSW 12 112,034,071 (GRCm39) missense probably benign 0.00
R7751:Tdrd9 UTSW 12 111,958,982 (GRCm39) missense probably benign 0.09
R7809:Tdrd9 UTSW 12 111,999,155 (GRCm39) missense probably damaging 0.99
R7844:Tdrd9 UTSW 12 111,964,386 (GRCm39) missense possibly damaging 0.63
R7854:Tdrd9 UTSW 12 112,013,395 (GRCm39) missense probably benign 0.00
R7903:Tdrd9 UTSW 12 112,018,410 (GRCm39) missense possibly damaging 0.95
R7938:Tdrd9 UTSW 12 111,997,649 (GRCm39) missense possibly damaging 0.86
R8018:Tdrd9 UTSW 12 112,010,822 (GRCm39) missense probably damaging 0.99
R8018:Tdrd9 UTSW 12 111,999,180 (GRCm39) missense probably benign 0.12
R8090:Tdrd9 UTSW 12 111,982,369 (GRCm39) missense probably damaging 1.00
R8157:Tdrd9 UTSW 12 111,951,500 (GRCm39) missense probably benign 0.44
R8198:Tdrd9 UTSW 12 112,006,863 (GRCm39) missense probably damaging 1.00
R8203:Tdrd9 UTSW 12 111,992,064 (GRCm39) missense probably damaging 1.00
R8512:Tdrd9 UTSW 12 112,012,627 (GRCm39) missense probably benign
R8721:Tdrd9 UTSW 12 112,002,889 (GRCm39) missense probably damaging 1.00
R8889:Tdrd9 UTSW 12 111,979,718 (GRCm39) missense probably benign 0.07
R8892:Tdrd9 UTSW 12 111,979,718 (GRCm39) missense probably benign 0.07
R9276:Tdrd9 UTSW 12 111,980,935 (GRCm39) critical splice donor site probably null
R9459:Tdrd9 UTSW 12 111,992,007 (GRCm39) missense probably damaging 1.00
R9484:Tdrd9 UTSW 12 112,012,684 (GRCm39) missense probably damaging 0.97
R9657:Tdrd9 UTSW 12 112,002,824 (GRCm39) missense possibly damaging 0.50
R9745:Tdrd9 UTSW 12 112,009,130 (GRCm39) missense probably damaging 0.99
X0018:Tdrd9 UTSW 12 112,005,763 (GRCm39) missense probably benign 0.24
Z1177:Tdrd9 UTSW 12 111,982,355 (GRCm39) missense probably damaging 1.00
Z1177:Tdrd9 UTSW 12 111,960,325 (GRCm39) missense probably damaging 0.96
Z1177:Tdrd9 UTSW 12 111,938,088 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- CTAGACCCCTGAAAGCCTTC -3'
(R):5'- CAGCGGAATTTCCAGAAACATAAAG -3'

Sequencing Primer
(F):5'- GGTCATACACTGTTCTGACTAGAAGC -3'
(R):5'- GAATTTGAGCTCTAAAGTAGCTTTCC -3'
Posted On 2014-12-29