Mutagenetix > Incidental Mutation

Incidental Mutation 'R2920:Vmn1r19'

255464

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r19

Ensembl Gene

ENSMUSG00000115799

Gene Name

vomeronasal 1 receptor 19

Synonyms

V1rc27

MMRRC Submission

040505-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.095) question?

Stock #

R2920 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

57403780-57406034 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 57404924 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Isoleucine at position 154 (N154I)

Ref Sequence

ENSEMBL: ENSMUSP00000087264 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089830]

AlphaFold

Q8R2C7

Predicted Effect

probably benign
Transcript: ENSMUST00000089830
AA Change: N154I

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000087264
Gene: ENSMUSG00000115799
AA Change: N154I

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	6.6e-58	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.6%
10x: 97.3%
20x: 95.0%

Validation Efficiency

96% (48/50)

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgb	A	G	10: 10,390,243	Y1025H	probably damaging	Het
Adgrv1	C	T	13: 81,448,865	A4122T	probably benign	Het
Aloxe3	C	T	11: 69,142,923	T621I	probably damaging	Het
Atp2b3	A	C	X: 73,533,920	T318P	probably benign	Het
Atrx	A	T	X: 105,830,868	V1962D	probably benign	Het
Chl1	C	A	6: 103,695,343	T531K	probably damaging	Het
Clca3b	T	A	3: 144,837,853	D405V	probably benign	Het
Clca3b	C	T	3: 144,846,931	D115N	probably benign	Het
Comtd1	A	G	14: 21,847,618	L149P	possibly damaging	Het
Cops7a	A	G	6: 124,962,362	V108A	probably benign	Het
Crebbp	A	G	16: 4,119,082	V343A	probably damaging	Het
Edrf1	T	A	7: 133,667,572	D1109E	probably benign	Het
Elmo3	A	G	8: 105,308,059	E359G	possibly damaging	Het
Ep400	C	A	5: 110,755,914	G273V	probably damaging	Het
Fgfr3	A	G	5: 33,733,940	N516S	probably damaging	Het
Glb1l	T	A	1: 75,209,190	E31D	probably benign	Het
Gm10093	A	G	17: 78,492,846	D422G	probably damaging	Het
Il12rb2	C	T	6: 67,360,568	V110I	probably damaging	Het
Ints3	T	C	3: 90,393,162	E884G	probably benign	Het
Lin7b	A	G	7: 45,368,397	V170A	possibly damaging	Het
Lrch2	A	T	X: 147,473,030	V750E	probably damaging	Het
Mepe	C	T	5: 104,338,247	R418C	probably damaging	Het
Mettl25	A	T	10: 105,765,177		probably null	Het
Mphosph9	G	A	5: 124,261,006	T982I	probably benign	Het
Mslnl	G	A	17: 25,742,934	V128M	probably damaging	Het
Myo10	G	T	15: 25,801,140	V1472L	probably damaging	Het
Myo9b	A	G	8: 71,325,857	K445R	probably damaging	Het
Ntng2	T	C	2: 29,204,211	M383V	probably benign	Het
Olfr1353	A	C	10: 78,970,012	D121A	probably damaging	Het
Olfr30	T	C	11: 58,455,577	Y124C	probably damaging	Het
Olfr702	C	T	7: 106,824,364	R54Q	probably benign	Het
Pak6	A	T	2: 118,694,007		probably benign	Het
Pcdh8	G	T	14: 79,768,714	P803Q	possibly damaging	Het
Pfkfb3	C	T	2: 11,484,327	V286I	probably benign	Het
Rbp3	C	T	14: 33,956,018	T641M	probably damaging	Het
Rint1	A	G	5: 23,805,402	E203G	probably benign	Het
Sdf2	G	C	11: 78,254,854	V126L	probably damaging	Het
Slc13a5	T	C	11: 72,247,791	E442G	possibly damaging	Het
Slc14a2	G	T	18: 78,158,297	S669*	probably null	Het
Slc38a7	A	G	8: 95,845,943	I157T	possibly damaging	Het
Slc4a5	T	C	6: 83,264,387	L215P	probably damaging	Het
Tbc1d9	T	C	8: 83,210,469	V60A	probably benign	Het
Tcerg1l	T	C	7: 138,248,379	R422G	probably damaging	Het
Tmem107	T	C	11: 69,071,421	L68P	probably damaging	Het
Ugt2b5	A	G	5: 87,125,407	F467L	possibly damaging	Het
Vmn2r69	T	A	7: 85,411,765	I204L	probably benign	Het
Zbtb1	T	A	12: 76,385,845	S202T	possibly damaging	Het

Other mutations in Vmn1r19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00948:Vmn1r19	APN	6	57405262	missense	probably benign	0.03
IGL01287:Vmn1r19	APN	6	57405194	missense	probably damaging	1.00
IGL01516:Vmn1r19	APN	6	57404872	missense	probably benign	0.03
IGL01895:Vmn1r19	APN	6	57405260	missense	probably benign	0.02
IGL02676:Vmn1r19	APN	6	57405040	missense	possibly damaging	0.94
IGL03040:Vmn1r19	APN	6	57405362	missense	unknown
IGL03087:Vmn1r19	APN	6	57404491	missense	probably benign	0.01
PIT4802001:Vmn1r19	UTSW	6	57405052	missense	probably damaging	1.00
R0319:Vmn1r19	UTSW	6	57404615	missense	possibly damaging	0.93
R1368:Vmn1r19	UTSW	6	57404671	missense	probably benign	0.01
R1997:Vmn1r19	UTSW	6	57405048	missense	probably damaging	1.00
R3857:Vmn1r19	UTSW	6	57405113	missense	possibly damaging	0.68
R4090:Vmn1r19	UTSW	6	57404735	missense	probably damaging	1.00
R4547:Vmn1r19	UTSW	6	57404789	missense	possibly damaging	0.56
R4823:Vmn1r19	UTSW	6	57405234	nonsense	probably null
R4951:Vmn1r19	UTSW	6	57404942	missense	probably benign	0.36
R5077:Vmn1r19	UTSW	6	57405041	missense	probably benign	0.00
R5459:Vmn1r19	UTSW	6	57404490	nonsense	probably null
R5625:Vmn1r19	UTSW	6	57405296	missense	probably damaging	1.00
R5690:Vmn1r19	UTSW	6	57404795	missense	probably benign	0.10
R5761:Vmn1r19	UTSW	6	57405353	missense	unknown
R6124:Vmn1r19	UTSW	6	57404617	missense	probably benign	0.02
R6373:Vmn1r19	UTSW	6	57405332	missense	unknown
R6476:Vmn1r19	UTSW	6	57404593	missense	probably damaging	0.99
R6938:Vmn1r19	UTSW	6	57405007	missense	possibly damaging	0.94
R7027:Vmn1r19	UTSW	6	57404490	nonsense	probably null
R7359:Vmn1r19	UTSW	6	57405095	missense	probably damaging	0.99
R7568:Vmn1r19	UTSW	6	57404828	missense	possibly damaging	0.69
R7893:Vmn1r19	UTSW	6	57404679	missense	probably damaging	1.00
R8481:Vmn1r19	UTSW	6	57404947	missense	probably damaging	0.99
R8487:Vmn1r19	UTSW	6	57405181	missense	probably benign	0.03
R8812:Vmn1r19	UTSW	6	57404451	start gained	probably benign
R8907:Vmn1r19	UTSW	6	57405006	missense	probably benign
R8976:Vmn1r19	UTSW	6	57404734	missense	probably benign	0.01
R9277:Vmn1r19	UTSW	6	57405337	missense	unknown

Predicted Primers

PCR Primer
(F):5'- GAGTGTATCCCAGGCTATCAC -3'
(R):5'- CAAGATGTTTTGGGTGGCCC -3'

Sequencing Primer
(F):5'- GTGTATCCCAGGCTATCACAATCAG -3'
(R):5'- ATGCTATGAAGATGCTTGCATTGCC -3'

Posted On

2014-12-29