Incidental Mutation 'R1557:Zfr2'
ID 256142
Institutional Source Beutler Lab
Gene Symbol Zfr2
Ensembl Gene ENSMUSG00000034949
Gene Name zinc finger RNA binding protein 2
Synonyms 2010013I23Rik, 9130206N08Rik
MMRRC Submission 039596-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R1557 (G1)
Quality Score 51
Status Validated
Chromosome 10
Chromosomal Location 81068989-81087957 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 81083225 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 634 (S634P)
Ref Sequence ENSEMBL: ENSMUSP00000113913 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117798]
AlphaFold E9Q5M4
Predicted Effect probably benign
Transcript: ENSMUST00000117798
AA Change: S634P

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000113913
Gene: ENSMUSG00000034949
AA Change: S634P

DomainStartEndE-ValueType
low complexity region 16 23 N/A INTRINSIC
low complexity region 44 62 N/A INTRINSIC
low complexity region 123 163 N/A INTRINSIC
ZnF_U1 202 236 3.58e-5 SMART
ZnF_C2H2 205 229 7.68e0 SMART
ZnF_U1 249 283 3.78e-4 SMART
ZnF_C2H2 252 276 4.12e0 SMART
ZnF_U1 397 431 3.78e-4 SMART
ZnF_C2H2 400 424 1.99e0 SMART
low complexity region 484 508 N/A INTRINSIC
DZF 585 837 2.06e-129 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128182
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132174
Predicted Effect probably benign
Transcript: ENSMUST00000137999
SMART Domains Protein: ENSMUSP00000120853
Gene: ENSMUSG00000034949

DomainStartEndE-ValueType
Pfam:DZF 2 162 1.3e-32 PFAM
low complexity region 166 178 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148029
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.1%
Validation Efficiency 96% (75/78)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700019A02Rik A C 1: 53,221,025 (GRCm39) D68E possibly damaging Het
Abca3 T C 17: 24,618,954 (GRCm39) V870A possibly damaging Het
Aldh3a2 A T 11: 61,139,885 (GRCm39) F416I probably damaging Het
Armc6 A T 8: 70,678,098 (GRCm39) L77Q possibly damaging Het
Asb17 A G 3: 153,556,570 (GRCm39) I226V probably benign Het
Aspm A G 1: 139,396,406 (GRCm39) I862V probably benign Het
Atr T A 9: 95,753,502 (GRCm39) D701E probably damaging Het
Baz1b C T 5: 135,247,097 (GRCm39) L849F possibly damaging Het
Cbr1 T C 16: 93,405,677 (GRCm39) V97A probably benign Het
Cep295 G A 9: 15,243,306 (GRCm39) Q1669* probably null Het
Cfap54 T C 10: 92,820,089 (GRCm39) T1242A possibly damaging Het
Chrm3 T A 13: 9,928,350 (GRCm39) T229S possibly damaging Het
Cimip4 C A 15: 78,270,474 (GRCm39) R98M probably damaging Het
Cnga3 A G 1: 37,300,066 (GRCm39) Y300C probably damaging Het
Col14a1 A C 15: 55,251,975 (GRCm39) I544L unknown Het
Crocc T C 4: 140,752,776 (GRCm39) E1208G probably damaging Het
Cyp2j8 A T 4: 96,358,713 (GRCm39) probably benign Het
Dcbld2 T C 16: 58,285,713 (GRCm39) I624T possibly damaging Het
Ddah1 A C 3: 145,597,227 (GRCm39) I258L probably benign Het
Dnah6 G A 6: 73,026,114 (GRCm39) Q3460* probably null Het
Dync2h1 T A 9: 7,140,911 (GRCm39) D1372V probably damaging Het
Egln1 G A 8: 125,674,980 (GRCm39) R272* probably null Het
Elf1 A G 14: 79,804,620 (GRCm39) D95G possibly damaging Het
Fkbp5 A G 17: 28,621,729 (GRCm39) F374L probably damaging Het
Fli1 T C 9: 32,372,540 (GRCm39) probably benign Het
Gabbr2 T C 4: 46,846,436 (GRCm39) T158A probably damaging Het
Gp2 A C 7: 119,049,302 (GRCm39) Y412D probably damaging Het
Hmcn1 A G 1: 150,610,283 (GRCm39) V1462A possibly damaging Het
Ide T C 19: 37,258,160 (GRCm39) probably null Het
Kalrn T C 16: 34,134,648 (GRCm39) K372R possibly damaging Het
Kcnj16 A G 11: 110,916,067 (GRCm39) D243G possibly damaging Het
Kif7 A G 7: 79,363,905 (GRCm39) M1T probably null Het
Klri2 A T 6: 129,709,174 (GRCm39) L226Q probably damaging Het
Kremen1 T C 11: 5,165,373 (GRCm39) probably null Het
Lama3 T C 18: 12,646,788 (GRCm39) probably benign Het
Lmln C A 16: 32,908,581 (GRCm39) R336S probably benign Het
Lrch4 T A 5: 137,635,818 (GRCm39) D266E probably benign Het
Lrrc28 C T 7: 67,209,677 (GRCm39) R174H probably damaging Het
Mib1 T A 18: 10,798,474 (GRCm39) D778E probably damaging Het
Msra T C 14: 64,360,775 (GRCm39) I125V possibly damaging Het
Or10c1 A G 17: 37,522,244 (GRCm39) F167L probably damaging Het
Or4k37 T A 2: 111,158,964 (GRCm39) S67T probably damaging Het
Or4p19 A T 2: 88,242,555 (GRCm39) V149E possibly damaging Het
Or52e18 A G 7: 104,609,747 (GRCm39) F64S probably damaging Het
Or6c75 C A 10: 129,337,491 (GRCm39) T246N probably damaging Het
Or8d23 A G 9: 38,841,955 (GRCm39) M163V possibly damaging Het
Pes1 T A 11: 3,926,824 (GRCm39) Y369N probably damaging Het
Pgam2 T C 11: 5,751,773 (GRCm39) D221G possibly damaging Het
Prl2c5 T C 13: 13,365,265 (GRCm39) V137A possibly damaging Het
Rasal1 T A 5: 120,814,914 (GRCm39) D721E possibly damaging Het
Sass6 G T 3: 116,412,381 (GRCm39) E385D possibly damaging Het
Sema5a A G 15: 32,460,418 (GRCm39) R60G probably benign Het
Sesn1 T C 10: 41,779,762 (GRCm39) S399P probably damaging Het
Skic2 G A 17: 35,067,398 (GRCm39) L47F probably damaging Het
Slc10a2 C T 8: 5,141,755 (GRCm39) V210M probably damaging Het
Slc8a3 C T 12: 81,362,331 (GRCm39) G163S probably damaging Het
Sorbs2 T C 8: 46,212,234 (GRCm39) probably benign Het
Speer4f1 T C 5: 17,684,490 (GRCm39) W173R probably damaging Het
Spon2 C A 5: 33,374,108 (GRCm39) G92W probably damaging Het
Sycp2 A T 2: 178,037,009 (GRCm39) probably benign Het
Tfb1m A G 17: 3,605,241 (GRCm39) V84A probably damaging Het
Tmem18 G T 12: 30,637,198 (GRCm39) probably null Het
Tom1l1 A G 11: 90,547,210 (GRCm39) L290S possibly damaging Het
Tube1 T G 10: 39,021,711 (GRCm39) probably null Het
Ugt2b35 T A 5: 87,155,156 (GRCm39) probably null Het
Unc93b1 T A 19: 3,992,403 (GRCm39) Y269N probably benign Het
Usp16 T C 16: 87,259,030 (GRCm39) probably null Het
Vmn1r38 A T 6: 66,753,370 (GRCm39) S249T probably benign Het
Vmn1r42 T A 6: 89,821,733 (GRCm39) M279L possibly damaging Het
Zdhhc23 T A 16: 43,791,829 (GRCm39) T315S possibly damaging Het
Zfp472 T C 17: 33,194,900 (GRCm39) F12L probably benign Het
Other mutations in Zfr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00672:Zfr2 APN 10 81,077,919 (GRCm39) missense probably damaging 0.96
IGL01622:Zfr2 APN 10 81,087,193 (GRCm39) missense probably benign
IGL01623:Zfr2 APN 10 81,087,193 (GRCm39) missense probably benign
IGL02719:Zfr2 APN 10 81,080,546 (GRCm39) missense probably damaging 1.00
IGL03036:Zfr2 APN 10 81,077,985 (GRCm39) missense probably benign 0.01
R0302:Zfr2 UTSW 10 81,087,170 (GRCm39) unclassified probably benign
R0837:Zfr2 UTSW 10 81,081,242 (GRCm39) missense probably damaging 1.00
R1714:Zfr2 UTSW 10 81,080,583 (GRCm39) missense probably damaging 1.00
R1737:Zfr2 UTSW 10 81,077,919 (GRCm39) missense probably damaging 0.96
R1991:Zfr2 UTSW 10 81,078,686 (GRCm39) missense possibly damaging 0.86
R2134:Zfr2 UTSW 10 81,078,735 (GRCm39) missense probably damaging 1.00
R2148:Zfr2 UTSW 10 81,077,950 (GRCm39) missense probably benign 0.13
R2150:Zfr2 UTSW 10 81,077,950 (GRCm39) missense probably benign 0.13
R3703:Zfr2 UTSW 10 81,081,913 (GRCm39) missense probably benign 0.40
R3704:Zfr2 UTSW 10 81,081,913 (GRCm39) missense probably benign 0.40
R3705:Zfr2 UTSW 10 81,081,913 (GRCm39) missense probably benign 0.40
R3715:Zfr2 UTSW 10 81,081,913 (GRCm39) missense probably benign 0.40
R4301:Zfr2 UTSW 10 81,078,018 (GRCm39) unclassified probably benign
R4654:Zfr2 UTSW 10 81,087,083 (GRCm39) splice site probably null
R4811:Zfr2 UTSW 10 81,079,547 (GRCm39) missense probably benign 0.07
R5290:Zfr2 UTSW 10 81,082,544 (GRCm39) frame shift probably null
R5781:Zfr2 UTSW 10 81,079,547 (GRCm39) missense probably benign 0.07
R7114:Zfr2 UTSW 10 81,080,559 (GRCm39) missense probably damaging 1.00
R8192:Zfr2 UTSW 10 81,078,649 (GRCm39) missense possibly damaging 0.83
R8359:Zfr2 UTSW 10 81,078,653 (GRCm39) missense possibly damaging 0.57
R8389:Zfr2 UTSW 10 81,081,323 (GRCm39) missense probably benign
R8827:Zfr2 UTSW 10 81,078,619 (GRCm39) missense probably benign 0.00
R8953:Zfr2 UTSW 10 81,084,271 (GRCm39) missense probably damaging 0.99
R9086:Zfr2 UTSW 10 81,076,029 (GRCm39) missense probably damaging 0.96
R9189:Zfr2 UTSW 10 81,080,496 (GRCm39) missense probably damaging 1.00
R9487:Zfr2 UTSW 10 81,075,969 (GRCm39) missense probably benign 0.33
R9592:Zfr2 UTSW 10 81,069,580 (GRCm39) missense unknown
R9645:Zfr2 UTSW 10 81,084,252 (GRCm39) nonsense probably null
X0063:Zfr2 UTSW 10 81,078,791 (GRCm39) critical splice donor site probably null
Z1177:Zfr2 UTSW 10 81,081,918 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CCTCTCAAGGATCAGGTTGCTTGTG -3'
(R):5'- GCCAGAACATGCCATTCTCTGTCTC -3'

Sequencing Primer
(F):5'- CATCTGTGTCCCCTGTAGAGG -3'
(R):5'- gtgtgtgccagggccag -3'
Posted On 2014-12-31