Incidental Mutation 'R3009:Tex11'
ID 257473
Institutional Source Beutler Lab
Gene Symbol Tex11
Ensembl Gene ENSMUSG00000009670
Gene Name testis expressed gene 11
Synonyms 4930565P14Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.237) question?
Stock # R3009 (G1)
Quality Score 222
Status Not validated
Chromosome X
Chromosomal Location 99882254-100103245 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 99977021 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Serine at position 487 (A487S)
Ref Sequence ENSEMBL: ENSMUSP00000109347 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009814] [ENSMUST00000113716] [ENSMUST00000113718]
AlphaFold Q14AT2
Predicted Effect possibly damaging
Transcript: ENSMUST00000009814
AA Change: A487S

PolyPhen 2 Score 0.705 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000009814
Gene: ENSMUSG00000009670
AA Change: A487S

DomainStartEndE-ValueType
Pfam:SPO22 176 431 1.1e-62 PFAM
low complexity region 702 713 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000113716
AA Change: A487S

PolyPhen 2 Score 0.705 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000109345
Gene: ENSMUSG00000009670
AA Change: A487S

DomainStartEndE-ValueType
Pfam:SPO22 175 433 2.1e-70 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000113718
AA Change: A487S

PolyPhen 2 Score 0.705 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000109347
Gene: ENSMUSG00000009670
AA Change: A487S

DomainStartEndE-ValueType
Pfam:SPO22 175 433 3.8e-70 PFAM
low complexity region 702 713 N/A INTRINSIC
Meta Mutation Damage Score 0.3188 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Miche homozygous for a knockout allele exhibit abnormal male meiosis. Mice homozygous for a conditional knockout exhibit male infertility and reduced female fecundity due to abnormal meiosis following cre recombination. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap12 A G 10: 4,307,891 (GRCm39) D1567G probably benign Het
Bmp3 T C 5: 99,027,696 (GRCm39) S439P probably damaging Het
Btnl2 C T 17: 34,582,492 (GRCm39) R353C probably damaging Het
Galc T C 12: 98,170,228 (GRCm39) D676G probably damaging Het
Gpd2 C T 2: 57,228,987 (GRCm39) R264* probably null Het
Gprc6a T C 10: 51,504,392 (GRCm39) T151A probably benign Het
Limk2 A G 11: 3,309,046 (GRCm39) I104T probably benign Het
Mei1 A G 15: 81,996,726 (GRCm39) H585R probably damaging Het
Mpp7 G A 18: 7,461,678 (GRCm39) P65L possibly damaging Het
Mtfr1 A T 3: 19,269,750 (GRCm39) T133S probably benign Het
Or12k8 T C 2: 36,975,089 (GRCm39) I224V probably benign Het
Or5h22 A G 16: 58,895,350 (GRCm39) V31A probably benign Het
Or6b13 T C 7: 139,782,669 (GRCm39) R5G probably benign Het
Or8k35 T C 2: 86,424,714 (GRCm39) T153A probably benign Het
Prkg1 G A 19: 31,641,512 (GRCm39) T57I possibly damaging Het
Sppl2c C T 11: 104,078,141 (GRCm39) P314S probably benign Het
Urb1 A G 16: 90,571,686 (GRCm39) I1041T probably benign Het
Vmn2r72 A T 7: 85,398,850 (GRCm39) M501K probably benign Het
Vmn2r91 G A 17: 18,325,717 (GRCm39) V112I probably benign Het
Other mutations in Tex11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00536:Tex11 APN X 100,076,165 (GRCm39) missense probably null 0.00
IGL00838:Tex11 APN X 100,015,724 (GRCm39) missense possibly damaging 0.92
IGL02385:Tex11 APN X 99,920,135 (GRCm39) splice site probably benign
R2958:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R2960:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R2963:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R3008:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R3010:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R3011:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R3745:Tex11 UTSW X 99,960,178 (GRCm39) missense probably benign 0.33
R3881:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R3882:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R4081:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R4082:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R4159:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R4172:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R4197:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R4201:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R4204:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R4206:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R4304:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R4305:Tex11 UTSW X 99,977,021 (GRCm39) missense possibly damaging 0.70
R8726:Tex11 UTSW X 100,059,191 (GRCm39) missense possibly damaging 0.82
R8727:Tex11 UTSW X 100,059,191 (GRCm39) missense possibly damaging 0.82
Predicted Primers PCR Primer
(F):5'- ATGATGGTTTCCCGAATTCTTG -3'
(R):5'- GAGTACTCCTCAACAATTGTGTC -3'

Sequencing Primer
(F):5'- CTTGTCCAATATTTGCCCATTTAAG -3'
(R):5'- GCCATAGCAGAAGTTGAG -3'
Posted On 2015-01-11