Incidental Mutation 'R2962:Cd24a'
ID 255927
Institutional Source Beutler Lab
Gene Symbol Cd24a
Ensembl Gene ENSMUSG00000047139
Gene Name CD24a antigen
Synonyms nectadrin, HSA, Ly-52, heat stable antigen, cluster of differentiation 24
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2962 (G1)
Quality Score 220
Status Not validated
Chromosome 10
Chromosomal Location 43454433-43460261 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 43455313 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 22 (T22A)
Ref Sequence ENSEMBL: ENSMUSP00000057983 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058714] [ENSMUST00000214476]
AlphaFold P24807
Predicted Effect probably benign
Transcript: ENSMUST00000058714
AA Change: T22A

PolyPhen 2 Score 0.292 (Sensitivity: 0.91; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000057983
Gene: ENSMUSG00000047139
AA Change: T22A

DomainStartEndE-ValueType
low complexity region 9 20 N/A INTRINSIC
Pfam:CD24 26 75 2.9e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214476
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214532
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mutation of this gene results in slight impairment of B cell development. Mutant erythrocytes have increased tendency to aggregate. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cdk5rap2 ATGTG ATG 4: 70,208,214 (GRCm39) probably null Het
Cog3 A G 14: 75,977,974 (GRCm39) probably null Het
Gm3371 A T 14: 44,646,155 (GRCm39) N103K probably benign Het
Gpd2 C T 2: 57,228,987 (GRCm39) R264* probably null Het
Hoxc10 A G 15: 102,875,735 (GRCm39) Y148C probably damaging Het
Jade1 C G 3: 41,567,762 (GRCm39) T610S probably benign Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Lhfpl7 T C 5: 113,385,922 (GRCm39) V123A possibly damaging Het
Malt1 A G 18: 65,581,406 (GRCm39) H278R probably benign Het
Mlxip C A 5: 123,578,887 (GRCm39) R178S probably damaging Het
Or13a25 A T 7: 140,247,862 (GRCm39) M214L probably benign Het
Pdxk A G 10: 78,279,667 (GRCm39) L236P probably damaging Het
Plekhg3 G A 12: 76,619,433 (GRCm39) probably null Het
Rufy2 G T 10: 62,836,039 (GRCm39) V323F probably damaging Het
Serpinb7 A G 1: 107,379,456 (GRCm39) T288A probably benign Het
Tet1 A T 10: 62,650,323 (GRCm39) C1628* probably null Het
Tgtp2 A G 11: 48,950,363 (GRCm39) S70P probably damaging Het
Trank1 C T 9: 111,181,148 (GRCm39) T390I probably damaging Het
Trim31 T C 17: 37,210,796 (GRCm39) S143P probably damaging Het
Ube3c C A 5: 29,863,416 (GRCm39) A897D possibly damaging Het
Unc79 A T 12: 103,061,378 (GRCm39) T1050S possibly damaging Het
Zfr G A 15: 12,162,319 (GRCm39) R823H probably benign Het
Other mutations in Cd24a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01914:Cd24a APN 10 43,458,699 (GRCm39) missense unknown
R6738:Cd24a UTSW 10 43,458,672 (GRCm39) missense possibly damaging 0.95
R6750:Cd24a UTSW 10 43,458,721 (GRCm39) missense unknown
R7179:Cd24a UTSW 10 43,458,636 (GRCm39) missense probably benign 0.07
R7647:Cd24a UTSW 10 43,458,747 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TCCCGGTATATAAGGTCCCG -3'
(R):5'- AAACCAGTTTGGACGGTGG -3'

Sequencing Primer
(F):5'- TATATAAGGTCCCGCCGGC -3'
(R):5'- GCGAAGACCTTCCGTGAG -3'
Posted On 2014-12-29