Incidental Mutation 'R2920:Mettl25'
ID 256596
Institutional Source Beutler Lab
Gene Symbol Mettl25
Ensembl Gene ENSMUSG00000036009
Gene Name methyltransferase like 25
Synonyms BC067068
MMRRC Submission 040505-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.115) question?
Stock # R2920 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 105763189-105841380 bp(-) (GRCm38)
Type of Mutation splice site (43 bp from exon)
DNA Base Change (assembly) A to T at 105765177 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000038665 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046638] [ENSMUST00000176924]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000046638
SMART Domains Protein: ENSMUSP00000038665
Gene: ENSMUSG00000036009

DomainStartEndE-ValueType
Pfam:Methyltransf_32 149 413 1.9e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000176924
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency 96% (48/50)
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgb A G 10: 10,390,243 Y1025H probably damaging Het
Adgrv1 C T 13: 81,448,865 A4122T probably benign Het
Aloxe3 C T 11: 69,142,923 T621I probably damaging Het
Atp2b3 A C X: 73,533,920 T318P probably benign Het
Atrx A T X: 105,830,868 V1962D probably benign Het
Chl1 C A 6: 103,695,343 T531K probably damaging Het
Clca3b T A 3: 144,837,853 D405V probably benign Het
Clca3b C T 3: 144,846,931 D115N probably benign Het
Comtd1 A G 14: 21,847,618 L149P possibly damaging Het
Cops7a A G 6: 124,962,362 V108A probably benign Het
Crebbp A G 16: 4,119,082 V343A probably damaging Het
Edrf1 T A 7: 133,667,572 D1109E probably benign Het
Elmo3 A G 8: 105,308,059 E359G possibly damaging Het
Ep400 C A 5: 110,755,914 G273V probably damaging Het
Fgfr3 A G 5: 33,733,940 N516S probably damaging Het
Glb1l T A 1: 75,209,190 E31D probably benign Het
Gm10093 A G 17: 78,492,846 D422G probably damaging Het
Il12rb2 C T 6: 67,360,568 V110I probably damaging Het
Ints3 T C 3: 90,393,162 E884G probably benign Het
Lin7b A G 7: 45,368,397 V170A possibly damaging Het
Lrch2 A T X: 147,473,030 V750E probably damaging Het
Mepe C T 5: 104,338,247 R418C probably damaging Het
Mphosph9 G A 5: 124,261,006 T982I probably benign Het
Mslnl G A 17: 25,742,934 V128M probably damaging Het
Myo10 G T 15: 25,801,140 V1472L probably damaging Het
Myo9b A G 8: 71,325,857 K445R probably damaging Het
Ntng2 T C 2: 29,204,211 M383V probably benign Het
Olfr1353 A C 10: 78,970,012 D121A probably damaging Het
Olfr30 T C 11: 58,455,577 Y124C probably damaging Het
Olfr702 C T 7: 106,824,364 R54Q probably benign Het
Pak6 A T 2: 118,694,007 probably benign Het
Pcdh8 G T 14: 79,768,714 P803Q possibly damaging Het
Pfkfb3 C T 2: 11,484,327 V286I probably benign Het
Rbp3 C T 14: 33,956,018 T641M probably damaging Het
Rint1 A G 5: 23,805,402 E203G probably benign Het
Sdf2 G C 11: 78,254,854 V126L probably damaging Het
Slc13a5 T C 11: 72,247,791 E442G possibly damaging Het
Slc14a2 G T 18: 78,158,297 S669* probably null Het
Slc38a7 A G 8: 95,845,943 I157T possibly damaging Het
Slc4a5 T C 6: 83,264,387 L215P probably damaging Het
Tbc1d9 T C 8: 83,210,469 V60A probably benign Het
Tcerg1l T C 7: 138,248,379 R422G probably damaging Het
Tmem107 T C 11: 69,071,421 L68P probably damaging Het
Ugt2b5 A G 5: 87,125,407 F467L possibly damaging Het
Vmn1r19 A T 6: 57,404,924 N154I probably benign Het
Vmn2r69 T A 7: 85,411,765 I204L probably benign Het
Zbtb1 T A 12: 76,385,845 S202T possibly damaging Het
Other mutations in Mettl25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00310:Mettl25 APN 10 105826434 missense probably benign
IGL00698:Mettl25 APN 10 105793340 missense probably null 0.31
IGL00766:Mettl25 APN 10 105779582 splice site probably benign
IGL01360:Mettl25 APN 10 105823197 missense probably damaging 1.00
IGL01954:Mettl25 APN 10 105823207 missense probably damaging 1.00
IGL02088:Mettl25 APN 10 105823250 missense probably damaging 1.00
IGL02623:Mettl25 APN 10 105826324 missense probably damaging 0.96
IGL03245:Mettl25 APN 10 105826497 missense possibly damaging 0.86
IGL03134:Mettl25 UTSW 10 105826027 nonsense probably null
R0238:Mettl25 UTSW 10 105826525 missense probably damaging 1.00
R0238:Mettl25 UTSW 10 105826525 missense probably damaging 1.00
R0239:Mettl25 UTSW 10 105826525 missense probably damaging 1.00
R0239:Mettl25 UTSW 10 105826525 missense probably damaging 1.00
R1297:Mettl25 UTSW 10 105823265 missense probably benign 0.11
R1482:Mettl25 UTSW 10 105826590 missense possibly damaging 0.61
R1526:Mettl25 UTSW 10 105832983 missense possibly damaging 0.56
R1542:Mettl25 UTSW 10 105826120 missense probably benign 0.04
R1589:Mettl25 UTSW 10 105779632 missense probably damaging 1.00
R1901:Mettl25 UTSW 10 105826087 missense probably damaging 0.96
R1902:Mettl25 UTSW 10 105826087 missense probably damaging 0.96
R2016:Mettl25 UTSW 10 105797306 missense probably benign 0.00
R2355:Mettl25 UTSW 10 105763455 missense probably benign 0.00
R3149:Mettl25 UTSW 10 105826353 missense probably benign 0.00
R4547:Mettl25 UTSW 10 105826017 missense probably damaging 1.00
R4646:Mettl25 UTSW 10 105826555 missense probably damaging 1.00
R4652:Mettl25 UTSW 10 105779648 nonsense probably null
R5020:Mettl25 UTSW 10 105826207 missense possibly damaging 0.87
R5435:Mettl25 UTSW 10 105779586 critical splice donor site probably null
R6947:Mettl25 UTSW 10 105826192 missense probably benign 0.00
R7075:Mettl25 UTSW 10 105829924 missense possibly damaging 0.68
R7729:Mettl25 UTSW 10 105766010 missense probably benign 0.03
R8074:Mettl25 UTSW 10 105826080 missense probably benign 0.02
R8108:Mettl25 UTSW 10 105823179 missense possibly damaging 0.53
R8415:Mettl25 UTSW 10 105826141 missense probably benign 0.05
R8937:Mettl25 UTSW 10 105765261 missense probably benign 0.17
R8949:Mettl25 UTSW 10 105832853 missense probably benign 0.00
RF009:Mettl25 UTSW 10 105833239 intron probably benign
Z1176:Mettl25 UTSW 10 105826098 missense possibly damaging 0.95
Predicted Primers
Posted On 2014-12-31