Incidental Mutation 'R3008:Gm10277'
ID |
257446 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Gm10277
|
Ensembl Gene |
ENSMUSG00000069804 |
Gene Name |
predicted gene 10277 |
Synonyms |
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.074)
|
Stock # |
R3008 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
11 |
Chromosomal Location |
77676279-77678573 bp(-) (GRCm39) |
Type of Mutation |
intron |
DNA Base Change (assembly) |
T to A
at 77676362 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000132149
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000000645]
[ENSMUST00000092883]
[ENSMUST00000092887]
[ENSMUST00000102488]
[ENSMUST00000108375]
[ENSMUST00000108376]
[ENSMUST00000130627]
[ENSMUST00000168348]
[ENSMUST00000169105]
|
AlphaFold |
Q6R5C6 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000000645
|
SMART Domains |
Protein: ENSMUSP00000000645 Gene: ENSMUSG00000000631
Domain | Start | End | E-Value | Type |
low complexity region
|
6 |
27 |
N/A |
INTRINSIC |
low complexity region
|
202 |
227 |
N/A |
INTRINSIC |
PDZ
|
229 |
311 |
5.72e-10 |
SMART |
MYSc
|
399 |
1183 |
1.53e-45 |
SMART |
IQ
|
1184 |
1206 |
1.11e-3 |
SMART |
Pfam:Myosin_tail_1
|
1219 |
1867 |
1.7e-34 |
PFAM |
|
Predicted Effect |
unknown
Transcript: ENSMUST00000092883
AA Change: Q203L
|
SMART Domains |
Protein: ENSMUSP00000090559 Gene: ENSMUSG00000069804 AA Change: Q203L
Domain | Start | End | E-Value | Type |
low complexity region
|
84 |
98 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000092887
|
SMART Domains |
Protein: ENSMUSP00000090563 Gene: ENSMUSG00000000631
Domain | Start | End | E-Value | Type |
low complexity region
|
6 |
27 |
N/A |
INTRINSIC |
low complexity region
|
202 |
227 |
N/A |
INTRINSIC |
PDZ
|
229 |
311 |
5.72e-10 |
SMART |
MYSc
|
399 |
1182 |
4.16e-47 |
SMART |
IQ
|
1183 |
1205 |
1.11e-3 |
SMART |
Pfam:Myosin_tail_1
|
1218 |
1866 |
3e-34 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000102488
|
SMART Domains |
Protein: ENSMUSP00000099546 Gene: ENSMUSG00000000631
Domain | Start | End | E-Value | Type |
low complexity region
|
6 |
27 |
N/A |
INTRINSIC |
low complexity region
|
202 |
227 |
N/A |
INTRINSIC |
PDZ
|
229 |
311 |
5.72e-10 |
SMART |
MYSc
|
399 |
1182 |
4.16e-47 |
SMART |
IQ
|
1183 |
1205 |
1.11e-3 |
SMART |
Pfam:Myosin_tail_1
|
1218 |
1866 |
3e-34 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000108375
|
SMART Domains |
Protein: ENSMUSP00000104012 Gene: ENSMUSG00000000631
Domain | Start | End | E-Value | Type |
low complexity region
|
6 |
27 |
N/A |
INTRINSIC |
low complexity region
|
202 |
227 |
N/A |
INTRINSIC |
PDZ
|
229 |
311 |
5.72e-10 |
SMART |
MYSc
|
399 |
1182 |
4.16e-47 |
SMART |
IQ
|
1183 |
1205 |
1.11e-3 |
SMART |
Pfam:Myosin_tail_1
|
1218 |
1838 |
6.8e-36 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000108376
|
SMART Domains |
Protein: ENSMUSP00000104013 Gene: ENSMUSG00000000631
Domain | Start | End | E-Value | Type |
low complexity region
|
6 |
27 |
N/A |
INTRINSIC |
low complexity region
|
202 |
227 |
N/A |
INTRINSIC |
PDZ
|
229 |
311 |
5.72e-10 |
SMART |
MYSc
|
399 |
1182 |
4.16e-47 |
SMART |
IQ
|
1183 |
1205 |
1.11e-3 |
SMART |
Blast:MYSc
|
1258 |
1387 |
1e-14 |
BLAST |
low complexity region
|
1396 |
1407 |
N/A |
INTRINSIC |
low complexity region
|
1743 |
1762 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000130627
|
SMART Domains |
Protein: ENSMUSP00000119839 Gene: ENSMUSG00000000631
Domain | Start | End | E-Value | Type |
low complexity region
|
6 |
27 |
N/A |
INTRINSIC |
low complexity region
|
202 |
227 |
N/A |
INTRINSIC |
PDZ
|
229 |
311 |
5.72e-10 |
SMART |
MYSc
|
411 |
1194 |
4.16e-47 |
SMART |
IQ
|
1195 |
1217 |
1.11e-3 |
SMART |
Pfam:Myosin_tail_1
|
1230 |
1850 |
6.9e-36 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000168348
|
SMART Domains |
Protein: ENSMUSP00000130696 Gene: ENSMUSG00000000631
Domain | Start | End | E-Value | Type |
low complexity region
|
6 |
27 |
N/A |
INTRINSIC |
low complexity region
|
202 |
227 |
N/A |
INTRINSIC |
PDZ
|
229 |
311 |
5.72e-10 |
SMART |
MYSc
|
447 |
1230 |
4.16e-47 |
SMART |
IQ
|
1231 |
1253 |
1.11e-3 |
SMART |
Blast:MYSc
|
1306 |
1435 |
1e-14 |
BLAST |
low complexity region
|
1444 |
1455 |
N/A |
INTRINSIC |
low complexity region
|
1828 |
1847 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000169105
|
SMART Domains |
Protein: ENSMUSP00000132149 Gene: ENSMUSG00000000631
Domain | Start | End | E-Value | Type |
low complexity region
|
6 |
27 |
N/A |
INTRINSIC |
low complexity region
|
202 |
227 |
N/A |
INTRINSIC |
PDZ
|
229 |
311 |
5.72e-10 |
SMART |
MYSc
|
411 |
1194 |
4.16e-47 |
SMART |
IQ
|
1195 |
1217 |
1.11e-3 |
SMART |
Pfam:Myosin_tail_1
|
1230 |
1878 |
7.3e-35 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.4%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 24 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aadacl2fm2 |
T |
C |
3: 59,652,930 (GRCm39) |
L123P |
possibly damaging |
Het |
Acap3 |
T |
C |
4: 155,990,139 (GRCm39) |
I773T |
probably benign |
Het |
Atm |
A |
C |
9: 53,392,050 (GRCm39) |
F1780V |
probably benign |
Het |
Cers5 |
A |
G |
15: 99,670,598 (GRCm39) |
|
probably benign |
Het |
Cldn19 |
T |
G |
4: 119,112,987 (GRCm39) |
L73R |
probably damaging |
Het |
Cntnap5c |
A |
G |
17: 58,666,204 (GRCm39) |
Y1078C |
probably damaging |
Het |
Foxo6 |
A |
T |
4: 120,125,961 (GRCm39) |
M278K |
probably benign |
Het |
Gm4871 |
A |
T |
5: 144,966,627 (GRCm39) |
D285E |
probably damaging |
Het |
Gpd2 |
C |
T |
2: 57,228,987 (GRCm39) |
R264* |
probably null |
Het |
Ighv1-85 |
A |
T |
12: 115,963,704 (GRCm39) |
Y99N |
probably damaging |
Het |
Ighv7-1 |
A |
T |
12: 113,860,071 (GRCm39) |
L107Q |
probably damaging |
Het |
Kif17 |
A |
G |
4: 138,005,476 (GRCm39) |
D347G |
probably damaging |
Het |
Med22 |
T |
C |
2: 26,798,396 (GRCm39) |
|
probably benign |
Het |
Mme |
T |
A |
3: 63,266,378 (GRCm39) |
N551K |
probably damaging |
Het |
Mpp7 |
G |
A |
18: 7,461,678 (GRCm39) |
P65L |
possibly damaging |
Het |
Muc2 |
A |
T |
7: 141,281,347 (GRCm39) |
H475L |
possibly damaging |
Het |
Nfix |
CAAAAA |
CAAAA |
8: 85,442,876 (GRCm39) |
|
probably null |
Het |
Or8s10 |
G |
A |
15: 98,335,857 (GRCm39) |
C169Y |
probably damaging |
Het |
Pdp2 |
T |
A |
8: 105,320,898 (GRCm39) |
I249N |
probably benign |
Het |
Rsf1 |
ATGGCG |
ATGGCGACGGTGGCG |
7: 97,229,111 (GRCm39) |
|
probably benign |
Het |
Slc26a9 |
G |
T |
1: 131,693,652 (GRCm39) |
G714V |
probably damaging |
Het |
Tarbp1 |
G |
A |
8: 127,174,160 (GRCm39) |
T882I |
possibly damaging |
Het |
Tex11 |
C |
A |
X: 99,977,021 (GRCm39) |
A487S |
possibly damaging |
Het |
Ubr5 |
A |
G |
15: 38,031,089 (GRCm39) |
S398P |
probably benign |
Het |
|
Other mutations in Gm10277 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
R1724:Gm10277
|
UTSW |
11 |
77,676,828 (GRCm39) |
frame shift |
probably null |
|
R1725:Gm10277
|
UTSW |
11 |
77,676,828 (GRCm39) |
frame shift |
probably null |
|
R1726:Gm10277
|
UTSW |
11 |
77,676,828 (GRCm39) |
frame shift |
probably null |
|
R1741:Gm10277
|
UTSW |
11 |
77,676,828 (GRCm39) |
frame shift |
probably null |
|
R1742:Gm10277
|
UTSW |
11 |
77,676,828 (GRCm39) |
frame shift |
probably null |
|
R1909:Gm10277
|
UTSW |
11 |
77,676,828 (GRCm39) |
frame shift |
probably null |
|
R2023:Gm10277
|
UTSW |
11 |
77,676,828 (GRCm39) |
frame shift |
probably null |
|
R2115:Gm10277
|
UTSW |
11 |
77,676,828 (GRCm39) |
frame shift |
probably null |
|
R2116:Gm10277
|
UTSW |
11 |
77,676,828 (GRCm39) |
frame shift |
probably null |
|
R3894:Gm10277
|
UTSW |
11 |
77,676,827 (GRCm39) |
intron |
probably benign |
|
R4732:Gm10277
|
UTSW |
11 |
77,676,923 (GRCm39) |
intron |
probably benign |
|
R4733:Gm10277
|
UTSW |
11 |
77,676,923 (GRCm39) |
intron |
probably benign |
|
R4771:Gm10277
|
UTSW |
11 |
77,676,534 (GRCm39) |
intron |
probably benign |
|
R7366:Gm10277
|
UTSW |
11 |
77,676,584 (GRCm39) |
missense |
unknown |
|
R8688:Gm10277
|
UTSW |
11 |
77,676,405 (GRCm39) |
missense |
unknown |
|
R8961:Gm10277
|
UTSW |
11 |
77,677,826 (GRCm39) |
intron |
probably benign |
|
R9012:Gm10277
|
UTSW |
11 |
77,676,848 (GRCm39) |
missense |
unknown |
|
|
Predicted Primers |
PCR Primer
(F):5'- AATGAGGTTCTGCAGGTGTCC -3'
(R):5'- CCAAGAGTATAGCAGTTCCCACAG -3'
Sequencing Primer
(F):5'- TGTCCGGAGCAGGATCCTG -3'
(R):5'- TATAGCAGTTCCCACAGGCCTG -3'
|
Posted On |
2015-01-11 |