Incidental Mutation 'R3014:Or1ad1'
ID 257609
Institutional Source Beutler Lab
Gene Symbol Or1ad1
Ensembl Gene ENSMUSG00000061952
Gene Name olfactory receptor family 1 subfamily AD member 1
Synonyms Olfr1377, MOR129-1, GA_x6K02T2QP88-4453480-4452557
MMRRC Submission 040535-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R3014 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 50875530-50876453 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 50875534 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 2 (D2G)
Ref Sequence ENSEMBL: ENSMUSP00000151087 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075177] [ENSMUST00000213291] [ENSMUST00000216101]
AlphaFold Q8VGH1
Predicted Effect probably benign
Transcript: ENSMUST00000075177
AA Change: D2G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000074672
Gene: ENSMUSG00000061952
AA Change: D2G

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2e-51 PFAM
Pfam:7tm_1 41 289 1.4e-26 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000118780
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204581
AA Change: D2G
SMART Domains Protein: ENSMUSP00000144855
Gene: ENSMUSG00000061952
AA Change: D2G

DomainStartEndE-ValueType
Pfam:7tm_4 31 237 5.9e-36 PFAM
Pfam:7TM_GPCR_Srsx 35 227 1.9e-4 PFAM
Pfam:7tm_1 41 235 1.3e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213291
AA Change: D2G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000216101
AA Change: D2G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.5%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Angpt4 G T 2: 151,771,517 (GRCm39) V278L probably benign Het
Dmbt1 A G 7: 130,633,827 (GRCm39) probably benign Het
Dnah2 A T 11: 69,321,304 (GRCm39) N3921K probably benign Het
Duxf4 G A 10: 58,071,356 (GRCm39) T286I possibly damaging Het
Fam193a A T 5: 34,623,016 (GRCm39) E1201D probably benign Het
Gm10220 G C 5: 26,322,826 (GRCm39) D195E probably damaging Het
Gmps A G 3: 63,922,857 (GRCm39) K607E possibly damaging Het
Gprin1 T A 13: 54,886,288 (GRCm39) D662V probably benign Het
Gria4 A G 9: 4,464,294 (GRCm39) I556T probably damaging Het
Grm7 G T 6: 110,623,309 (GRCm39) V161F probably damaging Het
Hcar2 A T 5: 124,002,768 (GRCm39) V245E probably damaging Het
Hmces T G 6: 87,894,823 (GRCm39) D62E probably benign Het
Ighv1-4 T A 12: 114,450,769 (GRCm39) Y113F possibly damaging Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Kng1 C T 16: 22,898,120 (GRCm39) H507Y possibly damaging Het
Lypd10 A G 7: 24,412,821 (GRCm39) I76M possibly damaging Het
Map3k5 A T 10: 19,970,175 (GRCm39) Y694F probably damaging Het
Myo1a T G 10: 127,552,214 (GRCm39) F778V probably damaging Het
Naip2 A C 13: 100,298,290 (GRCm39) I582S probably benign Het
Or4l1 G A 14: 50,166,489 (GRCm39) H171Y probably benign Het
Or6aa1 A G 7: 86,043,884 (GRCm39) V274A probably benign Het
Or6z6 A T 7: 6,491,470 (GRCm39) Y134* probably null Het
Parp3 C A 9: 106,348,514 (GRCm39) S507I possibly damaging Het
Ppip5k2 T A 1: 97,671,800 (GRCm39) T491S probably damaging Het
Psmg1 T A 16: 95,781,248 (GRCm39) I266F probably damaging Het
Ptpn23 T C 9: 110,218,763 (GRCm39) T476A probably benign Het
Rttn G C 18: 89,032,744 (GRCm39) V671L probably damaging Het
Srsf7 T C 17: 80,508,990 (GRCm39) E235G unknown Het
Sv2a G A 3: 96,096,751 (GRCm39) W416* probably null Het
Tas2r107 A G 6: 131,636,972 (GRCm39) Y26H probably benign Het
Tenm2 T C 11: 35,914,800 (GRCm39) T2245A probably damaging Het
Vmn2r13 T A 5: 109,319,627 (GRCm39) H451L possibly damaging Het
Xkr6 T C 14: 64,056,793 (GRCm39) Y235H unknown Het
Other mutations in Or1ad1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01069:Or1ad1 APN 11 50,875,830 (GRCm39) missense possibly damaging 0.94
R1386:Or1ad1 UTSW 11 50,876,194 (GRCm39) missense probably damaging 0.97
R1486:Or1ad1 UTSW 11 50,875,608 (GRCm39) missense probably benign 0.00
R1613:Or1ad1 UTSW 11 50,876,045 (GRCm39) missense probably damaging 1.00
R2224:Or1ad1 UTSW 11 50,876,059 (GRCm39) missense probably damaging 1.00
R2411:Or1ad1 UTSW 11 50,875,758 (GRCm39) missense probably damaging 0.98
R4080:Or1ad1 UTSW 11 50,875,683 (GRCm39) missense probably damaging 1.00
R4753:Or1ad1 UTSW 11 50,875,978 (GRCm39) missense probably benign 0.05
R4764:Or1ad1 UTSW 11 50,875,602 (GRCm39) missense probably benign 0.00
R4822:Or1ad1 UTSW 11 50,875,910 (GRCm39) nonsense probably null
R4865:Or1ad1 UTSW 11 50,876,370 (GRCm39) missense probably damaging 0.99
R5053:Or1ad1 UTSW 11 50,876,137 (GRCm39) missense probably damaging 1.00
R6054:Or1ad1 UTSW 11 50,875,631 (GRCm39) missense probably benign 0.00
R6368:Or1ad1 UTSW 11 50,875,613 (GRCm39) missense probably benign 0.00
R7589:Or1ad1 UTSW 11 50,875,857 (GRCm39) missense probably damaging 0.98
R7843:Or1ad1 UTSW 11 50,875,845 (GRCm39) missense probably benign 0.06
R8056:Or1ad1 UTSW 11 50,876,368 (GRCm39) missense probably damaging 0.98
R9189:Or1ad1 UTSW 11 50,876,166 (GRCm39) missense probably damaging 1.00
R9486:Or1ad1 UTSW 11 50,875,691 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- TGCAGTTCAGAAGCTGTGGAAG -3'
(R):5'- TCAACACTGGAGAGGTTGGC -3'

Sequencing Primer
(F):5'- TATGGGAAGCATGCTTGC -3'
(R):5'- CCAAGAAGAAGTACATGGGTGTGTG -3'
Posted On 2015-01-11