Incidental Mutation 'R2920:Or7a37'
ID 255480
Institutional Source Beutler Lab
Gene Symbol Or7a37
Ensembl Gene ENSMUSG00000042774
Gene Name olfactory receptor family 7 subfamily A member 37
Synonyms GA_x6K02T2QGN0-2842591-2841662, Olfr1353, MOR139-2
MMRRC Submission 040505-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R2920 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 78799143-78806446 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 78805846 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Alanine at position 121 (D121A)
Ref Sequence ENSEMBL: ENSMUSP00000145073 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039718] [ENSMUST00000204849] [ENSMUST00000205193]
AlphaFold Q8VGU8
Predicted Effect probably damaging
Transcript: ENSMUST00000039718
AA Change: D121A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000038992
Gene: ENSMUSG00000042774
AA Change: D121A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.9e-6 PFAM
Pfam:7tm_1 41 290 9.3e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000204849
AA Change: D121A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000145454
Gene: ENSMUSG00000042774
AA Change: D121A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.9e-6 PFAM
Pfam:7tm_1 41 290 9.3e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000205193
AA Change: D121A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000145073
Gene: ENSMUSG00000042774
AA Change: D121A

DomainStartEndE-ValueType
Pfam:7tm_4 31 95 5.8e-10 PFAM
Pfam:7tm_1 41 94 3.5e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219714
Meta Mutation Damage Score 0.6725 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency 96% (48/50)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgb A G 10: 10,265,987 (GRCm39) Y1025H probably damaging Het
Adgrv1 C T 13: 81,596,984 (GRCm39) A4122T probably benign Het
Aloxe3 C T 11: 69,033,749 (GRCm39) T621I probably damaging Het
Atp2b3 A C X: 72,577,526 (GRCm39) T318P probably benign Het
Atrx A T X: 104,874,474 (GRCm39) V1962D probably benign Het
Chl1 C A 6: 103,672,304 (GRCm39) T531K probably damaging Het
Clca3b T A 3: 144,543,614 (GRCm39) D405V probably benign Het
Clca3b C T 3: 144,552,692 (GRCm39) D115N probably benign Het
Comtd1 A G 14: 21,897,686 (GRCm39) L149P possibly damaging Het
Cops7a A G 6: 124,939,325 (GRCm39) V108A probably benign Het
Crebbp A G 16: 3,936,946 (GRCm39) V343A probably damaging Het
Edrf1 T A 7: 133,269,301 (GRCm39) D1109E probably benign Het
Elmo3 A G 8: 106,034,691 (GRCm39) E359G possibly damaging Het
Ep400 C A 5: 110,903,780 (GRCm39) G273V probably damaging Het
Fgfr3 A G 5: 33,891,284 (GRCm39) N516S probably damaging Het
Glb1l T A 1: 75,185,834 (GRCm39) E31D probably benign Het
Hdac1-ps A G 17: 78,800,275 (GRCm39) D422G probably damaging Het
Il12rb2 C T 6: 67,337,552 (GRCm39) V110I probably damaging Het
Ints3 T C 3: 90,300,469 (GRCm39) E884G probably benign Het
Lin7b A G 7: 45,017,821 (GRCm39) V170A possibly damaging Het
Lrch2 A T X: 146,256,026 (GRCm39) V750E probably damaging Het
Mepe C T 5: 104,486,113 (GRCm39) R418C probably damaging Het
Mettl25 A T 10: 105,601,038 (GRCm39) probably null Het
Mphosph9 G A 5: 124,399,069 (GRCm39) T982I probably benign Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Myo10 G T 15: 25,801,226 (GRCm39) V1472L probably damaging Het
Myo9b A G 8: 71,778,501 (GRCm39) K445R probably damaging Het
Ntng2 T C 2: 29,094,223 (GRCm39) M383V probably benign Het
Or13n4 C T 7: 106,423,571 (GRCm39) R54Q probably benign Het
Or2z2 T C 11: 58,346,403 (GRCm39) Y124C probably damaging Het
Pak6 A T 2: 118,524,488 (GRCm39) probably benign Het
Pcdh8 G T 14: 80,006,154 (GRCm39) P803Q possibly damaging Het
Pfkfb3 C T 2: 11,489,138 (GRCm39) V286I probably benign Het
Rbp3 C T 14: 33,677,975 (GRCm39) T641M probably damaging Het
Rint1 A G 5: 24,010,400 (GRCm39) E203G probably benign Het
Sdf2 G C 11: 78,145,680 (GRCm39) V126L probably damaging Het
Slc13a5 T C 11: 72,138,617 (GRCm39) E442G possibly damaging Het
Slc14a2 G T 18: 78,201,512 (GRCm39) S669* probably null Het
Slc38a7 A G 8: 96,572,571 (GRCm39) I157T possibly damaging Het
Slc4a5 T C 6: 83,241,369 (GRCm39) L215P probably damaging Het
Tbc1d9 T C 8: 83,937,098 (GRCm39) V60A probably benign Het
Tcerg1l T C 7: 137,850,108 (GRCm39) R422G probably damaging Het
Tmem107 T C 11: 68,962,247 (GRCm39) L68P probably damaging Het
Ugt2b5 A G 5: 87,273,266 (GRCm39) F467L possibly damaging Het
Vmn1r19 A T 6: 57,381,909 (GRCm39) N154I probably benign Het
Vmn2r69 T A 7: 85,060,973 (GRCm39) I204L probably benign Het
Zbtb1 T A 12: 76,432,619 (GRCm39) S202T possibly damaging Het
Other mutations in Or7a37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02135:Or7a37 APN 10 78,805,940 (GRCm39) missense probably damaging 1.00
IGL02159:Or7a37 APN 10 78,805,735 (GRCm39) missense probably damaging 1.00
R0355:Or7a37 UTSW 10 78,806,267 (GRCm39) missense probably damaging 1.00
R0561:Or7a37 UTSW 10 78,805,729 (GRCm39) nonsense probably null
R1305:Or7a37 UTSW 10 78,805,933 (GRCm39) missense probably benign 0.03
R1921:Or7a37 UTSW 10 78,805,975 (GRCm39) nonsense probably null
R1922:Or7a37 UTSW 10 78,805,975 (GRCm39) nonsense probably null
R2382:Or7a37 UTSW 10 78,805,990 (GRCm39) missense probably damaging 0.99
R4491:Or7a37 UTSW 10 78,806,151 (GRCm39) missense probably damaging 1.00
R5113:Or7a37 UTSW 10 78,806,037 (GRCm39) missense probably benign
R5305:Or7a37 UTSW 10 78,806,390 (GRCm39) missense possibly damaging 0.68
R5744:Or7a37 UTSW 10 78,806,017 (GRCm39) missense probably damaging 1.00
R5861:Or7a37 UTSW 10 78,805,765 (GRCm39) missense probably damaging 1.00
R6197:Or7a37 UTSW 10 78,805,974 (GRCm39) missense probably damaging 1.00
R6314:Or7a37 UTSW 10 78,806,179 (GRCm39) missense probably benign
R7693:Or7a37 UTSW 10 78,806,137 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGCTATTATTTCAGGCCCC -3'
(R):5'- TCACAGAAGAAGTGTGGGATTTCTG -3'

Sequencing Primer
(F):5'- ATTTCAGGCCCCCGACTG -3'
(R):5'- ATTTCTGGCTGTGTGCAGAAG -3'
Posted On 2014-12-29