|Institutional Source||Beutler Lab|
|Gene Name||transcription factor 7, T cell specific|
|Synonyms||Tcf1, T-cell factor 1, T cell factor-1, TCF-1|
|Is this an essential gene?||Probably essential (E-score: 0.767)|
|Stock #||R2938 (G1)|
|Chromosomal Location||52252371-52283014 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||A to T at 52282783 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000104699 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000086844] [ENSMUST00000109071]|
|Predicted Effect||probably benign
|Predicted Effect||probably null
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||100% (62/62)|
FUNCTION: This gene encodes a transcription factor which is a member of the T-cell specific transcription factor family. The encoded protein is distinct from the hepatic transcription factor, transcription factor 1, which is also referred to by the symbol Tcf1. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]
PHENOTYPE: Homozygous null mice have defects in T cell development leading to decreased numbers of T cells in the periphery. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Tcf7||
(F):5'- CCTATAAAGGTCAGGGCACC -3'
(R):5'- CACTGGTGAATGAGTCCGAAG -3'
(F):5'- CGGAAGTGACTCCAGCTCAG -3'
(R):5'- CGTCCGAGTACATGGAGAAGCC -3'