|Institutional Source||Beutler Lab|
|Gene Name||F-box protein 43|
|Synonyms||early mitotic inhibitor 2, XErp1 homolog, 4930533G20Rik, Emi2, endogenous meiotic inhibitor 2|
|Is this an essential gene?||Probably non essential (E-score: 0.155)|
|Stock #||R0322 (G1)|
|Chromosomal Location||36150060-36164884 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to C at 36152192 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000054125 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000058643]|
|Predicted Effect||probably benign
|Coding Region Coverage||
|Validation Efficiency||98% (58/59)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Fbxo43||
(F):5'- TCAGTAAACAGTGTCCTGGCAACC -3'
(R):5'- GAGAAAAGATTCCCTGCCTGACCC -3'
(F):5'- ACACTCAGTCTTCTAGGGACTCAG -3'
(R):5'- AGGGAAAGGTCCTGATGGTA -3'