Mutagenetix > Incidental Mutation

Incidental Mutation 'R2921:Rnf151'

255552

Institutional Source

Beutler Lab

Gene Symbol

Rnf151

Ensembl Gene

ENSMUSG00000008482

Gene Name

ring finger protein 151

Synonyms

1700010O16Rik

MMRRC Submission

040506-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R2921 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

24934813-24937031 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 24935235 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Aspartic acid at position 232 (G232D)

Ref Sequence

ENSEMBL: ENSMUSP00000008626 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000008626] [ENSMUST00000054289] [ENSMUST00000146867] [ENSMUST00000170715] [ENSMUST00000152407]

AlphaFold

Q9CQ29

Predicted Effect

possibly damaging
Transcript: ENSMUST00000008626
AA Change: G232D

PolyPhen 2 Score 0.633 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000008626
Gene: ENSMUSG00000008482
AA Change: G232D

Domain	Start	End	E-Value	Type
RING	20	57	1.76e-5	SMART
Pfam:zf-TRAF	102	158	7.5e-9	PFAM
low complexity region	176	193	N/A	INTRINSIC
low complexity region	203	216	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000054289

SMART Domains

Protein: ENSMUSP00000092502
Gene: ENSMUSG00000044533

Domain	Start	End	E-Value	Type
low complexity region	6	53	N/A	INTRINSIC
Pfam:Ribosomal_S5	102	166	5.7e-34	PFAM
Pfam:Ribosomal_S5_C	185	256	2.4e-30	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000104521

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000122809

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129580

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129984

Predicted Effect

probably benign
Transcript: ENSMUST00000146867

SMART Domains

Protein: ENSMUSP00000120715
Gene: ENSMUSG00000044533

Domain	Start	End	E-Value	Type
low complexity region	6	53	N/A	INTRINSIC
Pfam:Ribosomal_S5	102	166	1.7e-35	PFAM
Pfam:Ribosomal_S5_C	185	256	8.3e-32	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158630

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161706

Predicted Effect

probably benign
Transcript: ENSMUST00000170715

SMART Domains

Protein: ENSMUSP00000131474
Gene: ENSMUSG00000044533

Domain	Start	End	E-Value	Type
low complexity region	6	53	N/A	INTRINSIC
Pfam:Ribosomal_S5	101	167	1.1e-31	PFAM
Pfam:Ribosomal_S5_C	184	257	1.3e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000152407

SMART Domains

Protein: ENSMUSP00000114529
Gene: ENSMUSG00000044533

Domain	Start	End	E-Value	Type
low complexity region	6	53	N/A	INTRINSIC
Pfam:Ribosomal_S5	101	167	9.2e-32	PFAM
Pfam:Ribosomal_S5_C	184	257	1.2e-24	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.6%
10x: 97.2%
20x: 94.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts3	T	C	5: 90,009,393 (GRCm39)	D90G	possibly damaging	Het
Adipor1	T	C	1: 134,353,731 (GRCm39)	V172A	possibly damaging	Het
Akt2	A	G	7: 27,328,411 (GRCm39)	K146R	probably benign	Het
Atg4a	T	C	X: 139,941,768 (GRCm39)	V284A	possibly damaging	Het
Atp6v0a2	C	T	5: 124,794,981 (GRCm39)	T656M	possibly damaging	Het
Baz2a	AGCGGCGGTACTTGCGGG	AG	10: 127,960,946 (GRCm39)		probably null	Het
Ccdc116	T	C	16: 16,960,307 (GRCm39)	H170R	probably benign	Het
Ccn5	G	A	2: 163,674,266 (GRCm39)	R222Q	probably benign	Het
Cemip2	A	G	19: 21,795,303 (GRCm39)	D732G	possibly damaging	Het
Crygs	C	T	16: 22,624,301 (GRCm39)	G102D	possibly damaging	Het
Dpm3	C	T	3: 89,174,062 (GRCm39)	L8F	probably damaging	Het
Fhl3	T	C	4: 124,599,463 (GRCm39)	S13P	probably damaging	Het
Fndc1	A	G	17: 8,023,707 (GRCm39)	S83P	probably damaging	Het
Gapvd1	A	T	2: 34,578,875 (GRCm39)	I1249N	probably damaging	Het
Gbp7	A	T	3: 142,240,333 (GRCm39)	E17V	probably benign	Het
Gm57858	T	C	3: 36,080,077 (GRCm39)	M227V	probably null	Het
Golga4	T	A	9: 118,388,411 (GRCm39)	S1844R	possibly damaging	Het
Grm7	T	A	6: 111,472,866 (GRCm39)		probably null	Het
Hdc	G	A	2: 126,435,910 (GRCm39)	P654S	probably damaging	Het
Hgd	T	C	16: 37,439,330 (GRCm39)	F213L	probably damaging	Het
Hivep2	C	A	10: 14,004,713 (GRCm39)	T437K	probably benign	Het
Hoxb1	T	C	11: 96,257,119 (GRCm39)	L156P	probably benign	Het
Mboat2	T	A	12: 25,004,239 (GRCm39)	W347R	probably damaging	Het
Mlkl	T	C	8: 112,043,079 (GRCm39)	E356G	probably benign	Het
Ncor2	A	G	5: 125,132,855 (GRCm39)	F44S	probably damaging	Het
Nipal3	A	T	4: 135,204,776 (GRCm39)	I125N	probably damaging	Het
Nr1h4	A	T	10: 89,334,223 (GRCm39)	Y42N	probably damaging	Het
Nup155	A	C	15: 8,183,125 (GRCm39)	E1228D	probably damaging	Het
Or4c113	A	G	2: 88,884,843 (GRCm39)	V309A	probably benign	Het
Pde4dip	T	C	3: 97,626,885 (GRCm39)	N1218D	probably benign	Het
Ralgps1	A	T	2: 33,033,082 (GRCm39)	I449N	probably damaging	Het
Rdm1	T	A	11: 101,521,716 (GRCm39)	L157H	possibly damaging	Het
Rfx7	G	A	9: 72,524,946 (GRCm39)	G712D	possibly damaging	Het
Rpl22	C	A	4: 152,412,002 (GRCm39)	T26N	possibly damaging	Het
Rptn	A	G	3: 93,306,015 (GRCm39)	Y1116C	possibly damaging	Het
Safb2	A	G	17: 56,875,906 (GRCm39)	V89A	possibly damaging	Het
Setx	TGTGG	TG	2: 29,044,072 (GRCm39)		probably benign	Het
Setx	GTGGCT	GT	2: 29,044,073 (GRCm39)	1814	probably null	Het
Slc24a2	A	G	4: 86,909,591 (GRCm39)	V660A	possibly damaging	Het
Slc26a2	T	A	18: 61,335,007 (GRCm39)	I149F	probably damaging	Het
Slc6a15	A	G	10: 103,254,248 (GRCm39)	D728G	probably damaging	Het
Slfn3	A	G	11: 83,105,871 (GRCm39)	M623V	probably benign	Het
Smim1	A	G	4: 154,108,097 (GRCm39)		probably benign	Het
Spatc1	T	C	15: 76,168,125 (GRCm39)	S195P	probably damaging	Het
Tmx1	T	A	12: 70,512,895 (GRCm39)	C268S	probably benign	Het
Trpc6	A	T	9: 8,653,034 (GRCm39)	L613F	possibly damaging	Het
Vmn2r60	T	A	7: 41,790,459 (GRCm39)	V482E	probably damaging	Het
Zdhhc18	G	T	4: 133,360,455 (GRCm39)	H82Q	probably benign	Het
Zfp507	T	C	7: 35,494,224 (GRCm39)	E273G	probably damaging	Het

Other mutations in Rnf151

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0563:Rnf151	UTSW	17	24,936,430 (GRCm39)	unclassified	probably benign
R1254:Rnf151	UTSW	17	24,936,526 (GRCm39)	nonsense	probably null
R5930:Rnf151	UTSW	17	24,937,004 (GRCm39)	splice site	probably null
R6515:Rnf151	UTSW	17	24,935,391 (GRCm39)	missense	probably benign	0.09
R8105:Rnf151	UTSW	17	24,935,400 (GRCm39)	missense	probably benign	0.43
X0025:Rnf151	UTSW	17	24,936,450 (GRCm39)	missense	probably benign	0.15

Predicted Primers

PCR Primer
(F):5'- GAAATCCTGTCTCAGTGGGG -3'
(R):5'- ACGTGATGCTTGGGTCCAAC -3'

Sequencing Primer
(F):5'- AGGGCAGTGTCTAATATGG -3'
(R):5'- TTGGGTCCAACGCCATGAG -3'

Posted On

2014-12-29