Incidental Mutation 'R3019:Vmn1r64'
| ID |
257710 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r64
|
| Ensembl Gene |
ENSMUSG00000058399 |
| Gene Name |
vomeronasal 1 receptor 64 |
| Synonyms |
V1rd11 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.053)
|
| Stock # |
R3019 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
5886579-5887541 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 5887226 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 106
(S106P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000077568
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000078475]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000078475
AA Change: S106P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000077568
Gene: ENSMUSG00000058399
AA Change: S106P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
8 |
296 |
3.3e-13 |
PFAM |
|
Pfam:V1R
|
41 |
296 |
1.5e-19 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 92.5%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 15 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Atr |
C |
A |
9: 95,787,871 (GRCm39) |
A1488E |
possibly damaging |
Het |
| Bahd1 |
C |
T |
2: 118,746,887 (GRCm39) |
P169S |
probably damaging |
Het |
| Birc2 |
C |
T |
9: 7,857,390 (GRCm39) |
|
probably null |
Het |
| Cntnap5a |
T |
C |
1: 116,029,299 (GRCm39) |
L251P |
probably benign |
Het |
| Fryl |
G |
T |
5: 73,240,193 (GRCm39) |
H1406N |
probably benign |
Het |
| Heatr6 |
T |
A |
11: 83,669,658 (GRCm39) |
|
probably null |
Het |
| Hjurp |
GT |
GTT |
1: 88,194,246 (GRCm39) |
|
probably null |
Het |
| Lamb3 |
T |
C |
1: 193,013,717 (GRCm39) |
|
probably null |
Het |
| Lhx5 |
G |
T |
5: 120,578,070 (GRCm39) |
A297S |
probably benign |
Het |
| Med18 |
G |
A |
4: 132,187,128 (GRCm39) |
R124C |
probably damaging |
Het |
| Synpo2 |
A |
G |
3: 122,907,228 (GRCm39) |
V696A |
probably damaging |
Het |
| Tgfbr3 |
C |
A |
5: 107,285,412 (GRCm39) |
R563L |
possibly damaging |
Het |
| Tm6sf1 |
A |
G |
7: 81,525,813 (GRCm39) |
T207A |
probably benign |
Het |
| Vmn1r56 |
C |
A |
7: 5,199,061 (GRCm39) |
M185I |
probably benign |
Het |
| Vmn2r114 |
ATTT |
ATT |
17: 23,509,906 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn1r64 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00161:Vmn1r64
|
APN |
7 |
5,886,827 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01070:Vmn1r64
|
APN |
7 |
5,886,941 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01817:Vmn1r64
|
APN |
7 |
5,887,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02026:Vmn1r64
|
APN |
7 |
5,886,649 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02657:Vmn1r64
|
APN |
7 |
5,886,727 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL03352:Vmn1r64
|
APN |
7 |
5,887,070 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0200:Vmn1r64
|
UTSW |
7 |
5,886,817 (GRCm39) |
missense |
probably benign |
0.38 |
|
R0540:Vmn1r64
|
UTSW |
7 |
5,887,096 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0655:Vmn1r64
|
UTSW |
7 |
5,887,207 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1212:Vmn1r64
|
UTSW |
7 |
5,887,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1579:Vmn1r64
|
UTSW |
7 |
5,886,803 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2034:Vmn1r64
|
UTSW |
7 |
5,886,988 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2221:Vmn1r64
|
UTSW |
7 |
5,887,448 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2240:Vmn1r64
|
UTSW |
7 |
5,887,369 (GRCm39) |
nonsense |
probably null |
|
|
R2305:Vmn1r64
|
UTSW |
7 |
5,887,535 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4256:Vmn1r64
|
UTSW |
7 |
5,886,895 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4666:Vmn1r64
|
UTSW |
7 |
5,887,357 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4996:Vmn1r64
|
UTSW |
7 |
5,887,052 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5682:Vmn1r64
|
UTSW |
7 |
5,886,622 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5730:Vmn1r64
|
UTSW |
7 |
5,887,522 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7397:Vmn1r64
|
UTSW |
7 |
5,887,013 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9697:Vmn1r64
|
UTSW |
7 |
5,886,859 (GRCm39) |
missense |
probably benign |
0.04 |
|
X0063:Vmn1r64
|
UTSW |
7 |
5,887,349 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGGACCACTGACATACATTG -3'
(R):5'- GGACTGTGGGCAACATCTTTC -3'
Sequencing Primer
(F):5'- CCACTGACATACATTGGCATGTAAG -3'
(R):5'- TTGACTGACTCCCGACTGAG -3'
|
| Posted On |
2015-01-11 |
Incidental Mutation