Incidental Mutation 'R0152:Zmynd10'
Institutional Source Beutler Lab
Gene Symbol Zmynd10
Ensembl Gene ENSMUSG00000010044
Gene Namezinc finger, MYND domain containing 10
MMRRC Submission 038435-MU
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.701) question?
Stock #R0152 (G1)
Quality Score195
Status Not validated
Chromosomal Location107547298-107551319 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 107550945 bp
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000113252 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000010188] [ENSMUST00000010211] [ENSMUST00000093786] [ENSMUST00000122225] [ENSMUST00000156198] [ENSMUST00000193303]
Predicted Effect probably null
Transcript: ENSMUST00000010188
SMART Domains Protein: ENSMUSP00000010188
Gene: ENSMUSG00000010044

Pfam:zf-MYND 394 430 1.1e-10 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000010211
SMART Domains Protein: ENSMUSP00000010211
Gene: ENSMUSG00000010067

low complexity region 98 115 N/A INTRINSIC
RA 124 218 6.26e-24 SMART
PDB:4LGD|H 219 264 3e-13 PDB
Predicted Effect probably null
Transcript: ENSMUST00000093786
SMART Domains Protein: ENSMUSP00000091301
Gene: ENSMUSG00000010067

C1 44 101 4.7e-7 SMART
low complexity region 168 185 N/A INTRINSIC
RA 194 288 6.26e-24 SMART
PDB:4LGD|H 289 334 3e-12 PDB
Predicted Effect probably null
Transcript: ENSMUST00000122225
SMART Domains Protein: ENSMUSP00000113252
Gene: ENSMUSG00000010067

C1 44 105 1.92e-3 SMART
low complexity region 172 189 N/A INTRINSIC
RA 198 292 6.26e-24 SMART
Pfam:Nore1-SARAH 299 338 4.2e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125080
Predicted Effect probably benign
Transcript: ENSMUST00000156198
SMART Domains Protein: ENSMUSP00000117722
Gene: ENSMUSG00000010067

Blast:C1 44 83 6e-24 BLAST
SCOP:d1ptq__ 52 82 5e-10 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191832
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192445
Predicted Effect probably benign
Transcript: ENSMUST00000193303
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193782
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195158
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195627
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.3%
  • 20x: 89.5%
Validation Efficiency 87% (40/46)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass T C 6: 23,074,689 D834G probably damaging Het
Abca13 T A 11: 9,581,724 H4650Q probably damaging Het
Aqr T A 2: 114,159,010 T111S probably benign Het
Arfip2 G A 7: 105,637,223 T124M probably damaging Het
Arhgap44 G T 11: 65,011,919 A574E probably benign Het
Arhgef26 T C 3: 62,423,544 S560P probably damaging Het
Car5a T A 8: 121,916,446 N273I probably damaging Het
Cd4 G A 6: 124,867,746 Q359* probably null Het
Cgrrf1 G A 14: 46,853,913 C298Y probably damaging Het
Clip3 G A 7: 30,303,432 A416T probably benign Het
Dst C T 1: 34,189,119 P1606L probably damaging Het
Eif3e G A 15: 43,252,236 A378V possibly damaging Het
Ercc6 C G 14: 32,546,905 probably benign Het
Eri2 A G 7: 119,790,383 V104A probably damaging Het
Exph5 T A 9: 53,353,204 probably null Het
Hmcn1 A T 1: 150,663,879 Y2954N probably benign Het
Itga2 C T 13: 114,866,314 G547R probably benign Het
Kbtbd11 T C 8: 15,027,428 V9A probably damaging Het
Ldb2 T C 5: 44,541,799 D99G possibly damaging Het
Mfsd12 G T 10: 81,357,799 D68Y probably damaging Het
Mgarp T C 3: 51,388,963 D228G probably benign Het
Myh14 A T 7: 44,623,181 L1441Q probably damaging Het
Obscn T C 11: 59,052,576 D4810G probably benign Het
Olfr1331 T A 4: 118,868,886 I34N possibly damaging Het
Olfr1448 A G 19: 12,920,108 V67A possibly damaging Het
Olfr293 A T 7: 86,664,511 Y283F probably damaging Het
Olfr372 C T 8: 72,058,400 T240M probably damaging Het
Olfr948 A G 9: 39,319,461 I51T probably benign Het
Pdhx A G 2: 103,028,280 V393A probably benign Het
Pdpk1 C T 17: 24,106,946 R92H possibly damaging Het
Pgr A T 9: 8,965,022 I889F probably benign Het
Pum2 T A 12: 8,728,754 I468K possibly damaging Het
Recql5 A G 11: 115,894,673 S666P probably benign Het
Rims4 C T 2: 163,863,929 V262M possibly damaging Het
Slc17a3 C T 13: 23,855,858 S293F probably damaging Het
Slc26a4 T C 12: 31,529,498 I588M probably damaging Het
Slc9a2 A G 1: 40,742,804 T398A probably damaging Het
Snapc1 C T 12: 73,975,032 R81C probably damaging Het
Tub A T 7: 109,020,927 N93Y probably damaging Het
Usp3 T C 9: 66,540,150 T181A probably damaging Het
Vars2 A G 17: 35,660,027 L637P probably damaging Het
Vmn2r1 T C 3: 64,081,819 S60P possibly damaging Het
Wdcp A G 12: 4,851,583 S480G probably benign Het
Zbtb38 T C 9: 96,686,280 Y917C probably damaging Het
Zfp68 T C 5: 138,606,613 K445E probably damaging Het
Other mutations in Zmynd10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02007:Zmynd10 APN 9 107550532 missense probably damaging 0.96
R0749:Zmynd10 UTSW 9 107548683 missense probably damaging 0.96
R1899:Zmynd10 UTSW 9 107550037 missense probably benign 0.20
R1900:Zmynd10 UTSW 9 107550037 missense probably benign 0.20
R4111:Zmynd10 UTSW 9 107549052 nonsense probably null
R5403:Zmynd10 UTSW 9 107550586 missense possibly damaging 0.59
R5468:Zmynd10 UTSW 9 107550337 missense probably benign 0.00
R6430:Zmynd10 UTSW 9 107548712 nonsense probably null
R6743:Zmynd10 UTSW 9 107547880 missense possibly damaging 0.94
R7117:Zmynd10 UTSW 9 107547517 missense probably benign 0.22
R7247:Zmynd10 UTSW 9 107548777 missense possibly damaging 0.95
R7291:Zmynd10 UTSW 9 107549304 missense probably benign 0.00
R8263:Zmynd10 UTSW 9 107549317 missense possibly damaging 0.84
Predicted Primers
Posted On2015-01-14