Incidental Mutation 'R0322:Riox2'
ID 25636
Institutional Source Beutler Lab
Gene Symbol Riox2
Ensembl Gene ENSMUSG00000022724
Gene Name ribosomal oxygenase 2
Synonyms 1810047J07Rik, Mina, 2410057H13Rik, 3830408E23Rik
MMRRC Submission 038532-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.600) question?
Stock # R0322 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 59292138-59312824 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 59309752 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 369 (K369*)
Ref Sequence ENSEMBL: ENSMUSP00000125297 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023407] [ENSMUST00000044604] [ENSMUST00000120674] [ENSMUST00000160571] [ENSMUST00000172910]
AlphaFold Q8CD15
Predicted Effect probably null
Transcript: ENSMUST00000023407
AA Change: K369*
SMART Domains Protein: ENSMUSP00000023407
Gene: ENSMUSG00000022724
AA Change: K369*

DomainStartEndE-ValueType
JmjC 127 273 1.33e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000044604
SMART Domains Protein: ENSMUSP00000037682
Gene: ENSMUSG00000022723

DomainStartEndE-ValueType
low complexity region 258 273 N/A INTRINSIC
low complexity region 282 290 N/A INTRINSIC
XTALbg 430 516 2.78e-4 SMART
Pfam:Crystall 536 599 3.3e-7 PFAM
XTALbg 614 699 1.2e-21 SMART
XTALbg 707 790 5.73e-19 SMART
XTALbg 803 881 6.87e-5 SMART
XTALbg 889 969 1.28e-7 SMART
RICIN 972 1104 8.16e-14 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000120674
SMART Domains Protein: ENSMUSP00000112899
Gene: ENSMUSG00000022724

DomainStartEndE-ValueType
JmjC 127 273 1.33e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129762
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131272
Predicted Effect probably null
Transcript: ENSMUST00000160571
AA Change: K369*
SMART Domains Protein: ENSMUSP00000125297
Gene: ENSMUSG00000022724
AA Change: K369*

DomainStartEndE-ValueType
JmjC 127 273 1.33e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000172910
Predicted Effect probably benign
Transcript: ENSMUST00000232544
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.5%
  • 10x: 93.8%
  • 20x: 84.3%
Validation Efficiency 98% (58/59)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced allergic response to house dust mites. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130401M01Rik A T 15: 57,888,768 (GRCm39) S275T possibly damaging Het
Adam34 G T 8: 44,104,958 (GRCm39) T229N probably benign Het
Adgrb3 C A 1: 25,260,829 (GRCm39) probably benign Het
Ankhd1 T A 18: 36,791,061 (GRCm39) Y2478* probably null Het
Arl9 A G 5: 77,155,037 (GRCm39) probably benign Het
Bub1b G A 2: 118,470,099 (GRCm39) probably benign Het
Chl1 A T 6: 103,678,844 (GRCm39) probably benign Het
Cobl T A 11: 12,217,072 (GRCm39) E465V probably damaging Het
Cobll1 A T 2: 64,932,442 (GRCm39) M520K possibly damaging Het
Dll3 A G 7: 27,995,793 (GRCm39) V336A possibly damaging Het
Dnmbp T C 19: 43,843,285 (GRCm39) H1193R probably damaging Het
Fbxo43 T C 15: 36,152,338 (GRCm39) probably benign Het
Gart G A 16: 91,419,925 (GRCm39) probably benign Het
Gjc3 A T 5: 137,955,760 (GRCm39) M175K possibly damaging Het
Gpc5 T A 14: 115,636,563 (GRCm39) N415K probably benign Het
Idh2 C T 7: 79,748,005 (GRCm39) A232T probably damaging Het
Il7r A T 15: 9,510,301 (GRCm39) F251I probably benign Het
Insc A G 7: 114,391,500 (GRCm39) E141G probably damaging Het
Itm2c C T 1: 85,834,751 (GRCm39) T160M probably damaging Het
Mboat1 T C 13: 30,416,063 (GRCm39) probably benign Het
Mdm2 G T 10: 117,538,109 (GRCm39) H96Q possibly damaging Het
Mettl13 A G 1: 162,371,745 (GRCm39) probably benign Het
Mfsd4b3-ps T C 10: 39,823,526 (GRCm39) N245D probably damaging Het
Mroh2a C T 1: 88,158,402 (GRCm39) R150* probably null Het
Mtmr3 T C 11: 4,437,505 (GRCm39) Y982C possibly damaging Het
Mymk A T 2: 26,957,418 (GRCm39) L66Q probably damaging Het
Myo18a T C 11: 77,720,626 (GRCm39) S767P probably damaging Het
Ndufa8 T C 2: 35,926,634 (GRCm39) D134G probably benign Het
Noxa1 A G 2: 24,982,566 (GRCm39) F83S probably damaging Het
Npc1l1 T A 11: 6,179,042 (GRCm39) I123L probably benign Het
Ogdhl A G 14: 32,059,534 (GRCm39) T394A probably benign Het
Or4s2b T C 2: 88,509,011 (GRCm39) S264P probably damaging Het
Or5ae1 A G 7: 84,565,521 (GRCm39) Y178C probably damaging Het
Pcdh20 T C 14: 88,706,383 (GRCm39) T306A probably benign Het
Pcid2 G A 8: 13,140,775 (GRCm39) probably benign Het
Phyhip G A 14: 70,700,836 (GRCm39) V108M possibly damaging Het
Pnpla5 G T 15: 84,004,920 (GRCm39) L144M probably damaging Het
Psmb4 A G 3: 94,793,402 (GRCm39) Y160H probably benign Het
Rnf26rt T C 6: 76,473,401 (GRCm39) Y405C probably benign Het
Sh3tc1 G A 5: 35,863,905 (GRCm39) P761S possibly damaging Het
Slc6a3 T A 13: 73,709,045 (GRCm39) V323D possibly damaging Het
Smg7 A G 1: 152,725,624 (GRCm39) probably null Het
Srrt G A 5: 137,294,870 (GRCm39) R370C probably damaging Het
Stc1 T C 14: 69,266,858 (GRCm39) V7A probably benign Het
Svep1 G T 4: 58,057,996 (GRCm39) probably benign Het
Tbpl2 A G 2: 23,984,991 (GRCm39) V51A probably benign Het
Tecr A G 8: 84,298,872 (GRCm39) Y248H probably damaging Het
Tenm3 A G 8: 48,689,947 (GRCm39) probably benign Het
Tia1 C T 6: 86,397,369 (GRCm39) A114V probably damaging Het
Tmprss11f A T 5: 86,739,275 (GRCm39) M2K probably benign Het
Tnfsf8 T C 4: 63,752,403 (GRCm39) T221A probably damaging Het
Tubgcp5 G A 7: 55,464,726 (GRCm39) G536S probably damaging Het
Tyr A T 7: 87,142,125 (GRCm39) I145N probably benign Het
Ubr4 T A 4: 139,149,729 (GRCm39) V1809E probably damaging Het
Vmn2r65 A T 7: 84,595,756 (GRCm39) N309K probably benign Het
Other mutations in Riox2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02313:Riox2 APN 16 59,309,780 (GRCm39) missense probably benign 0.03
IGL02580:Riox2 APN 16 59,306,936 (GRCm39) missense probably benign 0.00
IGL03076:Riox2 APN 16 59,311,575 (GRCm39) missense possibly damaging 0.68
R0009:Riox2 UTSW 16 59,309,730 (GRCm39) missense probably benign 0.01
R0009:Riox2 UTSW 16 59,309,730 (GRCm39) missense probably benign 0.01
R0592:Riox2 UTSW 16 59,309,942 (GRCm39) unclassified probably benign
R0620:Riox2 UTSW 16 59,312,255 (GRCm39) missense probably benign 0.20
R1588:Riox2 UTSW 16 59,295,946 (GRCm39) missense possibly damaging 0.46
R1623:Riox2 UTSW 16 59,303,405 (GRCm39) missense probably damaging 1.00
R2863:Riox2 UTSW 16 59,309,756 (GRCm39) missense probably damaging 0.99
R4113:Riox2 UTSW 16 59,312,257 (GRCm39) missense probably benign 0.01
R4468:Riox2 UTSW 16 59,296,357 (GRCm39) intron probably benign
R4708:Riox2 UTSW 16 59,296,045 (GRCm39) missense probably benign 0.00
R4739:Riox2 UTSW 16 59,309,732 (GRCm39) missense probably benign
R5074:Riox2 UTSW 16 59,312,236 (GRCm39) missense possibly damaging 0.59
R5385:Riox2 UTSW 16 59,306,979 (GRCm39) missense probably benign 0.33
R8124:Riox2 UTSW 16 59,306,954 (GRCm39) missense probably benign 0.03
R8977:Riox2 UTSW 16 59,312,195 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TAAGTTCTCCACTGAGCCGCACAC -3'
(R):5'- ACAGGGAAACTCAATCAGGGACTCC -3'

Sequencing Primer
(F):5'- TGAGCCGCACACTTAGC -3'
(R):5'- TGCAGTAGATTAGGAAGCAAAGACC -3'
Posted On 2013-04-16