|Institutional Source||Beutler Lab|
|Gene Name||p21 (RAC1) activated kinase 6|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R2920 (G1)|
|Chromosomal Location||118663303-118698020 bp(+) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||A to T at 118694007 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000106477 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000099557] [ENSMUST00000110853]|
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||96% (48/50)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a null allele do not exhibit any abnormal phenotype. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Pak6||
(F):5'- TTCAATGAGGCTTGCACGG -3'
(R):5'- GGGCAAAGGGACTACAACTC -3'
(F):5'- ACCATGGGATGCTGTGC -3'
(R):5'- GGACTACAACTCCCAGGCTG -3'