Incidental Mutation 'R3004:Gpr158'
ID 257383
Institutional Source Beutler Lab
Gene Symbol Gpr158
Ensembl Gene ENSMUSG00000045967
Gene Name G protein-coupled receptor 158
Synonyms 5330427M13Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3004 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 21372378-21835355 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 21831810 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 970 (M970K)
Ref Sequence ENSEMBL: ENSMUSP00000049708 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055946]
AlphaFold Q8C419
Predicted Effect probably damaging
Transcript: ENSMUST00000055946
AA Change: M970K

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000049708
Gene: ENSMUSG00000045967
AA Change: M970K

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 110 125 N/A INTRINSIC
SCOP:d1edmb_ 313 359 5e-4 SMART
Blast:EGF 318 365 2e-27 BLAST
Pfam:7tm_3 426 669 1.2e-35 PFAM
low complexity region 840 863 N/A INTRINSIC
Meta Mutation Damage Score 0.1418 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alpk3 G A 7: 80,753,103 (GRCm39) W1553* probably null Het
Art2a T C 7: 101,203,972 (GRCm39) I189V probably benign Het
BC049715 A G 6: 136,816,790 (GRCm39) E10G possibly damaging Het
Ccdc158 A G 5: 92,796,929 (GRCm39) L469P probably damaging Het
Cspg4b T C 13: 113,502,688 (GRCm39) F131S probably damaging Het
Ctsm T C 13: 61,687,682 (GRCm39) I59V possibly damaging Het
Daam2 A G 17: 49,767,682 (GRCm39) F970L probably damaging Het
Gm21903 A T 17: 39,353,547 (GRCm39) probably benign Het
H2bc7 G A 13: 23,758,355 (GRCm39) probably benign Het
Hoxd10 T A 2: 74,522,706 (GRCm39) V128D probably benign Het
Ighv5-9 T C 12: 113,625,567 (GRCm39) T59A probably benign Het
Nlrp4c G A 7: 6,068,524 (GRCm39) V142M probably benign Het
Npc1 A G 18: 12,330,311 (GRCm39) F947L probably benign Het
Or1ak2 T A 2: 36,827,221 (GRCm39) I30N possibly damaging Het
Or56b1b G T 7: 108,164,151 (GRCm39) H284N probably benign Het
Piezo2 G T 18: 63,157,506 (GRCm39) Y223* probably null Het
Rhog A T 7: 101,889,345 (GRCm39) V36E probably damaging Het
Sbno1 G A 5: 124,519,771 (GRCm39) T1168I probably damaging Het
Sin3a T A 9: 57,004,118 (GRCm39) L290* probably null Het
Slco1c1 G T 6: 141,478,380 (GRCm39) A48S probably damaging Het
Slfn9 A T 11: 82,872,590 (GRCm39) S715R possibly damaging Het
Sox17 T C 1: 4,562,840 (GRCm39) E120G probably damaging Het
Other mutations in Gpr158
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Gpr158 APN 2 21,373,494 (GRCm39) missense probably damaging 1.00
IGL00469:Gpr158 APN 2 21,751,606 (GRCm39) splice site probably benign
IGL00706:Gpr158 APN 2 21,751,584 (GRCm39) missense probably damaging 1.00
IGL00780:Gpr158 APN 2 21,831,629 (GRCm39) nonsense probably null
IGL00885:Gpr158 APN 2 21,653,832 (GRCm39) missense probably damaging 1.00
IGL01339:Gpr158 APN 2 21,373,842 (GRCm39) missense possibly damaging 0.73
IGL01368:Gpr158 APN 2 21,831,909 (GRCm39) missense probably damaging 1.00
IGL02141:Gpr158 APN 2 21,788,101 (GRCm39) missense probably damaging 0.99
IGL02455:Gpr158 APN 2 21,373,511 (GRCm39) missense probably benign 0.00
IGL02554:Gpr158 APN 2 21,831,407 (GRCm39) missense probably benign
IGL02681:Gpr158 APN 2 21,820,441 (GRCm39) missense probably damaging 1.00
IGL02752:Gpr158 APN 2 21,831,638 (GRCm39) missense possibly damaging 0.95
IGL02756:Gpr158 APN 2 21,831,890 (GRCm39) missense possibly damaging 0.47
IGL03181:Gpr158 APN 2 21,787,972 (GRCm39) missense probably benign 0.02
IGL03258:Gpr158 APN 2 21,830,085 (GRCm39) missense probably damaging 1.00
IGL03386:Gpr158 APN 2 21,831,057 (GRCm39) missense probably damaging 1.00
PIT4810001:Gpr158 UTSW 2 21,831,682 (GRCm39) missense probably benign 0.01
R0071:Gpr158 UTSW 2 21,815,479 (GRCm39) missense probably benign 0.08
R0081:Gpr158 UTSW 2 21,831,528 (GRCm39) missense probably damaging 1.00
R0528:Gpr158 UTSW 2 21,830,019 (GRCm39) missense probably damaging 1.00
R0560:Gpr158 UTSW 2 21,830,085 (GRCm39) missense probably damaging 1.00
R0603:Gpr158 UTSW 2 21,820,480 (GRCm39) missense possibly damaging 0.67
R1560:Gpr158 UTSW 2 21,831,125 (GRCm39) missense probably damaging 1.00
R1561:Gpr158 UTSW 2 21,820,505 (GRCm39) splice site probably null
R1609:Gpr158 UTSW 2 21,788,104 (GRCm39) missense possibly damaging 0.61
R1741:Gpr158 UTSW 2 21,832,359 (GRCm39) missense probably benign 0.00
R1827:Gpr158 UTSW 2 21,832,129 (GRCm39) missense probably benign
R1854:Gpr158 UTSW 2 21,373,935 (GRCm39) missense probably damaging 1.00
R1871:Gpr158 UTSW 2 21,820,426 (GRCm39) missense probably damaging 1.00
R2151:Gpr158 UTSW 2 21,832,325 (GRCm39) missense possibly damaging 0.82
R2273:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R2275:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R3151:Gpr158 UTSW 2 21,581,771 (GRCm39) missense possibly damaging 0.68
R3943:Gpr158 UTSW 2 21,373,370 (GRCm39) missense possibly damaging 0.65
R4238:Gpr158 UTSW 2 21,373,362 (GRCm39) missense probably damaging 1.00
R4379:Gpr158 UTSW 2 21,830,025 (GRCm39) missense probably damaging 1.00
R4381:Gpr158 UTSW 2 21,832,403 (GRCm39) missense probably damaging 1.00
R4464:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4467:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4496:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4506:Gpr158 UTSW 2 21,831,810 (GRCm39) missense probably damaging 0.99
R4530:Gpr158 UTSW 2 21,373,811 (GRCm39) missense probably benign 0.03
R4646:Gpr158 UTSW 2 21,831,864 (GRCm39) missense probably benign
R4798:Gpr158 UTSW 2 21,787,993 (GRCm39) missense probably damaging 1.00
R4882:Gpr158 UTSW 2 21,830,059 (GRCm39) missense probably damaging 0.98
R4943:Gpr158 UTSW 2 21,831,968 (GRCm39) missense probably damaging 1.00
R5334:Gpr158 UTSW 2 21,832,316 (GRCm39) missense probably benign 0.01
R5560:Gpr158 UTSW 2 21,831,101 (GRCm39) missense possibly damaging 0.67
R5600:Gpr158 UTSW 2 21,832,046 (GRCm39) missense probably benign
R5637:Gpr158 UTSW 2 21,788,083 (GRCm39) missense probably benign 0.00
R5701:Gpr158 UTSW 2 21,751,520 (GRCm39) missense probably damaging 1.00
R5744:Gpr158 UTSW 2 21,373,331 (GRCm39) missense probably damaging 1.00
R5911:Gpr158 UTSW 2 21,373,932 (GRCm39) missense possibly damaging 0.95
R5991:Gpr158 UTSW 2 21,373,319 (GRCm39) missense probably damaging 0.99
R6200:Gpr158 UTSW 2 21,404,227 (GRCm39) missense probably damaging 0.97
R6306:Gpr158 UTSW 2 21,820,422 (GRCm39) missense possibly damaging 0.84
R6324:Gpr158 UTSW 2 21,815,365 (GRCm39) missense probably damaging 1.00
R6384:Gpr158 UTSW 2 21,831,099 (GRCm39) missense probably damaging 1.00
R6698:Gpr158 UTSW 2 21,831,921 (GRCm39) missense probably damaging 1.00
R6997:Gpr158 UTSW 2 21,653,802 (GRCm39) missense possibly damaging 0.46
R7086:Gpr158 UTSW 2 21,831,386 (GRCm39) missense probably benign 0.01
R7175:Gpr158 UTSW 2 21,373,113 (GRCm39) missense probably benign 0.13
R7197:Gpr158 UTSW 2 21,815,412 (GRCm39) missense probably damaging 0.99
R7293:Gpr158 UTSW 2 21,581,750 (GRCm39) missense possibly damaging 0.47
R7427:Gpr158 UTSW 2 21,832,129 (GRCm39) missense probably benign
R7515:Gpr158 UTSW 2 21,373,092 (GRCm39) missense probably damaging 1.00
R7730:Gpr158 UTSW 2 21,831,158 (GRCm39) missense probably damaging 1.00
R8122:Gpr158 UTSW 2 21,831,674 (GRCm39) missense probably benign
R8311:Gpr158 UTSW 2 21,373,701 (GRCm39) missense probably benign 0.00
R8754:Gpr158 UTSW 2 21,581,693 (GRCm39) missense probably benign 0.00
R8782:Gpr158 UTSW 2 21,404,149 (GRCm39) missense probably damaging 1.00
R8792:Gpr158 UTSW 2 21,558,137 (GRCm39) missense probably damaging 1.00
R8842:Gpr158 UTSW 2 21,581,751 (GRCm39) missense possibly damaging 0.88
R9009:Gpr158 UTSW 2 21,581,760 (GRCm39) missense probably damaging 1.00
R9102:Gpr158 UTSW 2 21,830,078 (GRCm39) missense probably damaging 1.00
R9150:Gpr158 UTSW 2 21,831,251 (GRCm39) missense probably benign 0.17
R9254:Gpr158 UTSW 2 21,373,042 (GRCm39) start gained probably benign
R9317:Gpr158 UTSW 2 21,832,037 (GRCm39) missense probably benign
R9379:Gpr158 UTSW 2 21,373,042 (GRCm39) start gained probably benign
R9428:Gpr158 UTSW 2 21,787,972 (GRCm39) missense probably benign
R9497:Gpr158 UTSW 2 21,831,825 (GRCm39) missense probably benign 0.00
R9667:Gpr158 UTSW 2 21,830,054 (GRCm39) missense probably damaging 0.99
R9681:Gpr158 UTSW 2 21,831,315 (GRCm39) missense probably damaging 0.99
X0062:Gpr158 UTSW 2 21,831,180 (GRCm39) missense probably damaging 1.00
Z1176:Gpr158 UTSW 2 21,815,501 (GRCm39) critical splice donor site probably null
Z1177:Gpr158 UTSW 2 21,832,083 (GRCm39) missense possibly damaging 0.46
Predicted Primers PCR Primer
(F):5'- TCAGTGTCATTGCAAGTGCC -3'
(R):5'- GAAGCAGGGTTTTGTTCCACTTC -3'

Sequencing Primer
(F):5'- TGTCATTGCAAGTGCCAAGGAG -3'
(R):5'- CACTTCAGAAGCTGCGATTG -3'
Posted On 2015-01-11