Incidental Mutation 'R2924:Or1e34'
ID 255668
Institutional Source Beutler Lab
Gene Symbol Or1e34
Ensembl Gene ENSMUSG00000056921
Gene Name olfactory receptor family 1 subfamily E member 34
Synonyms GA_x6K02T2P1NL-4043306-4042374, Olfr394, MOR135-8
MMRRC Submission 040509-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.256) question?
Stock # R2924 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 73778264-73779196 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 73778337 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 287 (I287T)
Ref Sequence ENSEMBL: ENSMUSP00000149527 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071478] [ENSMUST00000214284] [ENSMUST00000216608]
AlphaFold Q8VGR5
Predicted Effect probably damaging
Transcript: ENSMUST00000071478
AA Change: I287T

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000071415
Gene: ENSMUSG00000056921
AA Change: I287T

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.4e-55 PFAM
Pfam:7TM_GPCR_Srsx 33 303 4e-7 PFAM
Pfam:7tm_1 39 288 1.9e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214284
AA Change: I287T

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000216608
AA Change: I287T

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bcl9 A G 3: 97,117,069 (GRCm39) S542P probably benign Het
Cass4 A G 2: 172,268,592 (GRCm39) R225G possibly damaging Het
Ddx50 A T 10: 62,463,373 (GRCm39) V440E probably damaging Het
Dmrtc2 G A 7: 24,571,941 (GRCm39) C12Y probably damaging Het
Dock6 A T 9: 21,720,926 (GRCm39) I1693N probably damaging Het
Fuom T C 7: 139,679,862 (GRCm39) T110A probably benign Het
Gli2 C T 1: 118,764,089 (GRCm39) R1354H probably benign Het
Gm5478 A T 15: 101,552,229 (GRCm39) probably null Het
Hsp90aa1 T A 12: 110,662,114 (GRCm39) M1L possibly damaging Het
Hsp90aa1 C A 12: 110,662,115 (GRCm39) probably null Het
Il2rb T C 15: 78,376,049 (GRCm39) M1V probably null Het
Ints6l A G X: 55,550,196 (GRCm39) E483G probably benign Het
Kalrn C T 16: 33,810,180 (GRCm39) D2525N possibly damaging Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Man2b2 A G 5: 36,981,446 (GRCm39) F224L probably benign Het
Mrgpra1 G A 7: 46,984,618 (GRCm39) probably null Het
Mtbp G A 15: 55,483,210 (GRCm39) R429Q probably benign Het
Ncapg2 C A 12: 116,402,349 (GRCm39) T727K probably benign Het
Nsf C T 11: 103,821,578 (GRCm39) E26K possibly damaging Het
Nup214 A G 2: 31,888,015 (GRCm39) K15E probably damaging Het
Oxr1 T C 15: 41,689,353 (GRCm39) Y526H probably benign Het
Plec A G 15: 76,062,452 (GRCm39) F2563S probably damaging Het
Prex2 A G 1: 11,168,711 (GRCm39) T236A probably damaging Het
Rbbp5 G C 1: 132,420,401 (GRCm39) probably null Het
Slc24a2 A G 4: 86,929,961 (GRCm39) S512P probably benign Het
Srd5a1 A G 13: 69,734,834 (GRCm39) S191P probably damaging Het
Syt3 T A 7: 44,045,222 (GRCm39) V518E probably damaging Het
Tmem132e T C 11: 82,335,149 (GRCm39) S652P probably damaging Het
Uba6 A T 5: 86,307,130 (GRCm39) V102D probably damaging Het
Unc13a A G 8: 72,097,596 (GRCm39) V1158A possibly damaging Het
Upk3a A G 15: 84,902,350 (GRCm39) Y59C probably benign Het
Zc3hav1 T C 6: 38,331,045 (GRCm39) Y38C probably damaging Het
Zfp119a C A 17: 56,175,343 (GRCm39) D51Y possibly damaging Het
Other mutations in Or1e34
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00093:Or1e34 APN 11 73,779,075 (GRCm39) missense probably damaging 1.00
IGL01655:Or1e34 APN 11 73,778,753 (GRCm39) missense probably benign 0.01
IGL02173:Or1e34 APN 11 73,778,949 (GRCm39) missense possibly damaging 0.72
IGL02308:Or1e34 APN 11 73,779,121 (GRCm39) missense probably benign 0.09
IGL02656:Or1e34 APN 11 73,778,865 (GRCm39) missense probably damaging 0.98
R0079:Or1e34 UTSW 11 73,778,563 (GRCm39) missense probably benign 0.22
R0119:Or1e34 UTSW 11 73,778,656 (GRCm39) missense probably benign 0.11
R0136:Or1e34 UTSW 11 73,778,656 (GRCm39) missense probably benign 0.11
R0136:Or1e34 UTSW 11 73,778,611 (GRCm39) missense probably benign 0.00
R0255:Or1e34 UTSW 11 73,778,655 (GRCm39) missense probably benign
R0545:Or1e34 UTSW 11 73,778,843 (GRCm39) nonsense probably null
R0599:Or1e34 UTSW 11 73,778,730 (GRCm39) missense probably benign 0.19
R0655:Or1e34 UTSW 11 73,778,631 (GRCm39) missense possibly damaging 0.88
R0657:Or1e34 UTSW 11 73,778,656 (GRCm39) missense probably benign 0.11
R0657:Or1e34 UTSW 11 73,778,611 (GRCm39) missense probably benign 0.00
R0720:Or1e34 UTSW 11 73,778,688 (GRCm39) missense probably benign 0.12
R1112:Or1e34 UTSW 11 73,779,060 (GRCm39) missense probably damaging 0.99
R2353:Or1e34 UTSW 11 73,778,660 (GRCm39) missense probably benign 0.02
R4583:Or1e34 UTSW 11 73,778,629 (GRCm39) missense probably damaging 1.00
R5231:Or1e34 UTSW 11 73,778,781 (GRCm39) missense probably damaging 1.00
R5537:Or1e34 UTSW 11 73,778,523 (GRCm39) missense probably benign 0.02
R5806:Or1e34 UTSW 11 73,778,373 (GRCm39) missense probably damaging 0.99
R7131:Or1e34 UTSW 11 73,778,780 (GRCm39) nonsense probably null
R7325:Or1e34 UTSW 11 73,779,101 (GRCm39) missense probably benign 0.19
R7361:Or1e34 UTSW 11 73,778,827 (GRCm39) missense probably damaging 1.00
R9446:Or1e34 UTSW 11 73,778,530 (GRCm39) missense probably benign 0.18
R9711:Or1e34 UTSW 11 73,778,696 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GCATGGACTTCCTTGTAGGTC -3'
(R):5'- GGAGGGCTCATCATTGTTATTCC -3'

Sequencing Primer
(F):5'- CATGGACTTCCTTGTAGGTCCTATG -3'
(R):5'- TAAGGTTCCATCTACTCAAGGC -3'
Posted On 2014-12-29