Mutagenetix > Incidental Mutations

Incidental Mutation 'R2920:Mettl25'

256596

Institutional Source

Beutler Lab

Gene Symbol

Mettl25

Ensembl Gene

ENSMUSG00000036009

Gene Name

methyltransferase like 25

Synonyms

BC067068

MMRRC Submission

040505-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

R2920 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

105763189-105841380 bp(-) (GRCm38)

Type of Mutation

splice site (43 bp from exon)

DNA Base Change (assembly)

A to T at 105765177 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000038665 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046638] [ENSMUST00000176924]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000046638

SMART Domains

Protein: ENSMUSP00000038665
Gene: ENSMUSG00000036009

Domain	Start	End	E-Value	Type
Pfam:Methyltransf_32	149	413	1.9e-30	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000176924

Coding Region Coverage

1x: 99.1%
3x: 98.6%
10x: 97.3%
20x: 95.0%

Validation Efficiency

96% (48/50)

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgb	A	G	10: 10,390,243	Y1025H	probably damaging	Het
Adgrv1	C	T	13: 81,448,865	A4122T	probably benign	Het
Aloxe3	C	T	11: 69,142,923	T621I	probably damaging	Het
Atp2b3	A	C	X: 73,533,920	T318P	probably benign	Het
Atrx	A	T	X: 105,830,868	V1962D	probably benign	Het
Chl1	C	A	6: 103,695,343	T531K	probably damaging	Het
Clca3b	T	A	3: 144,837,853	D405V	probably benign	Het
Clca3b	C	T	3: 144,846,931	D115N	probably benign	Het
Comtd1	A	G	14: 21,847,618	L149P	possibly damaging	Het
Cops7a	A	G	6: 124,962,362	V108A	probably benign	Het
Crebbp	A	G	16: 4,119,082	V343A	probably damaging	Het
Edrf1	T	A	7: 133,667,572	D1109E	probably benign	Het
Elmo3	A	G	8: 105,308,059	E359G	possibly damaging	Het
Ep400	C	A	5: 110,755,914	G273V	probably damaging	Het
Fgfr3	A	G	5: 33,733,940	N516S	probably damaging	Het
Glb1l	T	A	1: 75,209,190	E31D	probably benign	Het
Gm10093	A	G	17: 78,492,846	D422G	probably damaging	Het
Il12rb2	C	T	6: 67,360,568	V110I	probably damaging	Het
Ints3	T	C	3: 90,393,162	E884G	probably benign	Het
Lin7b	A	G	7: 45,368,397	V170A	possibly damaging	Het
Lrch2	A	T	X: 147,473,030	V750E	probably damaging	Het
Mepe	C	T	5: 104,338,247	R418C	probably damaging	Het
Mphosph9	G	A	5: 124,261,006	T982I	probably benign	Het
Mslnl	G	A	17: 25,742,934	V128M	probably damaging	Het
Myo10	G	T	15: 25,801,140	V1472L	probably damaging	Het
Myo9b	A	G	8: 71,325,857	K445R	probably damaging	Het
Ntng2	T	C	2: 29,204,211	M383V	probably benign	Het
Olfr1353	A	C	10: 78,970,012	D121A	probably damaging	Het
Olfr30	T	C	11: 58,455,577	Y124C	probably damaging	Het
Olfr702	C	T	7: 106,824,364	R54Q	probably benign	Het
Pak6	A	T	2: 118,694,007		probably benign	Het
Pcdh8	G	T	14: 79,768,714	P803Q	possibly damaging	Het
Pfkfb3	C	T	2: 11,484,327	V286I	probably benign	Het
Rbp3	C	T	14: 33,956,018	T641M	probably damaging	Het
Rint1	A	G	5: 23,805,402	E203G	probably benign	Het
Sdf2	G	C	11: 78,254,854	V126L	probably damaging	Het
Slc13a5	T	C	11: 72,247,791	E442G	possibly damaging	Het
Slc14a2	G	T	18: 78,158,297	S669*	probably null	Het
Slc38a7	A	G	8: 95,845,943	I157T	possibly damaging	Het
Slc4a5	T	C	6: 83,264,387	L215P	probably damaging	Het
Tbc1d9	T	C	8: 83,210,469	V60A	probably benign	Het
Tcerg1l	T	C	7: 138,248,379	R422G	probably damaging	Het
Tmem107	T	C	11: 69,071,421	L68P	probably damaging	Het
Ugt2b5	A	G	5: 87,125,407	F467L	possibly damaging	Het
Vmn1r19	A	T	6: 57,404,924	N154I	probably benign	Het
Vmn2r69	T	A	7: 85,411,765	I204L	probably benign	Het
Zbtb1	T	A	12: 76,385,845	S202T	possibly damaging	Het

Other mutations in Mettl25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00310:Mettl25	APN	10	105826434	missense	probably benign
IGL00698:Mettl25	APN	10	105793340	missense	probably null	0.31
IGL00766:Mettl25	APN	10	105779582	splice site	probably benign
IGL01360:Mettl25	APN	10	105823197	missense	probably damaging	1.00
IGL01954:Mettl25	APN	10	105823207	missense	probably damaging	1.00
IGL02088:Mettl25	APN	10	105823250	missense	probably damaging	1.00
IGL02623:Mettl25	APN	10	105826324	missense	probably damaging	0.96
IGL03245:Mettl25	APN	10	105826497	missense	possibly damaging	0.86
IGL03134:Mettl25	UTSW	10	105826027	nonsense	probably null
R0238:Mettl25	UTSW	10	105826525	missense	probably damaging	1.00
R0238:Mettl25	UTSW	10	105826525	missense	probably damaging	1.00
R0239:Mettl25	UTSW	10	105826525	missense	probably damaging	1.00
R0239:Mettl25	UTSW	10	105826525	missense	probably damaging	1.00
R1297:Mettl25	UTSW	10	105823265	missense	probably benign	0.11
R1482:Mettl25	UTSW	10	105826590	missense	possibly damaging	0.61
R1526:Mettl25	UTSW	10	105832983	missense	possibly damaging	0.56
R1542:Mettl25	UTSW	10	105826120	missense	probably benign	0.04
R1589:Mettl25	UTSW	10	105779632	missense	probably damaging	1.00
R1901:Mettl25	UTSW	10	105826087	missense	probably damaging	0.96
R1902:Mettl25	UTSW	10	105826087	missense	probably damaging	0.96
R2016:Mettl25	UTSW	10	105797306	missense	probably benign	0.00
R2355:Mettl25	UTSW	10	105763455	missense	probably benign	0.00
R3149:Mettl25	UTSW	10	105826353	missense	probably benign	0.00
R4547:Mettl25	UTSW	10	105826017	missense	probably damaging	1.00
R4646:Mettl25	UTSW	10	105826555	missense	probably damaging	1.00
R4652:Mettl25	UTSW	10	105779648	nonsense	probably null
R5020:Mettl25	UTSW	10	105826207	missense	possibly damaging	0.87
R5435:Mettl25	UTSW	10	105779586	critical splice donor site	probably null
R6947:Mettl25	UTSW	10	105826192	missense	probably benign	0.00
R7075:Mettl25	UTSW	10	105829924	missense	possibly damaging	0.68
R7729:Mettl25	UTSW	10	105766010	missense	probably benign	0.03
R8074:Mettl25	UTSW	10	105826080	missense	probably benign	0.02
R8108:Mettl25	UTSW	10	105823179	missense	possibly damaging	0.53
R8415:Mettl25	UTSW	10	105826141	missense	probably benign	0.05
R8937:Mettl25	UTSW	10	105765261	missense	probably benign	0.17
R8949:Mettl25	UTSW	10	105832853	missense	probably benign	0.00
RF009:Mettl25	UTSW	10	105833239	intron	probably benign
Z1176:Mettl25	UTSW	10	105826098	missense	possibly damaging	0.95

Predicted Primers

Posted On

2014-12-31