Incidental Mutation 'R2920:Mphosph9'
ID 255463
Institutional Source Beutler Lab
Gene Symbol Mphosph9
Ensembl Gene ENSMUSG00000038126
Gene Name M-phase phosphoprotein 9
Synonyms 4930548D04Rik, MPP9, B930097C17Rik, 9630025B04Rik, MPP-9
MMRRC Submission 040505-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2920 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 124389022-124466001 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 124399069 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 982 (T982I)
Ref Sequence ENSEMBL: ENSMUSP00000138982 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031344] [ENSMUST00000147737] [ENSMUST00000184951]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000031344
AA Change: T952I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000031344
Gene: ENSMUSG00000038126
AA Change: T952I

DomainStartEndE-ValueType
low complexity region 102 119 N/A INTRINSIC
low complexity region 128 140 N/A INTRINSIC
low complexity region 414 428 N/A INTRINSIC
coiled coil region 574 736 N/A INTRINSIC
low complexity region 879 898 N/A INTRINSIC
low complexity region 957 971 N/A INTRINSIC
coiled coil region 1040 1105 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128027
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142498
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143476
Predicted Effect probably benign
Transcript: ENSMUST00000147737
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156745
Predicted Effect probably benign
Transcript: ENSMUST00000184951
AA Change: T982I

PolyPhen 2 Score 0.215 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000138982
Gene: ENSMUSG00000038126
AA Change: T982I

DomainStartEndE-ValueType
coiled coil region 102 130 N/A INTRINSIC
low complexity region 132 149 N/A INTRINSIC
low complexity region 158 170 N/A INTRINSIC
low complexity region 444 458 N/A INTRINSIC
coiled coil region 604 766 N/A INTRINSIC
low complexity region 909 928 N/A INTRINSIC
low complexity region 987 1001 N/A INTRINSIC
coiled coil region 1070 1135 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157159
Meta Mutation Damage Score 0.0716 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency 96% (48/50)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgb A G 10: 10,265,987 (GRCm39) Y1025H probably damaging Het
Adgrv1 C T 13: 81,596,984 (GRCm39) A4122T probably benign Het
Aloxe3 C T 11: 69,033,749 (GRCm39) T621I probably damaging Het
Atp2b3 A C X: 72,577,526 (GRCm39) T318P probably benign Het
Atrx A T X: 104,874,474 (GRCm39) V1962D probably benign Het
Chl1 C A 6: 103,672,304 (GRCm39) T531K probably damaging Het
Clca3b T A 3: 144,543,614 (GRCm39) D405V probably benign Het
Clca3b C T 3: 144,552,692 (GRCm39) D115N probably benign Het
Comtd1 A G 14: 21,897,686 (GRCm39) L149P possibly damaging Het
Cops7a A G 6: 124,939,325 (GRCm39) V108A probably benign Het
Crebbp A G 16: 3,936,946 (GRCm39) V343A probably damaging Het
Edrf1 T A 7: 133,269,301 (GRCm39) D1109E probably benign Het
Elmo3 A G 8: 106,034,691 (GRCm39) E359G possibly damaging Het
Ep400 C A 5: 110,903,780 (GRCm39) G273V probably damaging Het
Fgfr3 A G 5: 33,891,284 (GRCm39) N516S probably damaging Het
Glb1l T A 1: 75,185,834 (GRCm39) E31D probably benign Het
Hdac1-ps A G 17: 78,800,275 (GRCm39) D422G probably damaging Het
Il12rb2 C T 6: 67,337,552 (GRCm39) V110I probably damaging Het
Ints3 T C 3: 90,300,469 (GRCm39) E884G probably benign Het
Lin7b A G 7: 45,017,821 (GRCm39) V170A possibly damaging Het
Lrch2 A T X: 146,256,026 (GRCm39) V750E probably damaging Het
Mepe C T 5: 104,486,113 (GRCm39) R418C probably damaging Het
Mettl25 A T 10: 105,601,038 (GRCm39) probably null Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Myo10 G T 15: 25,801,226 (GRCm39) V1472L probably damaging Het
Myo9b A G 8: 71,778,501 (GRCm39) K445R probably damaging Het
Ntng2 T C 2: 29,094,223 (GRCm39) M383V probably benign Het
Or13n4 C T 7: 106,423,571 (GRCm39) R54Q probably benign Het
Or2z2 T C 11: 58,346,403 (GRCm39) Y124C probably damaging Het
Or7a37 A C 10: 78,805,846 (GRCm39) D121A probably damaging Het
Pak6 A T 2: 118,524,488 (GRCm39) probably benign Het
Pcdh8 G T 14: 80,006,154 (GRCm39) P803Q possibly damaging Het
Pfkfb3 C T 2: 11,489,138 (GRCm39) V286I probably benign Het
Rbp3 C T 14: 33,677,975 (GRCm39) T641M probably damaging Het
Rint1 A G 5: 24,010,400 (GRCm39) E203G probably benign Het
Sdf2 G C 11: 78,145,680 (GRCm39) V126L probably damaging Het
Slc13a5 T C 11: 72,138,617 (GRCm39) E442G possibly damaging Het
Slc14a2 G T 18: 78,201,512 (GRCm39) S669* probably null Het
Slc38a7 A G 8: 96,572,571 (GRCm39) I157T possibly damaging Het
Slc4a5 T C 6: 83,241,369 (GRCm39) L215P probably damaging Het
Tbc1d9 T C 8: 83,937,098 (GRCm39) V60A probably benign Het
Tcerg1l T C 7: 137,850,108 (GRCm39) R422G probably damaging Het
Tmem107 T C 11: 68,962,247 (GRCm39) L68P probably damaging Het
Ugt2b5 A G 5: 87,273,266 (GRCm39) F467L possibly damaging Het
Vmn1r19 A T 6: 57,381,909 (GRCm39) N154I probably benign Het
Vmn2r69 T A 7: 85,060,973 (GRCm39) I204L probably benign Het
Zbtb1 T A 12: 76,432,619 (GRCm39) S202T possibly damaging Het
Other mutations in Mphosph9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01363:Mphosph9 APN 5 124,400,084 (GRCm39) missense probably damaging 1.00
IGL01527:Mphosph9 APN 5 124,421,687 (GRCm39) splice site probably benign
IGL01784:Mphosph9 APN 5 124,403,373 (GRCm39) splice site probably benign
IGL01958:Mphosph9 APN 5 124,463,053 (GRCm39) utr 5 prime probably benign
IGL02020:Mphosph9 APN 5 124,397,013 (GRCm39) missense probably damaging 0.99
IGL02190:Mphosph9 APN 5 124,403,488 (GRCm39) missense possibly damaging 0.92
IGL02261:Mphosph9 APN 5 124,398,150 (GRCm39) missense probably damaging 1.00
IGL02569:Mphosph9 APN 5 124,435,634 (GRCm39) nonsense probably null
IGL02640:Mphosph9 APN 5 124,453,563 (GRCm39) missense possibly damaging 0.66
IGL02702:Mphosph9 APN 5 124,398,052 (GRCm39) missense probably damaging 1.00
IGL02793:Mphosph9 APN 5 124,421,800 (GRCm39) critical splice acceptor site probably null
IGL02813:Mphosph9 APN 5 124,453,691 (GRCm39) missense probably benign 0.37
IGL02875:Mphosph9 APN 5 124,421,800 (GRCm39) critical splice acceptor site probably null
IGL03149:Mphosph9 APN 5 124,401,074 (GRCm39) missense probably damaging 1.00
PIT4445001:Mphosph9 UTSW 5 124,436,853 (GRCm39) missense possibly damaging 0.82
R0304:Mphosph9 UTSW 5 124,436,892 (GRCm39) missense probably benign 0.01
R0437:Mphosph9 UTSW 5 124,453,631 (GRCm39) missense probably benign 0.27
R0483:Mphosph9 UTSW 5 124,445,033 (GRCm39) nonsense probably null
R0811:Mphosph9 UTSW 5 124,436,822 (GRCm39) missense probably damaging 1.00
R0812:Mphosph9 UTSW 5 124,436,822 (GRCm39) missense probably damaging 1.00
R0942:Mphosph9 UTSW 5 124,400,100 (GRCm39) nonsense probably null
R1175:Mphosph9 UTSW 5 124,453,739 (GRCm39) missense possibly damaging 0.94
R1372:Mphosph9 UTSW 5 124,421,808 (GRCm39) splice site probably null
R1442:Mphosph9 UTSW 5 124,403,461 (GRCm39) missense possibly damaging 0.62
R1533:Mphosph9 UTSW 5 124,405,204 (GRCm39) missense probably damaging 1.00
R1959:Mphosph9 UTSW 5 124,453,764 (GRCm39) missense possibly damaging 0.92
R2036:Mphosph9 UTSW 5 124,442,274 (GRCm39) missense probably damaging 0.97
R2256:Mphosph9 UTSW 5 124,421,722 (GRCm39) missense probably benign 0.00
R2919:Mphosph9 UTSW 5 124,399,069 (GRCm39) missense probably benign 0.22
R4064:Mphosph9 UTSW 5 124,428,980 (GRCm39) missense probably damaging 1.00
R4272:Mphosph9 UTSW 5 124,442,266 (GRCm39) missense probably damaging 0.96
R4430:Mphosph9 UTSW 5 124,403,509 (GRCm39) missense possibly damaging 0.83
R4883:Mphosph9 UTSW 5 124,437,108 (GRCm39) missense probably damaging 1.00
R4992:Mphosph9 UTSW 5 124,442,253 (GRCm39) missense probably damaging 1.00
R5815:Mphosph9 UTSW 5 124,453,481 (GRCm39) missense probably damaging 1.00
R5993:Mphosph9 UTSW 5 124,454,161 (GRCm39) missense probably benign 0.40
R6102:Mphosph9 UTSW 5 124,435,772 (GRCm39) missense possibly damaging 0.86
R6295:Mphosph9 UTSW 5 124,458,978 (GRCm39) missense possibly damaging 0.46
R6320:Mphosph9 UTSW 5 124,463,024 (GRCm39) missense probably damaging 0.99
R6628:Mphosph9 UTSW 5 124,436,825 (GRCm39) missense probably damaging 0.98
R6692:Mphosph9 UTSW 5 124,398,179 (GRCm39) missense probably damaging 1.00
R6705:Mphosph9 UTSW 5 124,429,027 (GRCm39) missense possibly damaging 0.83
R6747:Mphosph9 UTSW 5 124,435,762 (GRCm39) missense possibly damaging 0.93
R6787:Mphosph9 UTSW 5 124,399,090 (GRCm39) missense probably damaging 0.99
R6850:Mphosph9 UTSW 5 124,399,019 (GRCm39) missense probably damaging 1.00
R6956:Mphosph9 UTSW 5 124,435,621 (GRCm39) missense probably damaging 1.00
R7075:Mphosph9 UTSW 5 124,458,922 (GRCm39) missense probably damaging 0.99
R7604:Mphosph9 UTSW 5 124,454,180 (GRCm39) missense probably benign 0.01
R7789:Mphosph9 UTSW 5 124,453,650 (GRCm39) missense probably damaging 1.00
R7808:Mphosph9 UTSW 5 124,399,009 (GRCm39) missense probably damaging 0.99
R7823:Mphosph9 UTSW 5 124,442,319 (GRCm39) missense probably damaging 0.99
R7891:Mphosph9 UTSW 5 124,428,967 (GRCm39) missense probably damaging 1.00
R8210:Mphosph9 UTSW 5 124,405,174 (GRCm39) missense probably damaging 1.00
R8256:Mphosph9 UTSW 5 124,393,169 (GRCm39) missense probably damaging 1.00
R8385:Mphosph9 UTSW 5 124,450,785 (GRCm39) missense probably benign 0.19
R8438:Mphosph9 UTSW 5 124,430,455 (GRCm39) missense probably benign 0.19
R8692:Mphosph9 UTSW 5 124,450,875 (GRCm39) missense probably damaging 0.99
R8790:Mphosph9 UTSW 5 124,453,736 (GRCm39) missense probably damaging 1.00
R8818:Mphosph9 UTSW 5 124,463,027 (GRCm39) nonsense probably null
R8847:Mphosph9 UTSW 5 124,454,209 (GRCm39) missense possibly damaging 0.91
R9018:Mphosph9 UTSW 5 124,436,713 (GRCm39) missense probably benign 0.12
R9208:Mphosph9 UTSW 5 124,450,854 (GRCm39) missense probably damaging 0.97
R9221:Mphosph9 UTSW 5 124,403,427 (GRCm39) missense probably benign 0.10
R9603:Mphosph9 UTSW 5 124,463,015 (GRCm39) nonsense probably null
R9721:Mphosph9 UTSW 5 124,436,738 (GRCm39) missense possibly damaging 0.87
Predicted Primers PCR Primer
(F):5'- GTGACAATCAGCACCCGTACAG -3'
(R):5'- TGTCAGGAAAGCCAGGTTCC -3'

Sequencing Primer
(F):5'- CAGGCACAGAGTGAATGCTC -3'
(R):5'- CGTGCCAGCTTTGTCAGTCAATATG -3'
Posted On 2014-12-29