Incidental Mutation 'R3160:Camk1g'
ID 258088
Institutional Source Beutler Lab
Gene Symbol Camk1g
Ensembl Gene ENSMUSG00000016179
Gene Name calcium/calmodulin-dependent protein kinase I gamma
Synonyms CLICK-III, CaMKIgamma
MMRRC Submission 040611-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R3160 (G1)
Quality Score 128
Status Not validated
Chromosome 1
Chromosomal Location 193028654-193052606 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 193042115 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 45 (T45A)
Ref Sequence ENSEMBL: ENSMUSP00000128143 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000016323] [ENSMUST00000169907]
AlphaFold Q91VB2
Predicted Effect probably benign
Transcript: ENSMUST00000016323
AA Change: T45A

PolyPhen 2 Score 0.434 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000016323
Gene: ENSMUSG00000016179
AA Change: T45A

DomainStartEndE-ValueType
S_TKc 23 277 9.53e-112 SMART
low complexity region 376 389 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000163202
SMART Domains Protein: ENSMUSP00000131451
Gene: ENSMUSG00000016179

DomainStartEndE-ValueType
S_TKc 2 238 5.19e-72 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000165718
Predicted Effect possibly damaging
Transcript: ENSMUST00000169907
AA Change: T45A

PolyPhen 2 Score 0.657 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000128143
Gene: ENSMUSG00000016179
AA Change: T45A

DomainStartEndE-ValueType
S_TKc 23 277 9.53e-112 SMART
Meta Mutation Damage Score 0.1663 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein similar to calcium/calmodulin dependent protein kinase, however, its exact function is not known. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired dendritogenesis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy9 A G 16: 4,129,452 (GRCm39) L715P probably damaging Het
Amer2 A G 14: 60,616,000 (GRCm39) D65G probably damaging Het
Btnl2 T C 17: 34,577,039 (GRCm39) W65R probably damaging Het
Ccdc181 T A 1: 164,107,865 (GRCm39) S183T probably damaging Het
Cep350 T C 1: 155,738,910 (GRCm39) H2311R probably benign Het
Copa T A 1: 171,918,800 (GRCm39) C127S probably damaging Het
Crbn T C 6: 106,767,827 (GRCm39) Q221R probably benign Het
Dapk2 T G 9: 66,161,893 (GRCm39) V267G probably damaging Het
Decr1 T A 4: 15,930,972 (GRCm39) D120V probably damaging Het
Dennd1c C T 17: 57,373,562 (GRCm39) G637D possibly damaging Het
Disp1 T C 1: 182,868,806 (GRCm39) K1205E probably benign Het
Dnajc13 G T 9: 104,097,097 (GRCm39) N510K possibly damaging Het
Hnrnpu T C 1: 178,158,690 (GRCm39) probably benign Het
Iqgap1 G A 7: 80,402,086 (GRCm39) A393V probably benign Het
Irak2 G T 6: 113,649,721 (GRCm39) A119S probably benign Het
Itgb2l A G 16: 96,238,589 (GRCm39) L70P probably damaging Het
Itsn1 C A 16: 91,649,932 (GRCm39) S202* probably null Het
Mill2 A C 7: 18,590,099 (GRCm39) E127A probably benign Het
Msh6 T C 17: 88,292,909 (GRCm39) Y555H probably damaging Het
Myo18b A C 5: 112,840,594 (GRCm39) S2400A probably damaging Het
Naa25 A G 5: 121,573,135 (GRCm39) probably null Het
Nop2 A G 6: 125,111,555 (GRCm39) N96S probably benign Het
Or11g24 T A 14: 50,662,488 (GRCm39) C171S probably damaging Het
Or13c7b T A 4: 43,820,544 (GRCm39) K272N probably benign Het
Or2z2 T C 11: 58,346,053 (GRCm39) T241A probably damaging Het
Or4c52 T G 2: 89,845,365 (GRCm39) Y30* probably null Het
Pde5a T A 3: 122,575,277 (GRCm39) L356* probably null Het
Prss59 A G 6: 40,903,003 (GRCm39) M123T probably benign Het
Ralgapa1 A T 12: 55,756,371 (GRCm39) N1075K probably damaging Het
Rps2 G T 17: 24,939,952 (GRCm39) A129S probably benign Het
Serinc2 A G 4: 130,154,528 (GRCm39) S175P probably benign Het
Socs5 A T 17: 87,442,146 (GRCm39) Q362L probably damaging Het
Srbd1 A T 17: 86,437,643 (GRCm39) D233E probably benign Het
Srgap3 A G 6: 112,706,619 (GRCm39) V826A probably benign Het
Tns2 A G 15: 102,021,771 (GRCm39) E1118G possibly damaging Het
Topaz1 T C 9: 122,578,446 (GRCm39) I452T probably benign Het
Tuba8 A G 6: 121,199,697 (GRCm39) D127G possibly damaging Het
Tulp4 A G 17: 6,248,983 (GRCm39) M1V probably null Het
Urb1 A G 16: 90,594,791 (GRCm39) L247P probably damaging Het
Usp32 A G 11: 84,916,362 (GRCm39) W861R probably damaging Het
Vmn1r48 G A 6: 90,013,360 (GRCm39) T155I probably benign Het
Vmn2r117 A G 17: 23,679,352 (GRCm39) L624P probably damaging Het
Vstm5 T G 9: 15,168,594 (GRCm39) S53A probably benign Het
Yeats2 T C 16: 20,012,395 (GRCm39) V531A probably damaging Het
Other mutations in Camk1g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00433:Camk1g APN 1 193,029,657 (GRCm39) unclassified probably benign
IGL02637:Camk1g APN 1 193,030,696 (GRCm39) missense probably benign 0.38
G1patch:Camk1g UTSW 1 193,032,628 (GRCm39) missense possibly damaging 0.80
I2288:Camk1g UTSW 1 193,033,414 (GRCm39) splice site probably benign
R0375:Camk1g UTSW 1 193,038,709 (GRCm39) splice site probably benign
R0433:Camk1g UTSW 1 193,036,366 (GRCm39) missense probably damaging 0.99
R0967:Camk1g UTSW 1 193,032,604 (GRCm39) missense probably damaging 1.00
R1161:Camk1g UTSW 1 193,030,662 (GRCm39) missense probably benign
R1227:Camk1g UTSW 1 193,029,741 (GRCm39) missense possibly damaging 0.73
R1469:Camk1g UTSW 1 193,044,399 (GRCm39) missense possibly damaging 0.89
R1469:Camk1g UTSW 1 193,044,399 (GRCm39) missense possibly damaging 0.89
R1641:Camk1g UTSW 1 193,038,665 (GRCm39) missense probably benign 0.25
R3109:Camk1g UTSW 1 193,037,301 (GRCm39) missense probably damaging 1.00
R3161:Camk1g UTSW 1 193,042,115 (GRCm39) missense possibly damaging 0.66
R3162:Camk1g UTSW 1 193,042,115 (GRCm39) missense possibly damaging 0.66
R3162:Camk1g UTSW 1 193,042,115 (GRCm39) missense possibly damaging 0.66
R4638:Camk1g UTSW 1 193,038,667 (GRCm39) missense probably damaging 1.00
R4642:Camk1g UTSW 1 193,038,667 (GRCm39) missense probably damaging 1.00
R4644:Camk1g UTSW 1 193,038,667 (GRCm39) missense probably damaging 1.00
R4756:Camk1g UTSW 1 193,044,393 (GRCm39) missense probably benign 0.03
R4781:Camk1g UTSW 1 193,038,652 (GRCm39) missense probably benign 0.00
R4987:Camk1g UTSW 1 193,030,783 (GRCm39) missense probably damaging 0.99
R5224:Camk1g UTSW 1 193,037,342 (GRCm39) missense probably damaging 1.00
R5407:Camk1g UTSW 1 193,029,680 (GRCm39) splice site probably null
R5932:Camk1g UTSW 1 193,036,347 (GRCm39) missense probably benign 0.25
R6725:Camk1g UTSW 1 193,032,628 (GRCm39) missense possibly damaging 0.80
R7071:Camk1g UTSW 1 193,042,117 (GRCm39) missense probably benign 0.10
R7808:Camk1g UTSW 1 193,032,593 (GRCm39) missense possibly damaging 0.51
R7908:Camk1g UTSW 1 193,042,082 (GRCm39) missense probably damaging 1.00
R8135:Camk1g UTSW 1 193,036,335 (GRCm39) missense possibly damaging 0.79
R8355:Camk1g UTSW 1 193,033,355 (GRCm39) missense probably damaging 1.00
R8737:Camk1g UTSW 1 193,030,794 (GRCm39) critical splice acceptor site probably null
R8811:Camk1g UTSW 1 193,044,408 (GRCm39) missense probably damaging 1.00
R9506:Camk1g UTSW 1 193,030,363 (GRCm39) critical splice donor site probably null
R9680:Camk1g UTSW 1 193,030,483 (GRCm39) missense probably benign 0.00
R9688:Camk1g UTSW 1 193,031,029 (GRCm39) missense probably damaging 1.00
Z1176:Camk1g UTSW 1 193,044,408 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCACAATACCCACAGCTGTG -3'
(R):5'- AGCACACTGGTATGTCAGATAGG -3'

Sequencing Primer
(F):5'- CTGTGGAAATCAAGCTCATTTGCC -3'
(R):5'- CACTGGTATGTCAGATAGGCAGTG -3'
Posted On 2015-01-23