Mutagenetix > Incidental Mutation

Incidental Mutation 'R3009:Vmn2r72'

257458

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

Vmn2r72-ps, EG244114

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

R3009 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

85737784-85754981 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 85749642 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 501 (M501K)

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

AlphaFold

D3Z4N8

Predicted Effect

probably benign
Transcript: ENSMUST00000063425
AA Change: M501K

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: M501K

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.5%
20x: 95.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 19 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap12	A	G	10: 4,357,891 (GRCm38)	D1567G	probably benign	Het
Bmp3	T	C	5: 98,879,837 (GRCm38)	S439P	probably damaging	Het
Btnl2	C	T	17: 34,363,518 (GRCm38)	R353C	probably damaging	Het
Galc	T	C	12: 98,203,969 (GRCm38)	D676G	probably damaging	Het
Gpd2	C	T	2: 57,338,975 (GRCm38)	R264*	probably null	Het
Gprc6a	T	C	10: 51,628,296 (GRCm38)	T151A	probably benign	Het
Limk2	A	G	11: 3,359,046 (GRCm38)	I104T	probably benign	Het
Mei1	A	G	15: 82,112,525 (GRCm38)	H585R	probably damaging	Het
Mpp7	G	A	18: 7,461,678 (GRCm38)	P65L	possibly damaging	Het
Mtfr1	A	T	3: 19,215,586 (GRCm38)	T133S	probably benign	Het
Olfr1082	T	C	2: 86,594,370 (GRCm38)	T153A	probably benign	Het
Olfr190	A	G	16: 59,074,987 (GRCm38)	V31A	probably benign	Het
Olfr361	T	C	2: 37,085,077 (GRCm38)	I224V	probably benign	Het
Olfr524	T	C	7: 140,202,756 (GRCm38)	R5G	probably benign	Het
Prkg1	G	A	19: 31,664,112 (GRCm38)	T57I	possibly damaging	Het
Sppl2c	C	T	11: 104,187,315 (GRCm38)	P314S	probably benign	Het
Tex11	C	A	X: 100,933,415 (GRCm38)	A487S	possibly damaging	Het
Urb1	A	G	16: 90,774,798 (GRCm38)	I1041T	probably benign	Het
Vmn2r91	G	A	17: 18,105,455 (GRCm38)	V112I	probably benign	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85,749,646 (GRCm38)	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85,738,334 (GRCm38)	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85,749,646 (GRCm38)	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85,738,367 (GRCm38)	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85,738,166 (GRCm38)	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85,738,166 (GRCm38)	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85,738,166 (GRCm38)	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85,750,711 (GRCm38)	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85,737,962 (GRCm38)	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85,750,693 (GRCm38)	missense	probably benign
IGL02514:Vmn2r72	APN	7	85,738,699 (GRCm38)	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85,738,183 (GRCm38)	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85,738,671 (GRCm38)	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85,751,813 (GRCm38)	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85,752,041 (GRCm38)	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85,751,176 (GRCm38)	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85,754,954 (GRCm38)	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85,750,867 (GRCm38)	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85,751,836 (GRCm38)	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85,754,876 (GRCm38)	missense	probably benign
R0655:Vmn2r72	UTSW	7	85,738,111 (GRCm38)	nonsense	probably null
R0778:Vmn2r72	UTSW	7	85,749,739 (GRCm38)	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85,751,309 (GRCm38)	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85,751,944 (GRCm38)	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85,751,944 (GRCm38)	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85,751,944 (GRCm38)	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85,749,188 (GRCm38)	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85,738,257 (GRCm38)	missense	probably damaging	1.00
R1506:Vmn2r72	UTSW	7	85,749,211 (GRCm38)	missense	probably benign
R1632:Vmn2r72	UTSW	7	85,751,792 (GRCm38)	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85,738,170 (GRCm38)	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85,749,161 (GRCm38)	missense	probably benign	0.00
R2201:Vmn2r72	UTSW	7	85,738,236 (GRCm38)	missense	probably benign	0.12
R2290:Vmn2r72	UTSW	7	85,738,341 (GRCm38)	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85,738,256 (GRCm38)	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85,750,953 (GRCm38)	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85,751,269 (GRCm38)	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85,750,836 (GRCm38)	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85,750,836 (GRCm38)	missense	probably damaging	0.99
R2862:Vmn2r72	UTSW	7	85,750,836 (GRCm38)	missense	probably damaging	0.99
R3797:Vmn2r72	UTSW	7	85,738,077 (GRCm38)	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85,738,077 (GRCm38)	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85,749,735 (GRCm38)	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85,751,131 (GRCm38)	missense	probably benign	0.36
R3974:Vmn2r72	UTSW	7	85,749,809 (GRCm38)	missense	probably damaging	1.00
R4399:Vmn2r72	UTSW	7	85,738,500 (GRCm38)	missense	probably damaging	1.00
R4421:Vmn2r72	UTSW	7	85,738,500 (GRCm38)	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85,737,828 (GRCm38)	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85,751,926 (GRCm38)	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85,751,926 (GRCm38)	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85,751,926 (GRCm38)	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85,737,911 (GRCm38)	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85,737,861 (GRCm38)	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85,750,598 (GRCm38)	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85,751,109 (GRCm38)	missense	probably benign
R4991:Vmn2r72	UTSW	7	85,751,130 (GRCm38)	missense	probably damaging	0.99
R4995:Vmn2r72	UTSW	7	85,738,485 (GRCm38)	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85,737,853 (GRCm38)	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85,737,840 (GRCm38)	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85,738,254 (GRCm38)	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85,750,897 (GRCm38)	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85,751,942 (GRCm38)	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85,737,850 (GRCm38)	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85,737,929 (GRCm38)	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85,737,929 (GRCm38)	missense	probably damaging	1.00
R6354:Vmn2r72	UTSW	7	85,750,539 (GRCm38)	critical splice donor site	probably null
R6362:Vmn2r72	UTSW	7	85,751,174 (GRCm38)	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85,749,684 (GRCm38)	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85,737,996 (GRCm38)	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85,749,803 (GRCm38)	splice site	probably null
R7189:Vmn2r72	UTSW	7	85,754,917 (GRCm38)	missense	probably benign	0.36
R7266:Vmn2r72	UTSW	7	85,738,274 (GRCm38)	nonsense	probably null
R7323:Vmn2r72	UTSW	7	85,750,563 (GRCm38)	missense	probably benign
R7426:Vmn2r72	UTSW	7	85,751,140 (GRCm38)	missense	probably benign
R7606:Vmn2r72	UTSW	7	85,751,154 (GRCm38)	missense	possibly damaging	0.91
R7651:Vmn2r72	UTSW	7	85,751,938 (GRCm38)	missense	probably damaging	1.00
R7688:Vmn2r72	UTSW	7	85,754,890 (GRCm38)	missense	probably benign	0.32
R7753:Vmn2r72	UTSW	7	85,750,626 (GRCm38)	missense	probably damaging	1.00
R7843:Vmn2r72	UTSW	7	85,749,630 (GRCm38)	missense	probably benign	0.01
R8157:Vmn2r72	UTSW	7	85,751,233 (GRCm38)	missense	probably benign	0.09
R8254:Vmn2r72	UTSW	7	85,751,019 (GRCm38)	missense	probably damaging	1.00
R8389:Vmn2r72	UTSW	7	85,751,960 (GRCm38)	missense	probably damaging	0.99
R8444:Vmn2r72	UTSW	7	85,738,175 (GRCm38)	missense	probably benign
R8989:Vmn2r72	UTSW	7	85,754,926 (GRCm38)	missense	probably benign	0.10
R9015:Vmn2r72	UTSW	7	85,749,180 (GRCm38)	missense	probably benign	0.01
R9080:Vmn2r72	UTSW	7	85,738,256 (GRCm38)	missense	probably damaging	1.00
R9269:Vmn2r72	UTSW	7	85,751,203 (GRCm38)	missense	probably benign	0.03
R9317:Vmn2r72	UTSW	7	85,754,814 (GRCm38)	missense	probably benign	0.04
R9509:Vmn2r72	UTSW	7	85,754,867 (GRCm38)	missense	probably benign
Z1176:Vmn2r72	UTSW	7	85,749,191 (GRCm38)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- TCATCCAGTGATTCATACAACAGAG -3'
(R):5'- ATCCTGCTGGAGACCTAGTC -3'

Sequencing Primer
(F):5'- GGTGGCGTACTCCTTTATACCCAG -3'
(R):5'- CTGCTGGAGACCTAGTCAACATG -3'

Posted On

2015-01-11