Mutagenetix > Incidental Mutations

Incidental Mutation 'R2919:Taar2'

255435

Institutional Source

Beutler Lab

Gene Symbol

Taar2

Ensembl Gene

ENSMUSG00000059763

Gene Name

trace amine-associated receptor 2

Synonyms

Gpr58

MMRRC Submission

040504-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R2919 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

23938572-23941583 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 23941556 bp

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 331 (N331K)

Ref Sequence

ENSEMBL: ENSMUSP00000078137 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079134]

Predicted Effect

probably benign
Transcript: ENSMUST00000079134
AA Change: N331K

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000078137
Gene: ENSMUSG00000059763
AA Change: N331K

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	42	318	2.4e-10	PFAM
Pfam:7tm_1	48	303	2.9e-54	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.6%
20x: 95.9%

Validation Efficiency

98% (53/54)

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001J03Rik	C	T	5: 146,185,191	R27H	probably benign	Het
2310002L09Rik	A	T	4: 73,950,608	L31Q	probably damaging	Het
Agbl1	G	A	7: 76,414,658	D53N	probably damaging	Het
Aloxe3	C	T	11: 69,142,923	T621I	probably damaging	Het
Als2cl	A	T	9: 110,897,499		probably null	Het
Atg9b	T	A	5: 24,391,544	T125S	possibly damaging	Het
Casp8ap2	A	G	4: 32,645,343	D1472G	probably damaging	Het
Cd1d2	C	G	3: 86,987,680	P158A	probably damaging	Het
Cdc45	A	G	16: 18,808,793	I94T	probably benign	Het
Chd6	T	G	2: 160,967,880	D1487A	possibly damaging	Het
Edem2	T	C	2: 155,709,027	Y340C	probably damaging	Het
Fbxl12	C	T	9: 20,642,213	R26H	probably damaging	Het
Fgfr3	A	G	5: 33,733,940	N516S	probably damaging	Het
Gm10093	A	G	17: 78,492,846	D422G	probably damaging	Het
Gm5884	A	G	6: 128,645,058		noncoding transcript	Het
Inpp4b	C	A	8: 81,985,329	A425E	possibly damaging	Het
Kif1a	A	G	1: 93,046,742	Y964H	probably damaging	Het
Lrp1b	A	C	2: 41,770,899	C66G	probably damaging	Het
Lrp4	A	G	2: 91,490,730	I1034V	probably benign	Het
Mmrn2	T	C	14: 34,402,922	V820A	possibly damaging	Het
Mphosph9	G	A	5: 124,261,006	T982I	probably benign	Het
Mroh9	A	C	1: 163,056,772	M399R	probably damaging	Het
Mslnl	G	A	17: 25,742,934	V128M	probably damaging	Het
N4bp2	G	A	5: 65,807,098	G830D	probably benign	Het
Nagpa	G	A	16: 5,203,787		probably benign	Het
Olfr1000	G	A	2: 85,608,410	P167S	probably benign	Het
Olfr690	C	T	7: 105,329,860	V111M	probably damaging	Het
Oxgr1	T	A	14: 120,022,809		probably benign	Het
Parp3	T	A	9: 106,473,725	R323W	possibly damaging	Het
Pfkfb3	C	T	2: 11,484,327	V286I	probably benign	Het
Pfkp	C	T	13: 6,593,243	G513D	probably damaging	Het
Pla2g4d	T	C	2: 120,281,627		probably benign	Het
Rtl1	T	C	12: 109,591,148	E1419G	unknown	Het
Sdf2	G	C	11: 78,254,854	V126L	probably damaging	Het
Sgk2	T	G	2: 162,999,195	L175R	probably damaging	Het
Sgk2	C	A	2: 162,999,205	F178L	probably damaging	Het
Sim1	T	C	10: 50,909,815	Y255H	probably benign	Het
Slc13a5	T	C	11: 72,247,791	E442G	possibly damaging	Het
Slc38a3	A	T	9: 107,657,687	I163N	probably damaging	Het
Slc39a4	A	G	15: 76,616,670	L31P	probably damaging	Het
Slc5a11	GGTGC	G	7: 123,239,372		probably null	Het
Slfnl1	G	T	4: 120,533,078		probably benign	Het
Stradb	G	A	1: 58,992,669	V247M	probably benign	Het
Styk1	T	A	6: 131,313,004		probably benign	Het
Sult1d1	A	G	5: 87,559,755		probably benign	Het
Syk	C	T	13: 52,611,121	P95S	probably benign	Het
Thsd7b	A	G	1: 130,189,850		probably benign	Het
Tldc1	G	A	8: 119,768,317	A234V	probably benign	Het
Tmbim7	G	A	5: 3,673,188		probably null	Het
Tmem107	T	C	11: 69,071,421	L68P	probably damaging	Het
Tmem184c	A	T	8: 77,604,647	C158S	probably damaging	Het
Tmpo	A	G	10: 91,152,686	I310T	probably benign	Het
Ugt2b5	A	G	5: 87,125,407	F467L	possibly damaging	Het
Xirp1	T	C	9: 120,018,701	E372G	possibly damaging	Het
Zbtb5	T	C	4: 44,994,790	E198G	probably damaging	Het
Zfp804a	A	G	2: 82,235,816	N44D	probably damaging	Het

Other mutations in Taar2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Taar2	APN	10	23941368	missense	possibly damaging	0.50
IGL00807:Taar2	APN	10	23940675	missense	probably benign	0.00
IGL01346:Taar2	APN	10	23941099	missense	probably damaging	1.00
IGL01433:Taar2	APN	10	23940759	missense	probably benign	0.02
IGL01782:Taar2	APN	10	23941144	missense	probably damaging	1.00
IGL03106:Taar2	APN	10	23941297	missense	probably damaging	0.99
IGL03372:Taar2	APN	10	23941171	missense	probably benign	0.03
R0046:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0046:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0090:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0101:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0101:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0103:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0157:Taar2	UTSW	10	23941491	missense	probably damaging	1.00
R0189:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0190:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0226:Taar2	UTSW	10	23941063	missense	probably damaging	1.00
R0226:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0265:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0267:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0349:Taar2	UTSW	10	23941429	missense	possibly damaging	0.79
R0349:Taar2	UTSW	10	23941509	missense	probably benign	0.01
R0426:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R0556:Taar2	UTSW	10	23940895	missense	probably damaging	1.00
R0698:Taar2	UTSW	10	23941495	missense	probably benign	0.00
R1191:Taar2	UTSW	10	23941029	missense	probably damaging	1.00
R4615:Taar2	UTSW	10	23941365	missense	probably benign	0.43
R4658:Taar2	UTSW	10	23941503	missense	probably benign	0.04
R4766:Taar2	UTSW	10	23940771	missense	probably damaging	0.98
R4872:Taar2	UTSW	10	23940693	missense	probably benign	0.02
R5205:Taar2	UTSW	10	23940976	missense	probably benign	0.42
R5271:Taar2	UTSW	10	23941032	missense	probably damaging	0.97
R5517:Taar2	UTSW	10	23940729	missense	possibly damaging	0.92
R6033:Taar2	UTSW	10	23940976	missense	probably benign
R6033:Taar2	UTSW	10	23940976	missense	probably benign
R6325:Taar2	UTSW	10	23940717	missense	probably benign	0.05
R6398:Taar2	UTSW	10	23941279	missense	probably benign	0.00
R6762:Taar2	UTSW	10	23941402	missense	probably damaging	0.98
R7121:Taar2	UTSW	10	23940827	missense	probably damaging	1.00
R7209:Taar2	UTSW	10	23940699	missense	possibly damaging	0.57
R7709:Taar2	UTSW	10	23940723	missense	probably benign	0.00
R8045:Taar2	UTSW	10	23941488	missense	probably damaging	1.00
R8223:Taar2	UTSW	10	23941350	missense	probably damaging	1.00
R8743:Taar2	UTSW	10	23941471	missense	probably damaging	1.00
Z1176:Taar2	UTSW	10	23941186	missense	possibly damaging	0.94

Predicted Primers

PCR Primer
(F):5'- AGATCCGTTTCTGAATTTCTCTACG -3'
(R):5'- TGGGTTCCACTATACAGAGTCCTC -3'

Sequencing Primer
(F):5'- TGAATTTCTCTACGCCTGCAG -3'
(R):5'- CCACTATACAGAGTCCTCATTTTTC -3'

Posted On

2014-12-29