Mutagenetix > Incidental Mutations

Incidental Mutation 'R3014:Tas2r107'

257596

Institutional Source

Beutler Lab

Gene Symbol

Tas2r107

Ensembl Gene

ENSMUSG00000053389

Gene Name

taste receptor, type 2, member 107

Synonyms

T2R4, Tas2r7, mGR06, STC 5-1, mt2r43, T2R07

MMRRC Submission

040535-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

R3014 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

131659118-131660149 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 131660009 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 26 (Y26H)

Ref Sequence

ENSEMBL: ENSMUSP00000067082 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065781]

Predicted Effect

probably benign
Transcript: ENSMUST00000065781
AA Change: Y26H

PolyPhen 2 Score 0.300 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000067082
Gene: ENSMUSG00000053389
AA Change: Y26H

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	297	4e-106	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.5%
20x: 95.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Angpt4	G	T	2: 151,929,597	V278L	probably benign	Het
BC049730	A	G	7: 24,713,396	I76M	possibly damaging	Het
Dmbt1	A	G	7: 131,032,097		probably benign	Het
Dnah2	A	T	11: 69,430,478	N3921K	probably benign	Het
Fam193a	A	T	5: 34,465,672	E1201D	probably benign	Het
Gm10220	G	C	5: 26,117,828	D195E	probably damaging	Het
Gm4981	G	A	10: 58,235,534	T286I	possibly damaging	Het
Gmps	A	G	3: 64,015,436	K607E	possibly damaging	Het
Gprin1	T	A	13: 54,738,475	D662V	probably benign	Het
Gria4	A	G	9: 4,464,294	I556T	probably damaging	Het
Grm7	G	T	6: 110,646,348	V161F	probably damaging	Het
Hcar2	A	T	5: 123,864,705	V245E	probably damaging	Het
Hmces	T	G	6: 87,917,841	D62E	probably benign	Het
Ighv1-4	T	A	12: 114,487,149	Y113F	possibly damaging	Het
Kcnd3	C	T	3: 105,658,766	A421V	probably damaging	Het
Kng1	C	T	16: 23,079,370	H507Y	possibly damaging	Het
Map3k5	A	T	10: 20,094,429	Y694F	probably damaging	Het
Myo1a	T	G	10: 127,716,345	F778V	probably damaging	Het
Naip2	A	C	13: 100,161,782	I582S	probably benign	Het
Olfr1347	A	T	7: 6,488,471	Y134*	probably null	Het
Olfr1377	A	G	11: 50,984,707	D2G	probably benign	Het
Olfr303	A	G	7: 86,394,676	V274A	probably benign	Het
Olfr723	G	A	14: 49,929,032	H171Y	probably benign	Het
Parp3	C	A	9: 106,471,315	S507I	possibly damaging	Het
Ppip5k2	T	A	1: 97,744,075	T491S	probably damaging	Het
Psmg1	T	A	16: 95,980,048	I266F	probably damaging	Het
Ptpn23	T	C	9: 110,389,695	T476A	probably benign	Het
Rttn	G	C	18: 89,014,620	V671L	probably damaging	Het
Srsf7	T	C	17: 80,201,561	E235G	unknown	Het
Sv2a	G	A	3: 96,189,435	W416*	probably null	Het
Tenm2	T	C	11: 36,023,973	T2245A	probably damaging	Het
Vmn2r13	T	A	5: 109,171,761	H451L	possibly damaging	Het
Xkr6	T	C	14: 63,819,344	Y235H	unknown	Het

Other mutations in Tas2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02749:Tas2r107	APN	6	131659954	missense	probably damaging	1.00
IGL02751:Tas2r107	APN	6	131659484	missense	probably damaging	1.00
IGL02868:Tas2r107	APN	6	131659286	missense	probably benign	0.11
IGL02943:Tas2r107	APN	6	131659406	missense	probably damaging	0.99
R1564:Tas2r107	UTSW	6	131659822	missense	probably damaging	0.96
R1905:Tas2r107	UTSW	6	131659988	missense	probably benign	0.20
R1906:Tas2r107	UTSW	6	131659988	missense	probably benign	0.20
R1907:Tas2r107	UTSW	6	131659988	missense	probably benign	0.20
R2185:Tas2r107	UTSW	6	131659603	missense	probably damaging	0.98
R3824:Tas2r107	UTSW	6	131659330	missense	probably benign	0.00
R4465:Tas2r107	UTSW	6	131660009	missense	probably benign	0.30
R5058:Tas2r107	UTSW	6	131659742	missense	probably damaging	1.00
R5646:Tas2r107	UTSW	6	131659708	missense	probably benign	0.02
R5975:Tas2r107	UTSW	6	131659780	missense	probably benign	0.02
R6008:Tas2r107	UTSW	6	131659912	missense	possibly damaging	0.82
R6144:Tas2r107	UTSW	6	131660003	missense	possibly damaging	0.87
R6451:Tas2r107	UTSW	6	131660014	missense	possibly damaging	0.81
R6662:Tas2r107	UTSW	6	131659489	missense	possibly damaging	0.82
R6702:Tas2r107	UTSW	6	131659384	missense	probably benign	0.12
R7032:Tas2r107	UTSW	6	131659190	missense	possibly damaging	0.62
R7635:Tas2r107	UTSW	6	131659600	missense	possibly damaging	0.92
R8303:Tas2r107	UTSW	6	131659622	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- CAGTTATGTTTCCAGAGGTAAGC -3'
(R):5'- AAGAGCACCCATAAAGTTCTGAATC -3'

Sequencing Primer
(F):5'- TCCAGAGGTAAGCATGTGTG -3'
(R):5'- CTGAATCTATCACATGACAATAGGC -3'

Posted On

2015-01-11