Mutagenetix > Incidental Mutation

Incidental Mutation 'R2920:Vmn2r69'

255471

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r69

Ensembl Gene

ENSMUSG00000091006

Gene Name

vomeronasal 2, receptor 69

Synonyms

MMRRC Submission

040505-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

R2920 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

85404849-85417476 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 85411765 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 204 (I204L)

Ref Sequence

ENSEMBL: ENSMUSP00000132726 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171213]

AlphaFold

G3XA45

Predicted Effect

probably benign
Transcript: ENSMUST00000171213
AA Change: I204L

PolyPhen 2 Score 0.077 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000132726
Gene: ENSMUSG00000091006
AA Change: I204L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	465	1.3e-28	PFAM
Pfam:NCD3G	507	559	1.8e-20	PFAM
Pfam:7tm_3	592	827	3.2e-54	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000207880

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.6%
10x: 97.3%
20x: 95.0%

Validation Efficiency

96% (48/50)

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgb	A	G	10: 10,390,243	Y1025H	probably damaging	Het
Adgrv1	C	T	13: 81,448,865	A4122T	probably benign	Het
Aloxe3	C	T	11: 69,142,923	T621I	probably damaging	Het
Atp2b3	A	C	X: 73,533,920	T318P	probably benign	Het
Atrx	A	T	X: 105,830,868	V1962D	probably benign	Het
Chl1	C	A	6: 103,695,343	T531K	probably damaging	Het
Clca3b	T	A	3: 144,837,853	D405V	probably benign	Het
Clca3b	C	T	3: 144,846,931	D115N	probably benign	Het
Comtd1	A	G	14: 21,847,618	L149P	possibly damaging	Het
Cops7a	A	G	6: 124,962,362	V108A	probably benign	Het
Crebbp	A	G	16: 4,119,082	V343A	probably damaging	Het
Edrf1	T	A	7: 133,667,572	D1109E	probably benign	Het
Elmo3	A	G	8: 105,308,059	E359G	possibly damaging	Het
Ep400	C	A	5: 110,755,914	G273V	probably damaging	Het
Fgfr3	A	G	5: 33,733,940	N516S	probably damaging	Het
Glb1l	T	A	1: 75,209,190	E31D	probably benign	Het
Gm10093	A	G	17: 78,492,846	D422G	probably damaging	Het
Il12rb2	C	T	6: 67,360,568	V110I	probably damaging	Het
Ints3	T	C	3: 90,393,162	E884G	probably benign	Het
Lin7b	A	G	7: 45,368,397	V170A	possibly damaging	Het
Lrch2	A	T	X: 147,473,030	V750E	probably damaging	Het
Mepe	C	T	5: 104,338,247	R418C	probably damaging	Het
Mettl25	A	T	10: 105,765,177		probably null	Het
Mphosph9	G	A	5: 124,261,006	T982I	probably benign	Het
Mslnl	G	A	17: 25,742,934	V128M	probably damaging	Het
Myo10	G	T	15: 25,801,140	V1472L	probably damaging	Het
Myo9b	A	G	8: 71,325,857	K445R	probably damaging	Het
Ntng2	T	C	2: 29,204,211	M383V	probably benign	Het
Olfr1353	A	C	10: 78,970,012	D121A	probably damaging	Het
Olfr30	T	C	11: 58,455,577	Y124C	probably damaging	Het
Olfr702	C	T	7: 106,824,364	R54Q	probably benign	Het
Pak6	A	T	2: 118,694,007		probably benign	Het
Pcdh8	G	T	14: 79,768,714	P803Q	possibly damaging	Het
Pfkfb3	C	T	2: 11,484,327	V286I	probably benign	Het
Rbp3	C	T	14: 33,956,018	T641M	probably damaging	Het
Rint1	A	G	5: 23,805,402	E203G	probably benign	Het
Sdf2	G	C	11: 78,254,854	V126L	probably damaging	Het
Slc13a5	T	C	11: 72,247,791	E442G	possibly damaging	Het
Slc14a2	G	T	18: 78,158,297	S669*	probably null	Het
Slc38a7	A	G	8: 95,845,943	I157T	possibly damaging	Het
Slc4a5	T	C	6: 83,264,387	L215P	probably damaging	Het
Tbc1d9	T	C	8: 83,210,469	V60A	probably benign	Het
Tcerg1l	T	C	7: 138,248,379	R422G	probably damaging	Het
Tmem107	T	C	11: 69,071,421	L68P	probably damaging	Het
Ugt2b5	A	G	5: 87,125,407	F467L	possibly damaging	Het
Vmn1r19	A	T	6: 57,404,924	N154I	probably benign	Het
Zbtb1	T	A	12: 76,385,845	S202T	possibly damaging	Het

Other mutations in Vmn2r69

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01019:Vmn2r69	APN	7	85406531	missense	probably benign
IGL01457:Vmn2r69	APN	7	85406628	missense	possibly damaging	0.87
IGL01760:Vmn2r69	APN	7	85406864	missense	possibly damaging	0.90
IGL01834:Vmn2r69	APN	7	85412368	missense	probably damaging	1.00
IGL02001:Vmn2r69	APN	7	85407226	missense	probably benign	0.05
IGL02057:Vmn2r69	APN	7	85411782	missense	possibly damaging	0.93
IGL02289:Vmn2r69	APN	7	85406846	missense	probably damaging	1.00
IGL02472:Vmn2r69	APN	7	85409752	missense	probably benign	0.01
IGL02478:Vmn2r69	APN	7	85406681	missense	probably damaging	1.00
IGL02554:Vmn2r69	APN	7	85409806	missense	probably damaging	1.00
IGL02723:Vmn2r69	APN	7	85410208	missense	probably damaging	1.00
R0526:Vmn2r69	UTSW	7	85411503	missense	probably damaging	1.00
R0560:Vmn2r69	UTSW	7	85409714	critical splice donor site	probably null
R0909:Vmn2r69	UTSW	7	85406665	missense	probably benign	0.00
R0976:Vmn2r69	UTSW	7	85406900	missense	probably damaging	1.00
R1158:Vmn2r69	UTSW	7	85409850	splice site	probably benign
R1459:Vmn2r69	UTSW	7	85406700	nonsense	probably null
R1482:Vmn2r69	UTSW	7	85406874	missense	probably damaging	1.00
R1917:Vmn2r69	UTSW	7	85411683	missense	probably damaging	1.00
R2016:Vmn2r69	UTSW	7	85407285	missense	probably damaging	0.98
R2108:Vmn2r69	UTSW	7	85410196	missense	probably benign
R2571:Vmn2r69	UTSW	7	85415556	missense	probably benign
R2910:Vmn2r69	UTSW	7	85406710	missense	probably damaging	1.00
R3708:Vmn2r69	UTSW	7	85411821	missense	probably damaging	0.98
R3710:Vmn2r69	UTSW	7	85406393	missense	probably benign
R4757:Vmn2r69	UTSW	7	85412367	missense	probably damaging	0.99
R4823:Vmn2r69	UTSW	7	85411300	missense	probably benign	0.21
R4870:Vmn2r69	UTSW	7	85411585	missense	possibly damaging	0.93
R4918:Vmn2r69	UTSW	7	85406759	missense	probably benign	0.06
R5022:Vmn2r69	UTSW	7	85411159	missense	possibly damaging	0.72
R5174:Vmn2r69	UTSW	7	85415531	missense	possibly damaging	0.92
R5200:Vmn2r69	UTSW	7	85406509	missense	probably damaging	1.00
R5278:Vmn2r69	UTSW	7	85411783	missense	probably benign	0.02
R5643:Vmn2r69	UTSW	7	85407196	missense	probably damaging	0.98
R5996:Vmn2r69	UTSW	7	85411909	splice site	probably null
R6083:Vmn2r69	UTSW	7	85406503	missense	probably damaging	1.00
R6140:Vmn2r69	UTSW	7	85411449	missense	probably damaging	0.99
R6306:Vmn2r69	UTSW	7	85415591	missense	probably benign	0.04
R6330:Vmn2r69	UTSW	7	85411627	missense	probably benign
R6380:Vmn2r69	UTSW	7	85411859	missense	probably benign
R6466:Vmn2r69	UTSW	7	85407170	missense	probably benign	0.01
R6542:Vmn2r69	UTSW	7	85411205	nonsense	probably null
R6583:Vmn2r69	UTSW	7	85409809	missense	probably benign
R6623:Vmn2r69	UTSW	7	85407101	missense	possibly damaging	0.84
R6709:Vmn2r69	UTSW	7	85411861	missense	probably benign	0.03
R6732:Vmn2r69	UTSW	7	85411143	missense	probably benign	0.00
R6741:Vmn2r69	UTSW	7	85412516	missense	probably benign	0.01
R7070:Vmn2r69	UTSW	7	85411480	missense	probably damaging	0.98
R7234:Vmn2r69	UTSW	7	85407107	missense	probably benign	0.22
R7323:Vmn2r69	UTSW	7	85411764	missense	possibly damaging	0.95
R7427:Vmn2r69	UTSW	7	85411259	missense	probably benign	0.28
R7428:Vmn2r69	UTSW	7	85411259	missense	probably benign	0.28
R7453:Vmn2r69	UTSW	7	85411560	frame shift	probably null
R7532:Vmn2r69	UTSW	7	85410414	missense	probably benign	0.36
R7556:Vmn2r69	UTSW	7	85411560	frame shift	probably null
R7562:Vmn2r69	UTSW	7	85407212	missense	probably benign
R7592:Vmn2r69	UTSW	7	85411560	frame shift	probably null
R7708:Vmn2r69	UTSW	7	85412547	missense	possibly damaging	0.87
R7803:Vmn2r69	UTSW	7	85407116	missense	probably benign	0.00
R7960:Vmn2r69	UTSW	7	85406765	missense	probably benign
R7966:Vmn2r69	UTSW	7	85411554	missense	possibly damaging	0.81
R8071:Vmn2r69	UTSW	7	85406505	nonsense	probably null
R8237:Vmn2r69	UTSW	7	85411132	missense	probably benign	0.02
R8347:Vmn2r69	UTSW	7	85415630	missense	probably benign	0.00
R8737:Vmn2r69	UTSW	7	85406575	missense	probably damaging	1.00
R8795:Vmn2r69	UTSW	7	85415675	start codon destroyed	probably null	0.94
R8831:Vmn2r69	UTSW	7	85409810	nonsense	probably null
R8856:Vmn2r69	UTSW	7	85412455	missense	probably benign	0.00
R8998:Vmn2r69	UTSW	7	85411099	missense	probably benign	0.33
R8999:Vmn2r69	UTSW	7	85411099	missense	probably benign	0.33
R9161:Vmn2r69	UTSW	7	85406969	missense	possibly damaging	0.88
R9228:Vmn2r69	UTSW	7	85415489	missense	probably benign	0.01
R9494:Vmn2r69	UTSW	7	85406876	missense	probably benign	0.08
R9494:Vmn2r69	UTSW	7	85411560	missense	probably damaging	1.00
R9541:Vmn2r69	UTSW	7	85407001	missense	probably benign
R9620:Vmn2r69	UTSW	7	85412296	missense	probably benign	0.10
Z1176:Vmn2r69	UTSW	7	85406488	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGATATCCACAATGTGAGGGC -3'
(R):5'- GCAGTCCATCATGTTCATATTATTGCC -3'

Sequencing Primer
(F):5'- CCACAATGTGAGGGCATAATTTATGG -3'
(R):5'- ATTGCCTATGTACTGTATTTTTCAGC -3'

Posted On

2014-12-29