Incidental Mutation 'R2989:Zfp981'
ID |
257857 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp981
|
Ensembl Gene |
ENSMUSG00000056300 |
Gene Name |
zinc finger protein 981 |
Synonyms |
Gm13247 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.094)
|
Stock # |
R2989 (G1)
|
Quality Score |
113 |
Status
|
Not validated
|
Chromosome |
4 |
Chromosomal Location |
146586484-146623852 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 146622347 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Asparagine
at position 424
(I424N)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000136739
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105735]
[ENSMUST00000140089]
[ENSMUST00000179175]
|
AlphaFold |
A2A8V7 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000105735
AA Change: I424N
PolyPhen 2
Score 0.403 (Sensitivity: 0.89; Specificity: 0.89)
|
SMART Domains |
Protein: ENSMUSP00000101361 Gene: ENSMUSG00000056300 AA Change: I424N
Domain | Start | End | E-Value | Type |
KRAB
|
13 |
73 |
2.34e-15 |
SMART |
ZnF_C2H2
|
239 |
261 |
7.9e-4 |
SMART |
ZnF_C2H2
|
267 |
289 |
8.6e-5 |
SMART |
ZnF_C2H2
|
295 |
317 |
8.6e-5 |
SMART |
ZnF_C2H2
|
323 |
345 |
1.36e-2 |
SMART |
ZnF_C2H2
|
351 |
373 |
6.32e-3 |
SMART |
ZnF_C2H2
|
379 |
401 |
8.6e-5 |
SMART |
ZnF_C2H2
|
407 |
429 |
3.11e-2 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000140089
|
SMART Domains |
Protein: ENSMUSP00000115886 Gene: ENSMUSG00000056300
Domain | Start | End | E-Value | Type |
KRAB
|
13 |
73 |
2.34e-15 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000145269
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000179175
AA Change: I424N
PolyPhen 2
Score 0.403 (Sensitivity: 0.89; Specificity: 0.89)
|
SMART Domains |
Protein: ENSMUSP00000136739 Gene: ENSMUSG00000056300 AA Change: I424N
Domain | Start | End | E-Value | Type |
KRAB
|
13 |
73 |
2.34e-15 |
SMART |
ZnF_C2H2
|
239 |
261 |
7.9e-4 |
SMART |
ZnF_C2H2
|
267 |
289 |
8.6e-5 |
SMART |
ZnF_C2H2
|
295 |
317 |
8.6e-5 |
SMART |
ZnF_C2H2
|
323 |
345 |
1.36e-2 |
SMART |
ZnF_C2H2
|
351 |
373 |
6.32e-3 |
SMART |
ZnF_C2H2
|
379 |
401 |
8.6e-5 |
SMART |
ZnF_C2H2
|
407 |
429 |
3.11e-2 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000181199
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.4%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 23 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adgrv1 |
G |
A |
13: 81,729,866 (GRCm39) |
T205I |
probably damaging |
Het |
Arhgap32 |
T |
A |
9: 32,150,694 (GRCm39) |
N31K |
possibly damaging |
Het |
C1galt1 |
A |
G |
6: 7,866,622 (GRCm39) |
D156G |
possibly damaging |
Het |
Chrna3 |
C |
T |
9: 54,923,334 (GRCm39) |
C158Y |
probably damaging |
Het |
Cnot1 |
T |
C |
8: 96,470,906 (GRCm39) |
E1314G |
possibly damaging |
Het |
Coil |
C |
A |
11: 88,878,805 (GRCm39) |
A520D |
probably damaging |
Het |
Cpe |
G |
T |
8: 65,050,549 (GRCm39) |
N386K |
probably benign |
Het |
Fat4 |
T |
C |
3: 39,061,302 (GRCm39) |
I4295T |
probably benign |
Het |
Foxn1 |
C |
G |
11: 78,249,603 (GRCm39) |
G641R |
possibly damaging |
Het |
G530012D18Rik |
GAGAGAGACAGAGAGACAGAGA |
GAGAGAGACAGAGA |
1: 85,504,937 (GRCm39) |
|
probably null |
Het |
Intu |
A |
G |
3: 40,647,140 (GRCm39) |
K671R |
probably benign |
Het |
Jup |
T |
C |
11: 100,267,667 (GRCm39) |
D552G |
possibly damaging |
Het |
Kcnk9 |
T |
C |
15: 72,384,207 (GRCm39) |
T324A |
unknown |
Het |
Mettl5 |
G |
T |
2: 69,711,659 (GRCm39) |
A69E |
probably damaging |
Het |
Or8b3b |
A |
T |
9: 38,583,831 (GRCm39) |
M303K |
probably benign |
Het |
Rpf2 |
A |
G |
10: 40,115,749 (GRCm39) |
S77P |
probably benign |
Het |
Sgo1 |
A |
G |
17: 53,994,162 (GRCm39) |
Y97H |
probably benign |
Het |
Srsf12 |
T |
C |
4: 33,223,599 (GRCm39) |
Y33H |
probably damaging |
Het |
Tcerg1 |
T |
A |
18: 42,652,540 (GRCm39) |
M56K |
unknown |
Het |
Trafd1 |
T |
C |
5: 121,517,529 (GRCm39) |
T63A |
probably damaging |
Het |
Ttc28 |
G |
A |
5: 111,371,881 (GRCm39) |
V777I |
probably benign |
Het |
Ubr4 |
A |
G |
4: 139,190,869 (GRCm39) |
E937G |
possibly damaging |
Het |
Zfp677 |
T |
C |
17: 21,617,114 (GRCm39) |
I57T |
probably benign |
Het |
|
Other mutations in Zfp981 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02647:Zfp981
|
APN |
4 |
146,621,709 (GRCm39) |
nonsense |
probably null |
|
R0003:Zfp981
|
UTSW |
4 |
146,622,217 (GRCm39) |
missense |
probably damaging |
1.00 |
R1172:Zfp981
|
UTSW |
4 |
146,622,221 (GRCm39) |
missense |
probably benign |
|
R4158:Zfp981
|
UTSW |
4 |
146,622,339 (GRCm39) |
missense |
probably benign |
0.07 |
R4158:Zfp981
|
UTSW |
4 |
146,622,080 (GRCm39) |
missense |
probably benign |
|
R4778:Zfp981
|
UTSW |
4 |
146,622,112 (GRCm39) |
missense |
probably benign |
|
R5148:Zfp981
|
UTSW |
4 |
146,621,357 (GRCm39) |
missense |
possibly damaging |
0.86 |
R5352:Zfp981
|
UTSW |
4 |
146,621,462 (GRCm39) |
missense |
probably benign |
0.29 |
R6252:Zfp981
|
UTSW |
4 |
146,621,970 (GRCm39) |
missense |
probably benign |
0.22 |
R6674:Zfp981
|
UTSW |
4 |
146,619,950 (GRCm39) |
missense |
probably damaging |
0.98 |
R6765:Zfp981
|
UTSW |
4 |
146,622,363 (GRCm39) |
missense |
probably benign |
0.34 |
R7288:Zfp981
|
UTSW |
4 |
146,622,100 (GRCm39) |
missense |
probably benign |
0.32 |
R7816:Zfp981
|
UTSW |
4 |
146,622,100 (GRCm39) |
missense |
probably benign |
0.32 |
R7835:Zfp981
|
UTSW |
4 |
146,622,333 (GRCm39) |
missense |
probably benign |
0.01 |
R8020:Zfp981
|
UTSW |
4 |
146,621,825 (GRCm39) |
missense |
possibly damaging |
0.91 |
R8797:Zfp981
|
UTSW |
4 |
146,619,906 (GRCm39) |
nonsense |
probably null |
|
R8805:Zfp981
|
UTSW |
4 |
146,622,410 (GRCm39) |
missense |
possibly damaging |
0.86 |
R9145:Zfp981
|
UTSW |
4 |
146,622,410 (GRCm39) |
missense |
possibly damaging |
0.72 |
R9324:Zfp981
|
UTSW |
4 |
146,619,884 (GRCm39) |
missense |
possibly damaging |
0.95 |
R9471:Zfp981
|
UTSW |
4 |
146,622,080 (GRCm39) |
missense |
probably benign |
|
Z1176:Zfp981
|
UTSW |
4 |
146,621,547 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Predicted Primers |
PCR Primer
(F):5'- AATGTAGTGAATGCGACAAATGCT -3'
(R):5'- ATTGACTGCATTTGTAAGGCTTCT -3'
Sequencing Primer
(F):5'- TTCATTCTGGGAAAGCATCAGAG -3'
(R):5'- ATGAATTCTCTGATGCCTTCTCAGAG -3'
|
Posted On |
2015-01-11 |