Incidental Mutation 'R2929:Zfp202'
| ID |
254950 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp202
|
| Ensembl Gene |
ENSMUSG00000025602 |
| Gene Name |
zinc finger protein 202 |
| Synonyms |
C130037E22Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2929 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
40103612-40124900 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 40122984 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 582
(V582A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000026693
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000026693]
[ENSMUST00000168691]
[ENSMUST00000168832]
|
| AlphaFold |
Q8C879 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000026693
AA Change: V582A
PolyPhen 2
Score 0.943 (Sensitivity: 0.80; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000026693
Gene: ENSMUSG00000025602
AA Change: V582A
| Domain | Start | End | E-Value | Type |
|---|
|
SCAN
|
42 |
154 |
1.19e-75 |
SMART |
|
KRAB
|
237 |
297 |
1.7e-17 |
SMART |
|
ZnF_C2H2
|
391 |
413 |
9.44e-2 |
SMART |
|
ZnF_C2H2
|
419 |
441 |
6.42e-4 |
SMART |
|
ZnF_C2H2
|
473 |
495 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
501 |
523 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
529 |
551 |
1.64e-1 |
SMART |
|
ZnF_C2H2
|
557 |
579 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
585 |
607 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
613 |
635 |
3.39e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168691
|
| SMART Domains |
Protein: ENSMUSP00000130163
Gene: ENSMUSG00000025602
| Domain | Start | End | E-Value | Type |
|---|
|
SCAN
|
42 |
132 |
1.03e-56 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168832
|
| SMART Domains |
Protein: ENSMUSP00000132131
Gene: ENSMUSG00000025602
| Domain | Start | End | E-Value | Type |
|---|
|
SCAN
|
42 |
154 |
1.19e-75 |
SMART |
|
KRAB
|
237 |
277 |
5.32e-2 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 19 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Cd177 |
G |
A |
7: 24,453,704 (GRCm39) |
Q396* |
probably null |
Het |
| Cdadc1 |
A |
T |
14: 59,835,284 (GRCm39) |
M1K |
probably null |
Het |
| Cdc23 |
ACC |
AC |
18: 34,770,371 (GRCm39) |
|
probably null |
Het |
| Cnnm3 |
T |
A |
1: 36,563,140 (GRCm39) |
F701L |
possibly damaging |
Het |
| Cul7 |
C |
G |
17: 46,962,526 (GRCm39) |
D52E |
probably benign |
Het |
| Dennd4a |
T |
C |
9: 64,759,699 (GRCm39) |
V268A |
possibly damaging |
Het |
| Deup1 |
C |
T |
9: 15,486,484 (GRCm39) |
V399I |
probably benign |
Het |
| Dscam |
T |
A |
16: 96,486,612 (GRCm39) |
Q1021L |
possibly damaging |
Het |
| Dst |
A |
T |
1: 34,206,143 (GRCm39) |
K932* |
probably null |
Het |
| Neurl2 |
T |
C |
2: 164,675,264 (GRCm39) |
N33D |
possibly damaging |
Het |
| Pnma8b |
T |
C |
7: 16,680,617 (GRCm39) |
S534P |
possibly damaging |
Het |
| Pole2 |
G |
A |
12: 69,256,712 (GRCm39) |
T271M |
probably benign |
Het |
| Ppfibp2 |
A |
G |
7: 107,296,858 (GRCm39) |
M191V |
probably damaging |
Het |
| Rad51ap2 |
A |
G |
12: 11,507,185 (GRCm39) |
Q369R |
probably benign |
Het |
| Rbm45 |
A |
G |
2: 76,208,763 (GRCm39) |
I300V |
probably benign |
Het |
| Ro60 |
G |
A |
1: 143,633,616 (GRCm39) |
A494V |
possibly damaging |
Het |
| Sco1 |
T |
A |
11: 66,954,748 (GRCm39) |
I251K |
probably damaging |
Het |
| Spmip4 |
G |
A |
6: 50,551,285 (GRCm39) |
T388I |
probably benign |
Het |
| Zfp219 |
T |
A |
14: 52,246,436 (GRCm39) |
E230D |
probably benign |
Het |
|
| Other mutations in Zfp202 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00662:Zfp202
|
APN |
9 |
40,122,339 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01862:Zfp202
|
APN |
9 |
40,123,124 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL03069:Zfp202
|
APN |
9 |
40,122,695 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0028:Zfp202
|
UTSW |
9 |
40,123,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0158:Zfp202
|
UTSW |
9 |
40,120,212 (GRCm39) |
nonsense |
probably null |
|
|
R0278:Zfp202
|
UTSW |
9 |
40,119,778 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1132:Zfp202
|
UTSW |
9 |
40,122,318 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1404:Zfp202
|
UTSW |
9 |
40,122,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1404:Zfp202
|
UTSW |
9 |
40,122,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1764:Zfp202
|
UTSW |
9 |
40,121,762 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1928:Zfp202
|
UTSW |
9 |
40,121,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3153:Zfp202
|
UTSW |
9 |
40,119,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3948:Zfp202
|
UTSW |
9 |
40,119,721 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4190:Zfp202
|
UTSW |
9 |
40,122,633 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4273:Zfp202
|
UTSW |
9 |
40,118,790 (GRCm39) |
nonsense |
probably null |
|
|
R6181:Zfp202
|
UTSW |
9 |
40,118,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6182:Zfp202
|
UTSW |
9 |
40,118,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Zfp202
|
UTSW |
9 |
40,123,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6835:Zfp202
|
UTSW |
9 |
40,121,531 (GRCm39) |
splice site |
probably null |
|
|
R7382:Zfp202
|
UTSW |
9 |
40,122,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7493:Zfp202
|
UTSW |
9 |
40,118,640 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R7542:Zfp202
|
UTSW |
9 |
40,122,443 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7689:Zfp202
|
UTSW |
9 |
40,121,829 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7832:Zfp202
|
UTSW |
9 |
40,121,758 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8084:Zfp202
|
UTSW |
9 |
40,122,538 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8349:Zfp202
|
UTSW |
9 |
40,118,976 (GRCm39) |
nonsense |
probably null |
|
|
R8449:Zfp202
|
UTSW |
9 |
40,118,976 (GRCm39) |
nonsense |
probably null |
|
|
R8879:Zfp202
|
UTSW |
9 |
40,123,053 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9135:Zfp202
|
UTSW |
9 |
40,120,237 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9411:Zfp202
|
UTSW |
9 |
40,118,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9785:Zfp202
|
UTSW |
9 |
40,120,233 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0012:Zfp202
|
UTSW |
9 |
40,122,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACACCAAAGAATCCATGTTGG -3'
(R):5'- CAGTTGGCGGCGGAATTAAG -3'
Sequencing Primer
(F):5'- ATGTTGGAGGCAAGCCCTAC -3'
(R):5'- ATAAGGCCCCTAGCTAGGTCTTG -3'
|
| Posted On |
2014-12-29 |
Incidental Mutation