Incidental Mutation 'R3159:Zranb3'
ID 258047
Institutional Source Beutler Lab
Gene Symbol Zranb3
Ensembl Gene ENSMUSG00000036086
Gene Name zinc finger, RAN-binding domain containing 3
Synonyms 4933425L19Rik
MMRRC Submission 040610-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.146) question?
Stock # R3159 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 127881921-128030784 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 127900686 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 713 (I713T)
Ref Sequence ENSEMBL: ENSMUSP00000108157 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086614] [ENSMUST00000112538]
AlphaFold Q6NZP1
Predicted Effect probably benign
Transcript: ENSMUST00000086614
AA Change: I713T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000083806
Gene: ENSMUSG00000036086
AA Change: I713T

DomainStartEndE-ValueType
DEXDc 33 214 3.37e-19 SMART
HELICc 352 435 3.79e-13 SMART
ZnF_RBZ 619 643 6.93e-5 SMART
HNHc 985 1036 5.64e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000112538
AA Change: I713T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000108157
Gene: ENSMUSG00000036086
AA Change: I713T

DomainStartEndE-ValueType
Pfam:SNF2_N 40 98 6.6e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143389
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bltp1 T C 3: 37,013,564 (GRCm39) V1931A probably benign Het
Ccdc146 T C 5: 21,604,790 (GRCm39) E16G unknown Het
Ccr4 G T 9: 114,321,350 (GRCm39) N238K probably benign Het
Cdk15 T C 1: 59,340,440 (GRCm39) I313T probably damaging Het
Celsr3 T C 9: 108,704,909 (GRCm39) V464A possibly damaging Het
Cfap54 T C 10: 92,834,918 (GRCm39) I1096V probably benign Het
Dmpk A G 7: 18,826,944 (GRCm39) T579A probably benign Het
Dscam T C 16: 96,479,710 (GRCm39) T1146A probably benign Het
Galnt12 A G 4: 47,104,264 (GRCm39) D174G probably damaging Het
Gm5145 A G 17: 20,791,155 (GRCm39) I178V probably benign Het
Gxylt1 A G 15: 93,142,913 (GRCm39) I384T probably benign Het
Hmgcr C T 13: 96,802,355 (GRCm39) V110I probably damaging Het
Hsd17b2 A C 8: 118,485,491 (GRCm39) D318A probably damaging Het
Ighv8-6 A G 12: 115,129,508 (GRCm39) S83P probably damaging Het
Isg20 C A 7: 78,564,201 (GRCm39) A36E possibly damaging Het
Jade3 A G X: 20,345,783 (GRCm39) K54E probably damaging Het
Mark1 A T 1: 184,640,584 (GRCm39) Y505N probably damaging Het
Mmp11 C T 10: 75,762,948 (GRCm39) probably benign Het
Myo1g G T 11: 6,464,527 (GRCm39) T511K possibly damaging Het
Ociad1 A T 5: 73,467,688 (GRCm39) R155* probably null Het
Or5t7 A G 2: 86,506,855 (GRCm39) I274T probably benign Het
Pcdha2 C T 18: 37,074,250 (GRCm39) T627I probably damaging Het
Polg2 A C 11: 106,659,163 (GRCm39) V450G probably benign Het
Rbm48 A T 5: 3,646,105 (GRCm39) V33D possibly damaging Het
Rfx6 A T 10: 51,602,816 (GRCm39) R778W probably damaging Het
Sav1 A T 12: 70,031,326 (GRCm39) D65E probably benign Het
Sh3rf1 C T 8: 61,679,321 (GRCm39) P121L probably benign Het
Shank2 C A 7: 143,635,611 (GRCm39) N328K probably damaging Het
Slc8a3 C A 12: 81,361,766 (GRCm39) R351L probably damaging Het
Slc9b1 G A 3: 135,077,606 (GRCm39) G100E probably damaging Het
Slit1 A G 19: 41,592,812 (GRCm39) Y1214H probably benign Het
Smu1 T A 4: 40,754,529 (GRCm39) R123S possibly damaging Het
Tgfb3 A T 12: 86,105,760 (GRCm39) W332R probably damaging Het
Tmem132a C T 19: 10,836,901 (GRCm39) W680* probably null Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Trav4-4-dv10 A T 14: 53,921,559 (GRCm39) K86* probably null Het
Zfp667 T C 7: 6,308,999 (GRCm39) C556R probably damaging Het
Other mutations in Zranb3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00565:Zranb3 APN 1 127,943,877 (GRCm39) missense probably benign 0.01
IGL00818:Zranb3 APN 1 127,960,604 (GRCm39) missense probably damaging 1.00
IGL01360:Zranb3 APN 1 127,887,622 (GRCm39) nonsense probably null
IGL01704:Zranb3 APN 1 127,895,676 (GRCm39) missense possibly damaging 0.93
IGL02131:Zranb3 APN 1 127,920,688 (GRCm39) missense probably damaging 1.00
IGL02466:Zranb3 APN 1 127,943,829 (GRCm39) missense probably benign 0.08
IGL02825:Zranb3 APN 1 127,887,489 (GRCm39) missense probably benign 0.13
IGL02836:Zranb3 APN 1 127,888,562 (GRCm39) missense probably benign 0.00
R0088:Zranb3 UTSW 1 127,904,199 (GRCm39) missense probably benign
R0279:Zranb3 UTSW 1 127,891,510 (GRCm39) missense probably benign 0.01
R0423:Zranb3 UTSW 1 128,019,607 (GRCm39) missense probably damaging 1.00
R0499:Zranb3 UTSW 1 127,882,817 (GRCm39) splice site probably null
R0562:Zranb3 UTSW 1 127,964,295 (GRCm39) missense probably benign 0.04
R0972:Zranb3 UTSW 1 127,884,383 (GRCm39) missense probably damaging 1.00
R1480:Zranb3 UTSW 1 128,019,599 (GRCm39) missense probably damaging 1.00
R1552:Zranb3 UTSW 1 127,888,488 (GRCm39) splice site probably benign
R1704:Zranb3 UTSW 1 128,019,740 (GRCm39) start codon destroyed probably null 0.22
R1817:Zranb3 UTSW 1 127,945,293 (GRCm39) critical splice donor site probably null
R1818:Zranb3 UTSW 1 127,945,293 (GRCm39) critical splice donor site probably null
R1819:Zranb3 UTSW 1 127,945,293 (GRCm39) critical splice donor site probably null
R1951:Zranb3 UTSW 1 127,927,136 (GRCm39) missense probably damaging 1.00
R1953:Zranb3 UTSW 1 127,927,136 (GRCm39) missense probably damaging 1.00
R1988:Zranb3 UTSW 1 127,887,480 (GRCm39) missense probably benign
R2011:Zranb3 UTSW 1 128,019,638 (GRCm39) missense probably benign 0.00
R4179:Zranb3 UTSW 1 127,888,601 (GRCm39) missense possibly damaging 0.88
R4281:Zranb3 UTSW 1 127,891,614 (GRCm39) missense possibly damaging 0.69
R4400:Zranb3 UTSW 1 127,884,392 (GRCm39) missense possibly damaging 0.87
R5236:Zranb3 UTSW 1 127,968,726 (GRCm39) missense probably damaging 1.00
R5330:Zranb3 UTSW 1 127,887,457 (GRCm39) missense probably damaging 0.99
R5719:Zranb3 UTSW 1 127,891,613 (GRCm39) missense probably benign 0.00
R6125:Zranb3 UTSW 1 127,887,482 (GRCm39) missense probably benign
R6220:Zranb3 UTSW 1 127,927,141 (GRCm39) missense probably benign 0.44
R6414:Zranb3 UTSW 1 127,968,694 (GRCm39) missense probably benign 0.08
R6751:Zranb3 UTSW 1 127,887,556 (GRCm39) missense probably benign
R7229:Zranb3 UTSW 1 127,968,630 (GRCm39) missense probably benign 0.00
R7419:Zranb3 UTSW 1 127,891,588 (GRCm39) missense possibly damaging 0.86
R7537:Zranb3 UTSW 1 127,960,584 (GRCm39) critical splice donor site probably null
R7771:Zranb3 UTSW 1 127,960,605 (GRCm39) missense probably damaging 1.00
R7980:Zranb3 UTSW 1 128,030,671 (GRCm39) unclassified probably benign
R8152:Zranb3 UTSW 1 127,882,732 (GRCm39) missense probably damaging 1.00
R8370:Zranb3 UTSW 1 127,895,670 (GRCm39) missense probably benign 0.00
R8458:Zranb3 UTSW 1 127,920,647 (GRCm39) missense probably damaging 1.00
R8816:Zranb3 UTSW 1 127,964,347 (GRCm39) missense possibly damaging 0.95
R8969:Zranb3 UTSW 1 127,888,588 (GRCm39) missense possibly damaging 0.80
R9369:Zranb3 UTSW 1 127,887,828 (GRCm39) missense probably benign 0.00
R9468:Zranb3 UTSW 1 127,891,496 (GRCm39) critical splice donor site probably null
Z1176:Zranb3 UTSW 1 127,964,218 (GRCm39) missense probably benign 0.25
Z1176:Zranb3 UTSW 1 127,892,885 (GRCm39) missense possibly damaging 0.55
Predicted Primers PCR Primer
(F):5'- GGAGAGAGCCATCTGGTATTTAAAG -3'
(R):5'- TTGTAATCCTAGCTGGCCGC -3'

Sequencing Primer
(F):5'- TTGAAACAGGGTCTCATATAGCCCAG -3'
(R):5'- TGGCCGCAACCATCTTCAG -3'
Posted On 2015-01-23