Incidental Mutation 'R2922:Cdk11b'
ID 255567
Institutional Source Beutler Lab
Gene Symbol Cdk11b
Ensembl Gene ENSMUSG00000029062
Gene Name cyclin dependent kinase 11B
Synonyms Cdc2l2, PITSLRE proteins, Cdc2l1, CDK11-p110, CDK11-p46, CDK11-p58
MMRRC Submission 040507-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R2922 (G1)
Quality Score 217
Status Validated
Chromosome 4
Chromosomal Location 155709311-155734395 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) CAGAAGAAG to CAGAAG at 155725201 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000111488 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067081] [ENSMUST00000105598] [ENSMUST00000105600] [ENSMUST00000115821]
AlphaFold P24788
Predicted Effect probably benign
Transcript: ENSMUST00000067081
SMART Domains Protein: ENSMUSP00000070527
Gene: ENSMUSG00000029062

DomainStartEndE-ValueType
low complexity region 19 48 N/A INTRINSIC
low complexity region 93 112 N/A INTRINSIC
coiled coil region 123 214 N/A INTRINSIC
low complexity region 252 259 N/A INTRINSIC
low complexity region 261 272 N/A INTRINSIC
coiled coil region 290 337 N/A INTRINSIC
low complexity region 369 383 N/A INTRINSIC
S_TKc 427 712 5.05e-93 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000105598
SMART Domains Protein: ENSMUSP00000101223
Gene: ENSMUSG00000029062

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
low complexity region 59 78 N/A INTRINSIC
coiled coil region 89 180 N/A INTRINSIC
low complexity region 218 225 N/A INTRINSIC
low complexity region 227 238 N/A INTRINSIC
coiled coil region 256 303 N/A INTRINSIC
low complexity region 335 349 N/A INTRINSIC
S_TKc 393 678 5.05e-93 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000105600
SMART Domains Protein: ENSMUSP00000101225
Gene: ENSMUSG00000029062

DomainStartEndE-ValueType
low complexity region 19 48 N/A INTRINSIC
low complexity region 93 112 N/A INTRINSIC
coiled coil region 123 214 N/A INTRINSIC
low complexity region 252 259 N/A INTRINSIC
low complexity region 261 272 N/A INTRINSIC
coiled coil region 290 337 N/A INTRINSIC
low complexity region 369 383 N/A INTRINSIC
S_TKc 427 712 5.05e-93 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115821
SMART Domains Protein: ENSMUSP00000111488
Gene: ENSMUSG00000073682

DomainStartEndE-ValueType
SCOP:d1l9ha_ 17 52 2e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142513
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 100% (43/43)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
PHENOTYPE: Homozygous null embryos display embryonic lethality from cell cycle arrest. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts3 T C 5: 90,009,393 (GRCm39) D90G possibly damaging Het
Atp6v0a2 C T 5: 124,794,981 (GRCm39) T656M possibly damaging Het
Baz2a AGCGGCGGTACTTGCGGG AG 10: 127,960,946 (GRCm39) probably null Het
Bsn C T 9: 107,985,385 (GRCm39) V2890M unknown Het
Bsn T C 9: 107,992,668 (GRCm39) E1028G probably damaging Het
Ccdc116 T C 16: 16,960,307 (GRCm39) H170R probably benign Het
Cemip2 A G 19: 21,795,303 (GRCm39) D732G possibly damaging Het
Clpb A G 7: 101,372,035 (GRCm39) D257G probably benign Het
Crygs C T 16: 22,624,301 (GRCm39) G102D possibly damaging Het
Dlgap5 A G 14: 47,627,898 (GRCm39) probably null Het
Dmwd T C 7: 18,810,270 (GRCm39) F26L probably damaging Het
Eif5b T C 1: 38,057,100 (GRCm39) probably benign Het
Flii A G 11: 60,609,742 (GRCm39) Y622H probably damaging Het
Gbp7 A T 3: 142,240,333 (GRCm39) E17V probably benign Het
Ghrh T C 2: 157,173,797 (GRCm39) probably null Het
Gm20939 T A 17: 95,184,721 (GRCm39) H456Q probably damaging Het
Golga4 T A 9: 118,388,411 (GRCm39) S1844R possibly damaging Het
Hgd T C 16: 37,439,330 (GRCm39) F213L probably damaging Het
Hoxb1 T C 11: 96,257,119 (GRCm39) L156P probably benign Het
Itga11 A G 9: 62,675,912 (GRCm39) probably benign Het
Kcnn3 T C 3: 89,428,329 (GRCm39) V185A probably damaging Het
Lrriq1 T C 10: 103,050,536 (GRCm39) T739A probably benign Het
Mib1 C T 18: 10,760,831 (GRCm39) Q374* probably null Het
Myh9 A G 15: 77,697,384 (GRCm39) L10P probably damaging Het
Ncor2 A G 5: 125,132,855 (GRCm39) F44S probably damaging Het
Nr3c1 C A 18: 39,620,156 (GRCm39) A44S possibly damaging Het
Or10n1 G A 9: 39,525,060 (GRCm39) V66I probably benign Het
Or51a43 A G 7: 103,717,794 (GRCm39) V148A probably benign Het
Ovch2 A G 7: 107,389,596 (GRCm39) L317P possibly damaging Het
Pcolce2 T A 9: 95,576,767 (GRCm39) L346Q probably damaging Het
Rdm1 T A 11: 101,521,716 (GRCm39) L157H possibly damaging Het
Rptn A G 3: 93,306,015 (GRCm39) Y1116C possibly damaging Het
Scn7a A G 2: 66,530,551 (GRCm39) probably benign Het
Slc24a2 A G 4: 86,909,591 (GRCm39) V660A possibly damaging Het
Tet3 A G 6: 83,345,494 (GRCm39) S1648P probably damaging Het
Tmem198b G A 10: 128,638,062 (GRCm39) T167I probably damaging Het
Tmx1 T A 12: 70,512,895 (GRCm39) C268S probably benign Het
Ubr4 A G 4: 139,206,811 (GRCm39) N4886S possibly damaging Het
Usp47 A G 7: 111,692,405 (GRCm39) S956G probably damaging Het
Vmn2r60 T A 7: 41,790,459 (GRCm39) V482E probably damaging Het
Zfhx4 C T 3: 5,468,724 (GRCm39) P2986S probably damaging Het
Zfp507 T C 7: 35,494,224 (GRCm39) E273G probably damaging Het
Other mutations in Cdk11b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01764:Cdk11b APN 4 155,713,260 (GRCm39) missense possibly damaging 0.54
R0071:Cdk11b UTSW 4 155,733,880 (GRCm39) unclassified probably benign
R0071:Cdk11b UTSW 4 155,733,880 (GRCm39) unclassified probably benign
R0145:Cdk11b UTSW 4 155,726,076 (GRCm39) intron probably benign
R0372:Cdk11b UTSW 4 155,725,957 (GRCm39) intron probably benign
R0426:Cdk11b UTSW 4 155,726,969 (GRCm39) intron probably benign
R0471:Cdk11b UTSW 4 155,731,999 (GRCm39) unclassified probably benign
R0627:Cdk11b UTSW 4 155,725,229 (GRCm39) intron probably benign
R1475:Cdk11b UTSW 4 155,718,674 (GRCm39) missense probably damaging 1.00
R1611:Cdk11b UTSW 4 155,726,032 (GRCm39) intron probably benign
R1719:Cdk11b UTSW 4 155,732,854 (GRCm39) unclassified probably benign
R1750:Cdk11b UTSW 4 155,713,137 (GRCm39) splice site probably null
R2061:Cdk11b UTSW 4 155,726,061 (GRCm39) intron probably benign
R2274:Cdk11b UTSW 4 155,732,051 (GRCm39) unclassified probably benign
R3719:Cdk11b UTSW 4 155,711,343 (GRCm39) missense probably damaging 1.00
R3917:Cdk11b UTSW 4 155,711,258 (GRCm39) missense probably damaging 1.00
R4077:Cdk11b UTSW 4 155,724,204 (GRCm39) intron probably benign
R4078:Cdk11b UTSW 4 155,724,204 (GRCm39) intron probably benign
R5033:Cdk11b UTSW 4 155,733,282 (GRCm39) unclassified probably benign
R5212:Cdk11b UTSW 4 155,723,072 (GRCm39) splice site probably null
R5556:Cdk11b UTSW 4 155,718,604 (GRCm39) nonsense probably null
R5622:Cdk11b UTSW 4 155,714,674 (GRCm39) missense probably damaging 1.00
R5927:Cdk11b UTSW 4 155,732,697 (GRCm39) unclassified probably benign
R5975:Cdk11b UTSW 4 155,732,697 (GRCm39) unclassified probably benign
R6276:Cdk11b UTSW 4 155,718,647 (GRCm39) missense probably benign 0.11
R6278:Cdk11b UTSW 4 155,734,060 (GRCm39) unclassified probably benign
R6905:Cdk11b UTSW 4 155,726,065 (GRCm39) intron probably benign
R6998:Cdk11b UTSW 4 155,732,800 (GRCm39) nonsense probably null
R7021:Cdk11b UTSW 4 155,726,024 (GRCm39) intron probably benign
R7062:Cdk11b UTSW 4 155,711,268 (GRCm39) missense probably damaging 1.00
R7100:Cdk11b UTSW 4 155,710,050 (GRCm39) missense probably damaging 1.00
R7338:Cdk11b UTSW 4 155,732,008 (GRCm39) missense unknown
R7811:Cdk11b UTSW 4 155,724,359 (GRCm39) missense unknown
R8213:Cdk11b UTSW 4 155,724,338 (GRCm39) missense unknown
R8257:Cdk11b UTSW 4 155,732,398 (GRCm39) missense unknown
R8696:Cdk11b UTSW 4 155,732,779 (GRCm39) missense unknown
R9419:Cdk11b UTSW 4 155,724,302 (GRCm39) missense unknown
R9546:Cdk11b UTSW 4 155,733,589 (GRCm39) missense unknown
R9628:Cdk11b UTSW 4 155,734,154 (GRCm39) missense unknown
R9792:Cdk11b UTSW 4 155,732,378 (GRCm39) missense unknown
R9793:Cdk11b UTSW 4 155,732,378 (GRCm39) missense unknown
Z1088:Cdk11b UTSW 4 155,726,021 (GRCm39) intron probably benign
Predicted Primers PCR Primer
(F):5'- AACTTGCCTTATTCTGTGAGACTC -3'
(R):5'- GGAACAGCTTCAATTTATGGGG -3'

Sequencing Primer
(F):5'- CAATAGTAAAGTGCTTGCCACCTTC -3'
(R):5'- GCTTCAATTTATGGGGTTATTACACG -3'
Posted On 2014-12-29