Incidental Mutation 'R3005:Lcn6'
ID 257406
Institutional Source Beutler Lab
Gene Symbol Lcn6
Ensembl Gene ENSMUSG00000045684
Gene Name lipocalin 6
Synonyms 9230101D24Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R3005 (G1)
Quality Score 213
Status Not validated
Chromosome 2
Chromosomal Location 25566798-25571620 bp(+) (GRCm39)
Type of Mutation splice site (28 bp from exon)
DNA Base Change (assembly) T to A at 25567261 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000109837 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059693] [ENSMUST00000114197] [ENSMUST00000114199]
AlphaFold A2AJB9
Predicted Effect probably benign
Transcript: ENSMUST00000059693
SMART Domains Protein: ENSMUSP00000055660
Gene: ENSMUSG00000045684

Pfam:Lipocalin 7 106 1.4e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114197
SMART Domains Protein: ENSMUSP00000109835
Gene: ENSMUSG00000045684

Pfam:Lipocalin 7 106 4.8e-7 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000114199
SMART Domains Protein: ENSMUSP00000109837
Gene: ENSMUSG00000045684

signal peptide 1 21 N/A INTRINSIC
Pfam:Lipocalin 33 172 2.6e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139441
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice with loss of expression in the testes show premature acrosome reaction and elevated intracellular calcium levels in sperm. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cep162 C A 9: 87,114,113 (GRCm39) V320L probably benign Het
Cnga1 T A 5: 72,762,450 (GRCm39) I355F probably damaging Het
Csnk1e T C 15: 79,323,005 (GRCm39) I15V probably benign Het
Dele1 T A 18: 38,393,012 (GRCm39) N405K possibly damaging Het
Exosc8 T C 3: 54,639,568 (GRCm39) probably null Het
Garre1 T C 7: 33,984,209 (GRCm39) E138G probably damaging Het
Gstm3 G T 3: 107,874,923 (GRCm39) Q110K probably benign Het
Hace1 G A 10: 45,524,959 (GRCm39) G242R probably damaging Het
Msh6 A G 17: 88,295,713 (GRCm39) E1088G probably benign Het
Nlrp4c G A 7: 6,068,524 (GRCm39) V142M probably benign Het
Nup50 G A 15: 84,813,661 (GRCm39) probably null Het
Or51g2 C T 7: 102,622,465 (GRCm39) V245I possibly damaging Het
Ppp2r5a A T 1: 191,091,173 (GRCm39) F218Y probably damaging Het
Ptov1 T C 7: 44,513,886 (GRCm39) N52S probably damaging Het
Rif1 G A 2: 51,972,776 (GRCm39) A303T probably damaging Het
Ror1 T A 4: 100,298,961 (GRCm39) V778E probably damaging Het
Tcaf3 A T 6: 42,570,978 (GRCm39) L258H probably damaging Het
Utp20 C A 10: 88,613,317 (GRCm39) K1321N probably damaging Het
Vmn2r54 T A 7: 12,349,221 (GRCm39) Q787L probably benign Het
Other mutations in Lcn6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01086:Lcn6 APN 2 25,570,792 (GRCm39) missense probably benign 0.29
R0747:Lcn6 UTSW 2 25,567,184 (GRCm39) missense probably damaging 1.00
R1387:Lcn6 UTSW 2 25,567,149 (GRCm39) missense possibly damaging 0.86
R1500:Lcn6 UTSW 2 25,567,131 (GRCm39) missense probably benign 0.00
R1654:Lcn6 UTSW 2 25,570,787 (GRCm39) splice site probably null
R4821:Lcn6 UTSW 2 25,570,822 (GRCm39) missense probably damaging 1.00
R4972:Lcn6 UTSW 2 25,570,079 (GRCm39) missense probably damaging 1.00
R5011:Lcn6 UTSW 2 25,567,082 (GRCm39) splice site probably null
R5013:Lcn6 UTSW 2 25,567,082 (GRCm39) splice site probably null
R7779:Lcn6 UTSW 2 25,570,805 (GRCm39) missense probably benign
R8034:Lcn6 UTSW 2 25,566,883 (GRCm39) nonsense probably null
R8558:Lcn6 UTSW 2 25,570,718 (GRCm39) missense probably damaging 1.00
R8697:Lcn6 UTSW 2 25,567,166 (GRCm39) missense probably benign 0.01
R9227:Lcn6 UTSW 2 25,570,107 (GRCm39) missense probably damaging 1.00
R9312:Lcn6 UTSW 2 25,570,074 (GRCm39) missense probably benign 0.23
R9740:Lcn6 UTSW 2 25,571,191 (GRCm39) missense probably benign 0.00
R9749:Lcn6 UTSW 2 25,570,034 (GRCm39) start codon destroyed probably benign
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2015-01-11