Incidental Mutation 'R2989:Zfp981'
ID 257857
Institutional Source Beutler Lab
Gene Symbol Zfp981
Ensembl Gene ENSMUSG00000056300
Gene Name zinc finger protein 981
Synonyms Gm13247
Accession Numbers
Essential gene? Probably non essential (E-score: 0.094) question?
Stock # R2989 (G1)
Quality Score 113
Status Not validated
Chromosome 4
Chromosomal Location 146586484-146623852 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 146622347 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 424 (I424N)
Ref Sequence ENSEMBL: ENSMUSP00000136739 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105735] [ENSMUST00000140089] [ENSMUST00000179175]
AlphaFold A2A8V7
Predicted Effect probably benign
Transcript: ENSMUST00000105735
AA Change: I424N

PolyPhen 2 Score 0.403 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000101361
Gene: ENSMUSG00000056300
AA Change: I424N

DomainStartEndE-ValueType
KRAB 13 73 2.34e-15 SMART
ZnF_C2H2 239 261 7.9e-4 SMART
ZnF_C2H2 267 289 8.6e-5 SMART
ZnF_C2H2 295 317 8.6e-5 SMART
ZnF_C2H2 323 345 1.36e-2 SMART
ZnF_C2H2 351 373 6.32e-3 SMART
ZnF_C2H2 379 401 8.6e-5 SMART
ZnF_C2H2 407 429 3.11e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000140089
SMART Domains Protein: ENSMUSP00000115886
Gene: ENSMUSG00000056300

DomainStartEndE-ValueType
KRAB 13 73 2.34e-15 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145269
Predicted Effect probably benign
Transcript: ENSMUST00000179175
AA Change: I424N

PolyPhen 2 Score 0.403 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000136739
Gene: ENSMUSG00000056300
AA Change: I424N

DomainStartEndE-ValueType
KRAB 13 73 2.34e-15 SMART
ZnF_C2H2 239 261 7.9e-4 SMART
ZnF_C2H2 267 289 8.6e-5 SMART
ZnF_C2H2 295 317 8.6e-5 SMART
ZnF_C2H2 323 345 1.36e-2 SMART
ZnF_C2H2 351 373 6.32e-3 SMART
ZnF_C2H2 379 401 8.6e-5 SMART
ZnF_C2H2 407 429 3.11e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181199
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 G A 13: 81,729,866 (GRCm39) T205I probably damaging Het
Arhgap32 T A 9: 32,150,694 (GRCm39) N31K possibly damaging Het
C1galt1 A G 6: 7,866,622 (GRCm39) D156G possibly damaging Het
Chrna3 C T 9: 54,923,334 (GRCm39) C158Y probably damaging Het
Cnot1 T C 8: 96,470,906 (GRCm39) E1314G possibly damaging Het
Coil C A 11: 88,878,805 (GRCm39) A520D probably damaging Het
Cpe G T 8: 65,050,549 (GRCm39) N386K probably benign Het
Fat4 T C 3: 39,061,302 (GRCm39) I4295T probably benign Het
Foxn1 C G 11: 78,249,603 (GRCm39) G641R possibly damaging Het
G530012D18Rik GAGAGAGACAGAGAGACAGAGA GAGAGAGACAGAGA 1: 85,504,937 (GRCm39) probably null Het
Intu A G 3: 40,647,140 (GRCm39) K671R probably benign Het
Jup T C 11: 100,267,667 (GRCm39) D552G possibly damaging Het
Kcnk9 T C 15: 72,384,207 (GRCm39) T324A unknown Het
Mettl5 G T 2: 69,711,659 (GRCm39) A69E probably damaging Het
Or8b3b A T 9: 38,583,831 (GRCm39) M303K probably benign Het
Rpf2 A G 10: 40,115,749 (GRCm39) S77P probably benign Het
Sgo1 A G 17: 53,994,162 (GRCm39) Y97H probably benign Het
Srsf12 T C 4: 33,223,599 (GRCm39) Y33H probably damaging Het
Tcerg1 T A 18: 42,652,540 (GRCm39) M56K unknown Het
Trafd1 T C 5: 121,517,529 (GRCm39) T63A probably damaging Het
Ttc28 G A 5: 111,371,881 (GRCm39) V777I probably benign Het
Ubr4 A G 4: 139,190,869 (GRCm39) E937G possibly damaging Het
Zfp677 T C 17: 21,617,114 (GRCm39) I57T probably benign Het
Other mutations in Zfp981
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02647:Zfp981 APN 4 146,621,709 (GRCm39) nonsense probably null
R0003:Zfp981 UTSW 4 146,622,217 (GRCm39) missense probably damaging 1.00
R1172:Zfp981 UTSW 4 146,622,221 (GRCm39) missense probably benign
R4158:Zfp981 UTSW 4 146,622,339 (GRCm39) missense probably benign 0.07
R4158:Zfp981 UTSW 4 146,622,080 (GRCm39) missense probably benign
R4778:Zfp981 UTSW 4 146,622,112 (GRCm39) missense probably benign
R5148:Zfp981 UTSW 4 146,621,357 (GRCm39) missense possibly damaging 0.86
R5352:Zfp981 UTSW 4 146,621,462 (GRCm39) missense probably benign 0.29
R6252:Zfp981 UTSW 4 146,621,970 (GRCm39) missense probably benign 0.22
R6674:Zfp981 UTSW 4 146,619,950 (GRCm39) missense probably damaging 0.98
R6765:Zfp981 UTSW 4 146,622,363 (GRCm39) missense probably benign 0.34
R7288:Zfp981 UTSW 4 146,622,100 (GRCm39) missense probably benign 0.32
R7816:Zfp981 UTSW 4 146,622,100 (GRCm39) missense probably benign 0.32
R7835:Zfp981 UTSW 4 146,622,333 (GRCm39) missense probably benign 0.01
R8020:Zfp981 UTSW 4 146,621,825 (GRCm39) missense possibly damaging 0.91
R8797:Zfp981 UTSW 4 146,619,906 (GRCm39) nonsense probably null
R8805:Zfp981 UTSW 4 146,622,410 (GRCm39) missense possibly damaging 0.86
R9145:Zfp981 UTSW 4 146,622,410 (GRCm39) missense possibly damaging 0.72
R9324:Zfp981 UTSW 4 146,619,884 (GRCm39) missense possibly damaging 0.95
R9471:Zfp981 UTSW 4 146,622,080 (GRCm39) missense probably benign
Z1176:Zfp981 UTSW 4 146,621,547 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- AATGTAGTGAATGCGACAAATGCT -3'
(R):5'- ATTGACTGCATTTGTAAGGCTTCT -3'

Sequencing Primer
(F):5'- TTCATTCTGGGAAAGCATCAGAG -3'
(R):5'- ATGAATTCTCTGATGCCTTCTCAGAG -3'
Posted On 2015-01-11