Mutagenetix > Incidental Mutation

Incidental Mutation 'R2972:Vmn2r117'

255257

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r117

Ensembl Gene

ENSMUSG00000091407

Gene Name

vomeronasal 2, receptor 117

Synonyms

EG619788, V2Rp6

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.083) question?

Stock #

R2972 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

23678649-23698571 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23678830 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 798 (V798A)

Ref Sequence

ENSEMBL: ENSMUSP00000126885 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171996]

AlphaFold

K7N6V1

Predicted Effect

probably damaging
Transcript: ENSMUST00000171996
AA Change: V798A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000126885
Gene: ENSMUSG00000091407
AA Change: V798A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	2.6e-28	PFAM
Pfam:NCD3G	512	565	5e-20	PFAM
Pfam:7tm_3	595	833	8.2e-54	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
BC048507	T	C	13: 68,011,749 (GRCm39)	I42T	probably benign	Het
Card9	C	T	2: 26,247,222 (GRCm39)	R309H	probably damaging	Het
Clec14a	T	A	12: 58,314,360 (GRCm39)	R421W	probably damaging	Het
Crnkl1	A	G	2: 145,774,181 (GRCm39)	L94P	probably benign	Het
D930007J09Rik	C	T	13: 32,986,742 (GRCm39)		probably benign	Het
Dhrs7c	T	A	11: 67,706,697 (GRCm39)	I285N	possibly damaging	Het
Golga2	A	G	2: 32,195,671 (GRCm39)	N752S	probably benign	Het
Klrb1-ps1	A	G	6: 129,096,719 (GRCm39)		noncoding transcript	Het
Nin	G	A	12: 70,109,487 (GRCm39)	R151C	probably damaging	Het
Nsun6	A	C	2: 15,042,883 (GRCm39)		probably null	Het
Nyap2	C	T	1: 81,169,485 (GRCm39)	R81*	probably null	Het
Or1n2	G	A	2: 36,797,416 (GRCm39)	V153M	probably benign	Het
Or4a69	G	T	2: 89,313,120 (GRCm39)	R120S	possibly damaging	Het
Pkhd1l1	T	A	15: 44,410,644 (GRCm39)	M2717K	possibly damaging	Het
Ralgapa1	T	C	12: 55,867,540 (GRCm39)	K5E	possibly damaging	Het
Rnf130	T	A	11: 49,984,627 (GRCm39)	L309*	probably null	Het
Rsf1	ATGGCG	ATGGCGACGGTGGCG	7: 97,229,111 (GRCm39)		probably benign	Het
Rxrg	G	A	1: 167,466,715 (GRCm39)	R422H	probably damaging	Het
Serpinb9e	T	A	13: 33,439,126 (GRCm39)	V184E	probably benign	Het
Slc10a5	A	T	3: 10,399,517 (GRCm39)	I381N	probably damaging	Het
Slit1	G	A	19: 41,599,455 (GRCm39)	P1032L	probably benign	Het
Sptlc3	A	G	2: 139,431,581 (GRCm39)	T368A	probably damaging	Het
Ubr4	T	C	4: 139,133,847 (GRCm39)	Y748H	probably benign	Het
Ugt8a	T	C	3: 125,708,957 (GRCm39)	H51R	probably benign	Het
Vmn2r77	T	C	7: 86,452,893 (GRCm39)	Y537H	probably benign	Het

Other mutations in Vmn2r117

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r117	APN	17	23,698,520 (GRCm39)	missense	probably benign
IGL00990:Vmn2r117	APN	17	23,696,814 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r117	APN	17	23,694,403 (GRCm39)	missense	probably damaging	1.00
IGL01078:Vmn2r117	APN	17	23,696,778 (GRCm39)	missense	probably damaging	1.00
IGL01139:Vmn2r117	APN	17	23,696,778 (GRCm39)	missense	probably damaging	1.00
IGL01374:Vmn2r117	APN	17	23,697,356 (GRCm39)	missense	possibly damaging	0.46
IGL01779:Vmn2r117	APN	17	23,696,215 (GRCm39)	missense	probably benign	0.00
IGL02283:Vmn2r117	APN	17	23,694,356 (GRCm39)	missense	probably damaging	0.99
IGL02527:Vmn2r117	APN	17	23,696,199 (GRCm39)	missense	possibly damaging	0.65
IGL02612:Vmn2r117	APN	17	23,678,758 (GRCm39)	missense	possibly damaging	0.91
IGL02887:Vmn2r117	APN	17	23,694,552 (GRCm39)	splice site	probably benign
IGL03167:Vmn2r117	APN	17	23,696,681 (GRCm39)	missense	probably damaging	1.00
R0315:Vmn2r117	UTSW	17	23,679,139 (GRCm39)	missense	probably benign	0.11
R0610:Vmn2r117	UTSW	17	23,694,488 (GRCm39)	missense	probably benign	0.00
R0747:Vmn2r117	UTSW	17	23,694,477 (GRCm39)	nonsense	probably null
R1411:Vmn2r117	UTSW	17	23,679,527 (GRCm39)	missense	probably damaging	1.00
R1471:Vmn2r117	UTSW	17	23,697,447 (GRCm39)	missense	probably benign	0.00
R1853:Vmn2r117	UTSW	17	23,696,429 (GRCm39)	missense	probably damaging	0.99
R1925:Vmn2r117	UTSW	17	23,697,363 (GRCm39)	missense	probably benign	0.00
R1940:Vmn2r117	UTSW	17	23,696,454 (GRCm39)	missense	probably damaging	1.00
R2005:Vmn2r117	UTSW	17	23,696,618 (GRCm39)	missense	probably damaging	1.00
R2082:Vmn2r117	UTSW	17	23,679,230 (GRCm39)	missense	possibly damaging	0.55
R2698:Vmn2r117	UTSW	17	23,678,885 (GRCm39)	missense	probably damaging	0.98
R2973:Vmn2r117	UTSW	17	23,678,830 (GRCm39)	missense	probably damaging	1.00
R2974:Vmn2r117	UTSW	17	23,678,830 (GRCm39)	missense	probably damaging	1.00
R3160:Vmn2r117	UTSW	17	23,679,352 (GRCm39)	missense	probably damaging	1.00
R3161:Vmn2r117	UTSW	17	23,679,352 (GRCm39)	missense	probably damaging	1.00
R3162:Vmn2r117	UTSW	17	23,679,352 (GRCm39)	missense	probably damaging	1.00
R3847:Vmn2r117	UTSW	17	23,679,389 (GRCm39)	missense	probably damaging	0.97
R3848:Vmn2r117	UTSW	17	23,679,389 (GRCm39)	missense	probably damaging	0.97
R4082:Vmn2r117	UTSW	17	23,679,080 (GRCm39)	missense	probably benign	0.00
R4320:Vmn2r117	UTSW	17	23,698,487 (GRCm39)	frame shift	probably null
R4560:Vmn2r117	UTSW	17	23,678,851 (GRCm39)	missense	probably damaging	1.00
R4658:Vmn2r117	UTSW	17	23,697,390 (GRCm39)	missense	probably benign	0.01
R4881:Vmn2r117	UTSW	17	23,696,859 (GRCm39)	missense	probably damaging	1.00
R4908:Vmn2r117	UTSW	17	23,678,812 (GRCm39)	missense	probably damaging	1.00
R4910:Vmn2r117	UTSW	17	23,698,487 (GRCm39)	frame shift	probably null
R5078:Vmn2r117	UTSW	17	23,679,122 (GRCm39)	missense	probably damaging	1.00
R5327:Vmn2r117	UTSW	17	23,696,848 (GRCm39)	nonsense	probably null
R5774:Vmn2r117	UTSW	17	23,696,176 (GRCm39)	missense	probably damaging	0.98
R6014:Vmn2r117	UTSW	17	23,698,535 (GRCm39)	missense	probably damaging	0.97
R6390:Vmn2r117	UTSW	17	23,679,088 (GRCm39)	missense	possibly damaging	0.95
R6520:Vmn2r117	UTSW	17	23,679,193 (GRCm39)	missense	probably damaging	0.99
R6674:Vmn2r117	UTSW	17	23,679,023 (GRCm39)	nonsense	probably null
R6736:Vmn2r117	UTSW	17	23,697,282 (GRCm39)	missense	probably damaging	0.99
R6909:Vmn2r117	UTSW	17	23,698,479 (GRCm39)	missense	possibly damaging	0.67
R6913:Vmn2r117	UTSW	17	23,698,537 (GRCm39)	missense	probably damaging	0.99
R7220:Vmn2r117	UTSW	17	23,696,177 (GRCm39)	missense	probably damaging	1.00
R7260:Vmn2r117	UTSW	17	23,694,359 (GRCm39)	missense	probably benign	0.06
R7440:Vmn2r117	UTSW	17	23,694,539 (GRCm39)	missense	probably benign	0.26
R7443:Vmn2r117	UTSW	17	23,679,319 (GRCm39)	missense	probably damaging	1.00
R7443:Vmn2r117	UTSW	17	23,679,107 (GRCm39)	missense	probably benign	0.25
R7449:Vmn2r117	UTSW	17	23,678,869 (GRCm39)	missense	probably damaging	1.00
R7644:Vmn2r117	UTSW	17	23,696,265 (GRCm39)	missense	probably damaging	0.98
R7914:Vmn2r117	UTSW	17	23,679,100 (GRCm39)	missense	possibly damaging	0.95
R8001:Vmn2r117	UTSW	17	23,698,381 (GRCm39)	missense	possibly damaging	0.89
R8029:Vmn2r117	UTSW	17	23,696,744 (GRCm39)	missense	probably benign	0.00
R8340:Vmn2r117	UTSW	17	23,679,511 (GRCm39)	missense	probably benign	0.01
R8519:Vmn2r117	UTSW	17	23,698,442 (GRCm39)	missense	probably benign
R8723:Vmn2r117	UTSW	17	23,696,343 (GRCm39)	missense	probably damaging	1.00
R8914:Vmn2r117	UTSW	17	23,679,143 (GRCm39)	missense	probably benign	0.02
R9010:Vmn2r117	UTSW	17	23,679,445 (GRCm39)	missense	probably benign	0.10
R9129:Vmn2r117	UTSW	17	23,678,918 (GRCm39)	nonsense	probably null
R9244:Vmn2r117	UTSW	17	23,696,589 (GRCm39)	missense	probably damaging	0.98
R9464:Vmn2r117	UTSW	17	23,696,578 (GRCm39)	missense	probably benign	0.23
R9620:Vmn2r117	UTSW	17	23,697,450 (GRCm39)	missense	probably damaging	0.97
V5622:Vmn2r117	UTSW	17	23,698,479 (GRCm39)	missense	possibly damaging	0.67
V5622:Vmn2r117	UTSW	17	23,696,814 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r117	UTSW	17	23,678,740 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GAGCATTGGAAGATGATTTCACCC -3'
(R):5'- AGTCTGGCTGAGAGCTTCTC -3'

Sequencing Primer
(F):5'- TGGAAGATGATTTCACCCTGATC -3'
(R):5'- TGCACATTCTGAGCATGGAC -3'

Posted On

2014-12-29