Incidental Mutation 'R3011:Gm14403'
ID 257499
Institutional Source Beutler Lab
Gene Symbol Gm14403
Ensembl Gene ENSMUSG00000094786
Gene Name predicted gene 14403
Synonyms
MMRRC Submission 040533-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # R3011 (G1)
Quality Score 140
Status Not validated
Chromosome 2
Chromosomal Location 177190008-177201556 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 177200786 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 244 (D244G)
Ref Sequence ENSEMBL: ENSMUSP00000104575 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108940] [ENSMUST00000108947]
AlphaFold A2BFU4
Predicted Effect probably benign
Transcript: ENSMUST00000108940
SMART Domains Protein: ENSMUSP00000104568
Gene: ENSMUSG00000094786

DomainStartEndE-ValueType
internal_repeat_1 1 73 1.34e-11 PROSPERO
internal_repeat_1 169 241 1.34e-11 PROSPERO
Predicted Effect probably benign
Transcript: ENSMUST00000108947
AA Change: D244G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000104575
Gene: ENSMUSG00000094786
AA Change: D244G

DomainStartEndE-ValueType
KRAB 4 66 4.86e-13 SMART
ZnF_C2H2 76 97 2.31e2 SMART
ZnF_C2H2 103 125 1.2e-3 SMART
ZnF_C2H2 131 153 1.18e-2 SMART
ZnF_C2H2 159 179 4.57e0 SMART
ZnF_C2H2 187 209 5.59e-4 SMART
ZnF_C2H2 215 237 1.12e-3 SMART
ZnF_C2H2 243 265 1.18e-2 SMART
ZnF_C2H2 271 293 8.6e-5 SMART
ZnF_C2H2 299 321 3.16e-3 SMART
ZnF_C2H2 327 349 1.84e-4 SMART
ZnF_C2H2 355 377 3.44e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142549
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency 100% (29/29)
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap31 A C 16: 38,422,269 (GRCm39) C1266G possibly damaging Het
Brme1 C A 8: 84,893,539 (GRCm39) Y235* probably null Het
Cers5 A G 15: 99,670,598 (GRCm39) probably benign Het
Clasp2 C T 9: 113,730,581 (GRCm39) T905M probably damaging Het
Clec16a A G 16: 10,428,975 (GRCm39) N469S probably benign Het
Commd3 T A 2: 18,679,499 (GRCm39) V128D probably damaging Het
Cped1 A G 6: 22,088,695 (GRCm39) T253A probably damaging Het
Dnajc5b A T 3: 19,600,966 (GRCm39) Y21F probably damaging Het
Fhip2a T A 19: 57,373,720 (GRCm39) L660Q probably damaging Het
Gm5414 T C 15: 101,534,047 (GRCm39) D312G probably damaging Het
Ifi204 T C 1: 173,579,217 (GRCm39) S543G probably benign Het
Itga11 T A 9: 62,604,262 (GRCm39) I50N probably damaging Het
Lct C T 1: 128,229,109 (GRCm39) V795I possibly damaging Het
Lrrc37 T A 11: 103,503,929 (GRCm39) T504S possibly damaging Het
Map2 A G 1: 66,453,771 (GRCm39) D887G probably damaging Het
Mgat4e T A 1: 134,469,846 (GRCm39) D66V possibly damaging Het
Nqo1 C T 8: 108,115,743 (GRCm39) R178H probably benign Het
Or13e8 G T 4: 43,696,624 (GRCm39) A183E probably damaging Het
Or5h22 A G 16: 58,895,350 (GRCm39) V31A probably benign Het
Otof G A 5: 30,540,184 (GRCm39) A999V probably damaging Het
Phf20 A G 2: 156,129,946 (GRCm39) D506G probably benign Het
Pth2r C T 1: 65,376,147 (GRCm39) H97Y probably benign Het
Snx18 G A 13: 113,753,422 (GRCm39) Q504* probably null Het
Sppl2c C T 11: 104,078,141 (GRCm39) P314S probably benign Het
Srgap2 T A 1: 131,238,329 (GRCm39) Q520L probably damaging Het
Tex11 C A X: 99,977,021 (GRCm39) A487S possibly damaging Het
Tlr4 A T 4: 66,757,491 (GRCm39) K95* probably null Het
Tmem59l A T 8: 70,938,887 (GRCm39) C96S probably damaging Het
Tmtc3 G T 10: 100,283,444 (GRCm39) P704T possibly damaging Het
Upp2 T C 2: 58,680,107 (GRCm39) V293A probably damaging Het
Vps72 A G 3: 95,026,585 (GRCm39) K177E probably damaging Het
Other mutations in Gm14403
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01835:Gm14403 APN 2 177,199,049 (GRCm39) missense probably damaging 0.99
IGL02660:Gm14403 APN 2 177,201,257 (GRCm39) missense probably damaging 1.00
R0492:Gm14403 UTSW 2 177,200,359 (GRCm39) missense probably benign 0.09
R0932:Gm14403 UTSW 2 177,198,810 (GRCm39) missense probably benign 0.01
R0975:Gm14403 UTSW 2 177,201,217 (GRCm39) missense probably damaging 1.00
R1468:Gm14403 UTSW 2 177,199,024 (GRCm39) splice site probably benign
R1853:Gm14403 UTSW 2 177,200,932 (GRCm39) missense probably damaging 1.00
R3803:Gm14403 UTSW 2 177,200,569 (GRCm39) missense probably benign 0.04
R4589:Gm14403 UTSW 2 177,200,428 (GRCm39) missense probably benign 0.29
R4805:Gm14403 UTSW 2 177,200,492 (GRCm39) missense probably damaging 0.97
R5085:Gm14403 UTSW 2 177,200,282 (GRCm39) missense probably benign 0.04
R5311:Gm14403 UTSW 2 177,201,448 (GRCm39) unclassified probably benign
R5425:Gm14403 UTSW 2 177,201,448 (GRCm39) unclassified probably benign
R5643:Gm14403 UTSW 2 177,199,054 (GRCm39) missense possibly damaging 0.87
R5644:Gm14403 UTSW 2 177,199,054 (GRCm39) missense possibly damaging 0.87
R5739:Gm14403 UTSW 2 177,201,040 (GRCm39) missense probably damaging 1.00
R5982:Gm14403 UTSW 2 177,200,345 (GRCm39) missense probably damaging 0.98
R6197:Gm14403 UTSW 2 177,201,448 (GRCm39) unclassified probably benign
R6198:Gm14403 UTSW 2 177,201,448 (GRCm39) unclassified probably benign
R6892:Gm14403 UTSW 2 177,201,040 (GRCm39) missense probably damaging 1.00
R7090:Gm14403 UTSW 2 177,201,114 (GRCm39) missense possibly damaging 0.87
R7168:Gm14403 UTSW 2 177,201,318 (GRCm39) missense probably damaging 0.96
R7510:Gm14403 UTSW 2 177,200,403 (GRCm39) missense probably benign 0.01
R7623:Gm14403 UTSW 2 177,200,405 (GRCm39) missense probably benign
R8049:Gm14403 UTSW 2 177,200,311 (GRCm39) missense probably benign 0.00
R8557:Gm14403 UTSW 2 177,201,354 (GRCm39) missense probably damaging 0.99
R9224:Gm14403 UTSW 2 177,200,336 (GRCm39) missense probably benign
R9333:Gm14403 UTSW 2 177,200,919 (GRCm39) missense probably benign 0.42
R9632:Gm14403 UTSW 2 177,201,421 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TTGTTCTGCAGAGCAACCCT -3'
(R):5'- GCAAAGGCTTTACCACATTGGT -3'

Sequencing Primer
(F):5'- AGCCTTTGCAAGAAGCTGTC -3'
(R):5'- CCACATTGGTTACATTCATAGGG -3'
Posted On 2015-01-11