Incidental Mutation 'R3011:Ifi204'
| ID |
257495 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ifi204
|
| Ensembl Gene |
ENSMUSG00000073489 |
| Gene Name |
interferon activated gene 204 |
| Synonyms |
p204 |
| MMRRC Submission |
040533-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.166)
|
| Stock # |
R3011 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
173574859-173594509 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 173579217 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 543
(S543G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000106845
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000111214]
|
| AlphaFold |
P0DOV2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111214
AA Change: S543G
PolyPhen 2
Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000106845
Gene: ENSMUSG00000073489
AA Change: S543G
| Domain | Start | End | E-Value | Type |
|---|
|
PYRIN
|
6 |
84 |
8.33e-14 |
SMART |
|
low complexity region
|
120 |
154 |
N/A |
INTRINSIC |
|
low complexity region
|
190 |
206 |
N/A |
INTRINSIC |
|
Pfam:HIN
|
225 |
393 |
6.2e-78 |
PFAM |
|
Pfam:HIN
|
429 |
595 |
9.8e-78 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.0%
|
| Validation Efficiency |
100% (29/29) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arhgap31 |
A |
C |
16: 38,422,269 (GRCm39) |
C1266G |
possibly damaging |
Het |
| Brme1 |
C |
A |
8: 84,893,539 (GRCm39) |
Y235* |
probably null |
Het |
| Cers5 |
A |
G |
15: 99,670,598 (GRCm39) |
|
probably benign |
Het |
| Clasp2 |
C |
T |
9: 113,730,581 (GRCm39) |
T905M |
probably damaging |
Het |
| Clec16a |
A |
G |
16: 10,428,975 (GRCm39) |
N469S |
probably benign |
Het |
| Commd3 |
T |
A |
2: 18,679,499 (GRCm39) |
V128D |
probably damaging |
Het |
| Cped1 |
A |
G |
6: 22,088,695 (GRCm39) |
T253A |
probably damaging |
Het |
| Dnajc5b |
A |
T |
3: 19,600,966 (GRCm39) |
Y21F |
probably damaging |
Het |
| Fhip2a |
T |
A |
19: 57,373,720 (GRCm39) |
L660Q |
probably damaging |
Het |
| Gm14403 |
A |
G |
2: 177,200,786 (GRCm39) |
D244G |
probably benign |
Het |
| Gm5414 |
T |
C |
15: 101,534,047 (GRCm39) |
D312G |
probably damaging |
Het |
| Itga11 |
T |
A |
9: 62,604,262 (GRCm39) |
I50N |
probably damaging |
Het |
| Lct |
C |
T |
1: 128,229,109 (GRCm39) |
V795I |
possibly damaging |
Het |
| Lrrc37 |
T |
A |
11: 103,503,929 (GRCm39) |
T504S |
possibly damaging |
Het |
| Map2 |
A |
G |
1: 66,453,771 (GRCm39) |
D887G |
probably damaging |
Het |
| Mgat4e |
T |
A |
1: 134,469,846 (GRCm39) |
D66V |
possibly damaging |
Het |
| Nqo1 |
C |
T |
8: 108,115,743 (GRCm39) |
R178H |
probably benign |
Het |
| Or13e8 |
G |
T |
4: 43,696,624 (GRCm39) |
A183E |
probably damaging |
Het |
| Or5h22 |
A |
G |
16: 58,895,350 (GRCm39) |
V31A |
probably benign |
Het |
| Otof |
G |
A |
5: 30,540,184 (GRCm39) |
A999V |
probably damaging |
Het |
| Phf20 |
A |
G |
2: 156,129,946 (GRCm39) |
D506G |
probably benign |
Het |
| Pth2r |
C |
T |
1: 65,376,147 (GRCm39) |
H97Y |
probably benign |
Het |
| Snx18 |
G |
A |
13: 113,753,422 (GRCm39) |
Q504* |
probably null |
Het |
| Sppl2c |
C |
T |
11: 104,078,141 (GRCm39) |
P314S |
probably benign |
Het |
| Srgap2 |
T |
A |
1: 131,238,329 (GRCm39) |
Q520L |
probably damaging |
Het |
| Tex11 |
C |
A |
X: 99,977,021 (GRCm39) |
A487S |
possibly damaging |
Het |
| Tlr4 |
A |
T |
4: 66,757,491 (GRCm39) |
K95* |
probably null |
Het |
| Tmem59l |
A |
T |
8: 70,938,887 (GRCm39) |
C96S |
probably damaging |
Het |
| Tmtc3 |
G |
T |
10: 100,283,444 (GRCm39) |
P704T |
possibly damaging |
Het |
| Upp2 |
T |
C |
2: 58,680,107 (GRCm39) |
V293A |
probably damaging |
Het |
| Vps72 |
A |
G |
3: 95,026,585 (GRCm39) |
K177E |
probably damaging |
Het |
|
| Other mutations in Ifi204 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00906:Ifi204
|
APN |
1 |
173,587,197 (GRCm39) |
splice site |
probably benign |
|
|
IGL01922:Ifi204
|
APN |
1 |
173,589,288 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02296:Ifi204
|
APN |
1 |
173,576,880 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02419:Ifi204
|
APN |
1 |
173,576,946 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02505:Ifi204
|
APN |
1 |
173,583,220 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0938:Ifi204
|
UTSW |
1 |
173,579,311 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1363:Ifi204
|
UTSW |
1 |
173,576,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1834:Ifi204
|
UTSW |
1 |
173,575,172 (GRCm39) |
missense |
unknown |
|
|
R2031:Ifi204
|
UTSW |
1 |
173,580,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2254:Ifi204
|
UTSW |
1 |
173,589,296 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2379:Ifi204
|
UTSW |
1 |
173,583,559 (GRCm39) |
nonsense |
probably null |
|
|
R2408:Ifi204
|
UTSW |
1 |
173,583,198 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3617:Ifi204
|
UTSW |
1 |
173,583,283 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R3894:Ifi204
|
UTSW |
1 |
173,576,774 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3916:Ifi204
|
UTSW |
1 |
173,583,341 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4656:Ifi204
|
UTSW |
1 |
173,587,927 (GRCm39) |
intron |
probably benign |
|
|
R4657:Ifi204
|
UTSW |
1 |
173,587,927 (GRCm39) |
intron |
probably benign |
|
|
R4694:Ifi204
|
UTSW |
1 |
173,576,825 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4703:Ifi204
|
UTSW |
1 |
173,587,927 (GRCm39) |
intron |
probably benign |
|
|
R4704:Ifi204
|
UTSW |
1 |
173,587,927 (GRCm39) |
intron |
probably benign |
|
|
R4894:Ifi204
|
UTSW |
1 |
173,587,808 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4947:Ifi204
|
UTSW |
1 |
173,583,316 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5023:Ifi204
|
UTSW |
1 |
173,579,306 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5036:Ifi204
|
UTSW |
1 |
173,580,311 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5119:Ifi204
|
UTSW |
1 |
173,583,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5194:Ifi204
|
UTSW |
1 |
173,576,910 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5762:Ifi204
|
UTSW |
1 |
173,580,325 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6063:Ifi204
|
UTSW |
1 |
173,579,223 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6808:Ifi204
|
UTSW |
1 |
173,589,269 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7311:Ifi204
|
UTSW |
1 |
173,587,134 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7338:Ifi204
|
UTSW |
1 |
173,587,703 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7430:Ifi204
|
UTSW |
1 |
173,583,247 (GRCm39) |
missense |
probably benign |
0.43 |
|
R7528:Ifi204
|
UTSW |
1 |
173,579,406 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7985:Ifi204
|
UTSW |
1 |
173,587,772 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8021:Ifi204
|
UTSW |
1 |
173,586,919 (GRCm39) |
intron |
probably benign |
|
|
R8137:Ifi204
|
UTSW |
1 |
173,589,188 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8141:Ifi204
|
UTSW |
1 |
173,583,189 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8191:Ifi204
|
UTSW |
1 |
173,579,226 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8487:Ifi204
|
UTSW |
1 |
173,587,839 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9075:Ifi204
|
UTSW |
1 |
173,589,282 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9124:Ifi204
|
UTSW |
1 |
173,579,193 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9311:Ifi204
|
UTSW |
1 |
173,589,215 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R9498:Ifi204
|
UTSW |
1 |
173,583,537 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9712:Ifi204
|
UTSW |
1 |
173,576,924 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Ifi204
|
UTSW |
1 |
173,579,194 (GRCm39) |
missense |
probably null |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTGAGGAAGCCTGGTCTTG -3'
(R):5'- CTACCGTGGCTACTGAAACTG -3'
Sequencing Primer
(F):5'- GCCTGGTCTCTTTCTGCTATGG -3'
(R):5'- ACCGTGGCTACTGAAACTGAGTTC -3'
|
| Posted On |
2015-01-11 |
Incidental Mutation